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| 1 | Golgi protein-73:A biomarker for assessing cirrhosis and prognosis of liver disease patients显示文摘BACKGROUND Reliable biomarkers of cirrhosis,hepatocellular carcinoma(HCC),or progression of chronic liver diseases are missing.In this context,Golgi protein-73(GP73)also called Golgi phosphoprotein-2,was originally defined as a resident Golgi type II transmembrane protein expressed in epithelial cells.As a result,GP73 expression was found primarily in biliary epithelial cells,with only slight detection in hepatocytes.However,in patients with acute or chronic liver diseases and especially in HCC,the expression of GP73 is significantly up-regulated in hepatocytes.So far,few studies have assessed GP73 as a diagnostic or prognostic marker of liver fibrosis and disease progression.AIM To assess serum GP73 efficacy as a diagnostic marker of cirrhosis and/or HCC or as predictor of liver disease progression.METHODS GP73 serum levels were retrospectively determined by a novel GP73 ELISA(QUANTA Lite®GP73,Inova Diagnostics,Inc.,Research Use Only)in a large cohort of 632 consecutive patients with chronic viral and non-viral liver diseases collected from two tertiary Academic centers in Larissa,Greece(n=366)and Debrecen,Hungary(n=266).Aspartate aminotransferase(AST)/Platelets(PLT)ratio index(APRI)was also calculated at the relevant time points in all patients.Two hundred and three patients had chronic hepatitis B,183 chronic hepatitis C,198 alcoholic liver disease,28 autoimmune cholestatic liver diseases,15 autoimmune hepatitis,and 5 with other liver-related disorders.The duration of follow-up was 50(57)mo[median(interquartile range)].The development of cirrhosis,liver decompensation and/or HCC during follow-up were assessed according to internationally accepted guidelines.In particular,the surveillance for the development of HCC was performed regularly with ultrasound imaging and alpha-fetoprotein(AFP)determination every 6 mo in cirrhotic and every 12 mo in non-cirrhotic patients.RESULTS Increased serum levels of GP73(>20 units)were detected at initial evaluation in 277 out of 632 patients(43.8%).GP73-seropositivity correlated at baseline with the presence of cirrhosis(96.4%vs 51.5%,P<0.001),decompensation of cirrhosis(60.3%vs 35.5%,P<0.001),presence of HCC(18.4%vs 7.9%,P<0.001)and advanced HCC stage(52.9%vs 14.8%,P=0.002).GP73 had higher diagnostic accuracy for the presence of cirrhosis compared to APRI score[Area under the curve(AUC)(95%CI):0.909(0.885-0.934)vs 0.849(0.813-0.886),P=0.003].Combination of GP73 with APRI improved further the accuracy(AUC:0.925)compared to GP73(AUC:0.909,P=0.005)or APRI alone(AUC:0.849,P<0.001).GP73 levels were significantly higher in HCC patients compared to non-HCC[22.5(29.2)vs 16(20.3)units,P<0.001)and positively associated with BCLC stage[stage 0:13.9(10.8);stage A:17.1(16.8);stage B:19.6(22.3);stage C:32.2(30.8);stage D:45.3(86.6)units,P<0.001]and tumor dimensions[very early:13.9(10.8);intermediate:19.6(18.4);advanced:29.1(33.6)units,P=0.004].However,the discriminative ability for HCC diagnosis was relatively low[AUC(95%CI):0.623(0.570-0.675)].Kaplan-Meier analysis showed that the detection of GP73 in patients with compensated cirrhosis at baseline,was prognostic of higher rates of decompensation(P=0.036),HCC development(P=0.08),and liver-related deaths(P<0.001)during follow-up.CONCLUSION GP73 alone appears efficient for detecting cirrhosis and superior to APRI determination.In combination with APRI,its diagnostic performance can be further improved.Most importantly,the simple GP73 measurement proved promising for predicting a worse outcome of patients with both viral and nonviral chronic liver diseases. | Nikolaos K Gatselis Tamás Tornai Zakera Shums Kalliopi Zachou Asterios Saitis Stella Gabeta Roger Albesa Gary L Norman Mária Papp George N Dalekos | 2020 | World Journal of Gastroenterology2020，26，34： | 21 |
