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| 1 | Current developments in pharmacological therapeutics for chronic constipation显示文摘Chronic constipation is a common gastrointestinal disease severely affecting the patient's quality of life. The traditional treatment of constipation is the use of laxatives. Recently, several new drugs including lubiprostone, linaclotide and prucalopride have been approved for treatment of chronic constipation. However, a significant unmet medical need still remains, particularly among those patients achieving poor results by current therapies. The 5-HT4 receptor modulators velusetrag and naronapride,the guanylate cyclase C agonist plecanatide and the ileal bile acid transporter inhibitor elobixibat are recognized as the most promising drugs under investigation. Herein, we give a comprehensive review on the pharmacological therapeutics for the treatment of chronic constipation, with the purpose of reflecting the drug development trends in this field. | Chunhuan Jiang Qinglong Xu Xiaoan Wen Hongbin Sun | 2015 | Acta Pharmaceutica Sinica B2015，5，4： | 23 |
| 2 | The Chinese Hα Solar Explorer(CHASE) mission: An overview显示文摘The Chinese Hα Solar Explorer(CHASE), dubbed “Xihe”—Goddess of the Sun, was launched on October 14, 2021 as the first solar space mission of China National Space Administration(CNSA). The CHASE mission is designed to test a newly developed satellite platform and to acquire the spectroscopic observations in the Hα waveband. The Hα Imaging Spectrograph(HIS)is the scientific payload of the CHASE satellite. It consists of two observational modes: raster scanning mode and continuum imaging mode. The raster scanning mode obtains full-Sun or region-of-interest spectral images from 6559.7 to 6565.9 ? and from 6567.8 to 6570.6 ? with 0.024 ? pixel spectral resolution and 1 min temporal resolution. The continuum imaging mode obtains photospheric images in continuum around 6689 ? with the full width at half maximum of 13.4 ?. The CHASE mission will advance our understanding of the dynamics of solar activity in the photosphere and chromosphere. In this paper, we present an overview of the CHASE mission including the scientific objectives, HIS instrument overview, data calibration flow, and first results of on-orbit observations. | Chuan Li Cheng Fang Zhen Li MingDe Ding PengFei Chen Ye Qiu Wei You Yuan Yuan MinJie An HongJiang Tao XianSheng Li Zhe Chen Qiang Liu Gui Mei Liang Yang Wei Zhang WeiQiang Cheng JianXin Chen ChangYa Chen Qiang Gu QingLong Huang MingXing Liu ChengShan Han HongWei Xin ChangZheng Chen YiWei Ni WenBo Wang ShiHao Rao HaiTang Li Xi Lu Wei Wang Jun Lin YiXian Jiang LingJie Meng Jian Zhao | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，8： | 7 |
| 3 | Determinants of vigilance in a reintroduced population of Pere David's deer显示文摘 | Wei ZHENG Guy BEAUCHAMP Xuelei JIANG Zhongqiu LI Qinglong YANG | 2013 | Current Zoology2013，59，2： | 4 |
| 4 | Genetically encoded X-ray cellular imaging for nanoscale protein localization显示文摘Spatial resolution defines the physical limit of microscopes for probing biomolecular localization and interactions in cells.Whereas synchrotron-based X-ray microscopy(XRM)represents a unique approach for imaging a whole cell with nanoscale resolution due to its intrinsic nanoscale resolution and great penetration ability,existing approaches to label biomolecules rely on the use of exogenous tags that are multi-step and error-prone.Here,we repurpose engineered peroxidases as genetically encoded X-ray-sensitive tags(GXET)for site-specific labeling of protein-of-interest in mammalian cells.We find that 3,3-diaminobenzidine(DAB)polymers that are in-situ catalytically formed by fusion-expressed peroxidases are visible under XRM.Using this new tag,we imaged the protein location associated with the alteration of a DNA-methylation pathway with an ultra-high resolution of 30 nanometers.Importantly,the excellent energy resolution of XRM enables multicolor imaging using different peroxidase tags.The development of GXET enlightens the way to nanoscopic imaging for biological studies. | Huating Kong Jichao Zhang Jiang Li Jian Wang Hyun-Joon Shin Renzhong Tai Qinglong Yan Kai Xia Jun Hu Lihua Wang Ying Zhu Chunhai Fan | 2020 | National Science Review2020，7，7： | 3 |
| 5 | Preparation of Mg,N-co-doped lignin adsorbents for enhanced selectivity and high adsorption capacity of As(Ⅴ) from wastewater显示文摘Among various environmental problems,water pollution has drawn more and more attention.To develop an adsorbent with enhanced selectivity and high capacity for As(V)oxyanion,a novel lignin-based adsorbent was prepared by doping with N and modifying with Mg^(2+),using thiethylenetetramine(TETA)and MgCl_(2) as the source of N and Mg^(2+),respectively.N-doped lignin(NL)shows a high selectivity for As(Ⅴ),which is further enhanced by modifying with Mg^(2+)(MNL).MNL shows an excellent reusability.The adsorption isotherms and kinetics of MNL for As(Ⅴ)follow Langmuir isotherms model and pseudo-second-order kinetics model,respectively.The adsorption of MNL for As(Ⅴ)achieved a maximum adsorption capacity of 687.46 mg g^(−1) and the equilibrium was established within 30 min.This study offers a novel idea on the recycle of the waste of paper industry and provides a new technology for As(Ⅴ)adsorption from wastewater. | Xiaofeng Shi Junmao Hong Chao Wang Sifang Kong Junhua Li Duo Pan Jing Lin Qinglong Jiang Zhanhu Guo | 2021 | Particuology2021，19，5： | 2 |
