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| 1 | MicroRNAs:Role in hepatitis C virus pathogenesis显示文摘Hepatitis C virus(HCV)is a global health burden with an estimated 170e200 million peoples chronically infected worldwide.HCV infection remains as an independent risk factor for chronic hepatitis,liver cirrhosis,hepatocellular carcinoma,and a major reason for liver transplantation.Discovery of direct acting antiviral(DAA)drugs have shown promising results with more than 90%success rate in clearing the HCV RNA in patients,although long-term consequences remain to be evaluated.microRNAs(miRNAs)are important players in establishment of HCV infection and target crucial host cellular factors needed for productive HCV replication and augmented cell growth.Altered expression of miRNAs is involved in the pathogenesis associated with HCV infection by controlling signaling pathways such as immune response,proliferation and apoptosis.miRNA is emerging as a means of communication between various cell types inside the liver.There is likely possibility of developing circulating miRNAs as biomarkers of disease progression and can also serve as diagnostic tool with potential of early therapeutic intervention in HCV associated end stage liver disease.This review focuses on recent studies highlighting the contribution of miRNAs in HCV life cycle and their coordinated regulation in HCV mediated liver disease progression. | Shubham Shrivastava Robert Steele Ranjit Ray Ratna B.Ray | 2015 | Genes & Diseases2015，2，1： | 6 |
| 2 | Hepatitis C virus infection,microRNA and liver disease progression显示文摘Hepatitis C virus(HCV) is a global health problem with an estimated 170-200 million peoples(approximately3% of world population) are chronically infected worldwide and new infections are predicted to be on rise in coming years. HCV infection remains categorized as a major risk factor for chronic hepatitis,liver cirrhosis and hepatocellular carcinoma worldwide. There has been considerable improvement in our understanding of virus life cycle since,the discovery of HCV two-decades ago.MicroRNAs(miRNAs) are important players in establishment of HCV infection and their propagation in infected hepatocytes. They target crucial host cellular factors needed for productive HCV replication and augmented cell growth.Very first anti-miRNA oligonucleotides,miravirsen has been tested in clinical trial and shown promising results as therapeutic agent in treatment against chronic HCV infection.Deregulated expression of miRNAs has been linked to the pathogenesis associated with HCV infection by controlling signaling pathways such as,proliferation,apoptosis and migration. Circulating miRNAs emerging as growing field in identification of biomarkers in disease progression and their potential as a means of communication between cells inside the liver is an exciting area of research in future.This review focuses on recent studies enforcing the contribution of miRNAs in HCV life cycle and coordinated regulation in HCV mediated liver disease progression. | Shubham Shrivastava Anupam Mukherjee Ratna B Ray | 2013 | World Journal of Hepatology2013，5，9： | 6 |
| 3 | Hepatitis C Virus Induces Interleukin-1β (IL-1β)/IL-18 in Circulatory and Resident Liver Macrophages显示文摘 | Shubham Shrivastava Anupam Mukherjee Ranjit Ray Ratna B. Ray | 2013 | Journal of Virology2013，，22： | 1 |
| 4 | Hepatitis C Virus Infection Modulates Expression of Interferon Stimulatory Gene IFITM1 by Upregulating miR-130A显示文摘 | Joydip Bhanja Chowdhury Shubham Shrivastava Robert Steele Adrian M. Di Bisceglie Ranjit Ray Ratna B. Ray | 2012 | Journal of Virology2012，，18： | 1 |
| 5 | Ascorbic acid ameliorates isoniazid-rifampicin-induced hepatocellular damage in rats显示文摘Background:Phyto-constituents are widely recognized for hepatoprotective effects.Ascorbic acid is extensively studied for the radical scavenging effect.The objective of the present study was to evaluate the hepatoprotective effect of ascorbic acid against isoniazid and rifampicin-induced liver damage in rats.Methods:Wistar rats were used in the present study.Hepato-cellular damage was produced by the administration of isoniazid(100 mg/kg)and rifampicin(100 mg/kg)for 21 days.Ascorbic acid was administered in the dose of 50,100,and 200 mg/kg body weight.At the end of the study,blood was collected and biochemical studies were performed to determine antioxidant status.Results:Ascorbic acid administration(50,100,and 200 mg/kg body weight)caused restoration of serum glutamic oxaloacetic transaminase,serum glutamic-pyruvic transaminase,and serum alkaline phosphatase.The level of superoxide dismutase and catalase were also restored due to the administration of ascorbic acid.There was a decrement in the expression of tumor necrosis factor-α,interleukin-1β,interleukin-6,malondialdehyde and nitric oxide.Conclusion:The outcome of the study established ascorbic acid as a notable hepatoprotective effect.The radical scavenging and cytokine suppression effect is the possible mechanism associated with the hepatoprotective effect of ascorbic acid. | Shubham Patel Aman Chaturvedi Nazneen Dubey Abhishek Shrivastava Aditya Ganeshpurkar | 2022 | iLIVER2022，1，1： | 0 |
| 6 | Oncofertility:Treatment options from bench to bedside显示文摘In recent years,there has been continuous improvement in the treatment and diagnosis of cancer,which has led to a significant improvement in the survival rate of cancer patients.Treatments that include chemotherapy,radiotherapy,surgery,or combined therapy have several side effects that may lead to premature ovarian insufficiency in females or substantial male germ cell loss.Reproductive biologists recommend that all patients who are diagnosed with a malignant tumor must undergo a consultation for fertility protection and preservation.In this review,we discuss the background knowledge,methods,and options for fertility preservation and how these new strategies help oncologists,surgeons,pediatricians,and hematologists,conserve fertility and be aware of the concepts,methods,and importance of fertility guards.This review may aid in the advancement of novel personalized methods for fertility preservation according to patients’conditions. | Divya Gupta Shubham Singh Sangeeta Shukla Sadhana Shrivastava | 2023 | Cancer Pathogenesis and Therapy2023，1，4： | 0 |
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