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| 1 | Perioperative visual loss after spine surgery显示文摘Perioperative visual loss(POVL) is an uncommon, but devastating complication that remains primarily associated with spine and cardiac surgery. The incidence and mechanisms of visual loss after surgery remain difficult to determine. According to the American Society of Anesthesiologists Postoperative Visual Loss Registry, the most common causes of POVL in spine procedures are the two different forms of ischemic optic neuropathy: anterior ischemic optic neuropathy and posterior ischemic optic neuropathy, accounting for 89% of the cases. Retinal ischemia, cortical blindness, and posterior reversible encephalopathy are also observed, but in a small minority of cases. A recent multicenter case control study has identified risk factors associated with ischemic optic neuropathy for patients undergoing prone spinal fusion surgery. These include obesity, male sex, Wilson frame use, longer anesthetic duration, greater estimated blood loss, and decreased percent colloid administration. These risk factors are thought to contribute to the elevation of venous pressure and interstitial edema, resulting in damage to the optic nerve by compression of the vessels that feed the optic nerve, venous infarction or direct mechanical compression. This review will expand on these findings as well as the recently updated American Society of Anesthesiologists practice advisory on POVL. There are no effectivetreatment options for POVL and the diagnosis is often irreversible, so efforts must focus on prevention and risk factor modification. The role of crystalloids versus colloids and the use of α-2 agonists to decrease intraocular pressure during prone spine surgery will also be discussed as a potential preventative strategy. | Travis J Nickels Mariel R Manlapaz Ehab Farag | 2014 | World Journal of Orthopedics2014，5，2： | 7 |
| 2 | Comparison of novel and standard diagnostic tools for the detection of Schistosoma mekongi infection in Lao People’s Democratic Republic and Cambodia显示文摘Background:Given the restricted distribution of Schistosoma mekongi in one province in Lao People’s Democratic Republic(Lao PDR)and two provinces in Cambodia,together with progress of the national control programmes aimed at reducing morbidity and infection prevalence,the elimination of schistosomiasis mekongi seems feasible.However,sensitive diagnostic tools will be required to determine whether elimination has been achieved.We compared several standard and novel diagnostic tools in S.mekongi-endemic areas.Methods:The prevalence and infection intensity of S.mekongi were evaluated in 377 study participants from four villages in the endemic areas in Lao PDR and Cambodia using Kato-Katz stool examination,antibody detection based on an enzyme-linked immunosorbent assay(ELISA)and schistosome circulating antigen detection by lateral-flow tests.Two highly sensitive test systems for the detection of cathodic and anodic circulating antigens(CCA,CAA)in urine and serum were utilized.Results:Stool microscopy revealed an overall prevalence of S.mekongi of 6.4%(one case in Cambodia and 23 cases in Lao PDR),while that of Opisthorchis viverrini,hookworm,Trichuris trichiura,Ascaris lumbricoides and Taenia spp.were 50.4%,28.1%,3.5%,0.3%and 1.9%,respectively.In the urine samples,the tests for CCA and CAA detected S.mekongi infections in 21.0%and 38.7%of the study participants,respectively.In the serum samples,the CAA assay revealed a prevalence of 32.4%,while a combination of the CAA assay in serum and in urine revealed a prevalence of 43.2%.There was a difference between the two study locations with a higher prevalence reached in the samples from Lao PDR.Conclusions:The CCA,CAA and ELISA results showed substantially higher prevalence estimates for S.mekongi compared to Kato-Katz thick smears.Active schistosomiasis mekongi in Lao PDR and Cambodia might thus have been considerably underestimated previously.Hence,sustained control efforts are still needed to break transmission of S.mekongi.The pivotal role of highly sensitive diagnostic assays in areas targeting elimination cannot be overemphasised. | Youthanavanh Vonghachack Somphou Sayasone Virak Khieu Robert Bergquist Govert Jvan Dam Pytsje THoekstra Paul L.A.M.Corstjens Beatrice Nickel Hanspeter Marti Jürg Utzinger Sinuon Muth Peter Odermatt | 2017 | Infectious Diseases of Poverty2017，6，1： | 4 |
