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| 1 | 胃癌预防亚太地区共识指南显示文摘背景与目的:胃癌是亚太地区的主要健康负担之一,但对其预防策略尚缺乏共识。本共识会议旨在评价预防胃癌的策略。方法:多学科专家组应用德尔菲(Delphi)法制订共识条文,提呈相关数据,对证据等级、推荐强度以及共识水平予以分级。结果:幽门螺杆菌(H.pylori)感染是非贲门胃腺癌必要但非充分的致病因子。盐的高摄入与胃癌强烈相关。新鲜果蔬对胃癌具有预防作用,但维生素和其他饮食补充并不能预防胃癌。H.pylori感染中的宿主-细菌相互作用导致不同类型的胃炎和胃酸分泌,从而决定疾病结局。胃癌阳性家族史是一个重要的危险因素。低血清胃蛋白酶原反映胃萎缩程度,可作为检出胃癌高危人群的标志物。H.pylori筛查和治疗被推荐作为减少高危人群胃癌危险性的一种策略,该策略在萎缩性胃炎发生前实施最为有效,但并不排除对胃癌高危人群的内镜监测。对胃癌低危人群不推荐行H.pylori筛查。H.pylori感染的一线治疗应遵循国家治疗指南。结论:高危人群中H.pylori筛查和根除策略可能会减少胃癌的发生率,本共识根据现有证据予以推荐。 | Kwong Ming Fock Nick Talley Paul Moayyedi Richard Hunt Takeshi Azuma Kentaro Sugano Shu Dong Xiao Shiu Kum Lam Khean Lee Goh Tsutomu Chiba Naomi Uemura Jae G Kim Nayoung Kim Tiing Leong Ang Varocha Mahachai Hazel Mitchell Abdul Aziz Rani Jyh Ming Liou Ratha-korn Vilaichone Jose Sollanor 钱本余 | 2008 | 胃肠病学2008，13，4： | 37 |
| 2 | 亚太地区胃食管反流病的处理共识:更新版显示文摘背景与目的:自从2004年亚太地区胃食管反流病(GERD)共识发表以来,更多关于GERD流行病学和处理的文献资料相继出现。有必要对这些资料进行循证综述,对共识作出更新。方法:由多学科专家组应用德尔菲(Delphi)法制定共识条文,提呈相关资料,并对证据质量、推荐力度和共识水平进行分级。结果:亚洲GERD发生率日益增加。其危险因素包括老年、男性、种族、家族史、社会经济地位高、体重指数增加和吸烟。对于有典型症状而无报警症状的患者,对质子泵抑制剂(PPI)试验有症状应答具有诊断意义。如PPI试验失败,停止治疗后pH监测结果阴性可排除GERD。窄带成像、胶囊内镜检查和无线pH监测的作用尚未明确。亚洲诊断策略的制定须考虑到并存的胃癌和消化性溃疡。减轻体质量和抬高床头可改善反流症状。PPIs是最有效的内科治疗手段。对于非糜烂性反流病(NERD)患者,按需治疗较为适宜。有慢性咳嗽、喉炎和典型GERD症状的患者在排除非GERD病因后,应予PPI每天两次治疗。如有经验丰富的外科医师,GERD患者可行胃底折叠术。除临床试验外,GERD不应采用内镜治疗。结论:新的诊断方法和内镜治疗的作用有待进一步研究阐明。亚洲GERD诊断策略的制定须考虑到并存的胃癌和消化性溃疡。PPIs仍为治疗的基石。 | Kwong Ming Fock Nicholas J Talley Ronnie Fass Khean Lee Goh Peter Katelaris Richard Hunt Michio Hongo Tiing Leong Ang Gerald Holtmann Sanjay Nandurkar San Ren Lin Benjamin CY Wong Francis KL Chan Abdul Aziz Rani Young-Tae Bak Jose Sollano Khek Yu Ho Sathoporn Manatsathit 钱本余 | 2008 | 胃肠病学2008，13，7： | 21 |
| 3 | The Qitai radio telescope显示文摘This study presents a general outline of the Qitai radio telescope(QTT)project.Qitai,the site of the telescope,is a county of Xinjiang Uygur Autonomous Region of China,located in the east Tianshan Mountains at an elevation of about 1800 m.The QTT is a fully steerable,Gregorian-type telescope with a standard parabolic main reflector of 110 m diameter.The QTT has adopted an umbrella support,homology-symmetric lightweight design.The main reflector is active so that the deformation caused by gravity can be corrected.The structural design aims to ultimately allow high-sensitivity observations from 150 MHz up to115 GHz.To satisfy the requirements for early scientific goals,the QTTwill be equipped with ultra-wideband receivers and large field-of-view multi-beam receivers.A multi-function signal-processing system based on RFSo C and GPU processor chips will be developed.These will enable the QTT to operate in pulsar,spectral line,continuum and Very Long Baseline Interferometer(VLBI)observing modes.Electromagnetic compatibility(EMC)and radio frequency interference(RFI)control techniques are adopted throughout the system design.The QTT will form a world-class observational platform for the detection of lowfrequency(nano Hertz)gravitational waves through pulsar timing array(PTA)techniques,pulsar surveys,the discovery of binary black-hole systems,and exploring dark matter and the origin of life in the universe.The QTT will also play an important role in improving the Chinese and international VLBI networks,allowing high-sensitivity and high-resolution observations of the nuclei of distant galaxies and gravitational lensing systems.Deep astrometric observations will also contribute to improving the accuracy of the celestial reference frame.Potentially,the QTT will be able to support future space activities such as planetary exploration in the solar system and to contribute to the search for extraterrestrial intelligence. | Na Wang Qian Xu Jun Ma Zhiyong Liu Qi Liu Hailong Zhang Xin Pei Maozheng Chen Richard N.Manchester Kejia Lee Xingwu Zheng Hans J.Kärcher Wulin Zhao Hongwei Li Dongwei Li Martin Süss Matthias Reichert Zhongyi Zhu Congsi Wang Mingshuai Li Rui Li Ning Li Guljaina Kazezkhan Wenming Yan Gang Wu Lang Cui Ming Zhang Haitao Li | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，8： | 14 |
