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| 1 | Curative effect of Xuebijing injection on severe pulmonary contusion显示文摘OBJECTIVE: To investigate the curative effects of Xuebijing(XBJ) injection, a Chinese patent medicine, on severe pulmonary contusion(PC). METHODS: Sixty-three patients with PC were randomized to conventional therapy plus XBJ injection(n=33) or conventional therapy alone(n=30). Between groups differences in corticosteroid treatment, immune regulation therapy, hemofiltration, infusion volume, transfusion volume and antibiotic period were measured, as were intensive care unit (ICU)-free time, ventilation time, 28-day mortality rate and incidence of ventilation-associated pneumonia(VAP). Serum concentrations of procalcitonin(PCT), tumor necrosis factor-α(TNF-α), interleukin(IL)-6, and IL-10, white blood cell(WBC) counts and percentages of human leukocyte antigen DR/ CD14+(HLA-DR/CD14+) peripheral blood mononuclear cells were compared. Markers of ventilation were determined by blood gas analysis and ventilator parameters. RESULTS: WBC counts and serum concentrations of PCT, TNF-α, IL-6 and IL-10 were reduced significantly more quickly, and CD14+ percentage was increased significantly earlier, in the XBJ group than in the control group(P<0.05 each).The level of ventilation and oxygenation index were ameliorated earlier in the XBJ than in the control group(P< 0.05). XBJ treatment significantly reduced ICU-stay time, ventilation time and incidence of VAP(P<0.05 each), but had no effect on 28-day mortality rate(P>0.05). CONCLUSION: XBJ treatment can shorten ICU-free and ventilation times and reduce the incidence of VAP, improving outcomes in patients with severe PC. XBJ may act by regulating inflammation and immunity, alleviating systemic inflammatory response syndrome induced by trauma. | Yi Chen Huasheng Tong Wang Zhang Xingqin Zhang Zhigguo Pan Junming Qiu Ruihuan Pan Lei Su | 2013 | Journal of Traditional Chinese Medicine2013，33，6： | 6 |
| 2 | Research Status and Progress on Modification of Dietary Fiber at Home and Abroad显示文摘Studies have shown that modified dietary fiber has better physical and chemical properties and functions,and can better play its physiological effects.This paper systematically and comprehensively expounded the application progress of chemical separation method,microbial fermentation method,physical method,enzyme method and steam explosion method in dietary fiber modification,and expounded the development prospect of modified dietary fiber,so as to provide reference for further study on development and application of dietary fiber. | Xiaoran DUAN Suyan GAO Shoumin JIA Litian ZHANG Ruihuan DU Aili XIANG Biao QI Lei WANG | 2019 | Agricultural Biotechnology2019，8，4： | 5 |
| 3 | Identification of Histoplasma causing an unexplained disease cluster in Matthews Ridge, Guyana显示文摘Here,we report the identification of Histoplasma causing an unexplained disease cluster in Matthews Ridge,Guyana.In March 2019,14 employees of Chongqing Bosai Mining Company,China,working in a manganese mining of Guyana,had unexplained fever,and two of them died.We obtained lung and brain tissues as well as the blood samples from the two deceased cases(patient No.1 and 2),and bronchoscopy lavages and cerebrospinal fluid samples from one severe case(patient No.3),respectively.All samples were tested by pathological examination,high-throughput sequencing,and real-time PCR.Pathological detection showed the presence of spore-like structures in the lung tissue of patient No.1,indicating a fungal infection in this patient.Nanopore sequencing identified the existing of H.capsulatum in the lung tissue sample within 13 h.Next-generation sequencing identified specific fragments of H.capsulatum in all of the samples tested(lung,brain and blood serum from the deceased cases,and plasma from the severe case).Real-time PCR assays did not reveal any viral infection related to transmission from bat feces.We conclude that H.capsulatum was the causative pathogen of this disease cluster based on epidemiologic,clinical,pathological and nucleic acid evidence. | Ji Wang Weimin Zhou Hua Ling Xiaoping Dong Yi Zhang Jiandong Li Yong Zhang Jingdong Song William J.Liu Yang Li Ruiqing Zhang Wei Zhen Kun Cai Shuangli Zhu Dongyan Wang Jinbo Xiao Yigang Tong Wenli Liu Lihua Song Wei Wu Yang Liu Xiang Zhao Ruihuan Wang Sheng Ye Jing Wang Roujian Lu Baoying Huang Fei Ye Wenwen Lei Rongbao Gao Qi Shi Cao Chen Jun Han Wenbo Xu George F.Gao Xuejun Ma Guizhen Wu | 2019 | Biosafety and Health2019，1，3： | 3 |
