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| 1 | Effects of Saccharomycesboulardiion fecal short-chain fatty acids and microflora in patients on long-term total enteral nutrition显示文摘AIM: To assess the effects of Sb on fecal flora and shortchain fatty acids (SCFA) in patients on long-term TEN.METHODS: Ten patients (3 females, 7 males, 59±5.5 years),on TEN for a median of 13 mo (1-125), and 15 healthy volunteers (4 females, 11 males, 32±2.0 years) received Sb (0.5 g bid PO) for 6 d. Two stool samples were taken before, on the last 2 d and 9-10 d after treatment, for SCFA measurement and for culture and bacterial identification.Values (mean±SE) were compared using sign tests and ANOVA.RESULTS: Fecal butyrate levels were lower in patients(10.1±2.9 mmol/kg) than in controls (19.2±3.9, P= 0.02).Treatment with Sb increased total fecal SCFA levels in patients (150.2±27.2 vs 107.5±18.2 mmol/kg, P = 0.02)but not in controls (129.0±28.6 vs 113.0±15.2 mmol/kg,NS). At the end of treatment with Sb, patients had higher fecal butyrate (16.0±4.4 vs 10.1 [2.9] mmol/kg, P = 0.004).Total SCFAs remained high 9 d after treatment was discontinued. Before the treatment, the anaerobe to aerobe ratio was lower in patients compared to controls (2.4±2.3 vs69.8±1.8, P = 0.003). There were no significant changes in the fecal flora of TEN patients.CONCLUSION: Sb-induced increase of fecal SCFA concentrations (especially butyrate) may explain the preventive effects of this yeast on TEN-induced diarrhea. | Stéphane M Schneider Fernand Girard-Pipau Jér(o|^)me Filippi Xavier Hébuterne Dominique Moyse Gustavo Calle Hinojosa Anne Pompei Patrick Rampal | 2005 | World Journal of Gastroenterology2005，11，39： | 26 |
| 2 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 3 | Compartment-specific expression and function of the chemokine IP-10/CXCL10 in a model of renal endothelial microvascular injury显示文摘 | Panzer U Steinmetz O M Reinking R R Meyer T N Fehr S Schneider A | 2006 | J Am Soc Nephrol2006，17，： | 1 |
| 4 | The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex显示文摘 | Micheau o Thome M Schneider P | 2002 | J Biol Chem2002，277，45： | 1 |
| 5 | The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex显示文摘 | Micheau O Thome M Schneider P | 2002 | J Biol Chemistry2002，277，45： | 1 |
| 6 | Impact of alloanfigens and storageassociated factors on stim llated cytokine response in an in vitro model of blood transfus ion显示文摘 | Biedler A E Schneider S O Seyfert U | 2002 | Anesthesiology2002，97，5： | 1 |
| 7 | Mutations leading to X-linked hypohidrotic ectodermal dysplasia affect three major functional domains in the tumor necrosis factor family member ectodysplasin-A显示文摘 | Schneider P Street SL Gaide O Hertig S Tardivel A Tschopp J | 2001 | J Biol Chem2001，276，18： | 1 |
| 8 | The Bottlenose Dolphin Community of Doubtful Sound Features a Large Proportion of Long-lasting Associations: Can Geographic Isolation Explain This Unique Trait?显示文摘 | Lusseau D Schneider K Boisseau O J | 2003 | Behavioral Ecology and Sociobiology2003，54，4： | 1 |
| 9 | The bottlenose dolphin community of Doubtful Sound features a large proportion of long-lasting associations 显示文摘 | LUSSEAU D SCHNEIDER K BOISSEAU O J | | Behavioral Ecology and Soeiobiology0，54，4： | 1 |
| 10 | Differential display analysis of hemocytes from schistosome-resistant and schistosome-susceptible intermediate hosts 显示文摘 | Schneider O Zelck UE | 2001 | Parasitol Res2001，87，6： | 1 |
| 11 | Controlled degradability of polysaccharide multilayer films in vitro and in vivo 显示文摘 | PICART C SCHNEIDER A ETIENNE O | 2005 | Adv Funct Mater2005，15，11： | 1 |
| 12 | Laparoscopic abdomino-perineal resection of the rectum with high intersection of the inferior mesenteric artery显示文摘 | K(o)ckerling F Gastinger I Schneider B | 1992 | Chirurg1992，63，4： | 1 |
| 13 | Degradability of polysaccharides multilayer films in the oral environment : an in vitro and in vivo study 显示文摘 | ETIENNE O SCHNEIDER A TADDEI C | 2005 | Biomacromolecules2005，6，2： | 1 |
| 14 | Extracorpo- real perfusion of the Human uterus as an experimental model in gynaecology and reproductive medicin显示文摘 | Richer O Wardelmann E Schneider C | 2000 | Hum Reprod2000，15，6： | 1 |
| 15 | MOS- FET threshold voltage: Defnition, extraction, and some applications 显示文摘 | Siebel O F Schneider M C Galup-Montoro C | 2012 | Microelectronics Journal2012，43，5： | 1 |
| 16 | An evaluation of mandibular asymmetry in adults with unilateral posterior crossbite显示文摘 | O' Byrn B L Sadowsky C Schneider B | 1995 | Am J Orthod Dentofacial Orthop1995，107，4： | 1 |
| 17 | An evaluation of mandibular asymmetry in adults with unilateral posterior erossbite 显示文摘 | O'Byrn BL Ssdowsky C Schneider B | 1995 | Am J Orthod Dentofacial Orthop1995，107，4： | 1 |
| 18 | Oncological quality and Prelimin ary-long-term results in laparoscopic colorectal surgery显示文摘 | Seheidbach H Schneider C Hugel O | 2003 | Surg Endosc2003，17，6： | 1 |
| 19 | The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex显示文摘 | Micheau O Thome M Schneider P | 2002 | J Biol Chem2002，277，45： | 1 |
| 20 | Multiple molecular marker testing(p53, c-ki-ras, e-erbB-2)improves estimation of prognosis in potentially curative resected non-small cell lung cancer显示文摘 | Schneider PM Praeuer HW Stoeltzing O | 2000 | Br J Cancer2000，83，4： | 1 |
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