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| 1 | A 4-bp Insertion at ZmPLA 1 Encoding a Putative Phospholipase A Generates Haploid Induction in Maize显示文摘 | Chenxu Liu Xiang Li Dexuan Meng Yu Zhong Chen Chen Xin Dong Xiaowei Xu Baojian Chen Wei Li Liang Li Xiaolong Tian Haiming Zhao Weibin Song Haishan Luo Qinghua Zhang Jinsheng Lai Weiwei Jin Jianbing Yan Shaojiang Chen | 2017 | Molecular Plant2017，10，3： | 39 |
| 2 | Discovery of β-Dihydroagarofuran-Type Sesquiterpenoids from the Leaves of Tripterygium wilfordii with Neuroprotective Activities显示文摘Nine undescribed dihydro-β-agarofuran sesquiterpenoid derivatives(1—9),along with a known analogue(10),were obtained from the leaves of Tripterygium wilfordii.Their gross structures were determined via extensive spectroscopic data,and the absolute configurations were elucidated by means of single-crystal X-ray diffraction analysis and electron circular dichroism(ECD)techniques,which include ECD exciton chirality,octant rule of saturated cyclohexanone and comparison between the experimental and calculated ECD spectra.All the isolated compounds were tested for their neuroprotective activities against H2O2-induced cell injury in human neuroblastoma SH-SY5Y cells.Compounds 5 and 6 improved cell viability by 16.15%and 15.12%compared with the H2O2 treated group at 25μmol·L^(-1),respectively. | Shuhui Dong Bin Lin Xiaobian Xue Ming Bai Xiaoxiao Huang Shaojiang Song | 2021 | Chinese Journal of Chemistry2021，39，2： | 4 |
| 3 | Genkwadane F-I,New Daphnane-type Diterpenes from the Flower Buds of Daphne genkwa Sieb.et Zucc.Exhibit Anti-tumor Activities via lnducing Apoptosis显示文摘of main observation and conclusion Genkwadane F-I(1-4),four new diterpenes,along with four known ones(5-8),were isolated from the flower buds of D.genkwa.The structures including absolute configurations of 1-4 were determined based on the analysis of NMR and ECD calculations.All compounds were evaluated for their cytotoxicities against MCF-7 and Hep3B cell lines,among which compounds 3 and 4 showed significant activities.Compound 4 exhibited the most potent activity with IC50 values of 1.33μM against MCF-7,and the IC50 values of compound 3 against MCF-7 and Hep3B were 5.54μM and 8.73μM;respectively.Further studies by Hoechst 33258 staining and Annexin V/PI analysis demonstrated that compounds 3 and 4 could induce apoptosis to exhibit anti-tumor activities. | Xuewen Hou Jingjie Chen Xuefen Hou Pinyi Gao Jinlin Wang Shaojiang Song Lingzhi Li | 2020 | Chinese Journal of Chemistry2020，38，12： | 1 |
| 4 | New norlignan enantiomers from the fruit of Crataegus pinnatifida with neuroprotective activities显示文摘(±)-Crataegusnorin A(la/1b) and B(2a/2b),two pairs of rare 8,9’-epoxy-type norlignan enantiomers featuring a y-butyrolactone ring,were isolated from the fruit of Crataegus pinnatifida.Their structures were determined via extensive spectroscopic analyses.Gauge-independent atomic orbital(GIAO) NMR chemical shift calculations,combined with the advanced statistical method DP4+were employed to establish the relative configurations of four compounds.Next,chiral separation was accomplished by chiral chromatographic column and the absolute configurations of the four compounds were unambiguously assigned by comparison between their experimental electronic circular dichroism curves with the quantum-mechanically calculated curves based on time-dependent density functional theory(TDDFT).All the isolates were evaluated fo r their neuroprotective activities against H2O2-induced cell injury in human neuroblastoma SH-SY5Y cells.The results showed that two pairs of enantiomers 1a/1b and 2a/2b displayed diff;erent effect on neuroprotective activity.Among them,compound 2a displayed the most potent neuroprotective effect Further flow cytometry analysis indicated that 2a could protect SH-SY5Y cells from oxidative damage through inhibiting cell apoptosis. | Rui Guo Tianming Lv Fengying Han Zilin Hou Guodong Yao Bin Lin Xiaobo Wang Xiaoxiao Huang Shaojiang Song | 2020 | Chinese Chemical Letters2020，31，5： | 1 |
