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| 1 | Small Ubiquitin-Like Modifier Conjugating Enzyme with Active Site Mutation Acts as Dominant Negative Inhibitor of SUMO Conjugation in Arabidopsis显示文摘Small ubiquitin-like modifier (SUMO) conjugation affects a broad range of processes in plants, including growth, flower initiation, pathogen defense, and responses to abiotic stress. Here, we investigate in vivo and in vitro a SUMO conjugating enzyme with a Cys to Ser change in the active site, and show that it has a dominant negative effect. In planta expression significantly perturbs normal development, leading to growth retardation, early flowering and gene expression changes. We suggest that the mutant protein can serve as a probe to investigate sumoylation, also in plants for which poor genetic infrastructure precludes analysis via loss-of-function mutants. | Konstantin Tomanov Christian Hardtke Ruchika Budhiraja Rebecca Hermkes George Coupland Andreas Bachmair | 2013 | Journal of Integrative Plant Biology2013，55，1： | 4 |
| 2 | Successful Lobectomy for Pulmonary Arteriovenous Malformation Causing Recurrent Massive Haemoptysis显示文摘 | Ujjwal K. Chowdhury Shyam S. Kothari Arvind K. Bishnoi Ruchika Gupta Chander M. Mittal Srikrishna Reddy | 2008 | Heart, Lung and Circulation2008，，： | 1 |
| 3 | Recent advances in proteomics and metabolomics in plants显示文摘Over the past decade,systems biology and plant-omics have increasingly become the main stream in plant biology research.New developments in mass spectrometry and bioinformatics tools,and methodological schema to inte-grate multi-omics data have leveraged recent advances in proteomics and metabolomics.These progresses are driv-ing a rapid evolution in the field of plant research,greatly facilitating our understanding of the mechanistic aspects of plant metabolisms and the interactions of plants with their external environment.Here,we review the recent progresses in MS-based proteomics and metabolomics tools and workflows with a special focus on their applications to plant biology research using several case studies related to mechanistic understanding of stress response,gene/protein function characterization,metabolic and signaling pathways exploration,and natural product discovery.We also present a projection concerning future perspectives in MS-based proteomics and metabolomics development including their applications to and challenges for system biology.This review is intended to provide readers with an overview of how advanced MS technology,and integrated application of proteomics and metabolomics can be used to advance plant system biology research. | Shijuan Yan Ruchika Bhawal Zhibin Yin Theodore W.Thannhauser Sheng Zhang | 2022 | Molecular Horticulture2022，2，1： | 1 |
| 4 | Bladder cancer risk associated with genotypic polymorphism of the matrix metalloproteinase-1 and 7 in North Indian population显示文摘 | Priyanka Srivastava Ruchika Gangwar Rakesh Kapoor Rama D. Mittal | 2010 | Disease Markers2010，，1： | 1 |
| 5 | XPC gene variants: a risk factor for recurrence of urothelial bladder carcinoma in patients on BCG immunotherapy显示文摘 | Ruchika Gangwar Anil Mandhani Rama Devi Mittal | 2010 | Journal of Cancer Research and Clinical Oncology2010，，5： | 1 |
| 6 | Caspase 9 and Caspase 8 Gene Polymorphisms and Susceptibility to Bladder Cancer in North Indian Population显示文摘 | Ruchika Gangwar MSc Anil Mandhani MCh Rama Devi Mittal PhD | 2009 | Annals of Surgical Oncology2009，，7： | 1 |
