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| 1 | Comparison of frequency offset estimation techniques for burst OFDM显示文摘 | Patel S Cimini L J McNair B | 2002 | Vehicular Technology Conference IEEE 55th2002，2，： | 2 |
| 2 | High omega arachidonic acid/docosahexaenoic acid ratio induces mitochondrial dysfunction and altered lipid metabolism in human hepatoma cells显示文摘BACKGROUND Non-alcoholic fatty liver disease(NAFLD) is a common cause of liver disease worldwide and is a growing epidemic. A high ratio of omega-6 fatty acids to omega-3 fatty acids in the diet has been implicated in the development of NAFLD. However, the inflicted cellular pathology remains unknown. A high ratio may promote lipogenic pathways and contribute to reactive oxygen species(ROS)-mediated damage, perhaps leading to mitochondrial dysfunction.Therefore, these parameters were investigated to understand their contribution to NAFLD development.AIM To examine the effect of increasing ratios of omega-6:3 fatty acids on mitochondrial function and lipid metabolism mediators.METHODS Hep G2-derived VL-17 A cells were treated with normal(1:1, 4:1) and high(15:1,25:1) ratios of omega-6: omega-3 fatty acids [arachidonic acid(AA):docosahexaenoic acid(DHA)] at various time points. Mitochondrial activity and function were examined via MTT assay and Seahorse XF24 analyzer, respectively.Triglyceride accumulation was determined by using Enzy Chrom? and levels of ROS were measured by fluorescence intensity. Protein expression of the mediators of lipogenic, lipolytic and endocannabinoid pathways was assessed by Western blotting.RESULTS High AA:DHA ratio decreased mitochondrial activity(P < 0.01;up to 80%) and promoted intracellular triglyceride accumulation(P < 0.05;40%-70%).Mechanistically, it altered the mediators of lipid metabolism;increased the expression of stearoyl-Co A desaturase(P < 0.05;22%-35%), decreased the expression of peroxisome proliferator-activated receptor-alpha(P < 0.05;30%-40%) and increased the expression of cannabinoid receptor 1(P < 0.05;31%).Furthermore, the high ratio increased ROS production(P < 0.01;74%-115%) and reduced mitochondrial respiratory functions such as basal and maximal respiration, ATP production, spare respiratory capacity and proton leak(P < 0.01;35%-68%).CONCLUSION High AA:DHA ratio induced triglyceride accumulation, increased oxidative stress and disrupted mitochondrial functions. Stimulation of lipogenic and steroidal transcription factors may partly mediate these effects and contribute to NAFLD development. | Reem Ghazali Kosha J Mehta SW Annie Bligh Ihab Tewfik Dahn Clemens Vinood B Patel | 2020 | World Journal of Hepatology2020，12，3： | 2 |
| 3 | Regulation of carbonic-anhydrase activity,inorganic-carbon uptake and photosynthetic biomass yield in Chlamydomonas reinhardtii显示文摘 | Patel B N Merrett M J 1986 | 1986 | Planta1986，169，： | 1 |
| 4 | Influence of dates ofplanting and nitrogen levels on the smoke constituents ofbidi tobacco cultivars 显示文摘 | Patel J A Patel B K Patel G R | 1989 | Tobacco Research1989，15，1： | 1 |
| 5 | Effect of intravenous infusion of dexmedetomidine on perioperative haemodynamie changes and postoperative recovery:a study with entropy analysis 显示文摘 | PATEL C R ENGINEER S R SHAH B J | 2012 | Indian J Anaesth2012，56，6： | 1 |
| 6 | Van- comycin-resistant Staphylococcus aureus in the United States, 2002-2006 显示文摘 | SIEVERT D M RUDRIK J T PATEL J B | 2008 | Clin Infect Dis2008，，5： | 1 |
| 7 | Genotype and allele frequencies of kappa-casein and beta-lactoglobulin in Indian river buffalo bulls (Bubalus bubalis) 显示文摘 | Patel R K Chauhan J B Singh K M | 2007 | Buffalo Bulletin2007，26，3： | 1 |
| 8 | Effect of intravenous infusion of dexmedetomidine on perioperative? haemodynamic changes and postoperative recovery: A study with entropy analysis 显示文摘 | Patel C R Engineer S R Shah B J | 2012 | Indian J Anaesth2012，56，6： | 1 |
| 9 | Mupirocin Resistance显示文摘 | Jean B Patel Rachel J | | 0，，06： | 1 |
| 10 | Autonomically induced conversion of pulmonary vein focal firing into atrial fibrillation显示文摘 | Scherlag B J Yamanashi W Patel U | 2005 | J Am Coll Cardiol2005，45，： | 1 |
| 11 | Targeting of MIZ-1 is essential for MYC mediat-ed apoptosis 显示文摘 | PATEL J H MCMAHON S B | 2005 | J Biol Chem2005，12，： | 1 |
| 12 | Production of fungal protein and glucoamylase by Rhizopus oligosporus from starch processing wastewater 显示文摘 | JIN Bo van LEEUWEN H J PATEL B et ol | 1999 | Process Biochem1999，34，1： | 1 |
| 13 | Surface proteins and exotoxins are required for the pathogenesis of Staphylococ- cus aureus pneumonia显示文摘 | Wardenburg J B Patel R J Schneewind O | 2007 | Infect Immun2007，75，10： | 1 |
| 14 | Calculating postnatal growth velocity in very low birth weight (VLBW) premature infants显示文摘 | PatelAL Engstrom JL Meier PP Jegier B J Kimura RE | 2009 | J Perinatol2009，29，3： | 1 |
| 15 | Relationship between interdialytic weight gain and blood pressure among pre-alent hemodialysis patients显示文摘 | Inrig J K Patel U D Gillespie B S | 2007 | Am J Kidney Dis2007，50，1： | 1 |
| 16 | Measurement of gas holdup and mean bubble diameter in bubble column reactors by dynamic gas disengagement method显示文摘 | Daly J G Patel S A Bukur D B | | 0，，13： | 1 |
| 17 | Crash- worthiness Design Using Topology Optimization 显示文摘 | PATEL N M KANG B S RENAUD J E | 2009 | Journal of Mechanical Design2009，131，6： | 1 |
| 18 | Immunomodulatory effects of probiotics in the treatment of human immunodeficiency virus(HIV)infection显示文摘 | Patel A R Shah N P Prajapati J B | 2014 | Biomedicine and Preventive Nutrition2014，4，1： | 1 |
| 19 | Simultaneous optimization of capsule and tablet formulation using response surface methodology 显示文摘 | Iskandarani B Clair J H Patel P | 1993 | Drug Dev Ind Pharm1993，19，16： | 1 |
| 20 | Polyethylene made with in situ supported ni-diimine/SMAO: replication phenomenon and effect of polymerization conditions on polymer microstructure and morphology 显示文摘 | Simon L C Patel H Soares J B P | 2001 | Macromol Chem Phys2001，202，17： | 1 |
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