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| 1 | 一个熟悉的陌生人:在脂肪质的织物的 SVF 房间的 CD34 表示和通常认为的功能显示文摘 Human adipose tissue obtained by liposuction is easily accessible and an abundant potential source of autologous cells for regenerative medicine applications. After digestion of the tissue and removal of differentiated adipocytes, the so-called stromal vascular fraction (SVF) of adipose, a mix of various cell types, is obtained. SVF contains mesenchymal fibroblastic cells, able to adhere to culture plastic and to generate large colonies in vitro , that closely resemble bone marrow-derived colony forming units-fibroblastic, and whose expanded progeny, adipose mesenchymal stem/stromal cells (ASC), show strong similarities with bone marrow mesenchymal stem cells. The sialomucin CD34, which is well known as a hematopoietic stem cell marker, is also expressed by ASC in native adipose tissue but its expression is gradually lost upon standard ASC expansion in vitro . Surprisingly little is known about the functional role of CD34 in the biology and tissue forming capacity of SVF cells and ASC. The present editorial provides a short introduction to the CD34 family of sialomucins and reviews the data from the literature concerning ex- pression and function of these proteins in SVF cells and their in vitro expanded progeny. | Arnaud Scherberich Nunzia Di Maggio Kelly M McNagny | 2013 | World Journal of Stem Cells2013，5，1： | 8 |
| 2 | Intestinal epithelial barrier and neuromuscular compartment in health and disease显示文摘A number of digestive and extra-digestive disorders,including inflammatory bowel diseases,irritable bowel syndrome,intestinal infections,metabolic syndrome and neuropsychiatric disorders,share a set of clinical features at gastrointestinal level,such as infrequent bowel movements,abdominal distension,constipation and secretory dysfunctions.Several lines of evidence indicate that morphological and molecular changes in intestinal epithelial barrier and enteric neuromuscular compartment contribute to alterations of both bowel motor and secretory functions in digestive and extra-digestive diseases.The present review has been conceived to provide a comprehensive and critical overview of the available knowledge on the morphological and molecular changes occurring in intestinal epithelial barrier and enteric neuromuscular compartment in both digestive and extra-digestive diseases.In addition,our intent was to highlight whether these morphological and molecular alterations could represent a common path(or share some common features)driving the pathophysiology of bowel motor dysfunctions and related symptoms associated with digestive and extra-digestive disorders.This assessment might help to identify novel targets of potential usefulness to develop original pharmacological approaches for the therapeutic management of such disturbances. | Vanessa D’Antongiovanni Carolina Pellegrini Matteo Fornai Rocchina Colucci Corrado Blandizzi Luca Antonioli Nunzia Bernardini | 2020 | World Journal of Gastroenterology2020，26，14： | 6 |
| 3 | Investigation of compensatory postures with videofluoromanometry in dysphagia patients显示文摘AIM: To investigate the effectiveness of head compensatory postures to ensure safe oropharyngeal transit. METHODS: A total of 321 dysphagia patients were enrolled and assessed with videofluoromanometry (VFM). The dysphagia patients were classified as follows: safe transit; penetration without aspiration; aspiration before, during or after swallowing; multiple aspirations and no transit. The patients with aspiration or no transit were tested with VFM to determine whether compensatory postures could correct their swallowing disorder. RESULTS: VFM revealed penetration without aspiration in 71 patients (22.1%); aspiration before swallowing in 17 patients (5.3%); aspiration during swallowing in 32 patients (10%); aspiration after swallowing in 21 patients (6.5%); multiple aspirations in six patients (1.9%); no transit in five patients (1.6%); and safe transit in 169 patients (52.6%). Compensatory postures guaranteed a safe transit in 66/75 (88%) patients with aspiration or no transit. A chin-down posture achieved a safe swallow in 42/75 (56%) patients, a head-turned posture in 19/75 (25.3%) and a hyperextended head posture in 5/75 (6.7%). The compensatory postures were not effective in 9/75 (12%) cases. CONCLUSION: VFM allows the speech-language therapist to choose the most effective compensatory posture without a trial-and-error process and check the effectiveness of the posture. | Antonio Solazzo Luigi Monaco Lucia Del Vecchio Stefania Tamburrini Francesca Iacobellis Daniela Berritto Nunzia Luisa Pizza Alfonso Reginelli Natale Di Martino Roberto Grassi | 2012 | World Journal of Gastroenterology2012，18，23： | 3 |
