|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Sitagliptin,sitagliptin and metformin,or sitagliptin and amitriptyline attenuate streptozotocin-nicotinamide induced diabetic neuropathy in rats显示文摘Diabetic neuropathies are a family of nerve disorders caused by diabetes.Symptoms of the disease include nerve palsy,mononeuropathy,mononeuropathy multiplex,diabetic amyotrophy,painful polyneuropathy,autonomic neuropathy,and thoracoabdominal neuropathy.In this study,type 2 diabetes in rats was induced with nicotinamidestreptozotocin.Drug treatment was initiated on the d 15,with the combination regimen of metformin,pioglitazone and glimipiride or metformin and sitagliptin or sitagliptin,amitriptyline and sitagliptin and led to significantly improved glycemic control,increased grip strength and paw jumping response on d 21,28 and 35(P < 0.001).Significant increases in blood protein levels and decreases in urinary protein levels were observed in the animals treated with the different regimens on d 21,28 and 35(P < 0.001).Combined treatment of streptozotocin and nicotinamide caused marked degeneration of nerve cells,while administration of metformin and sitagliptin showed tissue regeneration and no body weight gain.In conclusion,treatment with sitagliptin and sitagliptin combined with metformin or amitriptyline results in no body weight gain,but causes an increase in grip strength and pain sensitivity,exhibits neural protection,and reverses the alteration of biochemical parameters in rats with streptozotocin-nicotinamide induced type 2 diabetes. | Ashish Kumar Sharma Akash Sharma Rita Kumari Kunal Kishore Divya Sharma Bharthu Parthsarthi Srinivasan Ashok Sharma Santosh Kumar Singh Samir Gaur Vijay Singh Jatav Prashant Sharma Varnika Srivastava Sneha Joshi Megha Joshi Prashant Kumar Dhakad Davender Singh Kanawat Akanksha Mishra Anil Sharma Dharmendra Singh Ravinder Pal Singh Himmat Singh Chawda Rambir Singh Sachin Kumar Raikwar Muneem Kumar Kurmi Pankaj Khatri Ashutosh Agarwal Arshee Munajjam | 2012 | The Journal of Biomedical Research2012，26，3： | 2 |
| 2 | Anti- hyperglycaemic, lipid lowering and anti-oxidant properties of -gingerol in db/db mice 显示文摘 | Singh A B Akanksha Singh N | 2009 | International Journal of Medicine and Medical Sciences2009，1，12： | 1 |
| 3 | Anti -hyperglycaemic, lipidlowering and anti-oxidant properties of (6)-gingerol in db/db mice显示文摘 | Singh AB Akanksha Singh N | 2009 | International Journal of Medicine and Medical Sciences2009，1，12： | 1 |
| 4 | Anti-hyperglycaemic, lipid lowering and anti-oxidant prop- erties of -gingerol in db/db mice显示文摘 | Amar Bahadur Singh Akanksha Nilendra Singh | 2009 | International Journal of Medicine and Medical Sciences2009，1，12： | 1 |
| 5 | A geometrical parameter for the formation of disordered solid solutions in multi-component alloys显示文摘 | Anil Kumar Singh Nitesh Kumar Akanksha Dwivedi Anandh Subramaniam | 2014 | Intermetallics2014，，： | 1 |
| 6 | EST-based identification of immune-relevant genes from spleen of Indian catfish, Clarias batrachus (Linnaeus, 1758)显示文摘 | Akanksha Singh Neeraj Sood U.K. Chauhan Vindhya Mohindra | 2012 | Gene2012，，1： | 1 |
| 7 | Anti-hyperglycaemic, lipid lowering and anti-oxidant properties of -gingerol in db/db mice 显示文摘 | Singh A B Akanksha Singh N | 2009 | International Journal of Medicine and Medical Sciences2009，1，12： | 1 |
| 8 | Evaluation of antifertility potential of Brahmi in male mouse显示文摘 | Akanksha Singh Shio Kumar Singh | 2009 | Contraception2009，，1： | 1 |
| 9 | Anti- hyperglycaemic, lipid lowering and anti-oxidant properties of-gingerol in db/ db mice 显示文摘 | Singh A B Akanksha Singh N | 2009 | International Journal of Medicine and Medical Sciences2009，1，12： | 1 |
| 10 | 屏风住宅 印度勒克瑙私宅显示文摘印度勒克瑙城拥有丰富的历史文化遗产,许多建筑都可追溯到18世纪。本文介绍的这幢住宅位于该市繁忙的主干道边,是一片私人住宅地块的边缘部分。项目采用了印度传统四合院的建筑形制,以回应城市特征和炎热的气候条件。业主希望在这个两层高的通风庭院中穿插设置一些有遮挡的开放式露台和景观花园。同时,除了6间卧室之外,还需要普伽室、书房、影视室以及多功能区域等,并希望这些空间均能通往露台和景观花园。 | 麦子(编译) 无 Nina Puri Sanjay Puri Ruchika Gupta Jinal Jain Nivedita Raverkar Nandita Rebello Akanksha Singh Swati Gadekar Dinesh Mehta(摄影) | 2020 | 室内设计与装修2020，，7： | 0 |