| 5 | Method for eliminating mode mixing of empirical mode decom- position based on the revised blind source separation 显示文摘 | Tang Baoping Dong Shaojiang Song Tao | 2012 | Signal Processing2012，92，1： | 1 |
| 6 | Uncovering the mechanism of Scutellariae Radix in the treatment of breast cancer based on network pharmacology显示文摘Breast cancer(BCa)is one of the most common malignant tumors that seriously affect women’s physical and mental health and even endanger their lives.Establishing a primary prevention program for BCa remains a challenge.Traditional Chinese medicine,Scutellariae Radix(SR),has been used to treat BCa while its pharmacological mechanism is still unclear.This study aims to reveal the pharmacological mechanism of SR in the treatment of BCa.Chemical constituents of SR were obtained and the targets of the compound were identified via Traditional Chinese Medicine Systems Pharmacology Database(TCMSP).GeneCards and DrugBank databases were used to collect BCa’s related target genes.Disease-compound common target protein interaction network was established by using the STRING database.The network diagrams of the active component-action target and protein-protein interaction(PPI)networks were constructed by Cytoscape software.Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analyses were carried out to further explore the BCa mechanism and therapeutic effect of SR.As a result,121 active compounds were obtained.The Venn diagram results showed that SR and BCa had 57 intersection targets,the more frequently targeted ones are TP53,JUN,CCND1,AKT1,which could affect biological processes such as response to steroid hormone and positive regulation of cell death.KEGG analysis revealed that these targets were related to IL-17 signaling pathway,p53 signaling pathway and PI3K-Akt signaling pathway.In conclusion,this study preliminarily verified the target and mode of action of SR in the treatment of BCa,laying a foundation for further research on its mechanism. | Qian Li Shaojiang Song | 2022 | Asian Journal of Traditional Medicines2022，17，4： | 0 |
| 7 | Virtual screening of active ingredients,potential targets and pathways from Elephantopus scaber L.against liver cancer based on network pharmacology显示文摘Elephantopus scaber L.,belonging to Elephantopus plant of Compositae,is widely used as the common Chinese herbal medicine in folk.According to the phytochemical investigations,E.scaber is used to treat several cancers,anemia and diarrhea on account of the property of the complex components and multi-targets.However,the underlying molecular mechanisms of herb remain unclear.In this report,network pharmacology method is used to analyze the relation among the small-molecule compounds of E.scaber,target proteins,biological pathways and liver cancer.The potential active compounds from the E.scaber,potential target proteins and the key pathways were predicted by network pharmacology models.We believe that our present study is useful to find novel lead compounds for liver cancer. | Shuhui Dong Ming Bai Xiaoxiao Huang Shaojiang Song | 2019 | Asian Journal of Traditional Medicines2019，14，6： | 0 |
| 8 | Volatile oil from Litsea lancilimba Merr.: a review of its chemical structure and biological activity显示文摘Litsea lancilimba Merr.is a Cinnamomum plant of Lauraceae.Phytochemical investigations of the Litsea lancilimba Merr.have resulted in the isolation of Volatile oil,flavonoid glycosides,tannins,alkaloids,lignans,organic acids and so on.Studies have showed that volatile oil is the main chemical component.Recent trials have demonstrated the efficacy of Litsea lancilimba Merr.in strengthening the function of stomach.The fruits have also been demonstrated to possess anti-inflammatory and bacteriostatic activities.This review deals mainly with the chemical structure and biological activities of Litsea lancilimba Merr.oil. | Yijie Zhang Ming Bai Weiyu Zhou Xiaoxiao Huang Shaojiang Song | 2022 | Asian Journal of Traditional Medicines2022，17，4： | 0 |