| 4 | Calcium signaling and T-type calcium channels in cancer cell cycling显示文摘Regulation of intracellular calcium is an important signaling mechanism for cell proliferation in both normal and cancerous cells. In normal epithelial cells, free calcium concentration is essential for cells to enter and accomplish the S phase and the M phase of the cell cycle. In contrast, cancerous cells can pass these phases of the cell cycle with much lower cytoplasmic free calcium concentrations, indicating an alternative mechanism has developed for fulfilling the intracellular calcium requirement for an increased rate of DNA synthesis and mitosis of fast replicating cancerous cells. The detailed mechanism underlying the altered calcium loading pathway remains unclear; however, there is a growing body of evidence that suggests the T-type Ca2+ channel is abnormally expressed in cancerous cells and that blockade of these channels may reduce cell proliferation in addition to inducing apoptosis. Recent studies also show that the expression of T-type Ca2+ channels in breast cancer cells is proliferation state dependent, i.e. the channels are expressed at higher levels during the fast-replication period, and once the cells are in a non-proliferation state, expression of this channel isminimal. Therefore, selectively blocking calcium entry into cancerous cells may be a valuable approach for preventing tumor growth. Since T-type Ca2+ channels are not expressed in epithelial cells, selective T-type Ca2+ channel blockers may be useful in the treatment of certain types of cancers. | James T Taylor Xiang-Bin Zeng Jonathan E Pottle Kevin Lee Alun R Wang Stephenie G Yi lennifer A S Scruggs Suresh S Sikka Ming Li | 2008 | World Journal of Gastroenterology2008，14，32： | 12 |
| 5 | Recent Progress in Dual-Polarization Radar Research and Applications in China显示文摘Dual-polarization(dual-pol)radar can measure additional parameters that provide more microphysical information of precipitation systems than those provided by conventional Doppler radar.The dual-pol parameters have been successfully utilized to investigate precipitation microphysics and improve radar quantitative precipitation estimation(QPE).The recent progress in dual-pol radar research and applications in China is summarized in four aspects.Firstly,the characteristics of several representative dual-pol radars are reviewed.Various approaches have been developed for radar data quality control,including calibration,attenuation correction,calculation of specific differential phase shift,and identification and removal of non-meteorological echoes.Using dual-pol radar measurements,the microphysical characteristics derived from raindrop size distribution retrieval,hydrometeor classification,and QPE is better understood in China.The limited number of studies in China that have sought to use dual-pol radar data to validate the microphysical parameterization and initialization of numerical models and assimilate dual-pol data into numerical models are summarized.The challenges of applying dual-pol data in numerical models and emerging technologies that may make significant impacts on the field of radar meteorology are discussed. | Kun ZHAO Hao HUANG Mingjun WANG Wen-Chau LEE Gang CHEN Long WEN Jing WEN Guifu ZHANG Ming XUE Zhengwei YANG Liping LIU Chong WU Zhiqun HU Sheng CHEN | 2019 | Advances in Atmospheric Sciences2019，36，9： | 12 |
