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| 1 | CIPK9: a calcium sensor-interacting protein kinase required for low-potassium tolerance in Arabidopsis显示文摘钾是为在植物的很多个细胞的过程的主要宏营养素必需品之一。在土壤的低钾水平为庄稼生产代表一个限制因子。最近的研究识别了涉及钾获得的钾运输 ers,并且他们中的一些为在低钾条件下面的钾营养是批评的。然而,很少在涉及低钾发信号和回答的分子的部件上被理解。我们这里在 Arabidopsis 作为低钾反应的一个批评管理者报导 calcineurin 象 B 一样交往蛋白质的 proteinkinase (CIPK9 ) 的鉴定。CIPK9 基因对不能生活的压力条件应答,并且它的抄本由钾剥夺在根和射击是可诱导的。CIPK9 功能的混乱使变异的植物变为过分敏感到低钾媒介。进一步的分析显示那 K (+) 举起和内容没在变异的植物被影响,暗示在钾利用的规定的 CIPK9 或察觉到过程。 | Girdhar K Pandey Yong Hwa Cheongx Beom-Gi Kim John J Grant Legong Li Sheng Luan | 2007 | Cell Research2007，17，5： | 23 |
| 2 | Aceclofenac-induced hepatotoxicity:An ameliorative effect of Terminalia bellirica fruit and ellagic acid显示文摘BACKGROUND Aceclofenac(ACF),a widely used nonsteroidal anti-inflammatory drug,has been associated with a number of severe cases of clinical hepatotoxicity.Terminalia bellirica,an evergreen tree,is known to have several ethnomedicinal uses including antioxidant and hepatoprotective effects.Hence T.bellirica fruit extracts and its phytoconstituent ellagic acid(EA)are expected to provide protection against oxidative stress and liver damage produced by long-term use of ACF.AIM To evaluate the antioxidant and hepatoprotective activities of T.bellirica fruit extracts and EA against ACF-induced toxicity in albino Wistar rats.METHODS The in vitro antioxidant activities of T.bellirica fruit ethyl acetate and aqueous extracts were measured by metal ion chelation and nitric oxide radical scavenging assays.The in vivo antioxidant and hepatoprotective effects of T.bellirica extracts(200 mg/kg)and EA(40 mg/kg)in ACF-induced hepatotoxic rats were assessed in serum and liver tissue after oral administration for 21 d.Silymarin(40 mg/kg)was used as a standard control.Oxidative stress markers in the blood(ferric reducing ability of plasma and lipid peroxidation inhibition)and liver tissues(superoxide dismutase,catalase and malondialdehyde)were analyzed using standard protocols.Liver function markers such as alkaline phosphatase,glutamic pyruvic transaminase,glutamic oxaloacetic transaminase,lactate dehydrogenase,γ-glutamyl transferase,creatinine,total protein,and uric acid were evaluated in rat serum.RESULTS The T.bellirica fruit ethyl acetate extract exhibited superior metal ion chelating and nitric oxide radical scavenging abilities during in vitro antioxidant assays as compared to aqueous extracts.Oral administration of ACF in rats(15 mg/kg)for 21 d produced oxidative stress and adversely affected liver function suggesting liver injury.Treatment with extracts(ethyl acetate and aqueous),EA and silymarin accounted for a significant reduction in the adverse effects of ACF on oxidative stress and liver function markers in serum and hepatic tissue in rats.Histopathological evaluation of the liver indicated that the extracts and EA significantly decreased the degree of liver damage.The in vivo efficacy of EA was higher than T.bellirica fruit extracts.Of these extracts,ethyl acetate extract revealed comparatively better antioxidant and hepatoprotective activity.CONCLUSION Ellagic acid and T.bellirica fruit extracts exhibited considerable hepatoprotective and antioxidant activities in long-term ACF-treated rats. | Ashutosh Gupta Abhay K Pandey | 2020 | World Journal of Hepatology2020，12，11： | 6 |
| 3 | Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates kidney injury in murine models of obesity and diabetes mellitus显示文摘AIM To investigate the role of glucagon-like peptide-1(GLP-1)/glucagon receptors coagonist on renal dysfunction associated with diabetes and obesity. METHODS Chronic high-fat diet fed C57 BL/6 J mice, streptozotocintreated high-fat diet fed C57 BL/6 J mice and diabeticC57 BLKS/J db/db mice were used as models of diabetes-induced renal dysfunction. The streptozotocintreated high-fat diet fed mice and db/db mice were treated with the GLP-1 and glucagon receptors coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) for twelve weeks, while in chronic high-fat diet fed mice, coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) treatment was continued for forty weeks. Kidney