| 9 | Network pharmacology-based study on compounds from Camptotheca acuminate inhibiting liver cancer cells显示文摘Camptotheca acuminate belongs to Nyssaceae family and has been used as traditional Chinese medicine for several years.A number of compounds with anti-tumor activities have been isolated from C.acuminate.However,the targets of some compounds have not been determined.In this study,network pharmacology methods were used to analyze 74 compounds from C.acuminate and 49 target proteins of liver cancer.The results showed that the target with the largest number of directed edges was Dihydroorotate Dehydrogenase(1d3g).The compound docked with 1d3g best was AL.23(19-O-methyangustoline).The results of this study provide further insight into the role of network pharmacology as an effective tool to illuminate the research on liver cancer. | Jingxian Ren Zhuoyang Cheng Xiaoxiao Huang Shaojiang Song | 2021 | Asian Journal of Traditional Medicines2021，16，1： | 0 |
| 10 | A review:The chemical components and pharmacological activities of Piper auritum Kunth显示文摘Piper auritum Kunth,a member of the Piperacea family,is a small shrub native to the Central American tropics.This plant was traditionally used in Latin American countries for the treatment of various medical conditions.Increase in the recent studies of P.auritum’s chemical components leads to the isolation of monoterpenoids,sesquiterpenoids,phenylpropanoids and several other compounds.Previous research has revealed that these secondary metabolites have diverse pharmacological activities including antidiabetic,antioxidant,anti-inflammatory,anti-pathogeny microorganism and repellent activity.This review summarizes relevant findings on P.auritum,and hopes to contribute to the exploration of its potentials for further development as an alternative medicine. | Jiayi Wang Weiyu Zhou Xiaoxiao Huang Shaojiang Song | 2021 | Asian Journal of Traditional Medicines2021，16，6： | 0 |
| 11 | Study on the pharmacological activities and chemical structures of Viburnum dilatatum显示文摘Viburnum dilatatum(jiami in Chinese),belonging to the Caprifollaceae family,is widely distributed in Japan and China.Phytochemical investigations of Viburnum dilatatum(V.dilatatum)have resulted in the isolation of triterpenoids,phenolic glycosides essential oil,norisoprenoids,etc.Research results have shown that the chemical constituents of V.dilatatum possess various pharmacological activities,including antihyperglycemic,antioxidant activity and antiulcer effects.This study reviewed the chemical constituents and pharmacological activities of V.dilatatum to provide practical and useful information for further research and development of this plant. | Zhiheng Gao Yufei Xi Man Wang Xiaoxiao Huang Shaojiang Song | 2023 | Asian Journal of Traditional Medicines2023，18，2： | 0 |
| 12 | Research review on the main chemical constituents and pharmacological effects of Chloranthus japonicus Sieb.显示文摘Chloranthus japonicus Sieb.,belonging to the Chloranthaceae family,is a perennial herb widely distributed in East Asia,including China,Japan and Korea.Previous phytochemical studies have revealed the presence of a variety of secondary metabolites,such as terpenoids,phenylpropanoids and phenolic derivatives.Among them,sesquiterpenes and dimers,as the main chemical constituents and research focus in this plant,have a variety of biological activities.This review mainly focuses on the research progress of pharmacological activity of sesquiterpenes in this plant,which will lay the foundation for the development and utilization of its medicinal value in the future. | Shuhe Jia Rui Guo Xiaoxiao Huang Shaojiang Song | 2022 | Asian Journal of Traditional Medicines2022，17，6： | 0 |
