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| 1 | Multicenter study of endoscopic preoperative biliary drainage for malignant distal biliary obstruction显示文摘AIM: To determine the optimal method of endoscopic preoperative biliary drainage for malignant distal biliary obstruction.METHODS: Multicenter retrospective study was conducted in patients who underwent plastic stent(PS) or nasobiliary catheter(NBC) placement for resectable malignant distal biliary obstruction followed by surgery between January 2010 and March 2012. Procedurerelated adverse events, stent/catheter dysfunction(occlusion or migration of PS/NBC, developmentof cholangitis, or other conditions that required repeat endoscopic biliary intervention), and jaundice resolution(bilirubin level < 3.0 mg/d L) were evaluated. Cumulative incidence of jaundice resolution and dysfunction of PS/NBC were estimated using competing risk analysis. Patient characteristics and preoperative biliary drainage were also evaluated for association with the time to jaundice resolution and PS/NBC dysfunction using competing risk regression analysis.RESULTS: In total, 419 patients were included in the study(PS, 253 and NBC, 166). Primary cancers included pancreatic cancer in 194 patients(46%), bile duct cancer in 172(41%), gallbladder cancer in three(1%), and ampullary cancer in 50(12%). The median serum total bilirubin was 7.8 mg/d L and 324 patients(77%) had ≥ 3.0 mg/d L. During the median time to surgery of 29 d [interquartile range(IQR), 30-39 d]. PS/NBC dysfunction rate was 35% for PS and 18% for NBC [Subdistribution hazard ratio(SHR) = 4.76; 95%CI: 2.44-10.0, P < 0.001]; the pig-tailed tip was a risk factor for PS dysfunction. Jaundice resolution was achieved in 85% of patients and did not depend on the drainage method(PS or NBC).CONCLUSION: PS has insufficient patency for preoperative biliary drainage. Given the drawbacks of external drainage via NBC, an alternative method of internal drainage should be explored. | Naoki Sasahira Tsuyoshi Hamada Osamu Togawa Ryuichi Yamamoto Tomohisa Iwai Kiichi Tamada Yoshiaki Kawaguchi Kenji Shimura Takero Koike Yu Yoshida Kazuya Sugimori Shomei Ryozawa Toshiharu Kakimoto Ko Nishikawa Katsuya Kitamura Tsunao Imamura Masafumi Mizuide Nobuo Toda Iruru Maetani Yuji Sakai Takao Itoi Masatsugu Nagahama Yousuke Nakai Hiroyuki Isayama | 2016 | World Journal of Gastroenterology2016，22，14： | 18 |
| 2 | Comparison of endoscopic stenting for malignant biliary obstruction: A single-center study显示文摘AIM: To evaluate the efficacy and safety of single-step endoscopic placement of self-expandable metallic stents(SEMS) for treatment of obstructive jaundice.METHODS: A retrospective study was performed among 90 patients who underwent transpapillary biliary metallic stent placement for malignant biliary obstruction(MBO) between April 2005 and October 2012. The diagnosis of primary disease and MBO was based on abdominal ultrasound, computed tomography, magnetic resonance imaging, endoscopic ultrasound, endoscopic retrograde cholangiopancreatography with brush cytology, biopsy, and/or a combination of these modalities. The type of SEMS(covered or non-covered, 8 mm or 10 mm in diameter) was determined by the endoscopist. Ninety patients were divided into two groups: group 1(49 patients) who underwent a singlestep SEMS placement and group 2(41 patients) who underwent a two-step SEMS placement. The technical success rate, complication rate, stent patency, and patient survival rate were compared between the groups. In addition, to identify the clinical prognostic factors associated with patient survival, the following variables were evaluated in Cox-regression analysis: gender, age, etiology of MBO(pancreatic cancer or nonpancreatic cancer), clinical stage(Ⅳb; with distant metastases or Ⅳa >; without distant metastases), chemotherapy(with or without), patency of the stent, and the use of single-step or two-step SEMS. RESULTS: Immediate technical success was achieved in 93.9%(46/49) in group 1 and in 95.1%(39/41) in group 2, with no significant difference(P = 1.0). Similarly, there was no difference in the complication rates between the groups(group 1, 4.1% and group 2, 4.9%; P = 0.62). Stent failure was observed in 10 cases in group 1(20.4%) and in 16 cases in group 2(39.0%). The patency of stent