| 4 | Psychopathological aspects of kidney transplantation: Efficacy of a multidisciplinary team显示文摘Renal transplantation is a well established treatment for end-stage renal disease, allowing most patients to return to a satisfactory quality of life. Studies have identified many problems that may affect adaptation to the transplanted condition and postoperative compliance. The psychological implications of transplantation have important consequences even on strictly physical aspects. Organ transplantation is very challenging for the patient and acts as an intense stressor stimulus to which the patient reacts with neurotransmitter and endocrine-metabolic changes. Transplantation can result in a psychosomatic crisis that requires the patient to mobilize all bio-psychosocial resources during the process of adaptation to the new foreign organ which may result in an alteration in self-representation and identity, with possible psychopathologic repercussions. These reactions are feasible in mental disorders, e.g., post-traumatic stress disorder, adjustment disorder, and psychosomatic disorders. In organ transplantation, the fruitful collaboration between professionals with diverse scientific expertise, calls for both a guarantee for mental health and greater effectiveness in challenging treatments for a viable association between patients, family members and doctors. Integrated and multidisciplinary care should include uniform criteria and procedures for standard assessments, for patient autonomy, adherence to therapy, new coping strategies and the adoption of more appropriate lifestyles. | Concetta De Pasquale Massimiliano Veroux Luisa Indelicato Nunzia Sinagra Alessia Giaquinta Michele Fornaro Pierfrancesco Veroux Maria L Pistorio | 2014 | World Journal of Transplantation2014，4，4： | 3 |
| 5 | Impact of radiogenomics in esophageal cancer on clinical outcomes: A pilot study显示文摘BACKGROUND Esophageal cancer(ESCA)is the sixth most common malignancy in the world,and its incidence is rapidly increasing.Recently,several microRNAs(miRNAs)and messenger RNA(mRNA)targets were evaluated as potential biomarkers and regulators of epigenetic mechanisms involved in early diagnosis.In addition,computed tomography(CT)radiomic studies on ESCA improved the early stage identification and the prediction of response to treatment.Radiogenomics provides clinically useful prognostic predictions by linking molecular characteristics such as gene mutations and gene expression patterns of malignant tumors with medical images and could provide more opportunities in the management of patients with ESCA.AIM To explore the combination of CT radiomic features and molecular targets associated with clinical outcomes for characterization of ESCA patients.METHODS Of 15 patients with diagnosed ESCA were included in this study and their CT imaging and transcriptomic data were extracted from The Cancer Imaging Archive and gene expression data from The Cancer Genome Atlas,respectively.Cancer stage,history of significant alcohol consumption and body mass index(BMI)were considered as clinical outcomes.Radiomic analysis was performed on CT images acquired after injection of contrast medium.In total,1302 radiomics features were extracted from three-dimensional regions of interest by using PyRadiomics.Feature selection was performed using a correlation filter based on Spearman’s correlation(ρ)and Wilcoxon-rank sum test respect to clinical outcomes.Radiogenomic analysis involvedρanalysis between radiomic features associated with clinical outcomes and transcriptomic signatures consisting of eight N6-methyladenosine RNA methylation regulators and five up-regulated miRNA.The significance level was set at P<0.05.RESULTS Of 25,five and 29 radiomic features survived after feature selection,considering stage,alcohol history and BMI as clinical outcomes,respectively.Radiogenomic analysis with stage as clinical outcome revealed that six of the eight mRNA regulators and two of the five up-regulated miRNA were significantly correlated with ten and three of the 25 selected radiomic features,respectively(-0.61<ρ<-0.60 and 0.53<ρ<0.69,P<0.05).Assuming alcohol history as clinical outcome,no correlation was found between the five selected radiomic features and mRNA regulators,while a significant correlation was found between one radiomic feature and three up-regulated miRNAs(ρ=-0.56,ρ=-0.64 andρ=0.61,P<0.05).Radiogenomic analysis with BMI as clinical outcome revealed that four mRNA regulators and one up-regulated miRNA were significantly correlated with 10 and two radiomic features,respectively(-0.67<ρ<-0.54 and 0.53<ρ<0.71,P<0.05).CONCLUSION Our study revealed interesting relationships between the expression of eight N6-methyladenosine RNA regulators,as well as five up-regulated miRNAs,and CT radiomic features associated with clinical outcomes of ESCA patients. | Valentina Brancato Nunzia Garbino Lorenzo Mannelli Marco Aiello Marco Salvatore Monica Franzese Carlo Cavaliere | 2021 | World Journal of Gastroenterology2021，27，36： | 3 |