| 4 | Study on Functional and Structure Properties of Soluble Dietary Fiber Modified by Extrusion-expansion Technology from Peanut Shells显示文摘[Objectives] This study was conducted to investigate the feasibility of using modified peanut dietary fiber as a functional food ingredient. [Methods]Using peanut shells as a test material,the process parameters of soluble dietary fiber( SDF) modified by extrusion and expansion were studied,and the functional and structural characteristics of SDF before and after modification were discussed. [Results] The optimum conditions were as follows: screw speed 200 rpm,temperature 130 ℃ and moisture content 20 %,and the SDF extraction yield was 22. 3%. The modified SDF showed BCmax values of( 378. 5 ± 5. 3),( 278. 3 ± 3. 2)and( 167. 2 ± 2. 5) μmol/g and BCmin of( 30. 4 ± 1. 3),( 63. 4 ± 3. 7) and( 71. 3 ± 4. 2) μmol/L,for Pb,As and Cu,respectively,indicating that the adsorption to the three heavy metals was enhanced. The modified SDF had a porous network like honeycomb and swelled structure. [Conclusions]Therefore,it is feasible to modify SDF by extrusion and expansion. | Xishuang XING Lixin QIANG Shuling SUN Xin ZHOU Ruihuan DU Yang LIU Zhe MENG Miaoshu WANG Weili ZHENG Lei WANG Xueying TANG | 2020 | Agricultural Biotechnology2020，9，3： | 1 |
| 5 | Pharmacological Studies of Meisoindigo: Absorption and Mechanism of Action显示文摘Meisoindigo, an indirubin derivative, is a new type of cancer chemotherapeutic agent. It exhibited higher activity against rodent tumors than indirubin itself. Experiments have shown the improved absorption of meisoindigo, compared to indirubin to be one of the major reasons for the enhancement of antitumor activity. Studies on the mechanism of meisoindigo action indicate that it strongly inhibits DNA biosynthesis in tumor cells. Strong inhibition of the drug on assembly of microtubule protein was also obtained. By means of FCM technique the effects of meisoindigo on mouse leukemia L1210 cell cycle were examined. Experimental results showed that under the action of meisoindigo the S phase cells accumulated and the traverse of the cells in G_2+M phase to G_1 phase may also be blocked to some extent. | Jl XlUJUAN, LIU XIAOMEI, LI KUN, CHEN RUIHUAN, AND WANG LONGGUIInstitute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China. | 1991 | Biomedical and Environmental Sciences1991，4，3： | 1 |
| 6 | Armored long RNA controls or standards for branched DNA assay for detection of human immunodeficiency virus type 1显示文摘 | Sien Zhan Jinming Li Ruihuan Xu Lunan Wang Kuo Zhang Rui Zhang | 2009 | J Clin Microbiol2009，47，8： | 1 |
| 7 | On the determination of particle impact breakage in selection function显示文摘This paper presents a thorough study of particle impact breakage in selection function with a unified breakage criterion.The impact mode and breakage pattern for particulate materials are classified based on a significant review of well-established impact testers.It was found that the lack of a unified breakage criterion to determine the breakage probability disables a direct comparison of particle breakage propensity from different impact loading testers.The literature breakage models to describe the breakage probability are reviewed where the advantage and drawback of these models are scrutinized.The sourced literature breakage models are compared with the zeolite breakage datasets in a unified breakage criterion to evaluate the model performance.A novel computational modelling workflow for a milling process is proposed to provide a guidance in implementing the digital twin in milling process prediction.The breakage probability models,i.e.the selection functions are comprehensively assessed in population balance model to examine the model serviceability.The model simplicity and fidelity in the model assessment are specifically discussed and the value of digital twin in substantially reducing the experimental trials is highlighted. | Li Ge Wang Ruihuan Ge Xizhong Chen | 2022 | Particuology2022，20，6： | 1 |
| 8 | Construction of Armored RNA Containing Long-Size Chimeric RNA by Increasing the Number and Affinity of the Pac Site in Exogenous RNA and Sequence Coding Coat Protein of the MS2 Bacteriophage显示文摘 | Wei Baojun Wei Yuxiang Zhang Kuo Yang Changmei Wang Jing Xu Ruihuan Zhan Sien Lin Guigao Wang Wei Liu Min Wang Lunan Zhang Rui Li Jinming | 2008 | Intervirology2008，，2： | 1 |
