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| 1 | Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis显示文摘CUL4B ubiquitin ligase 基因的变化有原因地被连接到 syndromic X 连接智力迟钝(XLMR ) 。然而,在 neuronal 和发展缺点的 CUL4B 变化的病原的角色没被理解。我们与 Cul4b 的指向的混乱产生了老鼠,并且与显著生长抑制观察了胚胎的致命性并且在胚胎外的纸巾增加了 apoptosis。Cul4b,然而并非它的 paralog Cul4a,在胚胎外的纸巾驿站培植在高水平被表示。在一根胚胎外的房间线的 CUL4B 表示的 Silencing 导致了 CUL4 底层 p21 Cip1/WAF 和 G2/M 房间周期逮捕 Cip1/WAF 。Cul4b 的 Epiblast 特定的删除阻止了胚胎的致命性并且产生了可行 Cul4b 空老鼠。因此,当时在胚胎非必需合适, Cul4b 在胚胎外的纸巾执行一个必要发展角色。我们的学习提供策略产生可行 Cul4b 缺乏的老鼠为潜在的 neuronal 和人的 CUL4B XLMR 病人的行为的缺乏建模。 | Liren Liu Yan Yin Yuewei Li Lisa Prevedel Elizabeth H Lacy Liang Ma Pengbo Zhou | 2012 | Cell Research2012，22，8： | 6 |
| 2 | Mechanical, tribological and heat resistant properties of fluorinated multi-walled carbon nanotube/bismaleimide/cyanate resin nanocomposites显示文摘Bismaleimide containing cyanate resin(BMI/CE) pre-ploymer was used as resin matrix. Fluorinated multiwalled carbon nanotubes(F-MWCNTs) were used as fillers to prepare F-MWCNT/BMI/CE nanocomposites via a solution intercalation method. The influence of F-MWCNT content on the mechanical, tribological and heat resistant properties of the nanocomposites was investigated. The morphology of the fracture surface and the wear surface of nanocomposites were characterized by scanning electron microscopy.Results show that the addition of F-MWCNTs is beneficial to improving the mechanical and tribological properties of the nanocomposites. It's worth noting that when the content of F-MWNTs was 0.6 wt%, the performances of nanocomposite are optimized(i.e., highest impact strength, lowest frictional coefficient and wear rate). In addition, the nanocomposites exhibit good thermal stability in comparison with BMI/CE. | Pengbo Li Tiehu Li Hongxia Yan | 2017 | Journal of Materials Science & Technology2017，33，10： | 5 |
| 3 | Prevalence and clinical significance of pathogenic germline BRCA1/2 mutations in Chinese non-small cell lung cancer patients显示文摘Objective: Germline alterations in the breast cancer susceptibility genes type 1 and 2, BRCA1 and BRCA2, predispose individuals to hereditary cancers, including breast, ovarian, prostate, pancreatic, and stomach cancers.Accumulating evidence suggests inherited genetic susceptibility to lung cancer.The present study aimed to survey the prevalence of pathogenic germline BRCA mutations(gBRCAm) and explore the potential association between gBRCAm and disease onset in Chinese advanced non-small cell lung cancer(NSCLC) patients.Methods: A total of 6,220 NSCLC patients were screened using capture-based ultra-deep targeted sequencing to identify patients harboring germline BRCA1/2 mutations.Results: Out of the 6,220 patients screened, 1.03%(64/6,220) of the patients harbored the pathogenic gB RCAm, with BRCA2 mutations being the most predominant mutations(49/64, 76.5%).Patients who developed NSCLC before 50 years of age were more likely to carry gBRCAm(P = 0.036).Among the patients harboring classic lung cancer driver mutations, those with concurrent gBRCAm were significantly younger than those harboring the wild-type gBRCA(P = 0.029).By contrast, the age of patients with or without concurrent gBRCAm was comparable to those of patients without the driver mutations(P = 0.972).In addition, we identified EGFR-mutant patients with concurrent gBRCAm who showed comparable progression-free survival but significantly longer overall survival(P = 0.002) compared to EGFR-mutant patients with wild-type germline BRCA.Conclusions: Overall, our study is the largest survey of the prevalence of pathogenic gBRCAm in advanced Chinese NSCLC patients.Results suggested a lack of association between germline BRCA status and treatment outcome of EGFR-TKI.In addition,results showed a positive correlation between pathogenic gB RCAm and an early onset of NSCLC. | Xingsheng Hu Dongyong Yang Yalun Li Li Li Yan Wang Peng Chen Song Xu Xingxiang Pu Wei Zhu Pengbo Deng Junyi Ye Hanhan Zhang Analyn Lizaso Hao Liu Xinru Mao Hai Huang Qian Chu Chengping Hu | 2019 | Cancer Biology & Medicine2019，16，3： | 4 |
| 4 | Urban biodiversity in China: Who are winners? Who are losers?显示文摘Rapid urbanization in the last three decades has impacted biogeographic patterns of wildlife in China profoundly.Large areas of natural habitats have been converted into concentrated industrial and residential areas[1].Remaining habitats in vicinities of cities are often fragmented and degraded[2].Besides land use/land cover changes,anthropogenic disturbances such as the introduction of exotic species further add pressure on local biodiversity[3].How does wildlife respond to these impacts?Who | Jun Yang Pengbo Yan Xueyan Li | 2016 | Science Bulletin2016，61，21： | 3 |
