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| 1 | Pancreatic regenerating protein (regⅠ) and regⅠreceptor mRNA are upregulated in rat pancreas after induction of acute pancreatitis显示文摘AIM: Pancreatic regenerating protein (regⅠ) stimulates pancreatic regeneration after pancreatectomy and is mitogenic to ductal andβ-cells. This suggests that regⅠand its receptor may play a role in recovery after pancreatic injury. We hypothesized that regⅠand its receptor are induced in acute pancreatitis. METHODS: Acute pancreatitis was induced in male Wistar rats by retrograde injection of 3% sodium taurocholate into the pancreatic duct. Pancreata and serum were collected 12, 24, and 36 hours after injection and from normal controls (4 rats/group). RegⅠreceptor mRNA, serum regⅠprotein, and tissue regⅠprotein levels were determined by Northern analysis, enzyme-linked immunosorbent assay (ELISA), and Western analysis, respectively. Immunohistochemistry was used to localize changes in regⅠand its receptor. RESULTS: Serum amylase levels and histology confirmed necrotizing pancreatitis in taurocholate treated rats. There was no statistically significant change in serum regⅠconcentrations from controls. However, Western blot demonstrated increased tissue levels of regⅠat 24 and 36 h. This increase was localized primarily to the acinar cells and the ductal cells by immunohistochemistry. Northern blot demonstrated a significant increase in regⅠreceptor mRNA expression with pancreatitis. Immunohistochemistry localized this increase to the ductal cells, islets, and acinar cells. CONCLUSION: Acute pancreatitis results in increased tissue regⅠprotein levels localized to the acinar and ductal cells, and a parallel threefold induction of regⅠreceptor in the ductal cells, islets, and acinar cells. These changes suggest that induction of reg I and its receptor may be important for recovery from acute pancreatitis. | Martin H Bluth Sameer A Patel Brian K Dieckgraefe Hiroshi Okamoto Michael E Zenilman | 2006 | World Journal of Gastroenterology2006，12，28： | 19 |
| 2 | Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates kidney injury in murine models of obesity and diabetes mellitus显示文摘AIM To investigate the role of glucagon-like peptide-1(GLP-1)/glucagon receptors coagonist on renal dysfunction associated with diabetes and obesity. METHODS Chronic high-fat diet fed C57 BL/6 J mice, streptozotocintreated high-fat diet fed C57 BL/6 J mice and diabeticC57 BLKS/J db/db mice were used as models of diabetes-induced renal dysfunction. The streptozotocintreated high-fat diet fed mice and db/db mice were treated with the GLP-1 and glucagon receptors coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) for twelve weeks, while in chronic high-fat diet fed mice, coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) treatment was continued for forty weeks. Kidney function, histology, fibrosis, inflammation, and plasma biochemistry were assessed at the end of the treatment. RESULTS Coagonist treatment decreased body weight, plasma lipids, insulin resistance, creatinine, blood urea nitrogen, urinary albumin excretion rate and renal lipids. In kidney, expression of lipogenic genes(SREBP-1 C, FAS, and SCD-1) was decreased, and expression of genes involved in β-oxidation(CPT-1 and PPAR-α) was increased due to coagonist treatment. In plasma, coagonist treatment increased adiponectin and FGF21 and decreased IL-6 and TNF-?. Coagonist treatment reduced expression of inflammatory(TNF-α, MCP-1, and MMP-9) and pro-fibrotic(TGF-β, COL1 A1, and α-SMA) genes and also improved histological derangement in renal tissue.CONCLUSION Coagonist of GLP-1 and glucagon receptors alleviated diabetes and obesity-induced renal dysfunction by reducing glucose intolerance, obesity, and hyperlipidemia. | Vishal J Patel Amit A Joharapurkar Samadhan G Kshirsagar Brijesh K Sutariya Maulik S Patel Hiren M Patel Dheerendra K Pandey Rajesh H Bahekar Mukul R Jain | 2018 | World Journal of Diabetes2018，9，6： | 5 |
| 3 | Fusion neutron and ion emission from deuterium and deuterated methane cluster plasmas显示文摘 | K W Madison P K Patel D Price A Edens, M Allen, T E Cowan, J Zweiback, T Ditmire | | 0，，： | 2 |