| 9 | Chronic pulmonary bacterial infection facilitates breast cancer lung metastasis by recruiting tumor-promoting MHCII^(hi) neutrophils显示文摘Breast cancer can metastasize to various organs,including the lungs.The immune microenvironment of the organs to be metastasized plays a crucial role in the metastasis of breast cancer.Infection with pathogens such as viruses and bacteria can alter the immune status of the lung.However,the effect of chronic inflammation caused by bacteria on the formation of a premetastatic niche within the lung is unclear,and the contribution of specific immune mediators to tumor metastasis also remains largely undetermined.Here,we used a mouse model revealing that chronic pulmonary bacterial infection augmented breast cancer lung metastasis by recruiting a distinct subtype of tumor-infiltrating MHCII^(hi) neutrophils into the lung,which exhibit cancer-promoting properties.Functionally,MHCII^(hi) neutrophils enhanced the lung metastasis of breast cancer in a cell-intrinsic manner.Furthermore,we identified CCL2 from lung tissues as an important environmental signal to recruit and maintain MHCII^(hi) neutrophils.Our findings clearly link bacterial-immune crosstalk to breast cancer lung metastasis and define MHCII^(hi) neutrophils as the principal mediator between chronic infection and tumor metastasis. | Teng Ma Yu Tang Taolin Wang Yang Yang Yige Zhang Ruihuan Wang Yongxin Zhang Yi Li Mingbo Wu Miao Tang Xueli Hu Chaoyu Zou Yuan Ren Huan Liu Qianhua Zhang Heyue Li Min Wu Jing Li Xikun Zhou | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 0 |
| 10 | Application of Liquid Chromatography-High Resolution Time-of-flight Mass Spectrometry in the Detection of Raw Milk and Dairy Products显示文摘Milk and dairy products are more and more popular with consumers due to their various nutrients, and their quality and safety issues have always been concerned. Therefore, the development of rapid, accurate and simple screening techniques is of great significance. Liquid chromatography-high resolution time-of-flight mass spectrometry has high-resolution and high-throughput detection functions, and has gradually begun to be applied in the detection of milk and dairy products. This paper summarized the application of milk and dairy products in liquid chromatography-high resolution time-of-flight mass spectrometry, laying a foundation for the development of new methods. | Yi LI Luman HUO Lixue DONG Xuesong WANG Litian ZHANG Ruihuan DU Aijun LI Lei WANG | 2021 | Agricultural Biotechnology2021，10，1： | 0 |
| 11 | Identification of Common Maize Diseases and Their Prevention and Control Methods显示文摘Agriculture is the basic industry of China's economic development,and maize is an important part of the agricultural economy.With the increase of global environmental warming and industrial pollution,as well as the adjustment of agricultural planting structure and the transformation of farming and cultivation methods in China,the breeding of maize varieties has been accelerated,and the planting area has increased rapidly,resulting in the condition that the occurrence of maize diseases and pests has been increasing.The damage of some minor diseases continued to increase nationwide or in local areas,and rose to major diseases,and some new diseases appeared in production,posing a threat to the safe production of maize.This paper summarized the occurrence status of important maize diseases in China,and put forward corresponding prevention and control countermeasures. | Xiaochun HUANG Huihui CAO Ruihuan DU Yajing WANG Shuhong ZHANG Liwu HAO Yanpo YAO Chaohui LI Jinwen ZHANG | 2022 | Agricultural Biotechnology2022，11，2： | 0 |
| 12 | Research Progression of Resveratrol on Its Physiology Function显示文摘Resveratrol(Res)is a non-flavonoid polyphenol compound containing a stilbene structure,which mainly exists in grape,peanut,mulberry,Polygonum cuspidatum and other plants.It has a variety of biological activity such as anti-oxidation,anti-aging,anti-tumor and cardiovascular disease prevention.In this paper,we reviewed the current research on resveratrol s biological activity and application,and prospected the application potential and development prospects of resveratrol in food,health products and biomedicine. | Lei WANG Ying WANG Huihui CAO Yanhua YAN Ruihuan DU Zhijun LIU Jianhua WANG Zhe MENG | 2021 | Agricultural Biotechnology2021，10，2： | 0 |
| 13 | The Development of Time-of-flight Mass Spectrometry( TOF-MS) and Its Applications in Screening Food Hazard Factors显示文摘The time-of-flight mass spectrometry(TOF-MS),one of the mass spectrometry techniques,has been widely applied in the field of rapid screening of food hazard factors as a superior analysis technique because of its wide mass range,high resolution and mass measurement accuracy,high sensitivity and high analysis speed.In this paper,research progresses of TOF-MS on the detection of food additives,food contaminants and residues,illegal additives,pesticide residues,veterinary drug residues and mycotoxin were reviewed,and its probable approaching applications were prospected. | Lei WANG Lixue DONG Yi LI Huihui CAO Yanhua YAN Ruihuan DU Aijun LI | 2020 | Agricultural Biotechnology2020，9，2： | 0 |
