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| 1 | Role of neurotrophic factors in enhancing linear axonal growth of ganglionic sensory neurons in vitro显示文摘Neurotrophins play a major role in the regulation of neuronal growth such as neurite sprouting or regeneration in response to nerve injuries. The role of nerve growth factor, neurotrophin-3, and brain-derived neurotrophic factor in maintaining the survival of peripheral neurons remains poorly understood. In regenerative medicine, different modalities have been investigated for the delivery of growth factors to the injured neurons, in search of a suitable system for clinical applications. This study was to investigate the influence of nerve growth factor, neurotrophin-3 and brain-derived neurotrophic factor on the growth of neurites using two in vitro models of dorsal root ganglia explants and dorsal root ganglia-derived primary cell dissociated cultures. Quantitative data showed that the total neurite length and tortuosity were differently influenced by trophic factors. Nerve growth factor and, indirectly, brain-derived neurotrophic factor stimulate the tortuous growth of sensory fibers and the formation of cell clusters. Neurotrophin-3, however, enhances neurite growth in terms of length and linearity allowing for a more organized and directed axonal elongation towards a peripheral target compared to the other growth factors. These findings could be of considerable importance for any clinical application of neurotrophic factors in peripheral nerve regeneration. Ethical approval was obtained from the Regione Piemonte Animal Ethics Committee ASLTO1(file # 864/2016-PR) on September 14, 2016. | Michele Fornaro Alessia Giovannelli Angelica Foggetti Luisa Muratori Stefano Geuna Giorgia Novajra Isabelle Perroteau | 2020 | Neural Regeneration Research2020，15，9： | 3 |
| 2 | Psychopathological aspects of kidney transplantation: Efficacy of a multidisciplinary team显示文摘Renal transplantation is a well established treatment for end-stage renal disease, allowing most patients to return to a satisfactory quality of life. Studies have identified many problems that may affect adaptation to the transplanted condition and postoperative compliance. The psychological implications of transplantation have important consequences even on strictly physical aspects. Organ transplantation is very challenging for the patient and acts as an intense stressor stimulus to which the patient reacts with neurotransmitter and endocrine-metabolic changes. Transplantation can result in a psychosomatic crisis that requires the patient to mobilize all bio-psychosocial resources during the process of adaptation to the new foreign organ which may result in an alteration in self-representation and identity, with possible psychopathologic repercussions. These reactions are feasible in mental disorders, e.g., post-traumatic stress disorder, adjustment disorder, and psychosomatic disorders. In organ transplantation, the fruitful collaboration between professionals with diverse scientific expertise, calls for both a guarantee for mental health and greater effectiveness in challenging treatments for a viable association between patients, family members and doctors. Integrated and multidisciplinary care should include uniform criteria and procedures for standard assessments, for patient autonomy, adherence to therapy, new coping strategies and the adoption of more appropriate lifestyles. | Concetta De Pasquale Massimiliano Veroux Luisa Indelicato Nunzia Sinagra Alessia Giaquinta Michele Fornaro Pierfrancesco Veroux Maria L Pistorio | 2014 | World Journal of Transplantation2014，4，4： | 3 |
| 3 | Bevacizumab with FOLFOXIRI (irinotecan, oxaliplatin, fluorouracil, and folinate) as first-line treatment for metastatic colorectal cancer: a phase 2 trial显示文摘 | Gianluca Masi Fotios Loupakis Lisa Salvatore Lorenzo Fornaro Chiara Cremolini Samanta Cupini Andrea Ciarlo Francesca Del Monte Enrico Cortesi Domenico Amoroso Cristina Granetto Gabriella Fontanini Elisa Sensi Cristiana Lupi Michele Andreuccetti Alfredo Fa | 2010 | Lancet Oncology2010，，9： | 2 |
| 4 | Obsessive-compulsive disorder and related disorders:a comprehensive survey显示文摘 | Michele Fornaro Filippo Gabrielli Claudio Albano | | 0，，13： | 1 |
| 5 | Obsessive-compulsive disorder and related disorders: a comprehensive survey显示文摘 | Michele Fornaro Filippo Gabrielli Claudio Albano | 2009 | Ann Gen Psychiatry2009，8，13： | 1 |
| 6 | Obsessive compulsive disorder and related disorders : a comprehensive survey 显示文摘 | Michele Fornaro Filippo Gabrieili Claudio Albano | 2009 | Ann Gen Psychiatry2009，8，13： | 1 |