| 4 | Incidental non-benign gallbladder histopathology after cholecystectomy in an United Kingdom population: Need for routine histological analysis?显示文摘AIM To analyse the range of histopathology detected in the largest published United Kingdom series of cholecystectomy specimens and to evaluate the rational for selective histopathological analysis.METHODS Incidental gallbladder malignancy is rare in the United Kingdom with recent literature supporting selective histological assessment of gallbladders after routine cholecystectomy.All cholecystectomy gallbladder specimens examined by the histopathology department at our hospital during a five year period between March 2008 and March 2013 were retrospectively analysed.Further data was collected on all specimens demonstrating carcinoma,dysplasia and polypoid growths.RESULTS The study included 4027 patients.The majority(97%) of specimens exhibited gallstone or cholecystitis related disease.Polyps were demonstrated in 44(1.09%),the majority of which were cholesterol based(41/44).Dysplasia,ranging from low to multifocal high-grade was demonstrated in 55(1.37%).Incidental primary gallbladder adenocarcinoma was detected in 6 specimens(0.15%,5 female and 1 male),and a single gallbladder revealed carcinoma in situ(0.02%).This large single centre study demonstrated a full range of gallbladder disease from cholecystectomy specimens,including more than 1% neoplastic histology and two cases of macroscopically occult gallbladder malignancies.CONCLUSION Routine histological evaluation of all elective and emergency cholecystectomies is justified in a United Kingdom population as selective analysis has potential to miss potentially curable life threatening pathology. | Krashna Patel Khaled Dajani Satheesh Iype Nikolaos A Chatzizacharias Saranya Vickramarajah Susan Davies Rebecca Brais Siong S Liau Simon Harper Asif Jah Raaj K Praseedom Emmanuel L Huguet | 2016 | World Journal of Gastrointestinal Surgery2016，8，10： | 2 |
| 5 | Flow-based multiadsorbate ellipsometric porosimetry for the characterization of mesoporous Pt- TiO2 and Au-TiO2 nanocomposites显示文摘 | May R A Patel M N Johnston K P | 2009 | Langmuir2009，25，8： | 1 |
| 6 | Transcatheter-closure of atrial septal defects in adults > or = 40 years of age : immediate and follow-up results 显示文摘 | Patel A Lopez K Banerjee A | 2007 | J Interv Cardiol2007，20，1： | 1 |
| 7 | Voltammetric sensor for barbituric acid based on a solgel derivated molecularly imprinted polymer brush grafted to graphite electrode显示文摘 | PATEL A K SHARMA P S PRASAD B B | 2009 | International Journal of Pharmaceutics2009，371，1： | 1 |
| 8 | Influence of dates ofplanting and nitrogen levels on the smoke constituents ofbidi tobacco cultivars 显示文摘 | Patel J A Patel B K Patel G R | 1989 | Tobacco Research1989，15，1： | 1 |
| 9 | An intrusiondetection and prevention system in cloud computing:Asystematic review显示文摘 | Patel A Mona T Bakhtiyari K | 2013 | Journal of Network and ComputerApplications2013，36，1： | 1 |
| 10 | Safety and efficacy of a single-rod etonogestrel implant (Implanon): results from 11 international clinical trials显示文摘 | Darney P Patel A Rosen K | 2009 | Fertil Steril2009，91，5： | 1 |
| 11 | Novel human SR-BI antibodies prevent infection and dissemination of HCV in vitro and in humanized mice显示文摘 | Lacek K Vercauteren K Grzyb K Naddeo M Verhoye L Slowikowski M P Fafi-Kremer S Patel A H Baumert T F Folgori A Leroux-Roels G Cortese R Meuleman P Nicosia A | 2012 | J Hepatol2012，57，1： | 1 |
| 12 | Identifying patients at high risk of peri-operative death from simultaneous urological and cardiac surgery for tumours involving the inferior vena eava (IVC)显示文摘 | FERNANDO A PATEL S THOMAS K | 2015 | Eur Urol Suppl2015，14，2： | 1 |
| 13 | Antigen-presenting property of mesenchymal stem cells occurs during a narrow window at low levels of interferon-gamma显示文摘 | Chan J L Tang K C Patel A P | 2006 | Blood2006，107，： | 1 |
| 14 | Albumin as an outcome measure in hemodialysis in patients: the different of variation in assay method显示文摘 | Carfray A Patel K Whitaker P | 2000 | Nephrol Dial Transplant2000，15，11： | 1 |
| 15 | Vibration response of a cracked rotor in presence of rotor-stator rub 显示文摘 | PATEL T H DARPE A K | 2008 | Journal of Sound and Vibration2008，317，35： | 1 |
| 16 | Identification of no-vel splice variants in horn cancer by RNA-Seq analysis in Zebucattle 显示文摘 | Patel A K Bhatt V D 丁Hpathi A K | 2013 | Genomics2013，101，1： | 1 |
| 17 | An intrusion detection and prevention system in cloud computing:a systematic review显示文摘 | Patel A Taghavi M Bakhtiyari K | 2013 | Journal of Network and Computer Applications2013，36，1： | 1 |
| 18 | Recent advances in solid-state fermentation 显示文摘 | Singhania R R Patel A k Soccol C R Pandey A | 2009 | Biochem Eng J2009，44，： | 1 |
| 19 | Volumetric error analysis of a Stewart platformbased machinetool显示文摘 | Patel A J Ehmann K F | 1997 | CIR PAnnals-Manufacturi-ng Technology1997，46，1： | 1 |
| 20 | Uncharted islands of chatter instability in milling显示文摘 | PATEL B R MANN B P YOUNG K A | 2008 | International Journal of Ma-chine Tools and Manufacture2008，48，1： | 1 |
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