| 2 | Mineralization and biodegradability enhancement of low level p-nitrophenol in water using Fenton's reagent显示文摘 | Eakalak K Roger B W Hsu T M | 2005 | Journal of Environmental Engineering2005，131，2： | 1 |
| 3 | Loss of transgelin in breast and colon tumors and in RIE-1 cells by Ras deregulation of gene expression through Raf -independent pathways显示文摘 | Shields J M Rogers Graham K Der C J | 2002 | J Biol Chem2002，277，12： | 1 |
| 4 | Effects of in-situ chemical vapour deposition using tetraethoxysilane on the catalytic and sorption properties of ZSM-5显示文摘 | Roger H P Kramer M Moiler K P | 1998 | Mieroporous Mesoporous Mater1998，21，46： | 1 |
| 5 | Illustrating the coupled human-environment system for vulnerability analysis three case studies显示文摘 | Turner II BL Roger E K Pamela A M | 2003 | The Proceedings of the National Academy of Sciences2003，14，： | 1 |
| 6 | The Supply Chain Management Process显示文摘 | Croxton K L Garcfa - Dastugue S J Lambert D M Rogers | 2001 | The International Jour- nal of Logistics Management2001，12，2： | 1 |
| 7 | The multiplayer perceptron as an approximation to a Bayes optimal discriminat function显示文摘 | Ruck D W Rogers S K Kabrisky M | 1990 | IEEE Transactions on Neural Networks1990，1，4： | 1 |
| 8 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 9 | Dielectric properties of M-type barium hexaferrite prepared by co-precipitation显示文摘 | Kajal K M Roger J G | | 0，，04： | 1 |
| 10 | The relationshipbetween check list scores on a communication OSCE and analoguepatients, perceptions of communication显示文摘 | MAZOR K M OCKENE J K ROGERS H J ct al | 2005 | Adv Health Sci EducTheory Pract2005，10，1： | 1 |
| 11 | Network density and R&D spillovers 显示文摘 | ROGERS M MEAGHER K | 2004 | Journal of Economic Behavior&Organization2004，，53： | 1 |
| 12 | Twenty-nine years after carbon monoxide intoxication 显示文摘 | Fereydoon R Roger W K Nirav M | 2001 | Cinical Neurology and Neurosurgery2001，103，： | 1 |
| 13 | Physiologically motivated image fusion for object detection using a pulse coupled neural network 显示文摘 | Broussard R P Rogers S K Oxley M E | 1999 | IEEE Transaction on neural networks1999，10，3： | 1 |
| 14 | Multi-sensor information fusion for targed detection and classification显示文摘 | Roggerman M C Mills J P Rogers S K | 1988 | SPIE1988，931，： | 1 |
| 15 | Dissociation of cognitive and emotional empathy in Adults with Asperger syndrome: Using the Multifaceted Empathy Test (MET)显示文摘 | Dziobek I Rogers K Fleck S Bahnemann M Heekeren H Wolf O Convit A | 2008 | Journal of Autism and Developmental Disorders2008，38，： | 1 |
| 16 | Biodegradation K inetics of Benzene,Toluene,and Phenol as Single and Mixed Substrates for Pseudomonas putida F1显示文摘 | Reardon K F M osteller D C Rogers J | 2000 | Biotechnol Bioeng2000，69，4： | 1 |
| 17 | Environmental protection and atmospheric sciences 显示文摘 | Rogers K R Mascini M | 2002 | Analytical Monitoring2002，，5： | 1 |
| 18 | Self-help housing strategy for temporary population in Guangzhou, China 显示文摘 | Roger C K Chan Y M Yao Simon X B Zhao | 2003 | Habitat International2003，，27： | 1 |
| 19 | iPod Forensics显示文摘 | Marsico C V Rogers M K | 2005 | International Journalof Digital Evidence2005，4，2： | 1 |
| 20 | An authenticated control framework for distributed voltage support on the smart grid显示文摘 | ROGERS K M KLUMP R KHURANA H | 2010 | IEEE Trans on Smart Grid2010，1，1： | 1 |
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