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| 1 | 固定低剂量三联抗高血压药物与常规治疗对斯里兰卡轻度至中度高血压患者血压控制的疗效差异:一项随机临床试验显示文摘控制不良的高血压是全球领先的公共卫生问题,需要新的治疗策略。该研究评估低剂量三联抗高血压药物治疗是否能达到比常规治疗更好的血压控制。研究者纳入2016年2月至2017年5月在斯里兰卡11所城市医院诊所就诊的需要开始抗高血压治疗(未治疗的患者)或接受单药治疗的患者,进行低剂量三联降压与常规治疗比较的随机、开放性试验,随访至2017年10月。 | Web-ster R Salam A de Silva HA Selak V Stepien S Rajapakse S Amarasekara S Amarasena N Billot L de Silva AP Fernando M Guggilla R Jan S Jayawardena J Maulik PK Mendis S Munasinghe J Naik N Prabhakaran D Ranasinghe G Thom S Tisserra N Senaratne V Wijekoon S Wijeyasingam S Rodgers A Patel A 刘莉 叶鹏 | 2018 | 中华高血压杂志2018，26，12： | 7 |
| 2 | Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates kidney injury in murine models of obesity and diabetes mellitus显示文摘AIM To investigate the role of glucagon-like peptide-1(GLP-1)/glucagon receptors coagonist on renal dysfunction associated with diabetes and obesity. METHODS Chronic high-fat diet fed C57 BL/6 J mice, streptozotocintreated high-fat diet fed C57 BL/6 J mice and diabeticC57 BLKS/J db/db mice were used as models of diabetes-induced renal dysfunction. The streptozotocintreated high-fat diet fed mice and db/db mice were treated with the GLP-1 and glucagon receptors coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) for twelve weeks, while in chronic high-fat diet fed mice, coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) treatment was continued for forty weeks. Kidney function, histology, fibrosis, inflammation, and plasma biochemistry were assessed at the end of the treatment. RESULTS Coagonist treatment decreased body weight, plasma lipids, insulin resistance, creatinine, blood urea nitrogen, urinary albumin excretion rate and renal lipids. In kidney, expression of lipogenic genes(SREBP-1 C, FAS, and SCD-1) was decreased, and expression of genes involved in β-oxidation(CPT-1 and PPAR-α) was increased due to coagonist treatment. In plasma, coagonist treatment increased adiponectin and FGF21 and decreased IL-6 and TNF-?. Coagonist treatment reduced expression of inflammatory(TNF-α, MCP-1, and MMP-9) and pro-fibrotic(TGF-β, COL1 A1, and α-SMA) genes and also improved histological derangement in renal tissue.CONCLUSION Coagonist of GLP-1 and glucagon receptors alleviated diabetes and obesity-induced renal dysfunction by reducing glucose intolerance, obesity, and hyperlipidemia. | Vishal J Patel Amit A Joharapurkar Samadhan G Kshirsagar Brijesh K Sutariya Maulik S Patel Hiren M Patel Dheerendra K Pandey Rajesh H Bahekar Mukul R Jain | 2018 | World Journal of Diabetes2018，9，6： | 5 |
| 3 | Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes显示文摘 | Patel A MacMahon S Chalmers J | | New England Journal of Medicine0，，： | 2 |
| 4 | Fusion neutron and ion emission from deuterium and deuterated methane cluster plasmas显示文摘 | K W Madison P K Patel D Price A Edens, M Allen, T E Cowan, J Zweiback, T Ditmire | | 0，，： | 2 |
| 5 | Regulation of MDR-1 (P-glycoprotein) by cyclooxygenase-2 显示文摘 | PATEL V A DUNN M J SOROKIN A | 2002 | J Biol Chem2002，277，38： | 1 |
| 6 | Volatile evolution from room temperature cured polysiloxane rubber induced by irradiation with He^2+ ions显示文摘 | ! PATEL M MURPHY J J SKINNER A R | 2003 | Polym Test2003，22，： | 1 |
| 7 | Endourological treatment of ureteral strictures: 2 referral centers 显示文摘 | Fushs G J Patel A Gutierez J | 1996 | J Urol1996，155，： | 1 |
| 8 | Patients with vascular dementia due to nicrovascular pathology have significant hippocampal neuronal loss显示文摘 | Kril J J Patel S Harding A J | 2002 | J Neurol Neurosurg Psychiatry2002，72，6： | 1 |
| 9 | Targeted killing of cancer ells in vivo and in vitro with EGF-directed carbon nanotube- based drug delivery显示文摘 | Bhirde A A Patel V Gavard J | 2009 | ACS Nano2009，3，2： | 1 |
| 10 | Noroviruses: a Compre- hensive Review显示文摘 | Patel M M Hall A J Vinje J | 2009 | J Clin Virol2009，44，1： | 1 |
| 11 | Influence of dates ofplanting and nitrogen levels on the smoke constituents ofbidi tobacco cultivars 显示文摘 | Patel J A Patel B K Patel G R | 1989 | Tobacco Research1989，15，1： | 1 |
| 12 | Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes显示文摘 | Patel A MacMahon S Chalmers J | 2008 | N Engl J Meal2008，358，24： | 1 |
| 13 | In situ encapsulation of horseradish peroxidase in electrospun porous silica fibers for potential biosensor applications显示文摘 | Patel A C Li S Yuan J M | 2006 | Nano Lett2006，6，： | 1 |
| 14 | The Incidence of Venous Throm- boembolism (VTE)-Mter Hip Arthroscopy显示文摘 | Alaia M J Patel D Levy A | 2014 | Bull Hosp Jt Dis2014，72，2： | 1 |
| 15 | Electrically tunable optical filter for infrared wavdength using liquid crystals in a FabryPemt etalon显示文摘 | Saifi M A Berreman D W | 1990 | Appl Phys Lett1990，57，17： | 1 |
| 16 | Regulation of MDR - 1 ( P - glycoprotein) by eyclooxygenase - 2 显示文摘 | Patel VA Dunn M J Sorokin A | 2002 | J Bio! Chem2002，277，38： | 1 |
| 17 | Routine sectioning of the C2 nerve root and ganglion for C1 lateral mass screw placement in children: surgical and functional out- comes显示文摘 | Patel A J Gressot L V Boatey J | 2013 | Childs Nerv Syst2013，29，1： | 1 |
| 18 | Sustained desensiti- zation to bacterial Toll-like receptor ligands after resolution of re- spiratory influenza infection 显示文摘 | Didierlaurent A Goulding J Patel S | 2008 | J Exp Med2008，205，2： | 1 |
| 19 | PARP inhibitionPARP1 and beyond显示文摘 | Rouleau M Patel A Hendzel M J | 2010 | Nat Rev Cancer2010，10，4： | 1 |
| 20 | Antigen-presenting property of mesenchymal stem cells occurs during a narrow window at low levels of interferon-gamma显示文摘 | Chan J L Tang K C Patel A P | 2006 | Blood2006，107，： | 1 |
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