| 6 | Undernutrition, risk of malnutrition and obesity in gastroenterological patients: A multicenter study显示文摘AIM: To investigate the prevalence of undernutrition, risk of malnutrition and obesity in the Italian gastroenterological population. METHODS: The Italian Hospital Gastroenterology Association conducted an observational, cross-sectional multicenter study. Weight, weight loss, and body mass index were evaluated. Undernutrition was defined as unintentional weight loss > 10% in the last threesix months. Values of Malnutrition Universal Screening Tool(MUST) > 2, NRS-2002 > 3, and Mini Nutritional Assessment(MNA) from 17 to 25 identified risk of malnutrition in outpatients, inpatients and elderly patients, respectively. A body mass index ≥ 30 indicated obesity. Gastrointestinal pathologies were categorized into acute, chronic and neoplastic diseases. RESULTS: A total of 513 patients participated in the study. The prevalence of undernutrition was 4.6% in outpatients and 19.6% in inpatients. Moreover, undernutrition was present in 4.3% of the gastrointestinal patients with chronic disease, 11.0% of those with acute disease, and 17.6% of those with cancer. The risk of malnutrition increased progressively and significantly in chronic, acute and neoplastic gastrointestinal diseases in inpatients and the elderly population. Logistical regression analysis confirmed that cancer was a risk factor for undernutrition(OR = 2.7; 95%CI: 1.2-6.44, P = 0.02). Obesity and overweight were more frequent in outpatients. CONCLUSION: More than 63% of outpatients and 80% of inpatients in gastroenterological centers suffered from significant changes in body composition and required specific nutritional competence and treatment. | Massimiliano Rizzi Silvia Mazzuoli Nunzia Regano Rosa Inguaggiato Margherita Bianco Gioacchino Leandro Elisabetta Bugianesi Donatella Noè Nicoletta Orzes Paolo Pallini Maria Letizia Petroni Gianni Testino Francesco William Guglielmi | 2016 | World Journal of Gastrointestinal Oncology2016，8，7： | 2 |
| 7 | New models of inter - firm networks within industrial districts 显示文摘 | NUNZIA CARBON | 2002 | Entrepreneurship and Regional Development2002，14，3： | 1 |
| 8 | Mitochontrial DNA and RNA isolation from small amounts of potato tissue显示文摘 | Nunzia S Teodoro C Laurence M | 2001 | Plant molecular biology reporter2001，19，： | 1 |
| 9 | Concession period for PPPs: A win win model for a fair risk shar- ing 显示文摘 | Nunzia Carbonara Nicola Costantino Roberta PeUegri- no | 2014 | International Journal of Project Management2014，，： | 1 |
| 10 | Mitochondrial DNA and RNA isolation from small amounts of potato tissue显示文摘 | Nunzia S Teodoro C Laurence M | 2001 | Plant Mol Bio Rep2001，19，： | 1 |
| 11 | Interstitial laser photocoagulation under ultrasound guidance of liver tumors: results in 104 treated patients显示文摘 | Antonio Giorgio Luciano Tarantino Giorgio de Stefano Nunzia Farella Orlando Catalano Bianca Cusati Luca Del Viscovo Alfredo Alaia Eugenio Caturelli | 2000 | European Journal of Ultrasound2000，，3： | 1 |
| 12 | Innovation Processes Within Geographical Clusters:A Cognitive Approach 显示文摘 | Nunzia Carbonara | 2004 | Technovation2004，24，： | 1 |
| 13 | Innovation processes within geographical clus- ters: a cognitive approach显示文摘 | Nunzia Carbonara | 2004 | Technovation2004，24，5： | 1 |
| 14 | Perfusion CT allows prediction of therapy response in non-small cell lung cancer treated with conventional and anti-angiogenic chemotherapy显示文摘 | Nunzia Tacelli Teresa Santangelo Arnaud Scherpereel Alain Duhamel Valérie Deken Ernst Klotz Alexis Cortot Jean-Jacques Lafitte Frédéric Wallyn Jacques Remy Martine Remy-Jardin | 2013 | European Radiology2013，，： | 1 |
| 15 | Innovation process with in geographical clusters: a cognitive approach 显示文摘 | Nunzia Carbonara | 2004 | Technovation ELSEVIER2004，24，： | 1 |
| 16 | A reproducible, rapid and inexpensive FolinCiocalteu micromethod in determining phenolics of plant methanol extracts 显示文摘 | Nunzia Cicco Maria T Lanorte Margherita Paraggio el al | 2009 | Microchemical Journal2009，91，： | 1 |
| 17 | Innovation Processes Within Geographical Clusters: A Cognitive Approach 显示文摘 | Nunzia Carbonara | 2004 | Technovation2004，24，1： | 1 |
| 18 | Emerging role of cyclooxygenase isoforms in the control of gastrointestinal neuromuscular functions显示文摘 | Matteo Fornai Luca Antonioli Rocchina Colucci Nunzia Bernardini Narcisa Ghisu Marco Tuccori Roberto De Giorgio Mario Del Tacca Corrado Blandizzi | 2009 | Pharmacology and Therapeutics2009，，1： | 1 |
| 19 | New models of inter - firm networks within in- dustrial districts显示文摘 | Nunzia C | 1995 | Entrepreneurship and Regional De- velopment1995，14，3： | 1 |
| 20 | Innovation process within geographical clusters: a cognitive approach显示文摘 | | 2004 | Technovation ELSEVIER2004，24，： | 1 |
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