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| 1 | Partial virological response to three different nucleotide analogues in naive patients with chronic hepatitis B显示文摘BACKGROUND: The definition of partial virological response(PVR) was proposed because of its clinical relevance. PVR relates to subsequent therapeutic failure which results in the modification of the regimen. Whether this rationale can be applied to all nucleotide analogues (NA) is not clear. This study was undertaken to analyze PVR influence on therapeutic outcomes during lamivudine, entecavir or tenofovir mono therapy in NA-naive patients with chronic hepatitis B in routine clinical practice.METHODS: We retrospectively analyzed 150 NA-naive patients with chronic hepatitis B. These subjects received lamivudine entecavir or tenofovir monotherapy between February 2001 and July 2013.RESULTS: Sixty-nine patients were treated with lamivudine, 35with entecavir, and 46 with tenofovir. The median therapeutic duration was 19.5 (6-147) months. PVR rates at 24 weeks were similar among three NAs (lamivudine 33.3%, entecavir 35.0%tenofovir 32.4%, P=0.981). For all three NAs, patients with a higher baseline viral load or HBeA g-positive status had a higher serum viral positive rate tested by polymerase chain reaction at week 24 and 48. Cumulative probability of virological breakthrough (VBR) for patients treated with lamivudine was67% at 5 years, and PVR at 24 weeks was the independent risk factor for VBR (HR: 3.09; 95% CI: 1.09-8.74; P=0.034); also lamivudine treated patients older than 50 years seemed to have a tendency for VBR (HR: 2.80; 95% CI: 0.99-8.18; P=0.052)A majority of entecavir and tenofovir partial responders achieved and maintained virological response with prolonged monotherapy, except one entecavir treated patient who experienced VBR due to resistance mutations.CONCLUSIONS: Management strategy for lamivudine treatment should include adaptation of regimen according to PVR as an on-treatment response parameter due to its relation with unacceptably high VBR probability. Similar conclusion should not be directly related to entecavir or tenofovir treatment. | Ender G Yegin Osman Cavit Ozdogan | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，6： | 5 |
| 2 | Cytokeratin-18 fragments and biomarkers of the metabolic syndrome in nonalcoholic steatohepatitis显示文摘Nonalcoholic fatty liver disease(NAFLD)remains a leading cause of chronic liver disease.In the context of NAFLD,the presence of nonalcoholic steatohepatitis (NASH)portends an adverse prognosis with greater risk of liver fibrosis and cirrhosis.Although liver biopsy is the keystone of patient management in NAFLD,it is also increasingly clear that such evaluation has its limitations.The availability of biochemical markers of NAFLD and NASH has tremendous potential to radically alter management strategies for these conditions,as well as to monitor disease activity.Our article provides an overview of biomarker discovery and selection in the setting of NAFLD and highlights future directions in the field. | Yusuf Yilmaz Alla Eldeen Kedrah Osman Ozdogan | 2009 | World Journal of Gastroenterology2009，15，35： | 4 |
| 3 | Spontaneous regres- sion of extruded lumbar disc herniation: report of two iUustrative case and review of the literature 显示文摘 | Sabuncuoglu H Ozdogan S Timurkaynak E | 2008 | Turk Neurosurg2008，18，4： | 1 |
| 4 | Comparison between locked intramedullary nailing and plate osteosynthesis in the management of adult forearm fractures 显示文摘 | Ozkayz U Kilic A Ozdogan U | 2009 | Acta Orthop Traumatol Turc2009，1，： | 1 |
| 5 | Langenbecks Arch Surg显示文摘 | Ozlem N Ozdogan M Gurer A Gomceli I Aydin R | | 0，，03： | 1 |
| 6 | Serum levels of omentin, chemerin and adipsin in patients with biopsy-proven nonalcoholic fatty liver disease显示文摘 | Yusuf Yilmaz Oya Yonal Ramazan Kurt Yesim Ozen Alahdab Fatih Eren Osman Ozdogan Cigdem Ataizi Celikel Nese Imeryuz Cem Kalayci Erol Avsar | 2011 | Scandinavian Journal of Gastroenterology2011，，1： | 1 |
| 7 | MELD score and clinical type predict prognosis in hepatorenal syndrome : relevance to liver transplantation显示文摘 | Alessartdria C Ozdogan O Guevara M | 2005 | Hepatology2005，41，6： | 1 |
| 8 | Experimental study on charging and discharging periods of water in a latent heat storage unit显示文摘 | Mehmet Akif Ezan Muhammet Ozdogan Aytunq Erek | 2011 | International Journal of Thermal Sciences2011，，50： | 1 |
| 9 | Thrombolysis via an operatively placed mesenteric catheter for portal and superior mesenteric vein thrombosis:report of a case显示文摘 | Ozdogan M Gurer A Gokakin AK | 2006 | Surg Today2006，36，9： | 1 |
| 10 | Mild hypothermia improves survival during hemorrhagic shock without affecting bacterial translocation显示文摘 | Deniz T Agalar C Ozdogan M | 2009 | J Invest Surg2009，22，1： | 1 |
| 11 | Beneficial effect of hyperbaric oxygenation on liver regeneration in cirrhosis显示文摘 | Ozdogan M Ersoy Z Dundar K | 2005 | Journal of Surgical Research2005，129，2： | 1 |
| 12 | The mean platelet volume in patients with obesity显示文摘 | Coban E Ozdogan M Yazicioglu G | | 0，，08： | 1 |
| 13 | Prospective comparison of local, spinal, and general types of anaesthesia regarding oxidative stess following Lichtenstein hernia repair 显示文摘 | KULACOGLU H OZDOGAN M GURER A | 2007 | Bratisl Lek Listy2007，108，8： | 1 |
| 14 | Effect of some antidepressants on glycaemia and insulin levels of normoglycaemic and alloxan-induced hyper glycaemic mice显示文摘 | Erenmemisoglu A Ozdogan UK Saraymen R | 1999 | J Pharm Pharmacol1999，51，6： | 1 |
| 15 | Estimation of CO2 emission factors of coals显示文摘 | OZDOGAN S | | 0，，14： | 1 |
| 16 | Transconjunetive 25-gauge sutureless vitrectomy and silicone oil injection in diabetic tractional retinal detachment 显示文摘 | Altan T Acar N Kapran Z Unver YB Ozdogan S | 2008 | Retina2008，28，9： | 1 |
| 17 | Variables affecting the occurrence of gastroesophageal reflux in obstructive sleep apnea patients显示文摘 | Ozturk 0 Ozturk L Ozdogan A | 2004 | EurArch Otorhinolaryngol2004，261，4： | 1 |
| 18 | Assessment ofcardiac remodeling in asymptomatic mitral regurgitation for surgery timing:a comparativestudy of echocardiography and magnetic resonance imaging显示文摘 | Ozdogan O Yuksel A Gurgun C | 2014 | Cardiovascular Ultrasound2014，13，4： | 1 |
| 19 | MELD score and clinical type predict prognosis in hepatorenal syndrome:relevance to liver trans-plantation显示文摘 | Alessandria C Ozdogan O Guevara M | 2004 | Hepatology2004，41，： | 1 |
| 20 | Percutaneous liver biopsy complications in patients with chronic renal failure 显示文摘 | Ozdogan M Ozgur O Boyacioglu S | 1996 | Nephron1996，74，2： | 1 |
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