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| 1 | Alcoholic liver disease:Utility of animal models显示文摘Alcoholic liver disease(ALD) is a major cause of acute and chronic liver injury. Extensive evidence has been accumulated on the pathological process of ALD during the past decades. However, effective treatment options for ALD are very limited due to the lack of suitable in vivo models that recapitulate the full spectrum of ALD. Experimental animal models of ALD, particularly rodents, have been used extensively to mimic human ALD. An ideal animal model should recapitulate all aspects of the ALD process, including significant steatosis, hepatic neutrophil infiltration, and liver injury. A better strategy against ALD depends on clear diagnostic biomarkers, accurate predictor(s) of its progression and new therapeutic approaches to modulate stop or even reverse the disease. Numerous models employing rodent animals have been established in the last decades to investigate the effects of acute and chronic alcohol exposure on the initiation and progression of ALD. Although significant progress has been made in gaining better knowledge on the mechanisms and pathology of ALD, many features of ALD are unknown, and require further investigation, ideally with improved animal models that more effectively mimic human ALD. Although differences in the degree and stages of alcoholic liver injury inevitably exist between animal models and human ALD, the acquisition and translational relevance will be greatly enhanced with the development of new and improved animal models of ALD. | Arantza Lamas-Paz Fengjie Hao Leonard J Nelson Maria Teresa Vázquez Santiago Canals Manuel Gómez del Moral Eduardo Martínez-Naves Yulia A Nevzorova Francisco Javier Cubero | 2018 | World Journal of Gastroenterology2018，24，45： | 26 |
| 2 | Screening pre-bariatric surgery patients for esophageal disease with esophageal capsule endoscopy显示文摘AIM:To determine if esophageal capsule endoscopy(ECE)is an adequate diagnostic alternative to esophagogastroduodenoscopy(EGD)in pre-bariatric surgery patients.METHODS:We conducted a prospective pilot study to assess the diagnostic accuracy of ECE(PillCam ESO2,Given Imaging)vs conventional EGD in pre-bariatric surgery patients.Patients who were scheduled for bariatric surgery and referred for pre-operative EGD were prospectively enrolled.All patients underwent ECE followed by standard EGD.Two experienced gastroenterologists blinded to the patient’s history and the findings of the EGD reviewed the ECE and documented their findings.The gold standard was the findings on EGD.RESULTS:Ten patients with an average body mass index of 50 kg/m2were enrolled and completed the study.ECE identified 11 of 14(79%)positive esophageal/gastroesophageal junction(GEJ)findings and 14of 17(82%)combined esophageal and gastric findings identified on EGD.Fisher’s exact test was used to compare the findings and no significant difference was found between ECE and EGD(P=0.64 for esophageal/GEJ and P=0.66 for combined esophageal and gastric findings respectively).Of the positive esophageal/GEJ findings,ECE failed to identify the following:hiatal hernia in two patients,mild esophagitis in two patients,and mild Schatzki ring in two patients.ECE was able to identify the entire esophagus in 100%,gastric cardia in0%,gastric body in 100%,gastric antrum in 70%,pylorus in 60%,and duodenum in 0%.CONCLUSION:There were no significant differences in the likelihood of identifying a positive finding using ECE compared with EGD in preoperative evaluation of bariatric patients. | Ashish Shah Erica Boettcher Marianne Fahmy Thomas Savides Santiago Horgan Garth R Jacobsen Bryan J Sandler Michael Sedrak Denise Kalmaz | 2013 | World Journal of Gastroenterology2013，19，37： | 7 |