and patient survival revealed no difference between the two groups with Kaplan-Meier analysis, with a mean patency of 111 ± 17 d in group 1 and 137 ± 19 d in group 2(P = 0.91), and a mean survival of 178 ± 35 d in group 1 and 222 ± 23 d in group 2(P = 0.57). On the contrary, the number of days of hospitalization associated with first-time SEMS placement in group 1 was shorter when compared with that number in group 2(28 vs 39 d; P < 0.05). Multivariate analysis revealed that a clinical stage of Ⅳa >(P = 0.0055), chemotherapy(P = 0.0048), and no patency of the stent(P = 0.011) were independent prognostic factors associated with patient survival.CONCLUSION: Our results showed that single-step endoscopic metal stent placement was safe and effective for treating obstructive jaundice secondary to various inoperable malignancies. | Ryuichi Yamamoto Masatomo Takahashi Yasuyo Osafune Katsuya Chinen Shingo Kato Sumiko Nagoshi Koji Yakabi | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，9： | 12 |
| 3 | Double balloon enteroscopy to retrieve an accidentally swallowed dental reamer deep in the jejunum显示文摘Accidentally swallowed foreign objects are not uncommon but difficult to manage without complications. We describe the case of a 68 year old man who accidentally a swallowed sharp-pointed dental reamer that had reached deep in his jejunum. Double balloon enteroscopic retrieval was performed with polypectomy snare but the reamer was entangled in the wire loop of the snare and penetrated the jejunal wall. After releasing the reamer by pushing and pulling the snare for approximately 30 min, the reamer was retrieved with biopsy forceps. This is the first report of double balloon enteroscopic removal of a dental reamer. Furthermore, this is a novel case with regard to decision making in situations when sharp objects are swallowed. | Shingo Kato Kazuhito Kani Hidehiko Takabayashi Ryuichi Yamamoto Koji Yakabi | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，4： | 4 |
| 4 | Overexpression of a 60-kDa heat shock protein enhances cytoprotective function of small intestinal epithelial cells显示文摘 | Makiko Takada Michiro Otaka Taiji Takahashi Yuko Izumi Kumiko Tamaki Tomoyoshi Shibuya Naoto Sakamoto Taro Osada Sou Yamamoto Ryuichi Ishida Masaru Odashima Hideaki Itoh Sumio Watanabe | 2010 | Life Sciences2010，，13： | 2 |
| 5 | Triassic bedded cherts in central Japan are not pelagic显示文摘 | SUGISAKI RYUICHI YAMAMOTO KOSHI ADACHI MAMORU | 1982 | Nature1982，298，5875： | 1 |
| 6 | Sodium alginate ameliorates indomethacin-induced gastrointestinal mucosal injury via inhibiting translocation in rats显示文摘AIM:To investigate the effects of sodium alginate(ALNa)on indomethacin-induced small intestinal lesions in rats.METHODS:Gastric injury was assessed by measuring ulcerated legions 4 h after indomethacin(25 mg/kg)administration.Small intestinal injury was assessed by measuring ulcerated legions 24 h after indomethacin(10mg/kg)administration.AL-Na and rebamipide were orally administered.Myeloperoxidase activity in the stomach and intestine were measured.Microvascular permeability,superoxide dismutase content,glutathione peroxidase activity,catalase activity,red blood cell count,white blood cell count,mucin content and enterobacterial count in the small intestine were measured.RESULTS:AL-Na significantly reduced indomethacininduced ulcer size and myeloperoxidase activity in the stomach and small intestine.AL-Na prevented increases in microvascular permeability,superoxide dismutase content,glutathione peroxidase activity and catalase activity in small intestinal injury induced by indomethacin.AL-Na also prevented decreases in red blood cells and white blood cells in small intestinal injury induced by indomethacin.Moreover,AL-Na suppressed mucin depletion by indomethacin and inhibited infiltration of enterobacteria into the small intestine.CONCLUSION:These results indicate that AL-Na ameliorates non-steroidal anti-inflammatory drug-induced small intestinal enteritis via bacterial translocation. | Atsuki Yamamoto Tomokazu Itoh Reishi Nasu Ryuichi Nishida | 2014 | World Journal of Gastroenterology2014，20，10： | 1 |