| 6 | New stability criteria for linear systems with interval time-varying delay显示文摘 | JIANG Xiefu HAN Qinglong | 2008 | Automatiea2008，44，10： | 1 |
| 7 | Role of the carrier gas flow rate in monolayer MoS2 growth by modified chemical vapor deposition显示文摘单层铝二硫化物(因为潜在的应用的变化,瞬间 2) 吸引了许多注意。然而,它的控制生长仍然是大挑战。这里,我们报导一个修改化学蒸汽免职方法种单层瞬间 2 。我们观察到瞬间 2 晶体的质量能被在加热阶段期间调节搬运人气体流动率极大地改进。这微妙的修正阻止在先锋之间的控制不了的反应,为高质量的单层瞬间 2 的生长的一个关键因素。基于优化煤气的流动率,瞬间 2 范围和薄片尺寸能被调整生长时间控制。 | Hengchang Liu Yuanhu Zhu Qinglong Meng Xiaowei Lu Shuang Kong Zhiwei Huang Peng Jiang Xinhe Bao | 2017 | Nano Research2017，10，2： | 1 |
| 8 | A new H∞ stabilization criterion for networked control sys- tems 显示文摘 | JIANG Xiefu HAN Qinglong LIU Shirong | 2008 | IEEE Transactions on Automatic Control2008，53，4： | 1 |
| 9 | Analysis of Volatile Components in Fresh Fruit of Morinda citrifolia L.from Different Origins Based on HS-SPME-GC/MS显示文摘[Objectives]This study was conducted to clarify the differences of volatile components in fresh fruit of Morinda citrifolia L.from different origins.[Methods]The method of HS-SPME-GC/MS detection was used to determine the volatile chemical components in fresh fruit of M.citrifolia.[Results]52,52 and 45 volatile components were identified from the fresh fruit of M.citrifolia from Xisha,Wanning and Haikou,respectively.Among them,the number and content of the identified esters were relatively high,mainly methyl caprylate,ethyl caprylate,4-pentenyl caproate,3-methylbuten-2-enyl caprylate,methyl caproate,and ethyl caproate.There were also fatty acids,alcohols,phenols,ketones,aldehydes and other substances.There were 33 common ingredients in the fruit from the three origins,mainly including caprylic acid,caproic acid,capric acid,methyl caprylate,ethyl caprylate,4-pentenyl caproate,3-methylbutene-2-enyl caprylate,methyl caproate,ethyl caproate,methyl caprate and hexyl caproate.[Conclusions]The types and contents of volatile components in fresh fruit of M.citrifolia from different origins were significantly different. | Dan WANG Qian JIANG Qinglong WANG Chao YUAN Maoyuan WANG Zuowang FAN Xiaolu CHEN Fulai YU | 2022 | Agricultural Biotechnology2022，11，4： | 1 |
| 10 | On designing fuzzy controllers for a class of nonlinear networked control systems显示文摘 | JIANG Xiefu HAN Qinglong | 2008 | IEEE Transactions on Fuzzy Systems2008，16，4： | 1 |
| 11 | On designing fuzzy controllers for a class of nonlinear networked control systems显示文摘 | Jiang Xiefu Han Qinglong | | 0，，： | 1 |
| 12 | Application Effect of Micropore Aeration Technique in Rearing Process of Summer Fingerlings of Silurus asotus from Poyang Lake显示文摘Application effect of micropore aeration technique in rearing process of summer fingerlings of Silurus asotus from Poyang Lake was studied.This study provides an efficient safe aeration solution for large-scale fingerling rearing of Silurus asotus. | Yi YAO Chunxian XIONG Liangqing XU Qinglong JIANG Lan LAN Lougen ZENG | 2016 | Agricultural Biotechnology2016，5，5： | 1 |
| 13 | New stability eriteria for linear systems with interval time-varying delay 显示文摘 | JIANG Xiefu HAN Qinglong | 2008 | Automatiea2008，44，17： | 1 |
| 14 | New Stability Criteria for Linear Systems with Interval Time-Varying Delay显示文摘 | Jiang Xiefu Han Qinglong | 2008 | Automati- ca2008，44，10： | 1 |
| 15 | A new H-infinity stabilization criterion for networked control systems显示文摘 | Jiang Xiefu Han Qinglong Liu Shirong | 2008 | IEEE Trans on Automatic Control2008，53，4： | 1 |
| 16 | A newHoo stabilization criterion for networked control sys- tems显示文摘 | Jiang Xiefu Han Qinglong Liu Shirong | 2008 | IEEE Transactions on Automatic Control2008，53，4： | 1 |
| 17 | New Stability Criteria for Linear Systems with Interval Time-Varying Delay显示文摘 | Jiang Xiefu Han Qinglong | 2008 | Automatica2008，44，10： | 1 |
| 18 | A new h- infinity stabilization criterion for networked control sys- tems显示文摘 | Jiang Xiefu Han Qinglong Liu Shirong | 2008 | IEEE Transactions on Automatic Control2008，53，4： | 1 |
| 19 | Delay-dependent robust stability for uncertain linear systems with interval time-varying delay 显示文摘 | Jiang Xiefu Han Qinglong | 2006 | Automatica2006，42，6： | 1 |
| 20 | New stability criteria for linear systems with interval time-varying delay显示文摘 | Jiang Xiefu Han Qinglong | 2008 | Automatica2008，44，10： | 1 |
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