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| 1 | Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer显示文摘AIM:To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer.METHODS:Genomic DNA was extracted from paraffinembedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals.Allelic discrimination was performed by quantitative real-time polymerase chain reaction.Genotyping was correlated with histopathologic parameters and with overall survival according to the Kaplan-Meier approach and with multivariate analysis by multiple stepwise regression.RESULTS:Thirty-nine(32%) patients displayed a CC genotype,57(46.7%) a CT genotype and 26(21.3%) a TT genotype.The frequency of the C allele(fC) in the patient group was 0.55,which was not signif icantly different from that of healthy blood donors.The distribution was compatible with the Hardy-Weinberg equilibrium.Analysis of clinicopathological parameters did not show any signif icant correlation of the T393C genotype with gender(P=0.50),differentiation(P=0.29),pT-category(P=0.19),pN-category(P=0.30),pM-category(P=0.25),R-category(P=0.95),the classifications according to WHO(P=0.34),Laurén(P=0.16),Goseki(P=1.00) and Ming(P=0.74).Dichotomization between C+(CC+CT) and C-genotypes(TT),however,revealed signif icantly more advanced tumor stages(P=0.023) and lower survival rates(P=0.043) for C allele carriers.CONCLUSION:The present study provides strong evidence to suggest that the GNAS1 T393C allele carrier status influences tumor progression and survival in gastric cancer with higher tumor stages and a worse outcome for C allele carriers. | Hakan Alakus Stefan P Mnig Ute Warnecke-Eberz Gül Alakus Günther Winde Uta Drebber Klaus J Schmitz Kurt W Schmid Kathrin Riemann Winfried Siffert Elfriede Bollschweiler Arnulf H Hlscher Ralf Metzger | 2009 | World Journal of Gastroenterology2009，15，48： | 3 |
| 2 | CD13 -not just a marker in leukemia typing显示文摘 | Riemann D Kehlen A Langner J | 1999 | Immunol Today1999，20，2： | 1 |
| 3 | Localization of the blood-testis barrier in the testis of the moth, Anagasta kuehniella显示文摘 | S2011osi A Riemann J Marcaillou C | 1980 | Journal of Uhrastructure Research1980，72，2： | 1 |
| 4 | Optical micro-charac- terization of group-Hl-nitrides: Correlation of structural, electronic and optical properties显示文摘 | Christen J Riemann T Bertram F | 2003 | Phys Status Solidi C2003，0，6： | 1 |
| 5 | DNA flow cytometric measurements in inflammatory and malignant human gastric lesions显示文摘 | Edgar Deinlein Helmut Schmidt Jürgen-Ferdinand Riemann Rolf Gr??el-Pietrusky Otto Paul Hornstein | 1983 | Virchows Archiv A Pathological Anatomy and Histopathology1983，，2： | 1 |
| 6 | Metastatic neu- roblastoma demonstrated by whole-body PET-CT using 11C- HED 显示文摘 | Franzius C Riemann B Vormoor J | 2005 | Nuklearmedizin2005，44，1： | 1 |
| 7 | Test–retest reliability and validity of the Pittsburgh Sleep Quality Index in primary insomnia显示文摘 | Backhaus J Junghanns K Broocks A Riemann D Hohagen F | 2002 | J Psychosom Res2002，53，： | 1 |
| 8 | Double duct sign: is it always cancer 显示文摘 | Schlauch D Kohler B Riemann J | 1993 | Endoscopy1993，25，7： | 1 |
| 9 | Diagnostic laparoscopy显示文摘 | RIEMANN J F | 2003 | Endosco- py2003，35，： | 1 |
| 10 | Cognitive processing of emotional information in panic disorder显示文摘 | McNally R J Riemann B C Kim C E | 1992 | Behav- ior Research and Therapy1992，30，2： | 1 |
| 11 | Diagnosis of Liver Cirrhosis: A Comparison of Modified Ultrasound and Laparoscopy in 100 Consecutive Patients显示文摘 | Uwe Weickert Andrea Buttmann Ralf Jakobs Dieter Schilling Axel Eickhoff Jürgen Ferdinand Riemann | 2005 | Journal of Clinical Gastroenterology2005，，6： | 1 |
| 12 | A double-blind,randomized and placebo-controlled study on the polysomnographic withdrawal effects of zopiclone,zolpidem and triazolam in healthy subjects显示文摘 | Voderholzer U Riemann J Hornyak M | 2001 | Eur Arch Psychiatry Clin Neurosci2001，251，3： | 1 |
| 13 | An experimental approach to the photolysis of pesticides adsorbed on soil: thidiazuron 显示文摘 | Klehr M Iwan J Riemann J | 1983 | Pesticide Science1983，14，4： | 1 |
| 14 | Sex comparison of extensibility,passive,and active stiffness of the knee flexors显示文摘 | BLACKBURN J T RIEMANN B L PADUA D A | | 0，，01： | 1 |
| 15 | CD13—not just a marker in leukemia typing显示文摘 | Dagmar Riemann Astrid Kehlen Jürgen Langner | 1999 | Immunology Today1999，，2： | 1 |
| 16 | Concept of stress ulcer prevention, Is re-thinking necessary? Med-Klin 显示文摘 | Kress S Schilling D Riemann J F | 1998 | 93 (8):486 ~ 4911998，93，8： | 1 |
| 17 | Virus production and lysate recycling in different sub-basins of the Northern Baltic Sea 显示文摘 | Holmfeldt K Titelman J Riemann L | 2010 | Microbial Ecology2010，60，3： | 1 |
| 18 | Trefoil factor 3 is induced during degenerative and inflammatory joint disease,activates matrix metalloproteinases,and enhances apoptosis of articular cartilage chondrocytes显示文摘 | R(o)sler S Haase T Claassen H Schulze U Schicht M Riemann D Brandt J Wohlrab D Müller-Hilke B Goldring MB Sel S Varoga D Garreis F Paulsen FP | | 0，，03： | 1 |
| 19 | Bright blue electrolu- minescence from an InGaN/GaN multiquantum-well diode on Si(111): Impact of an AIGaN/GaN multilayer显示文摘 | Dadgar A Christen J Riemann T | 2001 | Appl Phys Lett2001，78，15： | 1 |
| 20 | CD13-not just a marker in leukemia typing显示文摘 | Riemann D Kehlen A Langner J | 1999 | Immunol Today1999，20，2： | 1 |
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