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| 1 | Distribution and effects of polymorphic RANTES gene alleles in HIV/HCV coinfection - A prospective cross-sectional study显示文摘AIM: Chemokines and their receptors are crucial for immune responses in HCV and HIV infection. RANTES gene polymorphisms lead to altered gene expression and influence the natural course of HIV infection. Therefore,these mutations may also affect the course of HIV/HCV coinfection.METHODS: We determined allele frequencies of RANTES-403 (G→A), RANTES-28 (C→G) and RANTESIN1.1 (T→C) polymorphisms using real-time PCR and hybridization probes in patients with HIV (n = 85), HCV (n= 112), HIV/HCV coinfection (n = 121), and 109 healthy controls. Furthermore, HIV and HCV loads as well as CD4+ and CD8+ cell counts were compared between different RANTES genotypes.RESULTS: Frequencies of RANTES-403 A, RANTES-28 G and RANTES-IN1.1 C alleles were higher in HIV infected patients than in healthy controls (-403: 28.2% vs 15.1%,P = 0.002; -28: 5.4% vs 2.8%, not significant; IN1.1:19.0% vs 11.0%, P = 0.038). In HIV/HCV coinfected patients, these RANTES alleles were less frequent than in patients with HIV infection alone (15.4% P = 0.002;1.7%; P = 0.048; 12.0%; not significant). Frequencies of these alleles were not significantly different between HIV/HCV positive patients, HCV positive patients and healthy controls.CONCLUSION: All three RANTES polymorphisms showed increased frequencies of the variant allele exclusively in patients with HIV monoinfection. The finding that the frequencies of these alleles remained unaltered in HIV/HCV coinfected patients suggests that HCV coinfection interferes with selection processes associated with these alleles in HIV infection. | Golo Ahlenstiel Agathe Iwan Jacob Nattermann Karin Bueren Jürgen K Rockstroh Hans H Brackmann Bernd Kupfer Olfert Landt Amnon Peled Tilman Sauerbruch Ulrich Spengler Rainer P Woitas | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 2 | Direct observation of stray crystal formation in unidirectional solidification of Sn-Bi alloy by X-ray imaging显示文摘 | Yasuda H Ohnaka I Kawasaki K Sugiyama A Ohmichi T Iwane J Umetani K | 2004 | Journal of Crystal Growth2004，262，14： | 1 |
| 3 | On the formulations of strain space plasticity pith multiple loading surfaces显示文摘 | Yoder P J Iwan W D | 1981 | ASME Journal of Applied Mechanics1981，48，4： | 1 |
| 4 | Modelling the solution growth of TGS crystals in low gravity显示文摘 | Nadarjah Arunan Rosenberger Franz Alexander J Iwan D | 1990 | J Crystal Growth1990，104，2： | 1 |
| 5 | Nonlinear response of layer growth dynamics in the mixed kinetics-bulk-transport regime显示文摘 | Vekilov Peter G Alexander J Iwan D Rosenberger Franz | 1996 | Phys Rev E1996，54，6： | 1 |
| 6 | Autonomous vacuum cleaner 显示文摘 | Iwan R U Francesco M Nicoud J D | 1997 | Robotics and Autonomous Systems1997，19，2： | 1 |
| 7 | Dietary cis- and trans- monounsaturated and saturated FA and plasma lipids and lipoproteins in men 显示文摘 | Judd JT Baer D J Clevidence BA Kris-Etherton P Muesing RA Iwane M | 2002 | Lipids2002，37，2： | 1 |
| 8 | Do we need CAPM for capital budgeting?显示文摘 | RAVI J IWAN M | 2002 | Finacial management2002，，： | 1 |
| 9 | Control of a civil structure using an electric machine with semi active capability 显示文摘 | Scruggs J T Iwan W D | 2003 | Journal of Structural Engineering ASCE2003，129，7： | 1 |
| 10 | Hepatitis C virus E2 and CD81 interaction may be associated with altered trafficking of dendritic cells in chronic hepatitis C 显示文摘 | Nattermann J Zimmermann H Iwan A | 2006 | Hepatology2006，44，4： | 1 |
| 11 | An experimental approach to the photolysis of pesticides adsorbed on soil: thidiazuron 显示文摘 | Klehr M Iwan J Riemann J | 1983 | Pesticide Science1983，14，4： | 1 |
| 12 | Measurement and analysis of object reflectance spectra显示文摘 | Vrhel M J Gershon R Iwan L S | 1994 | Color Research and Application1994，19，： | 1 |
| 13 | On the formulation of strain-space plasticity with multiple loading surfaces显示文摘 | Yoder P J Iwan W D | 1981 | J Appl Mech Trans ASME1981，48，4： | 1 |
| 14 | Application of the lattice Bohzmann method to two-phase Rayleigh-Bfnard convection with a deformable interface 显示文摘 | Chang Q M Iwan J Alexander D | 2006 | Journalof Computational Physics2006，212，47： | 1 |
| 15 | Morphological Evolution of Growing Crystals:A Monte Carlo Simulation显示文摘 | Xiao Reng-Fu Iwan J Alexander D Resenherger Franz | 1988 | Physical Review A1988，38，5： | 1 |
| 16 | Curvature-dependent surface tension and nucleation theory显示文摘 | Jurn W P S Iwan G Jurn S J | 1996 | Colloid and Interface Science1996，178，： | 1 |
| 17 | Control of a civil structure using an electric machine with semiactive capability显示文摘 | Scruggs J T Iwan W D | 2003 | ASCE Journal of Structural Engineering2003，129，7： | 1 |
| 18 | Structure reactivity relationships for the inhibition of recombinant human cytochromes P450 by curcumin analogues 显示文摘 | APPIA H-OPONG R IWAN E COMMANDEUR J N M | 2008 | European Journal of Medicinal Chemistry2008，43，8： | 1 |
| 19 | Application of the lattice Boltzmann method to two-phase Rayleigh-Benard convection with a deformable interface显示文摘 | Chang Q M Iwan J Alexander D | 2006 | Joural of Computational Physics2006，212，： | 1 |
| 20 | Control of a civil structure using an electric machine with semiactive capability显示文摘 | Scruggs J T Iwan W D | 2003 | ASCE Journal of Structural Engineering2003，129，7： | 1 |
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