| 6 | Prognostic biomarkers for prediction of recurrence of hepatocellular carcinoma:Current status and future prospects显示文摘Hepatocellular carcinoma(HCC)is one of the leading causes of cancer death worldwide,with region specific etiologies.Despite improvements made in the diagnosis of HCC,the prognosis of HCC patients remains poor due to the high recurrence rate of HCC.There is an urgent need for development of prognostic biomarkers to predict the risk of recurrence in HCC patients after'curative'treatment.Such stratification may aid in patient management and development of personalized medicine for HCC treatment.Omics based studies facilitate the study of global changes in biomolecules in a disease in a high throughput manner,and hence are well poised to understand the complex changes which led to HCC recurrence.The quantitative nature of data obtained from omics based studies allow for development of prognostic biomarkers based on changes in gene,protein and metabolite expression.In this review,we surveyed the ap-plication of transcriptomics,proteomics and metabolomics in the study of HCC recurrence.We summarised the data in the literature from these three fields of studies that claimed to be prognostic for HCC recurrence.We critiqued on the limitations of each area of research and the challenges faced in translating the research results for clinical application in predicting HCC recurrence. | Seow Chong Lee Hwee Tong Tan Maxey Ching Ming Chung | 2014 | World Journal of Gastroenterology2014，20，12： | 11 |
| 7 | Improved corrosion resistance and thermal stability of sintered Nd-Fe-B magnets with holmium substitution显示文摘The effects of Ho substitution for Nd on the microstructure, corrosion resistance and thermal stability of the Nd-Fe-B magnets were investigated. The(Nd,Ho)-O phase was formed with increasing Ho substitution. The results of potentiodynamic polarization and highly accelerated stress test show improved corrosion resistance with increasing Ho substitution. The optimum mass loss 0.29 mg/cm^2 is achieved.Moreover, the average temperature coefficients for remanence and coercivity in the range of 25-150℃are both closer to zero, indicating improved thermal stability. The mechanisms for the improved corrosion resistance and thermal stability are discussed in relation to the microstructure featuring the(Nd,Ho)-O phase. | Jinghui Di Shuai Guo Ling Chen Pengpeng Yi Guangfei Ding Kan Chen Ming Li Don Lee Aru Yan | 2018 | Journal of Rare Earths2018，36，8： | 11 |
| 8 | A new prognostic histopathologic classification of nasopharyngeal carcinoma显示文摘Background:The current World Health Organization(WHO) classification of nasopharyngeal carcinoma(NPC) con?veys little prognostic information.This study aimed to propose an NPC histopathologic classification that can poten?tially be used to predict prognosis and treatment response.Methods:We initially developed a histopathologic classification based on the morphologic traits and cell differentia?tion of tumors of 2716 NPC patients who were identified at Sun Yat?sen University Cancer Center(SYSUCC)(training cohort).Then,the proposed classification was applied to 1702 patients(retrospective validation cohort) from hospitals outside SYSUCC and 1613 patients(prospective validation cohort) from SYSUCC.The efficacy of radiochemotherapy and radiotherapy modalities was compared between the proposed subtypes.We used Cox proportional hazards models to estimate hazard ratios(HRs) with 95% confidence intervals(CI) for overall survival(OS).Results:The 5?year OS rates for all