|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Tourette syndrome associated with attention deficit hyperactivity disorder: The impact of tics and psychopharmacological treatment options显示文摘Tourette syndrome(TS) is a neurodevelopmental disorder characterized by multiple chronic motor and vocal tics beginning in childhood. Several studies describe the association between TS and attention deficit hyperactivity disorder(ADHD). Fifty percent of children diagnosed with ADHD have comorbid tic disorder. ADHD related symptoms have been reported in 35% to 90% of children with TS. Since ADHD is the most prevalent comorbid condition with TS and those with concomitant TS and ADHD present with considerable psychosocial and behavioral impairments, it is essential for clinicians to be familiar with these diagnoses and their management. This paper highlights the association between treating ADHD with stimulants and the development of tic disorders. The two cases discussed underscore the fact that children with TS may present with ADHD symptomatology prior to the appearance of any TS related symptoms. Appropriate management of TS in a patient diagnosed with ADHD can lead to quality of life improvements and a reduction in psychosocial impairments. | Olumide O Oluwabusi Susan Parke Paul J Ambrosini | 2016 | World Journal of Clinical Pediatrics2016，5，1： | 27 |
| 2 | Design of multi-functional dual hole patterned carbon nanotube composites with superhydrophobicity and durability显示文摘关于 nanocomposites 的最当前的研究集中了于他们的体积属性,即,电,微波,热、机械的性质。在实际应用,如果内在的性质将被坚持说,象对环境污染的坚韧性那样的表面性质是批评设计考虑。这研究的目的是把 nanocomposites 的体积性质与 superhydrophobic 表面性质由印技术与提高的体积性质创造一个单个多功能的系统提供了相结合。我们报导高度传导性的 superhydrophobic nanotube 的发展合成,它直接通过印技术与一个持久的双洞模式被附加。双洞模式避免导致对物理损坏柔韧的表面的高苗条比率结构的使用。它的稳定的 superhydrophobic 性质理论上并且试验性地被描绘。由合并高方面比率碳 nanotubes (CNT ) ,双有图案的 composites 能有效地也为在低电压的形成和他们的快电的加热反应消除仍然是霜的他们的 superhydrophobic 表面压制冰的反糖衣和除去的应用被使用。另外,防护有效性(SE ) 的优异电磁的干扰(EMI ) 被达到,与曾经在文学报导的最高的价值之一。 | Sung-Hoon Park Eun-Hyoung Cho Jinseung Sohn Paul Theilmann Kunmo Chu Sunghee Lee Yoonchul Sohn Dongouk Kim Byunghoon Kim | 2013 | Nano Research2013，6，6： | 4 |
| 3 | Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study显示文摘 | Hedy L Kindler Tatsuya Ioka Dirk J Richel Jaafar Bennouna Richard Létourneau Takuji Okusaka Akihiro Funakoshi Junji Furuse Young Suk Park Shinichi Ohkawa Gregory M Springett Harpreet S Wasan Peter C Trask Paul Bycott Alejandro D Ricart Sinil Kim Eric Van | 2011 | Lancet Oncology2011，，3： | 4 |
| 4 | Activation of the pattern recognition receptor NOD1 augments colon cancer metastasis显示文摘While emerging data suggest nucleotide oligomerization domain receptor 1(NOD1),a cytoplasmic pattern recognition receptor,may play an important and complementary role in the immune response to bacterial infection,its role in cancer metastasis is entirely unknown.Hence,we sought to determine the effects of NOD1 on metastasis.NOD1 expression in paired human primary colon cancer,human and murine colon cancer cells were determined using immunohistochemistry and immunoblotting(WB).Clinical significance of NOD1 was assessed using TCGA survival data.A series of in vitro and in vivo functional assays,including adhesion,migration,and metastasis,was conducted to assess the effect of NOD1.C12-iE-DAP,a highly selective NOD1 ligand derived from gram-negative bacteria,was used to activate NOD1.ML130,a specific NOD1 inhibitor,was used to block C12-iE-DAP stimulation.Stable knockdown(KD)of NOD1 in human colon cancer cells(HT29)was constructed with shRNA lentiviral transduction and the functional assays were thus repeated.Lastly,the predominant signaling pathway of NOD1-activation was identified using WB and functional assays in the presence of specific kinase inhibitors.Our data demonstrate that NOD1 is highly expressed in human colorectal cancer(CRC)and human and murine CRC cell lines.Clinically,we demonstrate that this increased NOD1 expression negatively impacts survival in patients with CRC.Subsequently,we identify NOD1 activation by C12-iE-DAP augments CRC cell adhesion,migration and metastasis.These effects are predominantly mediated via the p38 mitogen activated protein kinase(MAPK)pathway.This is the first study implicating NOD1 in cancer metastasis,and thus identifying this receptor as a putative therapeutic target. | Henry Y.Jiang Sara Najmeh Guy Martel Elyse MacFadden-Murphy Raquel Farias Paul Savage Arielle Leone Lucie Roussel Jonathan Cools-Lartigue Stephen Gowing Julie Berube Betty Giannias France Bourdeau Carlos HFChan Jonathan D.Spicer Rebecca McClure Morag Park Simon Rousseau Lorenzo E.Ferri | 2020 | Protein & Cell2020，11，3： | 3 |
