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| 1 | The combined therapeutic effects of ^(131)iodinelabeled multifunctional copper sulfide-loaded microspheres in treating breast cancer显示文摘Compared to conventional cancer treatment, combination therapy based on well-designed nanoscale platforms may offer an opportunity to eliminate tumors and reduce recurrence and metastasis.In this study, we prepared multifunctional microspheres loading ^(131)I-labeled hollow copper sulfide nanoparticles and paclitaxel( ^(131)I-HCu SNPs-MS-PTX) for imaging and therapeutics of W256/B breast tumors in rats.18 F-fluordeoxyglucose(18 F-FDG) positron emission tomography/computed tomography(PET/CT) imaging detected that the expansion of the tumor volume was delayed(Po0.05) following intra-tumoral(i.t.) injection with ^(131)I-HCu SNPs-MS-PTX plus near-infrared(NIR) irradiation. The immunohistochemical analysis further confirmed the anti-tumor effect. The single photon emission computed tomography(SPECT)/photoacoustic imaging mediated by ^(131)I-HCu SNPs-MS-PTX demonstrated that microspheres were mainly distributed in the tumors with a relatively low distribution in other organs. Our results revealed that ^(131)I-HCu SNPs-MS-PTX offered combined photothermal, chemo-and radio-therapies, eliminating tumors at a relatively low dose, as well as allowing SPECT/CT and photoacoustic imaging monitoring of distribution of the injected agents non-invasively. The copper sulfide-loaded microspheres, ^(131)I-HCu SNPs-MS-PTX, can serve as a versatile theranostic agent in an orthotopic breast cancer model. | Qiufang Liu Yuyi Qian Panli Li Sihang Zhang Zerong Wang Jianjun Liu Xiaoguang Sun Michael Fulham Dagan Feng Zhigang Chen Shaoli Song Wei Lu Gang Huang | 2018 | Acta Pharmaceutica Sinica B2018，8，3： | 3 |
| 2 | Tobacco-free electronic cigarettes and cigars delivernicotine and generate concern显示文摘 | PANLY J LI Q BARRY M B | 2007 | Tob Control2007，16，5： | 1 |
| 3 | Synthesis of β,β'-Porphyrin Dimer Linked by Vinylene显示文摘一篇小说的合成, -tetraalkylporphyrin 更暗淡由 vinylene 连接了是 discribed,在哪个更暗淡乐意地经由 Wittig 反应从导出卟啉的 Wittig 试剂和 mono-formylated 卟啉被准备。在二枚卟啉戒指之间的变化形式都不是 obserbed,并且更暗淡在 trans 形式。 | Jiang,Xuliang Li,Panli Wang,Yucheng Shen,Qi Tao,Jingchao Shi,Weimin | 2012 | Chinese Journal of Chemistry2012，30，2： | 0 |
| 4 | YAP调控巨噬细胞极化和肠道微生物稳态进而加重炎症性肠病显示文摘文章简介炎症性肠病(IBD)是一种慢性肠道炎症紊乱的疾病。YAP是Hippo通路中的转录共激活因子,但目前尚不清楚YAP如何调控巨噬细胞极化、炎症反应及肠道微生物稳态。本研究发现,与YAP在肠道上皮细胞发挥保护IBD的作用不同,巨噬细胞中缺失YAP才能有效减轻IBD。 | 周欣 Weiyun Li Shuang Wang Panli Zhang Qiong Wang Jun Xiao Chi Zhang Xin Zheng Xiaoyan Xu Shengjie Xue Lijian Hui Hongbin Ji 魏滨 王红艳 | 2020 | 科学新闻2020，，2： | 0 |
| 5 | A Self-Biomineralized Novel Adenovirus Vectored COVID-19 Vaccine for Boosting Immunization of Mice显示文摘SARS-CoV-2 has caused more than 3.8 million deaths worldwide,and several types of COVID-19 vaccines are urgently approved for use,including adenovirus vectored vaccines.However,the thermal instability and pre-existing immunity have limited its wide applications.To circumvent these obstacles,we constructed a self-biomineralized adenovirus vectored COVID-19 vaccine(Sad23L-n Co V-S-Ca P)by generating a calcium phosphate mineral exterior(Ca P)based on Sad23L vector carrying the full-length gene of SARS-Co V-2 spike protein(S)under physiological condition.This Sad23L-n Co V-S-Ca P vaccine was examined for its characteristics of structure,thermostability,immunogenicity and avoiding the problem of preexisting immunity.In thermostability test,Sad23L-n Co V-S-Ca P could be stored at 4°C for over 45 days,26°C for more than 8 days and 37°C for approximately 2 days.Furthermore,Sad23L-n Co V-S-Ca P induced higher level of S-specific antibody and T cell responses,and was not affected by the pre-existing anti-Sad23L immunity,suggesting it could be used as boosting immunization on Sad23L-n Co V-S priming vaccination.The boosting with Sad23L-n Co V-S-Ca P vaccine induced high titers of 10^(5.01)anti-S1,10^(4.77)anti-S2 binding antibody,10^(3.04) pseudovirus neutralizing antibody(IC_(50)),and robust T-cell response of IFN-c(1466.16 SFCs/10^(6)cells)to S peptides,respectively.In summary,the selfbiomineralization of the COVID-19 vaccine Sad23L-n Co V-S-Ca P improved vaccine efficacy,which could be used in prime-boost regimen for prevention of SARS-Co V-2 infection in humans. | Shengxue Luo Panli Zhang Peng Zou Cong Wang Bochao Liu Cuiling Wu Tingting Li Ling Zhang Yuming Zhang Chengyao Li | 2021 | Virologica Sinica2021，36，5： | 0 |
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