| 3 | Leukocyte and Bacterial Counts Do Not Correlate With Severity of Symptoms in Men With Chronic Prostatitis: The National Institutes of Health Chronic Prostatitis Cohort Study显示文摘 | Anthony J. Schaeffer Jill S. Knauss J. Richard Landis Kathleen J. Propert Richard B. Alexander Mark S. Litwin J. Curtis Nickel Michael P. O’leary Robert B. Nadler Michel A. Pontari Daniel A. Shoskes Scott I. Zeitlin Jackson E. Fowler Carissa A. Mazurick J | 2002 | The Journal of Urology2002，，3： | 2 |
| 4 | A new signal adaptive approach to positive time- frequency distributions with suppressed interference terrns显示文摘 | Nickel R M Sang T H Williams W J | 1998 | ICASSP1998，，： | 1 |
| 5 | Antibiotic pharmacokinetics in the inflamed prostate显示文摘 | Nickel JC Downey J Clark J | 1995 | J Uro11995，153，5： | 1 |
| 6 | Reduction of liver Fas expression by an antisense oligonucleotide protects mice from fulminant hepatitis 显示文摘 | Zhang H Cook J Nickel J | 2000 | Nat Biotechnol2000，18，8： | 1 |
| 7 | Effective ofice management of chronic prostatitis 显示文摘 | Nickel J C | 1998 | Urol clin North Am1998，25，： | 1 |
| 8 | Stress field translation in the healthy human temporomandibular joint 显示文摘 | Gallo L M Nickel J C Iwasaki L R | 2000 | J Dent Res2000，79，10： | 1 |
| 9 | A randomized placebo- controlled multicentre study to evaluate the safety and efficacy of fi- nastefide for male chronic pelvic pain syndrome (category 111 A chronic nonbacterial prostatitis) 显示文摘 | Nickel JC Downey J Pontari MA | 2004 | BJU Int2004，93，7： | 1 |
| 10 | Determinationof the sedimentary microbial biomass by extractible lipidphosphate显示文摘 | White D C Davis W M Nickels J S | 1979 | Oecologia1979，40，1： | 1 |
| 11 | Prevalence of prostatitis like symptoms in a population based study using the National Institutes of Health Chronic Prostatitis Symptom Index 显示文摘 | Nickel JC Downey J Hunter D | 2001 | J Urol2001，165，： | 1 |
| 12 | Immunotherapy of an experimental adenocarcinoma of the prostate 显示文摘 | Morales A Nickel JC Downey J | 1995 | J Urol1995，153，5： | 1 |
| 13 | Thyroid gland:US screening in a random adult population显示文摘 | Brander A Viikinkoski P Nickels J | | 0，，03： | 1 |
| 14 | Randomized, doub- le - blind, dose - ranging study of pentosan polysulfate sodium for interstitial cystitis 显示文摘 | Nickel J C Barkin J Forrest J | 2005 | Urology2005，65，4： | 1 |
| 15 | Determination of barrier oxidation states in spin dependent tunneling structures 显示文摘 | Wang S X Nickel J H | 1999 | J Appl Phys1999，85，11： | 1 |
| 16 | The coat-mix procedure using carbon fillers 显示文摘 | LUHLEICH H DIAS F J NICKEL H | 1997 | Carbon1997，35，： | 1 |
| 17 | Prevalence of prostatitis-like symptoms in a population based study using the National Institutes of Health chronic prostatitis symptom index显示文摘 | Nickel J C Downey J Hunter D | 2001 | J Urol2001，165，3： | 1 |
| 18 | Predictors of quality of lifeand pain in chronic prostatitis/chronic pelvic pain syndrome : findingsfrom the National Institutes of Health Chronic Prostatitis Cohort Study显示文摘 | Tripp DA Curtis Nickel J Landis JR | 2004 | BJU International2004，94，： | 1 |
| 19 | D ifferential regulation of cardiac ANP and BNP mRNA in different stages of experin ental heart failure显示文摘 | Lange nickel T Page J Hohnel K Dietz R | 2000 | Am J Physiol Heart Cire Physiol2000，278，5： | 1 |
| 20 | Competition and Corporate Performance显示文摘 | Stephen J Nickell | 2011 | Journal of Political Economy2011，104，4： | 1 |
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