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| 1 | Synergistic antibacterial activity of physical-chemical multi-mechanism by TiO2 nanorod arrays for safe biofilm eradication on implant显示文摘Treatment of implant-associated infection is becoming more challenging,especially when bacterial biofilms form on the surface of the implants.Developing multi-mechanism antibacterial methods to combat bacterial biofilm infections by the synergistic effects are superior to those based on single modality due to avoiding the adverse effects arising from the latter.In this work,TiO2 nanorod arrays in combination with irradiation with 808 nearinfrared(NIR)light are proven to eradicate single specie biofilms by combining photothermal therapy,photodynamic therapy,and physical killing of bacteria.The TiO2 nanorod arrays possess efficient photothermal conversion ability and produce a small amount of reactive oxygen species(ROS).Physiologically,the combined actions of hyperthermia,ROS,and puncturing by nanorods give rise to excellent antibacterial properties on titanium requiring irradiation for only 15 min as demonstrated by our experiments conducted in vitro and in vivo.More importantly,bone biofilm infection is successfully treated efficiently by the synergistic antibacterial effects and at the same time,the TiO2 nanorod arrays improve the new bone formation around implants.In this protocol,besides the biocompatible TiO2 nanorod arrays,an extra photosensitizer is not needed and no other ions would be released.Our findings reveal a rapid bacteria-killing method based on the multiple synergetic antibacterial modalities with high biosafety that can be implemented in vivo and obviate the need for a second operation.The concept and antibacterial system described here have large clinical potential in orthopedic and dental applications. | Xiangyu Zhang Guannan Zhang Maozhou Chai Xiaohong Yao Weiyi Chen Paul KChu | 2021 | Bioactive Materials2021，6，1： | 7 |
| 2 | Tuning Superhydrophobic Materials with Negative Surface Energy Domains显示文摘Hydrophobic/superhydrophobic materials with intrinsic water repellence are highly desirable in engineering fields including antiicing in aerocrafts,antidrag and anticorrosion in ships,and antifog and self-cleaning in optical lenses,screen,mirrors,and windows.However,superhydrophobic material should have small surface energy(SE)and a micro/nanosurface structure which can reduce solid-liquid contact significantly.The low SE is generally found in organic materials with inferior mechanical properties that is undesirable in engineering.Intriguingly,previous theoretical calculations have predicted a negative SE forθ-alumina(θ-Al_(2)O_(3)),which inspires us to use it as a superhydrophobic material.Here,we report the experimental evidence of the small/negative SE ofθ-Al_(2)O_(3) and aθ-Al_(2)O_(3)-based superhydrophobic coating prepared by one-step scalable plasma arcing oxidation.The superhydrophobic coating has complete ceramic and desired micro/nanostructure and therefore exhibits excellent aging resistance,wear resistance,corrosion resistance,high-temperature tolerance,and burning resistance.Owing to the rarity of the small/negative SE in inorganic materials,the concept to reduce SE byθ-Al_(2)O_(3) may foster a blowout to develop robust superhydrophobicity by complete inorganic materials. | Zhongzhen Wu Liangliang Liu Shunning Li Shunping Ji Pinghu Chen Suihan Cui Zhengyong Ma Yuchang Weng Qian Huang Zhongcan Wu Hao Wu Yuan Lin Ricky KYFu Hai Lin Xiubo Tian Paul KChu Feng Pan | 2019 | Research2019，，1： | 6 |
| 3 | Hierarchical CuO-ZnO/SiO_(2) Fibrous Membranes for Efficient Removal of Congo Red and 4‑Nitrophenol from Water显示文摘Hierarchical CuO-ZnO/SiO_(2)(CZS)nanofibrous membranes are designed and fabricated to remove Congo red and 4-nitro-phenol two common small molecular pollutants in water.The electrospun SiO_(2) fibrous membrane is serves as the substrate for hydrothermal depositing CuO-ZnO nanosheets.The CZS nanofibrous membrane shows good adsorption characteristics for Congo red due to the hierarchical morphology and the adsorption kinetics where isotherm follows the pseudo-second-order model and Langmuir model,respectively.The maximum adsorption capacity for Congo red is 141.8 mg/g.Moreover,the membrane exhibits excellent catalytic reduction activity for 4-nitrophenol under mild conditions and over 96%of the pollut-ants are degraded within 90 s.The CZS nanofibrous membrane has promising prospects in applications in water treatment and environmental protection because of the good flexibility,easy fabrication,excellent adsorption,and catalytic activity. | Caihong Wang Ke Liu Dong Wang Guomin Wang Paul KChu Zheyi Meng Xuefen Wang | 2022 | Advanced Fiber Materials2022，4，5： | 2 |
