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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | 原发灶切除在无症状的、同时性的、转移灶不可切除的结直肠癌患者中的作用:一项多中心随机对照试验显示文摘目的:我们在同时性的、转移灶不可切除的无症状Ⅳ期结直肠癌患者中,评估接受原发灶切除术(primary tumor resection,PTR)续贯化疗的患者相比接受单纯化疗的患者的生存优势。方法:这是一项开放的前瞻性随机对照试验(ClnicalTrials.gov注册号:NCT01978249)。从2013年5月至2016年4月,在12所三级医院中将48例诊断为转移灶不可切除的、原发灶无症状的结直肠癌患者按1:1比例进行随机化分组,其中PTR组26例、化疗组22例。主要终点是两年总生存率,次要终点为与原发灶、PTR相关的并发症发生率以及转变为可切除状态的转化率。 | 卓长华 陈功 PARK E J BAEK J H CHOI G S | 2020 | 结直肠肛门外科2020，26，5： | 8 |
| 3 | Solidification microstructure and M2C carbine decomposition in a spray-formed high-speed steel显示文摘 | Lee E Park W Jung J Y Ahn S | 1998 | Metallurgical and Materials Transactions A1998，29，： | 2 |
| 4 | Characteristics of relaxor-based piezoelectric single crystals for ultrasonic transducers显示文摘 | PARK S E SHROUT T R | 1997 | IEEE Trans Ultroson Ferroelectr Freq Control1997，44，： | 2 |
| 5 | Live births after vitrification of oocytes in a stimulated in vitro fertilization-embryo transfer program显示文摘 | Kim T J Park S E | 2003 | Fertil Steril2003，79，： | 1 |
| 6 | Central nervous system concentrations of cyclooxygenase-2 inhibitors in humans显示文摘 | Dembo G Park S B Kharasch E D | 2005 | Anesthesiology2005，102，2： | 1 |
| 7 | A study on prediction of bead height in robotic arc welding using a neural network 显示文摘 | KIM S SON J S PARK C E | 2002 | Journal of Materials Processing Technology2002，130，2： | 1 |
| 8 | The role of diffusion-weighted imaging and the apparent diffusion coefficient (ADC) values for breast tumors显示文摘 | Park M J Cha E S Kang B J | 2007 | Korean J Radiol2007，8，5： | 1 |
| 9 | Corticosteroid inhibits IL-4singaling through down-regulation of IL-4 receptor and STAT6 activity显示文摘 | SO E Y KIM S H PARK H H | 2002 | FEBS Letters2002，518，： | 1 |
| 10 | Interleukin-3,GMCSF and G-CSF receptor expression on cell lines and primary leukemia cells:receptor heterogeneity and relationship to growth factor responsiveness显示文摘 | Park L S Waldron P E Friend D | 1989 | Blood1989，74，： | 1 |
| 11 | Further evidence of multiple NOx sorption sites on NOx storage/reduction catalysts显示文摘 | Epling W S Parks J E Campbell G C | 2004 | Catal Today2004，96，： | 1 |
| 12 | Hydrodechlorination of CCl4 over Pt/Al2O3 Effects of reaction pressure and diluent gases on distribution of products and catalyst stability 显示文摘 | Bae J W Park E D Lee J S | 2001 | Appl Catal A2001，217，： | 1 |
| 13 | Anti - inflammatory activity of mul- berry leaf extract through inhibition of NF - KB 显示文摘 | Park E Lee S Lee JE | 2013 | Journal of Functional Foods2013，5，1： | 1 |
| 14 | Effect of nitrate on the degradation of bisphenol A by UV/H202 and ozone/H2 02 oxi- dation in aqueous solution 显示文摘 | Park C G Choi E S Jeon H W | 2014 | Desalination and Water Treat- ment2014，52，46： | 1 |
| 15 | Limonoid derivatives and itspesticidal activities显示文摘 | PARK E S BAE I K JEON H J | 2014 | Entomological Research2014，44，4： | 1 |
| 16 | Regulated hypothermia reduces brain oxidative stress after hypoxic-ischemia显示文摘 | Laurence M Katz Amanda S Young Jonathan E Frank Yuanfan Wang Kyunam Park | 2004 | Brain Research2004，，1： | 1 |
| 17 | Government organizations’innovative use of the internet:the case of the twitter activity of South Korea's Ministry for Food,Agriculture,Forestry and Fisheries显示文摘 | CHO S E PARK H W | 2011 | Scientometrics2011，90，1： | 1 |
| 18 | Directconverison of cellulose into polyols or H2 over P t/N a (H )-Z S M -5 显示文摘 | YOU S J BEAK I G KIM Y T JEONG K E CHAE H J KIM T W KIM C U KIM T J CHUNG Y M OH S H PARK E D | | Korean J Chem Eng0，28，3： | 1 |
| 19 | Direct synthesis of dimethyl carbonate from methanol and carbon dioxide显示文摘 | SEO E S PARK N K CHANG W C | 2002 | Journal-Korean Institue of Chemical Engineers2002，40，1： | 1 |
| 20 | Decreased muscle strength and quality in older adults with type 2 diabetes:the health,aging,and body composition study显示文摘 | Park S W Goodpaster B H Strotmeyer E S | 2006 | Diabetes2006，55，6： | 1 |
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