| 11 | Revisiting the role of mesenchymal stem cells in tuberculosis and other infectious diseases显示文摘Mesenchymal stem cells(MsCs)play diverse roles ranging from regeneration and wound healing to immune signaling.Recent investigations have indicated the crucial role of these multipotent stem cells in regulating various aspects of the immune system.MsCs express unique signaling molecules and secrete various soluble factors that play critical roles in modulating and shaping immune responses,and in some other cases,MSCs can also exert direct antimicrobial effects,thereby helping with the eradication of invading organisms.Recently,it has been demonstrated that MSCs are recruited at the periphery of the granuloma containing Mycobacterium tuberculosis and exert'Janus'-like functions by harboring pathogens and mediating host protective immune responses.This leads to the establishment of a dynamic balance between the host and the pathogen.MsCs function through various immunomodulatory factors such as nitric oxide(NO),IDO,and immunosuppressive cytokines.Recently,our group has shown that M.tb uses MSCs as a niche to evade host protective immune surveillance mechanisms and establish dormancy.MSCs also express a large number of ABC efflux pumps;therefore,dormant M.tb residing in MSCs are exposed to a suboptimal dose of drugs.Therefore,it is highly likely that drug resistance is coupled with dormancy and originates within MSCs.In this review,we discussed various immunomodulatory properties of MsCs,their interactions with important immune cells,and soluble factors.We also discussed the possible roles of MsCs in the outcome of multiple infections and in shaping the immune system,which may provide insight into therapeutic approaches using these cells in different infection models. | Annu Devi Isha Pahuja Shashi Prakash Singh Akanksha Verma Debapriya Bhattacharya Ashima Bhaskar Ved Prakash Dwivedi Gobardhan Das | 2023 | Cellular & Molecular Immunology2023，20，6： | 0 |
| 12 | Cyanobacteria,Lyngbya aestuarii and Aphanothece bullosa as antifungal and antileishmanial drug resources显示文摘Objective:To investigate two cyanobacteria isolated from different origins i.e.Lyngbya aestuarii(L.aestuarii)from brackish water and Aphanothece bullosa(4.bullosa)from fresh water paddy fields for antifungal and antileishmanila activity taking Candida albicans and Leishmania donovain as targets.Methods:Biomass of L.aestuarii and A.bullosa were harvested after 40 and60 d respectively and lyophilized twice in methanol(100%)and redissolved in methanol(5%)for bioassay.Antifungal bioassay was done by agar well diffusion method while antileishmanial,by counting cell numbers and flageller motility observation of promastigotes and amastigotes from L.donovani.fluconazole and 5%methanol were used as control.Results:Both the cyanobacteria were found to be potent source of antifungal activity keeping fluconazole as positive control,however,methanolic crude extract(15 mg/mL)of A.bullosa was found more potent(larger inhibition zone)over that of methanolic crude extract of L.aestuarii,Similarly antileishmanial activity of crude extract(24.0 mg/mL)of A.bullosa was superior over that of methanolic crude extract of L.aestuarii(25.6 mg/mL).Conclusions:Antifungal and antileishmanial drugs are still limited in the market.Screening of microbes possessing antifungal and antileishmanial activity drug is of prime importance.Cyanobacteria are little explored in this context because most of the drugs in human therapy are derived from microorganisms,mainly bacterial,fungal and actinomycetes.Thus in the present study two cyanobacterial strains from different origins showed potent source of antifungal and antileishmanial biomolecules. | Maheep Kumar Manoj Kumar Tripathi Akanksha Srivastava Jalaj Kumar Gour Rakesh Kumar Singh Ragini Tilak Ravi Kumar Asthana | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，6： | 0 |
| 13 | Genotypic Variation in Spatial Distribution of Fe in Rice Grains in Relation to Phytic Acid Content and Ferritin Gene Expression显示文摘Rice varieties having high Fe concentration in the endospermic region can be used as a good source for Fe deficit population.In this study,303 Oryza sativa varieties and 1 Oryza rufipogon accession were assessed for spatial Fe accumulation in grains by Prussian blue staining method.Spatial ferritin protein distribution in grains was visualized by immunohistochemistry,and ferritin expression was assessed in selected rice varieties using semi-quantitative reverse transcription PCR.Three popular rice varieties,namely Sarjoo 52,Madhukar and Jalmagna,and the O.rufipogon variety showed Fe in all the regions of grains,and the highest Fe concentration was observed