function, histology, fibrosis, inflammation, and plasma biochemistry were assessed at the end of the treatment. RESULTS Coagonist treatment decreased body weight, plasma lipids, insulin resistance, creatinine, blood urea nitrogen, urinary albumin excretion rate and renal lipids. In kidney, expression of lipogenic genes(SREBP-1 C, FAS, and SCD-1) was decreased, and expression of genes involved in β-oxidation(CPT-1 and PPAR-α) was increased due to coagonist treatment. In plasma, coagonist treatment increased adiponectin and FGF21 and decreased IL-6 and TNF-?. Coagonist treatment reduced expression of inflammatory(TNF-α, MCP-1, and MMP-9) and pro-fibrotic(TGF-β, COL1 A1, and α-SMA) genes and also improved histological derangement in renal tissue.CONCLUSION Coagonist of GLP-1 and glucagon receptors alleviated diabetes and obesity-induced renal dysfunction by reducing glucose intolerance, obesity, and hyperlipidemia. | Vishal J Patel Amit A Joharapurkar Samadhan G Kshirsagar Brijesh K Sutariya Maulik S Patel Hiren M Patel Dheerendra K Pandey Rajesh H Bahekar Mukul R Jain | 2018 | World Journal of Diabetes2018，9，6： | 5 |
| 4 | Role of baicalin as a potential therapeutic agent in hepatobiliary and gastrointestinal disorders:A review显示文摘Baicalin is a natural bioactive compound derived from Scutellaria baicalensis,which is extensively used in traditional Chinese medicine.A literature survey demonstrated the broad spectrum of health benefits of baicalin such as antioxidant,anticancer,anti-inflammatory,antimicrobial,cardio-protective,hepatoprotective,renal protective,and neuroprotective properties.Baicalin is hydrolyzed to its metabolite baicalein by the action of gut microbiota,which is further reconverted to baicalin via phase 2 metabolism in the liver.Many studies have suggested that baicalin exhibits therapeutic potential against several types of hepatic disorders including hepatic fibrosis,xenobiotic-induced liver injury,fatty liver disease,viral hepatitis,cholestasis,ulcerative colitis,hepatocellular and colorectal cancer.During in vitro and in vivo examinations,it has been observed that baicalin showed a protective role against liver and gut-associated abnormalities by modifying several signaling pathways such as nuclear factor-kappa B,transforming growth factor beta 1/SMAD3,sirtuin 1,p38/mitogen-activated protein kinase/Janus kinase,and calcium/calmodulin-dependent protein kinase kinaseβ/adenosine monophosphate-activated protein kinase/acetyl-coenzyme A carboxylase pathways.Furthermore,baicalin also regulates the expression of fibrotic genes such as smooth muscle actin,connective tissue growth factor,β-catenin,and inflammatory cytokines such as interferon gamma,interleukin-6(IL-6),tumor necrosis factor-alpha,and IL-1β,and attenuates the production of apoptotic proteins such as caspase-3,caspase-9 and B-cell lymphoma 2.However,due to its low solubility and poor bioavailability,widespread therapeutic applications of baicalin still remain a challenge.This review summarized the hepatic and gastrointestinal protective attributes of baicalin with an emphasis on the molecular mechanisms that regulate the interaction of baicalin with the gut microbiota. | Risha Ganguly Ashutosh Gupta Abhay K Pandey | 2022 | World Journal of Gastroenterology2022，28，26： | 2 |
| 5 | Tobacco use and risk of myocardial infarction in 52 countries in the INTERHEART study: a case-control study显示文摘 | Koon K Teo Stephanie Ounpuu Steven Hawken MR Pandey Vicent Valentin David Hunt Rafael Diaz Wafa Rashed Rosario Freeman Lixin Jiang Xiaofei Zhang Salim Yusuf | 2006 | The Lancet . 2006 (9536)2006，，9536： | 2 |
