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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Power management unit chip design for automobile active-matrix organic light-emitting diode display module显示文摘A power management unit (PMU) chip supplying dual panel supply voltage, which has a low electro-magnetic interference (EMI) characteristic and is favorable for miniaturization, is designed. A two-phase charge pump circuit using external pumping capacitor increases its pumping current and works out the charge-loss problem by using bulk-potential biasing circuit. A low-power start-up circuit is also proposed to reduce the power consumption of the band-gap reference voltage generator. And the ring oscillator used in the ELVSS power circuit is designed with logic devices by supplying the logic power supply to reduce the layout area. The PMU chip is designed with MagnaChip’s 0.25 μm high-voltage process. The driving currents of ELVDD and ELVSS are more than 50 mA when a SPICE simulation is done. | KIM J H PARK J H KIM J H CAO T V LEE T Y BAN H J YANG K KIM H G HA P B KIM Y H | 2009 | Journal of Central South University2009，16，4： | 4 |
| 3 | Catalytic supercritical water oxidation of wastewater from terephthalie acid manufacturing process 显示文摘 | Park T J Lira J S Lee Y W | 2003 | The Journal of Supereritieal Fluids2003，26，3： | 1 |
| 4 | Short-term load forecasting using artificial neural networks显示文摘 | CHA Y T PARK J H | 1992 | IEEE Trans on Power System1992，7，1： | 1 |
| 5 | Abscisic acid inhibits type 2C protein phosphatases via the PYR/ PYL family of START proteins显示文摘 | PARK S Y FUNG P NISHIMURA N JENSEN D R FFUJII ZHAO Y LUMBA S SANTIAGO J RODRIGUES A CHOW T F | 2009 | Science2009，324，： | 1 |
| 6 | Toward secure distributed spectrum sensing in cognitive radio networks 显示文摘 | Chen R Park J M Hou Y T | 2008 | IEEE Commu- nication Magazine2008，4，： | 1 |
| 7 | Carbon source recovery from waste activated sludge by alkaline hydrolysis and gamma - ray irradiation for biological denitrification 显示文摘 | Kim T H Nam Y K Park C | 2009 | Bioresource Technology2009，100，： | 1 |
| 8 | Gas-phase dehydration of glycerol over ZSM-5 catalysts显示文摘 | KIM Y T JUNG K D PARK E D | 2010 | Microporous and Mesoporous Materials2010，131，13： | 1 |
| 9 | Lifetime expression of stem cell markers in the uterine endometrium显示文摘 | Cho N H Park Y K Kim Y T | 2004 | Fertil Steril2004，81，2： | 1 |
| 10 | Active contour model with gradient directional information: directional snake 显示文摘 | PARK H SCHOEPFLIN T KIM Y | 2001 | IEEE Transactions on Circuits System and Video Technology2001，15，2： | 1 |
| 11 | Stand-ardization of ^152Eu and ^88Y显示文摘 | PARK T S LEE J M HWANG H Y | 2002 | Applied Radiation and Isotopes2002，56，： | 1 |
| 12 | Assessment of siRNA pharmacokinetics using ELISA-based quanti? cation 显示文摘 | Kima E Park T Oh Y | 2010 | J Controlled Release2010，143，： | 1 |
| 13 | Large - scale nonhydrolytic sol- gel synthesis of uniform- sized ceria nanocrystals with spherical, wWire, and tadpole shapes 显示文摘 | Yu T Joo J Park Y I | 2005 | Ange- wandte Chemie2005，117，45： | 1 |
| 14 | A study on thermal characteristic analysis and shape optimization of a ventilated disc显示文摘 | JUNG S P KIM Y G PARK T W | | 0，，01： | 1 |
| 15 | Apreliminary design study for the HYPER system显示文摘 | PARK W S SONG T Y LEE B O | 2002 | Nuclear Engineering and Design2002，219，3： | 1 |
| 16 | LIN28B polymorphisms are associated with eentral precocious pubertyand early puber- ty in girls显示文摘 | Park S W Lee S T Sohn Y B | 2012 | Korean J Pediatr2012，55，10： | 1 |
| 17 | The expression of functional LPS receptor proteins CD14 and toll-like receptor 4 in human corneal cells 显示文摘 | Song P I Abraham T A Park Y | 2001 | Ophthalmology & Visual2001，42，12： | 1 |
| 18 | The influence of specific mechanical energy on cornmeal viscosity measured by an on - line systemduring twin - screw extrusion 显示文摘 | Chang Y K Martinez - Bustos F Park T S | 1999 | Brazilian Journal of Chemical Engineering1999，16，3： | 1 |
| 19 | Gas-phase dehydration of glycerol over supported silicotungstic acids catalysts显示文摘 | Kim Y T Jung K D Park E D | 2010 | Bull Korean Chem Soc2010，31，11： | 1 |
| 20 | Directconverison of cellulose into polyols or H2 over P t/N a (H )-Z S M -5 显示文摘 | YOU S J BEAK I G KIM Y T JEONG K E CHAE H J KIM T W KIM C U KIM T J CHUNG Y M OH S H PARK E D | | Korean J Chem Eng0，28，3： | 1 |
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