| 4 | Programmed surface on poly(aryl-ether-ether-ketone) initiating immune mediation and fulfilling bone regeneration sequentially显示文摘The immune responses are involved in every stage after implantation but the reported immune-regulated materials only work at the beginning without fully considering the different phases of bone healing.Here,poly(aryl-ether-ether-ketone)(PEEK)is coated with a programmed surface,which rapidly releases interleukin-10(IL-10)in the first week and slowly delivers dexamethasone(DEX)up to 4 weeks.Owing to the synergistic effects of IL-10 and DEX,an aptly weak inflammation is triggered within the first week,followed by significant M2 polarization of macrophages and upregulation of the autophagy-related factors.The suitable immunomodulatory activities pave the way for osteogenesis and the steady release of DEX facilitates bone regeneration thereafter.The sequential immune-mediated process is also validated by an 8-week implementation on a rat model.This is the first attempt to construct implants by taking advantage of both immune-mediated modulation and sequential regulation spanning all bone regeneration phases,which provides insights into the fabrication of advanced biomaterials for tissue engineering and immunological therapeutics. | Lingxia Xie Guomin Wang Yuzheng Wu Qing Liao Shi Mo Xiaoxue Ren Liping Tong Wei Zhang Min Guan Haobo Pan Paul KChu Huaiyu Wang | 2021 | The Innovation2021，2，3： | 0 |
| 5 | Surface bioactivity of plasma implanted silicon and amorphous carbon显示文摘Plasma immersion ion implantation and deposition (PIII&D) has been shown to be an effective tech- nique to enhance the surface bioactivity of materials. In this paper, recent progress made in our laboratory on plasma surface modification single-crystal silicon and amorphous carbon is reviewed. Silicon is the most important material in the integrated circuit industry but its surface biocompatibility has not been investigated in details. We have re- cently performed hydrogen PIII into silicon and observed the biomimetic growth of apatite on its surface in simulated body fluid. Diamond-like carbon (DLC) is widely used in the industry due to its excellent mechanical properties and chemical inertness. The use of this material in biomedical engineering has also attracted much attention. It has been observed in our laboratory that doping DLC with nitrogen by means of PIII can improve the surface blood compati- bility. The properties as well as in vitro biological test results will be discussed in this article. | Paul KCHU | 2004 | Nuclear Science and Techniques2004，15，3： | 0 |
| 6 | Rapid Ferroelectric‑Photoexcited Bacteria‑Killing of Bi_(4)Ti_(3)O_(12)/Ti_(3)C_(2)T_(x) Nanofiber Membranes显示文摘In this study,an antibacterial nanofiber membrane[polyvinylidene fluoride/Bi_(4)Ti_(3)O_(12)/Ti_(3)C_(2)T_(x)(PVDF/BTO/Ti_(3)C_(2)T_(x))]is fabricated using an electrostatic spinning process,in which the self-assembled BTO/Ti_(3)C_(2)T_(x) heterojunction is incorporated into the PVDF matrix.Benefiting from the internal electric field induced by the spontaneously ferroelectric polarization of BTO,the photoexcited electrons and holes are driven to move in the opposite direction inside BTO,and the electrons are transferred to Ti_(3)C_(2)T_(x) across the Schottky interface.Thus,directed charge separation and transfer are realized through the cooperation of the two components.The recombination of electron–hole pairs is maximumly inhibited,which notably improves the yield of reactive oxygen species by enhancing photocatalytic activity.Furthermore,the nanofiber membrane with an optimal doping ratio exhibits outstanding visible light absorption and photothermal conversion performance.Ulti-mately,photothermal effect and ferroelectric polarization enhanced photocatalysis endow the nanofiber membrane with the ability to kill 99.61%±0.28%Staphylococcus aureus and 99.71%±0.16%Escherichia coli under 20 min of light irradiation.This study brings new insights into the design of intelligent antibacterial textiles through a ferroelectric polarization strategy. | Zhiying Wang Jianfang Li Yuqian Qiao Xiangmei Liu Yufeng Zheng Zhaoyang Li Jie Shen Yu Zhang Shengli Zhu Hui Jiang Yanqin Liang Zhenduo Cui Paul KChu Shuilin Wu | 2023 | Advanced Fiber Materials2023，5，2： | 0 |
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