| 14 | Effects of Seed Dressing with Microbial Inoculum on Nutrient Composition and Biological Yield of Silage Corn显示文摘[Objectives]This study was conducted to understand the effects of microbial inocula on the biological yield and nutritional components of corn.[Methods]Silage corn varieties suitable for planting in Hebei Province were selected,and set with an experimental group and a control check group each.Meanwhile,at the late stage of milk ripening of silage corn growth cycle,the nutritional components and indexes of silage corn were determined and analyzed by a near-infrared analyzer and the NIRS technique.Meanwhile,the biological yield of silage corn was determined at the maturation stage of its growth period,aiming at comprehensively evaluating the regulation effects of the microbial inoculum tested on silage corn from the aspects of basic nutritional components,mineral element contents,energy and related indexes of corn,combined with agronomic characters and biological yield.[Results]The microbial inoculum improved the biological yield and nutritional indexes of silage corn,and had a positive regulation effect on the growth of silage corn.[Conclusions]The results of this study provide a theoretical basis for popularizing the planting methods and cultivation methods of silage corn with high yield and high quality. | Ruihuan DU Yanhua YAN Lei WANG Liang ZHANG Shuai WANG Shuo YANG Yajing WANG Huihui CAO | 2023 | Agricultural Biotechnology2023，12，5： | 0 |
| 15 | A possible mechanism of the Scandinavian ozone loss显示文摘Satellite data analysis shows an important Arctic ozone loss over the Scandinavia, with - 50 DU in winter, equivalent to 15% of the total ozone over this region. The study shows a possible mechanism causing the ozone loss. The North Atlantic current carries the heat energy northwards, and causes a relatively high surface temperature along the Scandinavia. The high temperature over the east of North Atlantic heats the atmosphere, induces an upward mass lifting, and therefore causes an ozone divergence near 330°K isoentropic surface, which leads to a decline in the total ozone. | ZOU Han(邹捍) ZHOU Libo(周立波) JI Chongping(季崇萍) WANG Wei(王维) JIAN Yongxiao(蹇泳啸) WU Ruihuan(吴瑞欢) | 2001 | Progress in Natural Science:Materials International2001，11，4： | 0 |
| 16 | Physiological Functions of Phytosterols and Their Application in Food显示文摘Phytosterols are a kind of active ingredients in plants with various physiological functions.Phytosterols have a good effect in antagonizing cholesterol and preventing cardiovascular diseases.They also have physiological functions including regulating growth,promoting protein synthesis,resisting inflammation,oxidation and cancer,and regulating immune and parahormones.In this paper,the physicochemical properties of phytosterols,the mechanism of lowering cholesterol,their application in food field and their development prospects were systematically reviewed. | Litian ZHANG Sining TANG Suyan GAO Yi ZHANG Ruihuan DU Aili XIANG Lei WANG | 2019 | Agricultural Biotechnology2019，8，3： | 0 |
| 17 | Observation of room‐temperature out‐of‐plane switchable electric polarization in supported 3R‐MoS_(2) monolayers显示文摘Two‐dimensional(2D)ferroelectrics have attracted considerable attention due to their potential in the development of devices of miniaturization and multifunction.Although several van der Waals(vdW)‐layered materials show ferroelectricity,the experimental demonstrations of ferroelectric behavior in monolayers are very limited.Here we report the observation of room‐temperature out‐of‐plane switchable electric polarization in supported MoS_(2) monolayers exfoliated from 3R‐stacked bulk crystals under ambient conditions.Using in situ piezoelectric force microscopy and Kelvin probe force microscopy in a glovebox,we reveal that trapped water/ice molecules are responsible for this switchable electric polarization and this conclusion is strongly supported by theoretical simulations.It is worth noting that the water/ice trapping in the monolayers exfoliated from 2H‐stacked MoS_(2) crystals is not as much as that in 3R monolayers and,consequently,the out‐of‐plane electric polarization is missing there.Our findings indicate that monolayers with a trapped single layer of polar molecules might be emerging alternatives to 2D ferroelectrics.Furthermore,the stacking sequences may bring new properties and applications to 2D vdW materials not only when we stack them up but also when we thin them down. | Li Ma Liu Yang Yuqiang Fang Manzhang Xu Ruihuan Duan Vanessa Li Zhang Xuewen Wang Fuqiang Huang Menghao Wu Zheng Liu Ting Yu | 2023 | SmartMat2023，4，2： | 0 |
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