| 7 | Ultrasensitive Electro chemical Imnmnosensor for Oral Cancer Biomarker IL 6 Using Carbon Nanotube Forest Electrodes and Multilabel Amplifica- tion 显示文摘 | Ruchika M Vyomesh P Jose PV | 2010 | Analytical chemistry2010，82，8： | 1 |
| 8 | A functional MRI investigation of the association between childhood aerobic fitness and neurocognitive control显示文摘 | Laura Chaddock Kirk I. Erickson Ruchika Shaurya Prakash Michelle W. Voss Matt VanPatter Matthew B. Pontifex Charles H. Hillman Arthur F. Kramer | 2011 | Biological Psychology2011，，1： | 1 |
| 9 | Leiomyomatosispertonea lis disseminate w ith malignant changein a post-menopausal woman显示文摘 | Prashant SK Uma CH Ruchika GU | 2004 | Gynecologic Ontology2004，95，3： | 1 |
| 10 | Influence of Sex on the Survival of Patients With Esophageal Cancer显示文摘 | Pierre Bohanes Dongyun Yang Ruchika S. Chhibar Melissa J. Labonte Thomas Winder Yan Ning Armin Gerger Léonor Benhaim David Paez Takeru Wakatsuki Fotios Loupakis Rita El-Khoueiry Wu Zhang Heinz-Josef Lenz | 2012 | Journal of Clinical Oncology2012，，18： | 1 |
| 11 | Leiomyomatosis pertonealis disseminate with malignant change in a post-menopausal woman显示文摘 | Prashant S K Uma Ch Ruchika Gu | 2004 | Gynecologic Oncology2004，95，： | 1 |
| 12 | New highly toxic bile acids derived from deoxycholic acid,chenodeoxycholic acid and lithocholic acid显示文摘 | Ferenc M Ruchika S Claire M | 2014 | Bioorg Medic Chem2014，22，1： | 1 |
| 13 | Leiomyomatosis pertonealis disseminate with malignant change in a postmenopausal woman显示文摘 | Prashant S K Uma Ch Ruchika Gu | 2004 | Gynecologic Oncology2004，95，： | 1 |
| 14 | Sacral myxopapillary ependymoma with extensive osteolysis显示文摘 | Ruchika G Rishi A Suri V | 2008 | J Neurooncol2008，86，3： | 1 |
| 15 | Potential of nutraceuticals and medicinal plants in the management of osteoarthritis显示文摘 | Ruchika K Ghanekar PR | 2012 | Acta Biologica Indica2012，1，1： | 1 |
| 16 | Antioxidative,antimicrobial and anti-inflammatory activities and release of ultra-filtered antioxidative and antimicrobial peptides during fermentation of sheep milk:In-vitro,in-silico and molecular interaction studies显示文摘The antioxidative,antimicrobial,and anti-inflammatory properties of fermented sheep milk with L.fermentum (KGL4),as well as the generation of antioxidative and antimicrobial peptides,are evaluated in the study.Antioxidative and antibacterial activities in sheep milk fermented with KGL4 increased with incubation hours,along with varied antioxidative properties (ABTS assay:35.12%,hydroxyl free radical scavenging assay:29.12%,superoxide free radical scavenging activity:36.38%).Antimicrobial activity of fermented sheep milk against E.faecalis (19 mm),S.typhimurium (15.67 mm),B.cereus (14 mm),and E.coli (13 mm) was also observed.Furthermore,after 48 h,the KGL4 showed maximum proteolysis (10.40 mg/ml) at 2.5% rate of addition sheep milk.The antioxidative and antimicrobial activities of fermented sheep milk fractions (3 kDa and 10 kDa permeates and retentates) were also investigated.The highest ABTS activity (26.90%) was found in 10 kDa permeate,whereas the 3 kDa retentate had higher hydroxyl free radical scavenging activity (69.20%) and 3 kDa permeate showed maximum superoxide free radical scavenging activity (32.85%).The 10 kDa retentate had shown maximum antimicrobial activity against S.typhimurium (13.67 mm) and E.faecalis (17.00 mm).Proteins spotted on 2D gel electrophoresis of KGL4 were varied from 10 to 70 kDa.RP-LC/MS was used to identify 5 novel peptide sequences from 2-D gel spots.Searches in the BIOPEP database confirmed the antioxidative and antimicrobial effects of the novel fermented sheep milk peptides.Fermented sheep milk with KGL4 (SMKGL4) significantly reduced excessive TNF-α,IL-6,& IL-1β production in LPS-activated RAW 264.7 cells. | Jodhani Keyur Ashokbhai Bethsheba Basaiawmoit Sujit Das Amar Sakure Ruchika Maurya Mahendra Bishnoi Kanthi Kiran Kondepudi Srichandan Padhi Amit Kumar Rai Zhenbin Liu Subrota Hatia | 2022 | Food Bioscience2022，47，3： | 1 |