NPC patients who were diagnosed with epithelial carcinoma(EC;3708 patients),mixed sarcomatoid?epithelial carcinoma(MSEC;1247 patients),sarcomatoid carcinoma(SC;823 patients),and squamous cell carcinoma(SCC;253 patients) were 79.4%,70.5%,59.6%,and 42.6%,respectively(P < 0.001).In mul?tivariate models,patients with MSEC had a shorter OS than patients with EC(HR = 1.44,95% CI = 1.27–1.62),SC(HR = 2.00,95% CI = 1.76–2.28),or SCC(HR = 4.23,95% CI = 3.34–5.38).Radiochemotherapy significantly improved survival compared with radiotherapy alone for patients with EC(HR 49–0.75),and possibly for those with SCC(HR = 0.67,95% CI = 0.56–0.80),MSEC(HR = 0.58,95% CI = 0..74–1.28).= 0.63;95% CI = 0.40–0.98),but not for patients with SC(HR = 0.97,95% CI = 0Conclusions:The proposed classification offers more information for the prediction of NPC prognosis compared with the WHO classification and might be a valuable tool to guide treatment decisions for subtypes that are associ?ated with a poor prognosis. | Hai-Yun Wang Yih-Leong Chang Ka-Fai To Jacqueline S.G.Hwang Hai-Qiang Mai Yan-Fen Feng Ellen T.Chang Chen-Ping Wang Michael Koon Ming Kam Shie-Lee Cheah Ming Lee Li Gao Hui-Zhong Zhang Jie-Hua He Hao Jiang Pei-Qing Ma Xiao-Dong Zhu Liang Zeng Chun-Yan Chen Gang Chen Ma-Yan Huang Sha Fu Qiong Shao An-Jia Han Hai-Gang Li Chun-Kui Shao Pei-Yu Huang Chao-Nan Qian Tai-Xiang Lu Jin-Tian Li Weimin Ye Ingemar Ernberg Ho Keung Ng Joseph T.S.Wee Yi-Xin Zeng Hans-Olov Adami Anthony T.C.Chan Jian-Yong Shao | 2016 | Chinese Journal of Cancer2016，35，6： | 10 |
| 9 | Stroke in China: epidemiology, prevention, and management strategies显示文摘 | Ming Liu Bo Wu Wen-Zhi Wang Li-Ming Lee Shi-Hong Zhang Ling-Zhi Kong | 2007 | Lancet Neurology2007，，5： | 9 |
| 10 | Application of Cellulose Nanofibril as a Wet-end Additive in Papermaking:A Brief Review显示文摘Recently,cellulose nanofibril(CNF)has emerged as a promising,sustainable reinforcement with outstanding potential in material science.Owing to the properties of CNF,it has been explored in food,cosmetic,and pharmaceutical applications,as well as in industrial applications such as paints,drill muds,packaging,and papermaking.The application of CNF in papermaking is expected to be implemented in the near future to broaden the commercial market of cellulose.Numerous studies and patents have reported on the manufacturing,properties,and applications of nanocellulose.This present paper focuses on the recent progresses in the application of CNF as a wet-end additive in papermaking. | Guihua Yang Guangrui Ma Ming He Xinxiang Ji Hye Jung Youn Hak Lae Lee Jiachuan Chen | 2020 | Paper And Biomaterials2020，5，2： | 9 |
| 11 | 颅脑有限元模型演化规律及其生物力学研究进展显示文摘交通事故中头颈部损伤因其较高的致命性,已成为最严重的损伤类型。有限元模型在创伤性脑损伤生物力学机理研究中得到日益广泛应用。回顾头颈部有限元模型的生物力学研究历史和现状,并阐述车辆碰撞交通事故中人体颅脑典型交通伤演化规律和生物力学研究进展,探索头颈部损伤安全防护的方法,以期为车辆碰撞事故中人体颅脑损伤生物力学研究和相应的汽车安全防护装置研制提供理论依据。 | 羊玢 曹立波 陈宁 Tse Kwong Ming Lee Heow Pueh | 2014 | 医用生物力学2014，29，6： | 8 |
| 12 | A middle-aged lady with a pyogenic liver abscess caused by Clostridium perfringens显示文摘The pyogenic liver abscess caused by Clostridium perfringens (C. perfringens ) is a rare, but rapidly fatal infection. It is usually associated with malignancy and immunosuppression. We report the case of 50-year-old lady with the secondary liver metastases from rectal cancer presented with fever and epigastric pain. The identification of Grampositive bacilli septicaemia, the presence of gas-forming liver abscess and massive intravascular hemolysis should lead to the suspicion of C. perfringens infection. Here we review twenty cases published since 1990 and their clinical features are discussed. The importance of 'an aggressive treatment policy' with multidisciplinary team approach is emphasized. | Siu-Tong Law Ming Kai Lee | 2012 | World Journal of Hepatology2012，4，8： | 8 |