| 3 | PIV measurements of a micro-channel flow 显示文摘 | Meinhart C Werely S Santiago J | 1999 | Exp In Fluids1999，27，： | 2 |
| 4 | A particle image velocimetry system for microfluidics 显示文摘 | SANTIAGO J G WERELEY S T MEINHART C D | 1998 | Exp in Fluids1998，25，4： | 2 |
| 5 | The occurrence of a Maillard-type protein-polysaccharide reaction between β-lactoglobulin and chitosan显示文摘 | Beatriz Miralles Adolfo Martínez-Rodríguez Alejandro Santiago Jürgen van de Lagemaat Angeles Heras | 2005 | Food Chemistry2005，，3： | 2 |
| 6 | Abscisic acid inhibits type 2C protein phosphatases via the PYR/ PYL family of START proteins显示文摘 | PARK S Y FUNG P NISHIMURA N JENSEN D R FFUJII ZHAO Y LUMBA S SANTIAGO J RODRIGUES A CHOW T F | 2009 | Science2009，324，： | 1 |
| 7 | haparoscopic liver resectiOn for malignant liver tumors:preliminary results of a multicenter European study显示文摘 | Gigot JF Glineur D Santiago Azagra J | 2002 | Ann Surg2002，236，1： | 1 |
| 8 | An applica- tion of satellite-derived sea surface temperature data to the skip- jack (Katsuwonus pelamis Linnaeus, 1758 ) and albacore tuna ( Thunnus alalunga Bonaterre, 1788 ) fisheries in the north-east Atlantic显示文摘 | RAMOS A G SANTIAGO J SANGRA P | 1996 | lnt J Rein Sens1996，17，： | 1 |
| 9 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 10 | An integrated growth study forNorth Atlantic albacore(Thunnus alalunga)显示文摘 | Santiago J Arrizabalaga H | 2005 | ICES J MarSci2005，62，74： | 1 |
| 11 | Ischemia/Reperfusion injury protection by mesenchymal stem cell derived antioxidant capacity显示文摘 | De Santiago J Bare DJ Banach K | 2013 | Stem Cells Dev2013，22，18： | 1 |
| 12 | Relaxation Modulus in the Fitting of Polycarbonate and Poly Viscoelastic Polymers by a Fractional Maxwell Model显示文摘 | Jimenez A H Jara B V Santiago J H | 2002 | Colloid and Polymer Science2002，280，5： | 1 |
| 13 | A particle image velocimetry system for microfluidics 显示文摘 | Santiago J G Werely S T Meinhart C D | 1998 | Exp in Fluids1998，25，： | 1 |
| 14 | Acoustic behaviour of Abudefduf luridus显示文摘 | SANTIAGO J A CASTRO J J | 1997 | Journal of Fish Biology1997，51，： | 1 |
| 15 | Cellular localization and changes in expression of prolactin receptor isoforms in sheep ovary throughout the estrous cycle显示文摘 | Picazo R A Garcia Ruiz J P Santiago Moreno J | 2004 | Reproduction2004，128，5： | 1 |
| 16 | Electrokinetic instability mieromixing显示文摘 | Oddy M H Santiago J G Mikkelsen J C | 2001 | Analytical Chemistry2001，73，24： | 1 |
| 17 | Laparoscopic liver resection for malignant liver tumors:preliminary results of amulti center European study显示文摘 | Gigot JF Glineur D Santiago Azagra J | 2002 | Ann Surg2002，236，1： | 1 |
| 18 | Role of monocyte chemotactic protein-3 and -4 in children with virus exacerbation of asthma 显示文摘 | Santiago J Hernandez-Cruz JL Manjarrez-Zavala ME l | 2008 | Eur Respir J2008，32，5： | 1 |
| 19 | PIV measurements of a microchannel flow 显示文摘 | Meinhart C D Werely S T Santiago J G | 1999 | Exp in Fluids1999，27，： | 1 |
| 20 | The first oxotitanium phthalocyanine metallomesogen as a liquid crystalline photoconductor:2,3,9,1 0,1 6,1 7,23,24-octakis(n-octadecylthio)显示文摘 | Santiago J Sugino T Shimizu Y | 1999 | Molecular Crystals and Liquid Crystals Science and Technology Section A--Molecular Crystals and Liquid Crystals1999，332，： | 1 |
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