| 17 | Cardiac Morbidity and Mortality After Breast Conservation Treatment in Patients with Early - Stage Breast Cancer and Preexisting Cardiac Dis- ease 显示文摘 | Ruchika Gutt Candaee R Correa | 2008 | Clinical Breast Cancer2008，8，5： | 1 |
| 18 | Perioperative management of anticoagulated patients having cataract surgery显示文摘 | Ruchika Batra Anna Maino Sun W. Ch'ng Ian B. Marsh | 2009 | Journal of Cataract & Refractive Surgery2009，，10： | 1 |
| 19 | 屏风住宅 印度勒克瑙私宅显示文摘印度勒克瑙城拥有丰富的历史文化遗产,许多建筑都可追溯到18世纪。本文介绍的这幢住宅位于该市繁忙的主干道边,是一片私人住宅地块的边缘部分。项目采用了印度传统四合院的建筑形制,以回应城市特征和炎热的气候条件。业主希望在这个两层高的通风庭院中穿插设置一些有遮挡的开放式露台和景观花园。同时,除了6间卧室之外,还需要普伽室、书房、影视室以及多功能区域等,并希望这些空间均能通往露台和景观花园。 | 麦子(编译) 无 Nina Puri Sanjay Puri Ruchika Gupta Jinal Jain Nivedita Raverkar Nandita Rebello Akanksha Singh Swati Gadekar Dinesh Mehta(摄影) | 2020 | 室内设计与装修2020，，7： | 0 |
| 20 | Amebic liver abscess: An update显示文摘Amebic liver abscess(ALA)is still a common problem in the tropical world,where it affects over three-quarters of patients with liver abscess.It is caused by an anaerobic protozoan Entamoeba hystolytica,which primarily colonises the cecum.It is a non-suppurative infection of the liver consisting primarily of dead hepatocytes and cellular debris.People of the male gender,during their reproductive years,are most prone to ALA,and this appears to be due to a poorly mounted immune response linked to serum testosterone levels.ALA is more common in the right lobe of the liver,is strongly associated with alcohol consumption,and can heal without the need for drainage.While majority of ALA patients have an uncomplicated course,a number of complications have been described,including rupture into abdomino-thoracic structures,biliary fistula,vascular thrombosis,bilio-vascular compression,and secondary bacterial infection.Based on clinico-radiological findings,a classification system for ALA has emerged recently,which can assist clinicians in making treatment decisions.Recent research has revealed the role of venous thrombosis-related ischemia in the severity of ALA.Recent years have seen the development and refinement of newer molecular diagnostic techniques that can greatly aid in overcoming the diagnostic challenge in endemic area where serology-based tests have limited accuracy.Metronidazole has been the drug of choice for ALA patients for many years.However,concerns over the resistance and adverse effects necessitate the creation of new,safe,and potent antiamebic medications.Although the indication of the drainage of uncomplicated ALA has become more clear,high-quality randomised trials are still necessary for robust conclusions.Percutaneous drainage appears to be a viable option for patients with ruptured ALA and diffuse peritonitis,for whom surgery represents a significant risk of mortality.With regard to all of the aforementioned issues,this article intends to present an updated review of ALA. | Ramesh Kumar Rishabh Patel Rajeev Nayan Priyadarshi Ruchika Narayan Tanmoy Maji Utpal Anand Jinit R Soni | 2024 | World Journal of Hepatology2024，16，3： | 0 |
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