| 13 | 开关电容PWM DC-DC电压调节模块显示文摘介绍了一种开关电容PWM DC-DC电压调节模块,该变换器是开关电容变换器和PWM变换器的结合,具有如下优点:①开关管的零电压开关(Zero-Voltage-Switching,ZVS);②运用自耦变压器实现同步整流管(Synchronous Rectifier,SR)的自驱动,减小了驱动损耗和体二极管导通损耗;③变压器漏感对效率的影响小,可以使用常规的分立式变压器,从而降低成本;④变换器是单相的,结构简单,应用灵活。在理论分析的基础上,搭建了一台四相700kHz 1.2V/130AVRM原理样机验证了理论分析的正确性。 | 曹文静 金科 Ming Xu F C Lee | 2012 | 电工技术学报2012，27，10： | 8 |
| 14 | Phosphorylation of Serine 186 of bHLH Transcription Factor SPEECHLESS Promotes Stomatal Development in Arabidopsis显示文摘在 Arabidopsis 的有气孔的系和随后的不对称的部门的开始要求基本 helix-loop-helix 抄写因素的活动哑(SPCH ) 。SPCH 也激活 MITOGEN 的蛋白质 KINASE (MAPK ) 串联或象 GSK3 一样 kinase BRASSINOSTEROID 作为底层控制入口进有气孔的系,这被显示出感觉迟钝 2 (BIN2 ) 。这里,我们证明 SPCH 的三丝氨酸残余看起来是 Cyclin 依赖的 Kinases A 的主要 phosphorylation 目标; 1 (CDKA; 1 ) invitro,并且在他们之中,丝氨酸 186 在有气孔的形成起一个关键作用。怀有在丝氨酸 186 残余上导致 phosphorylation 缺乏的一个变化的 SPCH 构造的表示没能在 spch 0 异种救有气孔的缺点。phosphorylation 模仿异种 SPCH S186D 在怀有主导否定的 CDKA 的指向的表示的转基因的线补充了有气孔的生产缺点; 1 .N146。除了 SPCH 上的调停 MAPK 、调停 BIN2 的 phosphorylation,因此,在丝氨酸 186 点的 phosphorylation 断然在调整有气孔的开发为 SPCH 功能被要求。 | Ke-Zhen Yang Min Jiang Ming Wang Shan Xue Ling-Ling Zhu Hong-Zhe Wang Jun-Jie Zou Eun-Kyoung Lee Fred Sack Jie Le | 2015 | Molecular Plant2015，8，5： | 7 |
| 15 | Effect of platinum on the photocatalytic degradation of chlorinated organic compound显示文摘TiO 2 nanoparticles, doped with different Pt contents, were prepared by a modified photodeposition method using Degussa P-25 TiO 2 , H 2 PtCl 6 ·6H 2 O and methanol as the solvents. The physicochemical properties of Pt/TiO 2 were investigated by the nitrogen adsorption and desorption isotherm measurement technique, X-ray diffraction analysis and photoluminescence spectra, respectively. Reaction rates from photocatalytic removal of dichloromethane over Degussa P-25 TiO 2 and Pt/TiO 2 were evaluated. The average diameter and BET surface area of the TiO 2 catalyst particles were 300 nm and 50 m 2 /g, respectively. The degradation efficiency was 99.0%, 82.7%, 55.2%, and 57.9% with TiO 2 at inlet concentrations of 50, 100, 200, and 300 ppm, respectively. And the degradation efficiency was 99.3%, 79.7%, 76.5%, and 73.4% with a 0.005 wt.% Pt/TiO 2 at inlet concentrations of 50, 100, 200, and 300 ppm, respectively. In addition, we found that the photoluminescence emission peak intensities decreased with increases in the doping amount of Pt, which indicates that the irradiative recombination was weakened. Furthermore, the results showed that the UV/0.005 wt.% Pt/TiO 2 process was capable of efficiently decomposing gaseous DCM in air. | Chih Ming Ma Ya Wen Lee Gui Bing Hong Te Li Su Je Lueng Shie Chang Tang Chang | 2011 | Journal of Environmental Sciences2011，23，4： | 5 |
| 16 | NUTRIENT LOAD ESTIMATION METHODS FOR RIVERS显示文摘Pollutant load estimation is essential for watershed management and water pollution control. For most watersheds, only sparse water quality measurements (e.g. monthly data) are available. The influence of input data on the accuracy of non-point source pollution load estimation is studied using the water quality and stream flow data from a small watershed in Hong Kong. Comparison and analysis of the results using 8 different methods show that the accuracy of stream-flow runoff is the single most important factor for the calculation of pollutant load. Based on the results, the stream flow correction coefficient is advanced to provide a more reliable load estimation. The improved method of pollutant load estimation can be easily applied in practice since the stream-flow runoff can be measured by hydrological station or estimated with various hydrological methods. | Huai-en LI. Joseph Hun-Wei LEE and Ming CM Professor, Environmental Science Institute, Xi’an University of Technology. Xi’an 710048. Shaanxi, P.R. China.Professor, Department of Civil Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong.P.R. China, 1 Ph.D. student in Hydrology and Water Resources. Environmental Science Institute, Xi’an University ofTechnology, Xi’an 710048, Shaanxi, P.R. China | 2003 | International Journal of Sediment Research2003，18，4： | 5 |