| 5 | Electrochemical sensor for naphthols based on gold nanoparticles/hollow nitrogendoped carbon microsphere hybrids functionalized with SH-β-cyclodextrin显示文摘 | ZHU Gangbing GAI Pengbo YANG Yan | 2012 | Analytica Chimica Acta2012，723，： | 1 |
| 6 | Photon penetration depth in human brain for light stimulation and treatment:A realistic Monte Carlo simulation study显示文摘Light has been clinically utilized as a stimulation in medical treatment,such as Low-level laser therapy and photodynamic thenapy,which has been more and more widely accepted in public.The penetration depth of the treatment light is important for precision treatment and safety control.The isue of light penetration has been highlighted in biomedical optics field for decades.However,quantitative research is sparse and even there are conflicts of view on the capability of near-infrared light penet ration into brain tissue.This study attempts to quantitatively revisit this issue by innovative high-realistic 3D Monte Caro modeling of stimulated light penetnation within high precision Visible Chinese human head.The properties of light,such as its wave-length,ilumination profle and size are concern in this study.We made stra ightforward and quantitative comparisons among the ffects by the light properties(i.e.,wavelengths:660,810 and 980 nn;beam types:Gaussi an and flat beamn;bear dianeters:0,2,4 and 6 cm)which are in the range of light treatment.The findings include about 3%of light dosage within brain tisue;the combination of Gaussian beam and 810nm light make the max imum light penetration(>5cm),which allows light to cross through gray matter into white mater.This study offered us,the first time as we know,quantitative guide for light stimulation parameter optimization in medical treatment. | Ting Li Chang Xue Pengbo Wang Yan Li Lanhui Wu | 2017 | Journal of Innovative Optical Health Sciences2017，，5： | 1 |
| 7 | Erratum to Prevalence and clinical significance of pathogenic germline BRCA1/2 mutations in Chinese non-small cell lung cancer patients显示文摘In the published article1,the affiliation for the first author,Xingshcng Hu,is'Department of Medical Oncology,Cancer Hospital,Chinese Academy of Medical Sciences',we would like to update it to'Department of Medical Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100021,China'.We apologize for the errors and for any confusion it may have caused. | Xingsheng Hu Dongyong Yang Yalun Li Li Li Yan Wang Peng Chen Song Xu Xingxiang Pu Wei Zhu Pengbo Deng Junyi Ye Hanhan Zhang Analyn Lizaso Hao Liu Xinru Mao Hai Huang Qian Chu Chengping Hu | 2020 | Cancer Biology & Medicine2020，17，2： | 1 |
| 8 | Tribological properties of bismaleimide composites with surface-modified SiO2 nanoparticles 显示文摘 | Yan Hongxia Li Pengbo Ning Rongchang | 2008 | Journal of Applied Polymer Science2008，110，3： | 1 |
| 9 | Modeling and control of a novel X-Y parallel piezoelectric-actuator driven nanopositioner 显示文摘 | Pengbo Liu Peng Yan Zhen Zhang | 2014 | ISA Transactions2014，，10： | 1 |
| 10 | 3-41 Bio-audiovisual Feedback Breathing Guidance Technique for Synchrotron-based Ion Beam Delivery显示文摘Based on the periodic synchrotron-based beam delivery,a bio-audiovisual feedback breathing guidance technique has been developed to mitigate the interplay between target motion and dynamic beam delivery for ion beam therapy,in which variable beam extraction and generation of individualized breathing guidance curve are two key factors.Shown in Fig.1 is the schematic diagram of the breathing guidance technique.Through the simulations with 15 healthy volunteers for the breathing guidance technique,we found not only the treatment efficiency of synchrotron-based pulsed ion beam could be increased effectively,but also the residual movement of respiration during gating window could be reduced. | Li Qiang He Pengbo Liu Xinguo Dai Zhongying Ma Yuanyuan Shen Guosheng Yan Yuanlin Huang Qiyan Fu Tingyan | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 11 | 3-42 Fast Calibration of EBT Films in Scanned Ion Therapy显示文摘In the quality assurance of photon and ion beam radiotherapy with EBT films, the dose response curves of thesefilms should previously be calibrated. The traditional calibration method is to cut a big piece of EBT film intomany small ones, which are separately irradiated with different doses. Then these small EBT films are digitizedwith a commercial flatbed color scanner to get the net optical density (netOD) values, which are fitted against thedoses. In this work, we present a fast calibration method of EBT films in scanned ion radiotherapy. | Liu Xinguo Li Qiang Dai Zhongying He Pengbo Huang Qiyan Yan Yuanlin | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 12 | 3-44 Monte Carlo Simulation Study on Optimizing the Active Beam Delivery System at HIRFL显示文摘To obtain carbon ion beam suitable for the active spot scanning beam delivery system at the Heavy Ion ResearchFacility in Lanzhou (HIRFL), the Monte Carlo (MC) program SHIELD-HIT12A was used to study the influencesof beam delivery distance and structure period of mini ridge filter on full width at the half maximum (FWHM) ofbeam spot and dose flatness at the iso-center of the treatment room. | Yan Yuanlin Liu Xingguo Dai Zhongying Ma Yuanyuan Huang Qiyan He Pengbo Shen Guosheng Fu Tingyan Li Qiang | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 13 | Drainage pattern recognition method considering local basin shape based on graph neural network显示文摘Drainage pattern recognition is crucial for geospatial understanding and hydrologic modelling.Currently,drainage pattern recognition methods employ geometric measures of overall and local features of river networks but lack measures of river basin unit shape features,so that potential correlations between river segments are usually ignored,resulting in poor drainage pattern recognition results.In order to overcome this problem,this paper proposes a supervised graph neural network method that considers the local basin unit shape of river networks.First,based on the overall hierarchy of the river networks,the confluence angle of river segments and the shape of river basin units,multiple drainage pattern classification features are extracted.Then,typical drainage pattern samples from the multi-scale NSDI and USGS databases are used to complete the training,validation and testing steps.Experimental results show that the drainage pattern indexes proposed can describe the characteristics of different drainage patterns.The method can effectively sample the adjacent river segments,flexibly transfer the associated pattern features among river segment neighbours,and aggregate the deeper characteristics of the river networks,thus improving the drainage pattern recognition accuracy relative to other methods and reliably distinguishing different drainage patterns. | Wenning Wang Haowen Yan Xiaomin Lu Yi He Tao Liu Wende Li Pengbo Li Fang Xu | 2023 | International Journal of Digital Earth2023，16，1： | 0 |
| 14 | Research on Measures for TBT of Pork Export显示文摘With the deepening of economic globalization and increasingly fierce competition of trade liberalization in WTO member countries,the effect of traditional trade protection measures is gradually weakening or even removed. In recent years,Technical Barriers to Trade( TBT)as a category of nontariff barriers to trade,are the widely divergent measures that countries use to regulate markets,protect their consumers,or preserve their natural resources( among other objectives),but they also can be used( or perceived by foreign countries) to discriminate against imports in order to protect domestic industries. These directly or indirectly lead to gradual rise of trade friction of China's pork export. This paper analyzed background and significance of measures for TBT of pork export,current situations of researches on TBT both at home and abroad,and came up with new ideas and viewpoints for further strengthening measures for TBT of pork export. | Hua YU Yubao YAN Pengbo CUI | 2014 | Asian Agricultural Research2014，6，11： | 0 |
| 15 | 3 - 74 A Motion Platform System with Independently Programmable 3D Target Motion for Dosimetric Measurements in Carbon Ion Radiotherapy显示文摘 | He Pengbo Li Qiang Liu Xinguo Dai Zhongying Huang Qiyang Yan Yuanlin | 2012 | IMP & HIRFL Annual Report2012，，1： | 0 |
| 16 | 3-46 Heavy Ion Cancer Therapy-related Research in the Group of Medical Physics显示文摘With the construction of the Heavy Ion Mecial Machine (HIMM) in Wuwei, more and more work related to the research and development of heavy ion cancer therapy have been done in the group of Medical Physics this year. On the one hand, we focused our work on setting up a heavy ion radiotherapy treatment planning system for the HIMM project, aiming at building a bridge between the HIMM facility and clinical application; on the other hand, we continued to explore the mechanisms underlying heavy ion radiation-induced biological effects in order to provide theoretical basis for heavy ion cancer therapy, trying either to improve the efficacy of heavy ion therapy or to reduce the radiation-induced damage to normal tissues as much as possible. | Li Qiang Liu Xinguo Dai Zhongying Jin Xiaodong Li Ping Liu Xiongxiong He Pengbo Ye Fei Chen Weiqiang Liu Yan | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
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