in the embryo region.Some high-yielding varieties like Swarna,Swarna Sub 1,CSR13 and NDRR359 had lower Fe concentration in the embryo region.The highest Fe concentration was detected in O.rufipogon(49.8μg/g),followed by Sarjoo 52(26.1μg/g)and Madhukar(25.7μg/g).Phytic acid concentration was the minimum in O.rufipogon(5.75 mg/g)followed by Sarjoo 52(5.83 mg/g).Western blot and semi-quantitative reverse transcription PCR showed higher expression of ferritin gene in O.rufipogon,Sarjoo 52 and Madhukar.In conclusion,O.rufipogon and Sarjoo 52 had higher Fe concentration in the embryo regions as well as endosperm and aleurone layer,whereas the other varieties had lower Fe concentration in the endosperm.Sarjoo 52 could be used as a donor in the rice breeding program for the generation of new varieties with elevated grain Fe concentration. | Anurag MISHRA MdSHAMIM MdWASIM Siddiqui Akanksha SINGH Deepti SRIVASTAVA K.N.SINGH | 2020 | Rice science2020，27，3： | 0 |
| 14 | Herbal tea formulation using different flavoured herbs with dried corn silk powder and its sensory and phytochemical analysis显示文摘The aim of this study was to use dried corn silk powder variety of VL Baby corn-1 for formulation of flavoured herbal tea with different combination of Thyme(Trachyspermum ammi),Clove(Syzygium aromaticum),Cinnamon powder(Cinnamomum verum),Timur(Zanthoxylum alatum),Tulsi(Holy basil)(Ocimum tenuiflorum),Gandraini(Achillea millefolium),Lemon grass(Cymbopogon citratus),Blend(Clove+Timur+Gandraini),and one only corn silk without any other herbs and to know antioxidant properties of developed tea.Result of sensory evaluation experiment showed that all combinations were liked moderately.Lemon grass flavour followed by cinnamon and clove blend obtained highest score.Total phenolic content,total flavonoid content,DPPH free radical scavenging activity and total antioxidant activity for all flavour are analyzed and reported.Results on DPPH free radical scavenging activity indicated that corn silk tea had 81.215±0.75μg/mL whereas blend with Timur had significant highest value and Thyme blend had lowest value 64.20±0.40 among all eight different blends with corn silk.The values for total antioxidant capacity blends with Timur(Zanthoxylum alatu)in corn silk showed significantly(P<0.05)highest value and Clove,Timur,Gandraini blends got lowest value. | Akanksha Singh Rita Singh Raghuvanshi Amit Bhatnagar | 2021 | Systems Microbiology and Biomanufacturing2021，1，3： | 0 |
| 15 | Update on the preclinical and clinical assessment of Withania somnifera: from ancient Rasayana to modern perspectives显示文摘The Rasayana plant Withania somnifera(W.somnifera)Dunal,also known as“Ashwagandha”,has been mentioned in various classical Ayurvedic texts,such as Charaka Samhita,Sushruta Samhita,and Nighantus.This Ayurvedic drug has been referred to as a tonic that renews the body,provides physical and mental vigor in weakened states,and promotes endurance and longevity.W.somnifera possesses notable biological activity in many ailments,such as diabetes,conjunctivitis,insomnia,senile dementia,Parkinson’s disease,nervous system disorders,rheumatism,and arthritis.These pharmacological activities are due to the presence of diverse active components and their derivatives.Some lead compounds are found to be effective against anxiety and other central nervous system disorders.W.somnifera has been proven to be effective and safe for a wide range of ailments from ancient to modern times.Its reported properties represent the traditional use of W.somnifera as indicated in the literature;furthermore,W.somnifera is one of the most important prescribed drugs in Ayurveda for its multimodal effects.This current review highlights the bioactive present and provides an overview of the toxicological and pharmacological studies on W.somnifera,including preclinical and clinical studies.From its earliest utilization to its current application,W.somnifera has been recognized to be effective at clinical levels for human health and welfare.Greater attention to the safety and efficacy of W.somnifera would provide more scientific evidence,promoting global acceptance of the Ayurvedic plant. | Akanksha Rashmi Singh Atiqul Islam Rimpi Arora Harjeet Singh Alok Sharma | 2022 | Traditional Medicine Research2022，7，5： | 0 |
