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| 1 | Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders显示文摘Inappropriate T cell responses in the central nervous system(CNS)affect the pathogenesis of a broad range of neuroinflammatory and neurodegenerative disorders that include,but are not limited to,multiple sclerosis,amyotrophic lateral sclerosis,Alzheimer’s disease and Parkinson’s disease.On the one hand immune responses can exacerbate neurotoxic responses;while on the other hand,they can lead to neuroprotective outcomes.The temporal and spatial mechanisms by which these immune responses occur and are regulated in the setting of active disease have gained significant recent attention.Spatially,immune responses that affect neurodegeneration may occur within or outside the CNS.Migration of antigen-specific CD4+T cells from the periphery to the CNS and consequent immune cell interactions with resident glial cells affect neuroinflammation and neuronal survival.The destructive or protective mechanisms of these interactions are linked to the relative numerical and functional dominance of effector or regulatory T cells.Temporally,immune responses at disease onset or during progression may exhibit a differential balance of immune responses in the periphery and within the CNS.Immune responses with predominate T cell subtypes may differentially manifest migratory,regulatory and effector functions when triggered by endogenous misfolded and aggregated proteins and cell-specific stimuli.The final result is altered glial and neuronal behaviors that influence the disease course.Thus,discovery of neurodestructive and neuroprotective immune mechanisms will permit potential new therapeutic pathways that affect neuronal survival and slow disease progression. | Kristi M Anderson Katherine E Olson Katherine A Estes Ken Flanagan Howard E Gendelman R Lee Mosley | 2014 | Translational Neurodegeneration2014，3，1： | 8 |
| 2 | MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca^sup 2+^ overload and cell death显示文摘 | Aurora Arin B Mahmoud Ahmed I Luo Xiang Johnson Brett A van Rooij Eva Matsuzaki Satoshi Humphries Kenneth M Hill Joseph A Bassel-Duby Rhonda Sadek Hesham A Olson Eric N | 2012 | EN2012，，4： | 2 |
| 3 | Ordinal judgments in multiattribute decision analysis显示文摘 | Moshkovich H M Mechitov A I Olson D L | | 0，，03： | 1 |
| 4 | Effects of salt concentration and freezing on Mozzarella cheese texture显示文摘 | CERVANTES M A LUND D B OLSON N F | 1983 | J Dairy Sci1983，66，2： | 1 |
| 5 | Biology of Cryptosporidium parvum in pigs:from weaning to market显示文摘 | Guselle N J Appelbee A J Olson M E | 2003 | Vet Parasitol2003，113，1： | 1 |
| 6 | Nitrogen and water affect direct and indirect plant systemic induced defense in cotton 显示文摘 | Olson D M Cortesero A M Rains G C | 2009 | Biological Control2009，49，3： | 1 |
| 7 | The nucleolus: an old fac- tory with unexpected capabilities显示文摘 | Olson MOJ Dundr M Szebeni A | 2000 | Trends in Cell Biology2000，10，5： | 1 |
| 8 | Characterization and differential expression of dhn/lea/rab-like genes during cold acclimation and drought stress in Arabidopsis thaliana显示文摘 | WELIN BV OLSON A NYLANDER M | 1994 | Plant Mol Biol1994，26，1： | 1 |
| 9 | Human K(ATP) channelopathies:diseases of metabolic homeostasis显示文摘 | Olson T M Terzic A | 2010 | Pflugers Arch2010，460，29： | 1 |
| 10 | Winter effects on hydraulic conductivity of compacted clay显示文摘 | Benson C H Abichou T H Olson M A | 1995 | Journal of Geotechnical Engineering1995，121，1： | 1 |
| 11 | Implicit measures in social cogn ition research: their meaning and use 显示文摘 | FAZIO R H OLSON M A | | Annual Review of Psychology 200 30，54，： | 1 |
| 12 | 查看详情显示文摘 | L A Overbey C C Olson M D Todd | | 0，，： | 1 |
| 13 | Regulation of mus cle differentiation by the MEF2 family of MADS box transcrip- tion factors 显示文摘 | OLSON E N PERRY M SCHULZR R A | 1995 | Dev Biol1995，172，1： | 1 |
| 14 | Synthesis of gra-phene aerogel with high electrical conductivity 显示文摘 | Wors|ey M A Pauzauskie P J Olson T Y | 2010 | Journal of the American Chemical Society2010，132，14： | 1 |
| 15 | Knowledge Organization in Research: A Conceptual Model for Organizing data 显示文摘 | Lisa M Given Hope A Olson | 2003 | Library & Information Science Reserch2003，，25： | 1 |
| 16 | Functional heterogeneity in cingulate cortex:the anterior executive and posterior evaluative regions显示文摘 | Vogt B A Finch D M Olson C R | 1992 | Cereb Cortex1992，2，6： | 1 |
| 17 | Aqueous chlorination kinetics and mechanism of substitued dihydroxybenzenes显示文摘 | Rebenne L M Gonzalez A C Olson T M | 1996 | Environ SciTechnol1996，30，： | 1 |
| 18 | Damage to the pore structure of hardened portland cement paste by mercury intrusion显示文摘 | OLSON R A NEUBAUER C M JENNINGS H M | 1997 | J Am Ceram Soc1997，80，9： | 1 |
| 19 | A phosphothreonine residue at the C-Terminal end of the plasma membrane H1-ATPase is protected by fusicoccininduced 14-3-3 binding显示文摘 | Olson A Svennelid F EK B Sommarin M Larsson C | 1998 | Plant Physiol1998，118，： | 1 |
| 20 | Effect of low dose irradiation of pork loins on the microflora, sensory characteristics and fat stabity 显示文摘 | Mattison M L Kraft A A Olson D G | 1986 | JofFoodSci1986，51，2： | 1 |
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