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| 1 | Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders显示文摘Inappropriate T cell responses in the central nervous system(CNS)affect the pathogenesis of a broad range of neuroinflammatory and neurodegenerative disorders that include,but are not limited to,multiple sclerosis,amyotrophic lateral sclerosis,Alzheimer’s disease and Parkinson’s disease.On the one hand immune responses can exacerbate neurotoxic responses;while on the other hand,they can lead to neuroprotective outcomes.The temporal and spatial mechanisms by which these immune responses occur and are regulated in the setting of active disease have gained significant recent attention.Spatially,immune responses that affect neurodegeneration may occur within or outside the CNS.Migration of antigen-specific CD4+T cells from the periphery to the CNS and consequent immune cell interactions with resident glial cells affect neuroinflammation and neuronal survival.The destructive or protective mechanisms of these interactions are linked to the relative numerical and functional dominance of effector or regulatory T cells.Temporally,immune responses at disease onset or during progression may exhibit a differential balance of immune responses in the periphery and within the CNS.Immune responses with predominate T cell subtypes may differentially manifest migratory,regulatory and effector functions when triggered by endogenous misfolded and aggregated proteins and cell-specific stimuli.The final result is altered glial and neuronal behaviors that influence the disease course.Thus,discovery of neurodestructive and neuroprotective immune mechanisms will permit potential new therapeutic pathways that affect neuronal survival and slow disease progression. | Kristi M Anderson Katherine E Olson Katherine A Estes Ken Flanagan Howard E Gendelman R Lee Mosley | 2014 | Translational Neurodegeneration2014，3，1： | 8 |
| 2 | Status review of mercury control options for coal-fired power plants显示文摘 | John H Pavlish Everett A Sondreal Michael D Mann Edwin S Olson Kevin C Galbreath Dennis L Laudal Steven A Benson | 2003 | Fuel Processing Technology2003，，2： | 4 |
| 3 | MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca^sup 2+^ overload and cell death显示文摘 | Aurora Arin B Mahmoud Ahmed I Luo Xiang Johnson Brett A van Rooij Eva Matsuzaki Satoshi Humphries Kenneth M Hill Joseph A Bassel-Duby Rhonda Sadek Hesham A Olson Eric N | 2012 | EN2012，，4： | 2 |
| 4 | Posterior wall fractures显示文摘 | OLSON S A FINKEMEIER C G | 1999 | Operative Techniques in Orthopaedics1999，9，3： | 1 |
| 5 | Expression of chemokine (C-C motif) ligand 18 in human macrophages and atherosclerotic plaques 显示文摘 | Hagg D A Olson F J Kjelldahl J | 2009 | Atherosclerosis2009，204，2： | 1 |
| 6 | Ordinal judgments in multiattribute decision analysis显示文摘 | Moshkovich H M Mechitov A I Olson D L | | 0，，03： | 1 |
| 7 | Effects of salt concentration and freezing on Mozzarella cheese texture显示文摘 | CERVANTES M A LUND D B OLSON N F | 1983 | J Dairy Sci1983，66，2： | 1 |
| 8 | Astigmatic decay following small incision, self-sealing cataract surgery 显示文摘 | Feil SH Crandall A S Olson RJ | 1994 | Cataract Refract Surg1994，20，1： | 1 |
| 9 | Cardiac plasticity显示文摘 | Hill J A Olson E N | 2008 | New England J Med2008，358，13： | 1 |
| 10 | Stratification of sudden death risk in patients receiving long-term amiodarone treatment for sustained ventricular tachycardia or ventricular fibrillation显示文摘 | WOELFEL A SIMPSON R J | 1993 | Am J Cardiol1993，71，10： | 1 |
| 11 | The development of posttraumatic arthritis after articular fracture显示文摘 | Furman B D Olson S A Guilak F | 2006 | J Orthop Trauma2006，20，： | 1 |
| 12 | Finite faults and inversion theory with applications to the 1979 Imperial valley earthquake 显示文摘 | Olson A H Apsel R | 1982 | Bulletin of the Seismological Society of America1982，72，： | 1 |
| 13 | The role of nitric oxide and metalloproteinases in the pathogenesis of hyperoxia - induced lung injury in neonatal rat显示文摘 | Radomski A Sawicki G Olson DM | 1998 | Br J Pharmacol1998，125，7： | 1 |
| 14 | Effective metabolism and long intracellular half life of the anti-hepatitis B agent adefovir in hepatic cells显示文摘 | Ray AS Vela JE Olson L Fridland A | 2004 | Biochem Pharmacol2004，68，： | 1 |
| 15 | The role of nitric oxide and metalloproteinases in the pathogenesis of hyperoxia-induced lung injury in neonate rat显示文摘 | Radomski A Sawicki G Olson DM | 1998 | Br J Pharmacol1998，125，7： | 1 |
| 16 | Biology of Cryptosporidium parvum in pigs:from weaning to market显示文摘 | Guselle N J Appelbee A J Olson M E | 2003 | Vet Parasitol2003，113，1： | 1 |
| 17 | Biological actions of carotenoids 显示文摘 | Bendich A Olson J A | 1989 | FASEB Journal1989，，3： | 1 |
| 18 | Antidepressant effects of exercise: evidence for an adult-neurogenesis hypothesis? 显示文摘 | ERNST C OLSON A K PINEL J P | 2006 | J Psy Neuro2006，31，2： | 1 |
| 19 | Resveratrol pre- vents monocrotaline-induced pulmonary hypertension in rats 显示文摘 | Csiszar A Labinskyy N Olson S | 2009 | Hypertension2009，54，3： | 1 |
| 20 | Nitrogen and water affect direct and indirect plant systemic induced defense in cotton 显示文摘 | Olson D M Cortesero A M Rains G C | 2009 | Biological Control2009，49，3： | 1 |
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