| 16 | The assessment of good and bad bacteria in holy basil(Ocimum sanctum)leaves显示文摘Holy basil(Tulsi,Ocimum sanctum)is considered to be a pious plant.It is used not only in many of the rituals of Hindus but is also known for its innumerable medicinal qualities.Holy basil leaves(HBLs)are often consumed raw thus it is pertinent to detect the bacteria on Tulsi leaves.This study was conducted to understand the diversity of the aerobically growing microbiome of edible holy basil leaves.A total of 112 samples of leaves were collected from households of six localities in and around Bareilly,India for detecting culturable bacteria growing aerobically.A sum of 579 bacterial isolates belonging to 106 different species was identified.Pantoea agglomerans isolates were detected in 43 samples followed by isolates Virgibacillus pantothenticus(21),Bacillus coagulans(18),Bacillus cereus(17),Geobacillus stearothermophilus(16),Klebsiella pneumoniae(13),Citrobacter freundii(12),Lysinibacillus sphaericus(12),Acinetobacter calcoaceticus(11),Escherichia coli(11),and Xenorhabdus bovienii(11).Isolates of 95 species of bacteria were detected on<10 samples of HBLs.Of 579 isolates,161 isolates detected in 68(60.71%)samples were of putatively good bacteria belonging to eight genera(Bacillus,Brevibacillus,Lysinibacillus,Paenibacillus,Photobacter,Siccibacter,Virgibacillus,Xenoirhabdus)and 23 species.However,418 bacterial isolates detected in 108(96.43%)of the HBL samples were classified as potentially pathogenic for humans and animals belonging to 34 genera and 73 species.There were only four samples(three from Mahanagar and one from Bhojipura)that had no potential pathogenic bacteria detected in this study.The analysis indicated that HBL leaves from the ICAR-IVRI campus had a lower probability(P<0.04)of harbouring good bacteria than samples from Bhojpura,Mahanagar,North City and Rajendra Nagar.Cinnamaldehyde inhibiting 96.72%of the isolates and carvacrol inhibiting 96.37%of the isolates were the best herbal antimicrobials and among antibiotics,meropenem inhibited 98.96%of bacterial isolates.Antimicrobial resistance in non-pathogenic or good bacteria was significantly more common(P<0.01)for ajowan oil but they were more often(P<0.05)susceptible to holy basil oil,lemongrass oil,citral,P.embalica leaf extract,P.longifolia seed oil,nitrofurantoin,ciprofloxacin,chloramphenicol,colistin and minocycline than isolates of potentially pathogenic bacteria.The study concludes that HBLs may harbour both good and bacteria,and should be consumed raw only after proper decontamination. | Bhoj R Singh Mudit Chandra Himani Agri Ravichandran Karthikeyan Akanksha Yadav Varsha Jayakumar | 2023 | Infectious Diseases Research2023，4，4： | 0 |
| 17 | Effect of picking multiple colonies on antimicrobial susceptibility diagnostic outcome in a clinical bacteriology setting显示文摘giving results of antimicrobial susceptibility testing(AST)even if the infection is detected due to a single type of bacteria.However,what should be the minimum number of colonies?The clinical laboratory manuals are silent and give different numbers.Thus,the present study was conducted to evaluate the impact of picking up more than one colony for antimicrobial susceptibility.Method:The study was conducted on those clinical samples yielding Escherichia coli either as pure culture or as a prominent cause of infection.The impact of testing multiple colonies of Escherichia coli isolates was assessed on AST results through the detection of extended-spectrum β-lactamase(ESBL)producing and Metallo-β-lactamase(MBL)producing Escherichia coli carriage in clinical samples.Results:A total of 1031 samples having E.coli as the most prominent or single pathogen were analyzed.It included testing either one,two,three,four,five,or more than five(6-10)representative E.coli colonies from 526,247,115,76,31,and 36 samples,respectively.The study revealed that testing of less than three representative colonies significantly(p<0.05)impacts the outcome.However,the best outcome was when≥6 representative colonies were tested for AST.Conclusion:The study suggested that≥6 representative colonies should be emulsified for antimicrobial susceptibility tests not to miss possible infection with ESBL or MBL-producing mutants,even in mono-culture infections. | Bhoj R Singh Dharmendra K Sinha Varsha Jayakumar Himani Agri Akanksha Yadav Ravichandran Karthikeyan | 2023 | Infectious Diseases Research2023，4，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员