| 13 | Network pharmacology-based prediction and verification of the molecular targets and pathways for Piper longum Linn,against liver cancer显示文摘Liver cancer is a common malignant tumor,which is one of the most common causes of cancer related deaths worldwide,specially,in China.Piper longum Linn,is a traditional Chinese medicine that is used to treat and prevent diseases in clinical practice,however,the active ingredients and potential targets of its action against liver cancer remain unclear.In this study,network pharmacology approach was used to identify active ingredients and the major targets of Piper longum against liver cancer.In addition,the key pathways were also predicted on the network pharmacology level,which might be beneficial to the chemical basis and pharmacological studies of this plant. | Liwei Lu Jie Wang Xiaoxiao Huang Shaojiang Song | 2019 | Asian Journal of Traditional Medicines2019，14，4： | 0 |
| 14 | Research review on the main chemical constituents and pharmacological effects of Elephantopus scaber L.显示文摘Elephantopus scaber L.belongs to Elephantopus plant of Compositae,is widely used as the common Chinese herbal medicine in folk.Phytochemical investigations of the E.scaber have resulted in the isolation of triterpennoids,sesquiterpene lactones,sesquiterpene phenols,steroids,flavones,anthraquinones,peptides,lipid compounds and aryl compounds.It possesses the effects of antibacterial,clearing away heat and detoxification,detumescence and diuresis,and is used for treating lung cancer,cervical cancer,liver cancer,nasopharyngeal cancer,breast cancer,anemia and diarrhea.The research progress in the chemical constituents ofE scaber and pharmacological effects are reviewed for better explore and utilize theE scaber resource. | Shuhui Dong Ming Bai Xiaoxiao Huang Shaojiang Song | 2019 | Asian Journal of Traditional Medicines2019，14，4： | 0 |
| 15 | Network pharmacology-based virtual screening of the active volatile oil ingredients of Litsea lancilimba Merr. and their potential targets for treating liver cancer显示文摘Liver cancer remains the dominant cause of cancer-related death, despite the advent of targeted therapies and immunotherapies. Therefore, there is an urgent need to explore novel chemotherapeutic agents and effective strategies against the cancer. There are a lot of monoterpenes and sesquiterpenoids in L. lancilimba. It has been reported that monoterpenes and sesquiterpenoids have certain anti-tumor effects. Literature investigation has also shown that Litsea lancilimba Merr. has antibacterial and antiviral effects. In this experiment, we used network pharmacology to screen the active compounds from L. lancilimba and their potential targets for treating liver cancer. Four active volatile oil ingredients and four potential targets have been identified. Our results provide the lead compound from L. lancilimba in the treatment of liver cancer. | Yijie Zhang Ming Bai Weiyu Zhou Xiaoxiao Huang Shaojiang Song | 2022 | Asian Journal of Traditional Medicines2022，17，2： | 0 |
| 16 | Research progress on chemical constituents in Periploca forrestii and their pharmacological activities显示文摘Periploca forrestii Schltr.belonging to the family of Apocynaceae,is one of the“three treasures of Miao medicine”,which was utilized by the Miao people in China for the treatment of rheumatoid arthritis,fractures and wound.Phytochemical investigations have discovered that the main constituents of Periploca forrestii were steroids,terpenoids,flavonoids and their glycosides,flavanols,quinones and phenylpropanoids.Modern pharmacological studies have shown that it possesses a wide range of biological activities,such as anti-inflammatory,anti-rheumatoid arthritis,anticancer,immunosuppressive,neuroprotective and other properties.This paper summarized the primary chemical constituents and pharmacological effects of Periploca forrestii,hoping to provide a reference for its further development and utilization. | Shuang Qiu Peng Zhao Xiaoxiao Huang Shaojiang Song | 2020 | Asian Journal of Traditional Medicines2020，15，6： | 0 |