| 6 | Mechanism of crustal extension in the Laxmi Basin,Arabian Sea显示文摘Continental rifting and magmatism has been extensively studied worldwide as it is believed that continental rifting, break up of continents and associated magmatism lead to genesis of new oceanic crust. However, various regions of the world show that these processes may lead to genesis of other types of crust than the oceanic crust. Laxmi Basin in the western continental margin of the India is one such region with an enigmatic crust.Due to its extreme strategic significance for the palaeogeographic reconstruction of continents during Cretaceous continental breakup of India, this basin has attracted various workers for more than two decades. However, still the issue of nature of crust in the basin remains controversial. In this contribution, in order to identify nature of crust, mechanism of continental extension in the Laxmi Basin has been studied for the first time through newly acquired seismic data from the basin. Here, we propose a plausible mechanism of crustal extension in the Laxmi Basin which eventually constrains the nature of crust of the Laxmi Basin. We have demonstrated that the crust in the Laxmi Basin can be categorised in two zones of stretched and transitional crust. In the stretched zone several fault bounded horst and graben structures are identified which preserve syn- and post-rift sediments along with different periods of hiatus in sedimentations as unconformities. These faults are identified as listric faults in the upper crust which sole out in the detachment faults.Detachment faults decouples the upper brittle and lower ductile crust. The transitional crust is identified as heavily intruded by sills and basaltic volcanic which were emplaced due to melting of subcontinental mantle(SCM) after hyper-stretching of crust and serpentinisation of the SCM. Panikkar Ridge is proposed to be one such basaltic volcanic body derived from melting of lower part of the SCM. | Pandey Anju Pandey Dhananjai K | 2015 | Geodesy and Geodynamics2015，6，6： | 2 |
| 7 | Biotreatment of waste gas containing pyridine in a biofilter 显示文摘 | Pandey R A Padoley K V Mukherji S S | 2007 | Bioresource Technology2007，98，12： | 1 |
| 8 | NAD-alcohol dehydrogenase and superoxide dismutase activity in Zea mays under hypoxic and posthypoxic stress regime显示文摘 | Pandey O P Asha K Hoque H | 2000 | Plant Biology2000，27，1： | 1 |
| 9 | Optimum part depo-sition orintati-on in fused deposition modeling显示文摘 | Thrimurthulu K Pandey P Reddy N V | 2004 | International Journal of Machine Tools & Manufacture2004，44，： | 1 |
| 10 | Damage Detection in Structures Using Changes in Flexibility显示文摘 | Pandey A K&Biswas M | 1994 | Journal of Sound and Vibration1994，169，： | 1 |
| 11 | Nitrogen fertilizater re- sponse and use efficiency for three cereal crops in Niger 显示文摘 | Pandey R K Maranville J W Bako Y | 2001 | Communications in Soil Science and Plant Analysis2001，32，9： | 1 |
| 12 | Influence of source and time of potassium application on potato growth, yield, economics and crisp quality 显示文摘 | Kumar P Pandey S K Singh B P | 2007 | Potato Research2007，50，： | 1 |
| 13 | K, Evolution of gametophytic and sporophytic systems of selfincompatibility in angiosperm 显示文摘 | Pandey K | 1960 | Evolution1960，14，： | 1 |
| 14 | Influence of Nd^3+ and Sm^3+ substitution on the magnetic properties of strontium ferrite sintered magnets显示文摘 | Puneet Sharma Amitabh Verma R K Sidhu O P Pandey | 2003 | Journal of Alloys and Compounds2003，361，： | 1 |
| 15 | Stabilization of high hapliod inducer lines显示文摘 | Sarkar K R Pandey A Cayen P | 1994 | Maize Genet News Lett1994，68，： | 1 |
| 16 | Concentrations of heavy metals and aquatic macrophytes of Govind Ballabh Pant Sagar an anthropogenic lake affected by coal mining effluent显示文摘 | MISHRA V K UPADHYAY A R PANDEY S K | 2008 | Environmental Monitoring and Assessment2008，141，： | 1 |
| 17 | Experimental investiga- tion on waste heat recovery by refinery oil sludge incinera- tion using fluidised-bed technique 显示文摘 | Sankaran S Pandey S Sumathy K | 1998 | J Environ SciHealth Part A1998，33，5： | 1 |
| 18 | Protection of Procambarus clarkii against white spot syndrome virus using recombi nant subunit injection vaccine expressed in Pichia pastoris显示文摘 | Jha R K Xu Z R Pandey A | 2006 | Fisheries Sei2006，72，： | 1 |
| 19 | Epidemiology of ischemic andhemorrhagic stroke:incidence,prevalence,mortality,and risk factors显示文摘 | Grysiewicz RA Thomas K Pandey DK | 2008 | Neurol Clin2008，26，4： | 1 |
| 20 | Fabrication and applications of cellulose nanoparticle-based polymer composites显示文摘 | Pandey J K Nakagaito A N Takagi H | 2013 | Polym Eng Sci2013，53，1： | 1 |
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