| 17 | A cross-sectional study on compliance with topical glaucoma medication and its associated socioeconomic burden for a Chinese population显示文摘AIM: To estimate the overall drug compliance for local Chinese glaucoma patients on long-term topical treatment.METHODS: This was a retrospective cross-sectional study.Fifty-seven primary glaucoma patients from the subspecialty clinic of a publicly-funded tertiary care hospital in Hong Kong completed a questionnaire on compliance with topical glaucoma medication,attitude towards glaucoma and therapy and vision related quality of life.Noncompliance was defined as reporting missing more than or equal to 10% of the prescribed topical glaucoma medication during the 2wk immediately prior to the consultation.Relationships between noncompliance and demographics,attitude,disease and treatment status was studied.Cost was estimated with quality of life and direct medical cost involved with noncompliance.Multivariable logistic regression on noncompliance was performed on selected factors.RESULTS: Compliance was calculated as 75%(95% CI: 64%-87%) among 57 subjects(mean age 69 y,female 51%).No statistical significant relationship was established between noncompliance and any single factors or outcomes.Age(P=0.048) and forgetfulness(P=0.064) were found to be marginally significant predictive factors on noncompliance in multivariable logistic regression.Noncompliance might be related(P=0.130) to poorer self-rated vision-associated quality of life.The societal cost of noncompliance was estimated to be over 2510 life-years and US$ 3.7 million territory-wide.CONCLUSION: The compliance of Chinese glaucoma patients in Hong Kong is comparable to other parts in the world,and carries detrimental impacts on individual and societal levels.Age and forgetfulness are two possible independent predictors for noncompliance. | Man-Hin Lui Jason Chun Ho Lam Yi Lee Kwong Tak Siu Wong Pak Long Cheung Sherri Shun Yan Lai Pak Lun Yuen Wai Yiu Lam Ho Yan Chan Yiu Fai Wong Jimmy Shiu Ming Lai Kendrick Co Shih | 2017 | International Journal of Ophthalmology(English edition)2017，10，2： | 5 |
| 18 | IMPACTS OF CLIMATE CHANGE ON TROPICAL CYCLONES IN THE WESTERN NORTH PACIFIC BASIN. PART Ⅱ: LATE TWENTY-FIRST CENTURY PROJECTIONS显示文摘This paper reviews the latest studies on the relationship between projected late 21 st century climate changes and tropical cyclone(TC) activity in the western North Pacific(WNP) basin, which is the region of the United Nations Economic and Social Commission for Asia and the Pacific(ESCAP)/World Meteorological Organization(WMO) Typhoon Committee members. Existing studies of projected changes of TC activity in this basin, such as frequency, intensity, precipitation, genesis location and track pattern are summarized, based on an assumed A1 B future climate change scenario. A review of available studies on projected future changes in WNP landfalling TC activity is also included.While it remains uncertain whether there has been any detectable human influence on tropical cyclone frequency, intensity, precipitation, track, or related aggregated storm activity metrics in the basin, modeling studies suggest changes in future tropical cyclone activity for the WNP basin. More models project decreases than increases in tropical storm frequency(range-70% to +60%);most studies project an increase in the TC intensity(range-3% to +18%);and all six available studies that include the WNP basin project increases in TC precipitation rates(range +5 to +30%). | MING YING THOMAS R.KNUTSON HIROTAKA KAMAHORI TSZ-CHEUNG LEE | 2012 | Tropical Cyclone Research and Review2012，1，2： | 4 |