| 17 | Network pharmacology-based screening of the active ingredients and potential targets of the genus of Croton for application to lung cancer显示文摘Lung cancer has been the most common cancer in the world for several decades,and it was also the most common cause of death from cancer.Despite the several advances in the last few years into treatment of lung cancer,the survival remains extremely low.There is an urgent need to discover viable leads that can be developed into new clinically therapeutic drugs with good treatment effects.The analysis of current reported literatures suggest that natural products possess strong inhibitory efficacy against lung cancer.The plants of Croton genus belonging to Euphorbiaceae family,are widely used as herbal medicine in the folk.Which are reported to have abilities to treat several cancer cell lines especially lung cancer,a successive study was carried out to identify selective anticancer agents from these plants specie.Herein we employed a network pharmacological approach to understand its multi-therapeutics potentiality in Croton genus against lung cancer.In total,the database of the compound was established based on the methods of network pharmacology prediction and the compound-disease target network was constructed.We believed that our study would provide important clues for finding novel drug inhibitors for lung cancer. | Shaochun Shi Yeqing Du Chunxin Zou Qingbo Liu Shaojiang Song | 2019 | Asian Journal of Traditional Medicines2019，14，5： | 0 |
| 18 | Research review on the main chemical constituents and pharmacological properties of the leaves of Isatis indigotica Fortune显示文摘Isatis indigotica Fortune,belonging to Isatis genus of Cruciferae family,is widely used as a common Chinese herbal medicine in folk.As a traditional medicinal agent,a wide spectrum of chemical constituents have been isolated from the leaves,including alkaloids,flavonoids,flavonoid glycosides,organic acids and glycosides.The research shows that the leaves had multiple activities and good development prospect,which has attracted a wide range of attention.Hence,this article is presented as a review concentrating on chemical constituents and pharmacological activities of the leaves of I.indigotica Fort.,aiming at supporting practical and useful information for the further research and development of this plant. | Wei Hong Yufei Xi Weiyu Zhou Xiaoxiao Huang Shaojiang Song | 2019 | Asian Journal of Traditional Medicines2019，14，5： | 0 |
| 19 | Chemical constituents and pharmacological properties of Sarcandra glabra(Thunb.)Nakai.显示文摘Sarcandra glabra(Thunb.)Nakai.,belonging to Chloranthaceae genus of Sarcandra family,is widely used as the common Chinese herbal medicine in folk.As a traditional medicinal agent,a wide spectrum of chemical constituents have been isolated from the S.glabra,including sesquiterpenoids,triperpenoids,flavonoids,coumarins,phenolic acids and volatile oil.Modern pharmacological studies have shown that S.glabra has many biological activities such as anti-cancer,hepatoprotective activity,anti-inflammatory and anti-asthmatic activities.For the further development of this plant,the primary chemical constitutions of S.glabra and their activities have been summarized in this study. | Hao Zhang Peng Zhao Yangyang Zhang Xiaoxiao Huang Shaojiang Song | 2019 | Asian Journal of Traditional Medicines2019，14，5： | 0 |
| 20 | Isolation,structure elucidation and antioxidant activity of natural products from the root bark of Ailanthus altissima(Mill.)Swingle显示文摘Eight compounds(1-8)were isolated from Ailanthus altissima(Mill.)Swingle,including four lignans,three phenylpropanoids and a simple aromatic compound,their structures were identified by nuclear magnetic resonance spectra and mass spectrometry data.Among them,compounds 1,3,5 and 8 were first obtained from this genus.In addition,free radical scavenging ability of compounds 1-8 were evaluated using DPPH,ABTS,and FRAP assays and the results showed that compound 2 exhibited potent antioxidant activity in DPPH and ABTS radical scavenging assays and compound 7 showed the highest value of FRAP radical scavenging. | Ye Chang Yuxi Wang Xiaoxiao Huang Shaojiang Song | 2020 | Asian Journal of Traditional Medicines2020，15，5： | 0 |
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