| 7 | A diclofenac suppository–nabumetone combination therapy for arthritic pain relief and a monitoring method for the diclofenac binding capacity of HSA site II in rheumatoid arthritis显示文摘 | Nao Setoguchi Norito Takamura Ken‐ichi Fujita Kenji Ogata Jin Tokunaga Toyotaka Nishio Etsuo Chosa Kazuhiko Arimori Keiichi Kawai Ryuichi Yamamoto | 2013 | Biopharm Drug Dispos2013，，2： | 1 |
| 8 | Hydrothermal chert and associated siliceous rocks from the Northern Pacific: their geological significance as indication of ocean ridge activity显示文摘 | Mamoru Adachi Koshi Yamamoto Ryuichi Sugisaki | 1986 | Sedimentary Geology1986，47，12： | 1 |
| 9 | Endothelial Apoptosis Induced by Oxidative Stress Through Activation of NF-κB: Antiapoptotic Effect of Antioxidant Agents on Endothelial Cells显示文摘 | Motokuni Aoki Toshie Nata Ryuichi Morishita Hidetsugu Matsushita Hironori Nakagami Kei Yamamoto Keita Yamazaki Mari Nakabayashi Toshio Ogihara Yasufumi Kaneda | 2001 | Hypertension: Journal of the American Heart Association2001，，1： | 1 |
| 10 | Mitogenic and Antiapoptotic Actions of Hepatocyte Growth Factor Through ERK, STAT3, and Akt in Endothelial Cells显示文摘 | Hironori Nakagami Ryuichi Morishita Kei Yamamoto Yoshiaki Taniyama Motokuni Aoki Kunio Matsumoto Toshikazu Nakamura Yasufumi Kaneda Masatsugu Horiuchi Toshio Ogihara | 2001 | Hypertension: Journal of the American Heart Association ( Part Suppl)2001，，2： | 1 |
| 11 | Ribozyme oligonucleotides against transforming growth factor-β inhibited neointimal formation after vascular injury in rat model显示文摘 | Kei Yamamoto Ryuichi Mofishita Naruya T | 2000 | Circulation2000，102，15： | 1 |
| 12 | Intraoperative circulatory management using the F lo T racTM system in laparoscopic liver resection显示文摘 | Kazuhiko Kitaguchi Naoto Gotohda Hiroyuki Yamamoto Yuichiro Kato Shinichiro Takahashi Masaru Konishi Ryuichi Hayashi | 2015 | Asian J Endosc Surg2015，，2： | 1 |
| 13 | Improvement in fatigue strength of thennite welds on rails显示文摘 | Ueyama Katsuyoshi Yasuto Fukada Yamamoto Ryuichi | 2003 | Yosetsu Gakkai Ronbunshu/Quarterly Journal of the Japan Welding Society2003，21，1： | 1 |
| 14 | Dermal neoformation during partial-thickness skin wound healing显示文摘 | Naoto Yamamoto Mashaki Nambu Ryuichi Azuma | 2004 | Ann Plast Surg2004，56，： | 1 |
| 15 | Oral nuclear factor-κB decoy oligonucleotides delivery system with chitosan modified poly( d , l -lactide-co-glycolide) nanospheres for inflammatory bowel disease显示文摘 | Kohei Tahara Sota Samura Kaori Tsuji Hiromitsu Yamamoto Yusuke Tsukada Yohei Bando Hiroyuki Tsujimoto Ryuichi Morishita Yoshiaki Kawashima | 2010 | Biomaterials2010，，3： | 1 |
| 16 | Medical Markup Language (MML) for XML-based Hospital Information Interchange显示文摘 | Kenji Araki Katsuhiro Ohashi Shunji Yamazaki Yasuyuki Hirose Yoshinori Yamashita M.D. Ryuichi Yamamoto Kazushi Minagawa Norihiro Sakamoto Hiroyuki Yoshihara | 2000 | Journal of Medical Systems2000，，3： | 1 |
| 17 | Jumbo biopsy is useful for the diagnosis of colonic prolapsing mucosal polyps with diverticulosis显示文摘我们这里在 S 字形的冒号与憩室形成报导多重 prolapsing 粘膜息肉的一个案例。因为流血腹泻,一个 52 岁的人进入我们的医院。结肠镜检查和钡灌肠在 S 字形的冒号在他们的顶上与粘液显示出多重憩室,显著地变厚的粘膜褶层和水虫息似的损害。内视镜的 ultrasonography 出现了粘膜、粘膜下层的层变厚。几个内视镜的活体检视标本从水虫息似的损害被拿。组织学的检查揭示了仅仅长期的煽动性的房间渗入。以便获得明确的诊断,我们在获得知情同意以后为水虫息似的损害执行了内视镜的巨大的活体检视。揭示的组织学的检查在薄板 propria 标记淋巴细胞渗入,含铁血黄素存款和纤维肌性涂去,粘膜 prolapsing 的类似于那些的特征症候群。在 anti-diarrhetic 处理以后,临床的调查结果被改进。因此,巨大的活体检视为 prolapsing 粘膜息肉的诊断和处理是有用的。 | Shingo Kato Kazutoshi Hashiguchi Ryuichi Yamamoto Mitsuru Seo Takashi Matsuura Kazuro Itoh Akinori Iwashita Soichiro Miura | 2006 | World Journal of Gastroenterology2006，12，10： | 1 |
| 18 | The effect of trunk muscle exercises in patients over 40 years of age with chronic low back pain显示文摘 | Norihiko Handa Hiroshi Yamamoto Toshikazu Tani Teruhiko Kawakami Ryuichi Takemasa | 2000 | Journal of Orthopaedic Science2000，，3： | 1 |
| 19 | Mild Heat Shock Induces Autophagic Growth Arrest, But Not Apoptosis in U251-MG and U87-MG Human Malignant Glioma Cells显示文摘 | Tadashi Komata Takao Kanzawa Takeo Nashimoto Hiroshi Aoki Shin Endo Masaaki Nameta Hideaki Takahashi Tadashi Yamamoto Seiji Kondo Ryuichi Tanaka | 2004 | Journal of Neuro - Oncology2004，，2： | 1 |
| 20 | Enhancement of pedicle screw stability using calcium phosphate cement in osteoporotic vertebrae: in vivo biomechanical study显示文摘 | Yoshimichi Taniwaki Ryuichi Takemasa Toshikazu Tani Hiroo Mizobuchi Hiroshi Yamamoto | 2003 | Journal of Orthopaedic Science2003，，3： | 1 |
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