| 19 | Multi-timescale robust dispatching for coordinated automatic generation control and energy storage显示文摘The increasing penetration of renewable energy into power grids is reducing the regulation capacity of automatic generation control(AGC).Thus,there is an urgent demand to coordinate AGC units with active equipment such as energy storage.Current dispatch decision-making methods often ignore the intermittent effects of renewable energy.This paper proposes a two-stage robust optimization model in which energy storage is used to compensate for the intermittency of renewable energy for the dispatch of AGC units.This model exploits the rapid adjustment capability of energy storage to compensate for the slow response speed of AGC units,improve the adjustment potential,and respond to the problems of intermittent power generation from renewable energy.A column and constraint generation algorithm is used to solve the model.In an example analysis,the proposed model was more robust than a model that did not consider energy storage at eliminating the effects of intermittency while offering clear improvements in economy and efficiency. | Yiran Ma Xueshan Han Ming Yang Wei-Jen Lee | 2020 | Global Energy Interconnection2020，3，4： | 4 |
| 20 | Heat shock protein inhibitor, quercetin, as a novel adjuvant agent to improve radiofrequency ablation-induced tumor destruction and its molecular mechanism显示文摘Background: We investigated the effect of a small molecular inhibitor of heat shock protein(HSP), quercetin, on tumor radiofrequency(RF) ablation, and explored the underlying molecular mechanisms.Methods: In in vivo study, rats with R3230 breast adenocarcinoma were sacrificed 24 h post-treatment and gross coagulation areas were compared, and next, randomized into four treatment arms(control, quercetin alone, RF alone, and combination) for Kaplan-Meier analysis of defined endpoint survival. Then the distribution and expression levels of heat shock protein 70(HSP70), cleaved caspase-3 and heat shock factor 1(HSF1) were analyzed after different treatments. In in vitro study, we used quercetin to promote SKHEP-1(hepatic) and MCF-7(breast) cancer cell apoptosis in heat shock cell model, and si RNA was used to block c-Jun and to explore the role of activating protein-1(AP-1) signaling pathways.Results: We found the effects of quercetin plus RFA resulted in increase on the tumor destruction/endpoint survival(26.5±3.4 d) in vivo, compared with RF alone(17.6±2.5 d) and quercetin alone(15.7±3.1 d). Most importantly, quercetin-induced cancer cell death required the presence of HSF1 in animal model. Furthermore, quercetin directly down-regulated expression of HSF1 in vitro, which our findings have revealed, required the activation of AP-1 signaling pathways by loss-of-function analysis using si RNA mediated targeting of c-Jun.Conclusions: These results indicated a protective role of quercetin in tumor ablation and highlighted a novel mechanism involving HSP70 with HSF1 pathway in thermal ablation of solid tumors. | Wei Yang Ming Cui Jungchieh Lee Wei Gong Song Wang Jingjing Fu Gongxiong Wu Kun Yan | 2016 | Chinese Journal of Cancer Research2016，28，1： | 4 |
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