| 7 | Neurogenesis in the adult peripheral nervous system显示文摘Most researchers believe that neurogenesis in mature mammals is restricted only to the subgranular zone of the dentate gyrus and the subventricular zone of the lateral ventricle in the central nervous system. In the peripheral nervous system, neurogenesis is thought to be active only during prenatal development, with the exception of the olfactory neuroepithelium. However, sensory ganglia in the adult peripheral nervous system have been reported to contain precursor cells that can proliferate in vitro and be induced to differentiate into neurons. The occurrence ofinsult-induced neurogenesis, which has been reported by several investigators in the brain, is limited to a few recent reports for the peripheral nervous system. These reports suggest that damage to the adult nervous system induces mechanisms similar to those that control the generation of new neurons during prenatal development. Understanding conditions under which neurogenesis can be induced in physiologically non-neurogenic regions in adults is one of the major challenges for developing therapeutic strategies to repair neurological damage. However, the induced neurogenesis in the peripheral nervous system is still largely unexplored. This review presents the history of research on adult neurogenesis in the peripheral nervous system, which dates back more than 100 years and reveals the evidence on the under estimated potential for generation of new neurons in the adult peripheral nervous system. | Krzysztof Czaja Michele Fornaro Stefano Geuna | 2012 | Neural Regeneration Research2012，7，14： | 1 |
| 8 | Hippocampal plasticity after a vagus nerve injury in the rat显示文摘Stimulation of the vagus nerve has been previously reported to promote neural plasticity and neurogenesis in the brain. Several studies also revealed plastic changes in the spinal cord after injuries to somatosensory nerves originating from both the brachial and lumbo-sacral plexuses. However, the neurogenic responses of the brain to the injury of the viscerosensory innervation are not as yet well understood. In the present study, we investigated whether cells in the dentate gyrus of the hippocampus respond to a chemical and physical damage to the vagus nerve in the adult rat. Intraperitoneal capsaicin administration was used to damage non-myelinated vagal afferents while subdiaphragmatic vagotomy was used to damage both the myelinated and non-myelinated vagal afferents. The 5-bromo-2-deoxyuridine (BrdU) incorporation together with cell-specific markers was used to study neural proliferation in subgranular zone, granule cell layer, molecular layer and hilus of the dentate gyrus. Microglia activation was determined by quantifying changes in the intensity of fluorescent staining with a primary antibody against ionizing calcium adapter-binding molecule 1. Results revealed that vagotomy decreased BrdU incorporation in the hilus 15 days after injury compared to the capsaicin group. Capsaicin administration decreased BrdU incorporation in the granular cell layer 60 days after the treatment. Capsaicin decreased the number of doublecortin-expressing cells in the dentate gyrus, whereas vagotomy did not alter the expression of doublecortin in the hippocampus. Both the capsaicinand the vagotomy-induced damage to the vagus nerve decreased microglia activation in the hippocampus at 15 days after the injury. At 30 days post injury, capsaicin-treated and vagotomized rats revealed significantly more activated microglia. Our findings show that damage to the subdiaphragmatic vagus in adult rats is followed by microglia activation and long-lasting changes in the dentate gyrus, leading to alteration of neurogenesis. | Giulia Ronchi Vitaly Ryu Michele Fornaro Krzysztof Czaja | 2012 | Neural Regeneration Research2012，7，14： | 0 |
| 9 | Effects of chemical and physical cues in enhancing neuritogenesis and peripheral nerve regeneration显示文摘Peripheral nerve injuries are most often a consequence of axonal damage leading to functional losses that may vary from lack of sensitivity distal to the site of injury to complete loss of motor control.The consequences of such injuries are immense because of the high cost of health care,limited ability to work and emotional trauma that follows the injury.The spontaneous regrowth that the peripheral nervous system(PNS) | CaseyD. Sigerson Christopher J. Dipollina Michele Fornaro | 2016 | Neural Regeneration Research2016，11，2： | 0 |
| 10 | Psychological perspective of medication adherence in transplantation显示文摘AIM To identify the risk factors and the post-transplant psychological symptoms that affect adherence to therapy in a population of kidney transplant recipients. METHODS The study examined the psychological variables likely responsible for the non-adherent behavior using a psychological-psychiatric assessment, evaluation of the perception of patients' health status, and an interview regarding the anti-rejection drug therapy assumption. The study included 74 kidney transplant recipients. RESULTS Individuals with a higher level of education and more years since transplantation showed better mental balance. Regarding gender, women appeared to be less adherent to therapy. Further, the years since transplantation adversely affected the proper pharmacological assumption. Adherence to therapy did not significantly change with the mental health index. CONCLUSION The biopsychosocial illness model provides a conceptualframe of reference in which biological, psychological, and social aspects take on the same importance in the adherence to treatment protocols. For effective management, it is necessary to understand the patients' personal experiences, their assumptions about the disease, health status perception, and mood, and to identify any 'barriers' that could cause them to become noncompliant. | Concetta De Pasquale Massimiliano Veroux Michele Fornaro Nunzia Sinagra Giusi Basile Cecilia Gozzo Roberta Santini Alessandra Costa Maria Luisa Pistorio | 2016 | World Journal of Transplantation2016，6，4： | 0 |
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