| 5 | Effect of surface mechanical attrition treatment of titanium using alumina balls: surface roughness, contact angle and apatite forming ability显示文摘 | M. JAMESH T. S. N. SANKARA NARAYANAN Paul K. CHU II Song PARK Min Ho LEE | 2013 | Frontiers of Materials Science2013，7，3： | 3 |
| 6 | Treatment of C2 body fracture with unusual distractive and rotational components resulting in gross instability显示文摘Cervical fractures can result in severe neurological compromise and even death. One of the most commonly injured segments is the C2 vertebrae, which most frequently involves the odontoid process. In this report, we present the unusual case of a 28-year-old female who sustained a C2 vertebral body fracture(comminuted transverse fracture through the body and both transverse processes) that had both a significant distractive and rotational component, causing the fracture to be highly unstable. Application of halo bracing was unsuccessful. The patient subsequently required a C1-C4 posterior spinal fusion. Follow-up computer tomography imaging confirmed fusion and the patient did well clinically thereafter. | Darryl Lau Samuel S Shin Rakesh Patel Paul Park | 2013 | World Journal of Orthopedics2013，4，4： | 3 |
| 7 | 应对全球气候变化:全科医生的临床经验和方法显示文摘背景气候变化是全球公共卫生问题,需要全面深入的思考才能获得行之有效的解决方法。本文从理论上阐述全科医生临床经验和方法对于解决气候变化问题的借鉴意义。讨论我们认为全科医生的经验和特殊思考方式对解决气候变化问题是一笔宝贵的财富。这些财富包括,毕生对'首先不造成伤害'和'处理不确定性'的认知、反思和践行,'面对不完整信息时做出必要决策'的能力,对'复杂自适应系统'的认识,对稳态的维持,对意外后果的警醒,对'跨学科和跨专业'重要性的认识。总结全科医生一直以来都是公共卫生的拥护者。他们对复杂人类问题的处理方式也可用于应对气候变化。 | Grant Blashki Alan Abelsohn Robert Woollard Neil Arya Margot W Parkes Paul Kendal Erica Bell R Warren Bell 邵钧 | 2013 | 中国全科医学2013，16，10： | 2 |
| 8 | A randomized comparison of oral and intravaginal misoprostol for labor induction显示文摘 | Deborah A Wing Maureen R Park Richard H Paul | 2000 | Obstetrics & Gynecology2000，，6： | 2 |
| 9 | Experimental studies of transgastric gallbladder surgery: cholecystectomy and cholecystogastric anastomosis (videos) <ce:link locator='fx1'/>显示文摘 | Per-Ola Park Maria Bergstr?m Keiichi Ikeda Annette Fritscher-Ravens Paul Swain | 2005 | Gastrointestinal Endoscopy2005，，4： | 1 |
| 10 | A randomized comparison of oral of oral and intravaginal Misoprostol for labor induction显示文摘 | Wing DA Park MR Paul RH | 2000 | Obstet Gynecol2000，95，6： | 1 |
| 11 | A randomized comparison of oral of oral and intravaginal misoprostol for labor induction显示文摘 | Wing DA Park MR Paul RH | 2000 | Obstet GynecoI2000，95，6： | 1 |
| 12 | 显示文摘 | Sung-Chul Han Young-Soo Lee Paul S | 2001 | J Power Sources2001，102，： | 1 |
| 13 | Aligning organizational control practices with competitive outsourcing performance显示文摘 | Mingu Kang Xiaobo Wu Paul Hong Youngwon Park | 2011 | Journal of Business Research2011，，8： | 1 |
| 14 | Arandomized comparison of oral and intravaginal misoprostol for labor induction显示文摘 | Wing DA Park MR Paul RH | 2000 | Obstet Gynecol2000，95，6： | 1 |
| 15 | A randomized comparison of oral and intravaginalmisoprostolfor labor induction显示文摘 | Wing DA Park MR Paul RH | 2000 | Obstet Gynecol2000，95，6： | 1 |
| 16 | Fabrication of metallic electrodes with nanometer separation by electromigration显示文摘 | Park Hongkun K L Lim Andrew Alivisatos A Paul | 1999 | Appl Phys Lett1999，75，2： | 1 |
| 17 | Adjacent Segment Disease after Lumbar or Lumbosacral Fusion: Review of the Literature显示文摘 | Paul Park Hugh J. Garton Vishal C. Gala Julian T. Hoff John E. McGillicuddy | 2004 | Spine2004，，17： | 1 |
| 18 | Neuropeptide Y induces torpor-like hypothermia in Siberian hamster显示文摘 | PAUL M J FREEMAN D A PARK J H | 2005 | Brain Res2005，1055，12： | 1 |
| 19 | A randomized comparison of oral orintravaginal misoprostol for labor induction显示文摘 | Wing DA Park MR Paul RH | 2000 | Obstet Gynecol2000，95，6： | 1 |
| 20 | Electrochemical properties of LiCoO2-coated LiMn2O4 prepared by solution-based chemical process 显示文摘 | Park Sung-Chul Hart Yong-Soo Kang Youn-Seon Lee Paul S Ahn Soonho Lee Hyang-Mok Lee Jai-Yong | 2001 | Journal of the Electrochemical Society2001，148，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员