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| 1 | prevalence of colorectal neoplasms in young, average risk individuals: A turning tide between East and West显示文摘AIM To determine the prevalence of colorectal neoplasia in average risk persons 40-59 years of age in Israel and to compare the results with other populations. METHODS We reviewed the results of asymptomatic average-risk subjects, aged 40 to 59 years, undergoing their first screening colonoscopy between April 1994 and January 2014. The detection rates of adenoma, advanced adenoma(AA) and colorectal cancer(CRC) were determined in the 40's and 50's age groups by gender. The prevalence of lesions was compared between age groups. After meticulous review of the literature, these results were compared to published studies addressing the prevalence of colorectal neoplasia in similar patient groups, in a variety of geographical locations.RESULTS We included first screening colonoscopy results of 1750 individuals. The prevalence of adenomas, AA and CRC was 8.3%, 1.0% and 0.2% in the 40-49 age group and 13.7%, 2.4% and 0.2% in the 50-59 age group, respectively. Age-dependent differences in adenoma and AA rates were significant only among men(p < 0.005). Literature review disclosed 17 relevant studies. As expected, in both Asian and Western populations, the risks for overall adenoma and advanced adenoma was significantly higher in the 50's age group as compared to the 40's age group in a similar fashion. The result of the current study were similar to previous studies on Western populations. A substantially higher rate of adenoma, was observed in studies conducted among Asian populations in both age groups.CONCLUSION The higher rate of colorectal neoplasia in Asian populations requires further investigation and reconsideration as to the starting age of screening in that population. | Ari Leshno Menachem Moshkowitz Maayan David Lior Galazan Alfred I Neugut Nadir Arber Erwin Santo | 2016 | World Journal of Gastroenterology2016，22，32： | 1 |
| 2 | Inflammation and colorectal cancer显示文摘 | Sarah Kraus Nadir Arber | 2009 | Current Opinion in Pharmacology2009，，4： | 1 |
| 3 | Overexpression of cyclin D1 occurs in both squamous carcinomas and adenocarcinomas of the esophagus and in adenocarcinomas of the stomach显示文摘 | Nadir Arber Marilie D Gammon Hanina Hibshoosh Julie A Britton Yen Zhang Janet B Schonberg Heidrun Roterdam Ina Fabian Peter R Holt I.Bernard Weinstein | 1999 | Human Pathology1999，，： | 1 |
| 4 | Inflammation and colorectal cancer显示文摘 | Sarah Kraus Nadir Arber | 2009 | Current Opinion in Pharmacology2009，，4： | 1 |
| 5 | Celecoxib leads to G 2 /M arrest by induction of p 21 and down-regulation of cyclin B1 expression in a p 53-independent manner显示文摘 | Hadas Dvory-Sobol Efrat Cohen-Noyman Diana Kazanov Arie Figer Shlomo Birkenfeld Liora Madar-Shapiro Robert Benamouzig Nadir Arber | 2005 | European Journal of Cancer2005，，3： | 1 |
| 6 | Do aspirin and other NSAIDs protect against colorectal cancer? 显示文摘 | Sarah Kraus Nadir Arber | 2011 | Nat Rev Gastro- enterol Hepatol2011，8，： | 1 |
| 7 | Inflammation and colorectal cancer显示文摘 | Sarah Kraus Nadir Arber | 2009 | Current Opinion in Pharmacology2009，，4： | 1 |
| 8 | Appendectomy is more frequent but not a risk factor in Crohn’s disease while being protective in ulcerative colitis: a comparison of surgical procedures in inflammatory bowel disease显示文摘 | Shimon Reif Alexandra Lavy Daniel Keter Efrat Broide Yaron Niv Aharon Halak Yishai Ron Rami Eliakim Shmuel Odes Julian Patz Alexander Fich Yael Villa Nadir Arber Tuvia Gilat | 2001 | The American Journal of Gastroenterology2001，，3： | 1 |
| 9 | Incidence of colorectal neoplasms among male pilots显示文摘AIM: To assess the prevalence of colorectal neoplasms(adenomas, advanced adenomas and colorectal cancers) among Israeli military and commercial airline pilots.METHODS: Initial screening colonoscopy was performed on average-risk(no symptoms and no family history) airline pilots at the Integrated Cancer Prevention Center(ICPC) in the Tel-Aviv Medical Center. Visualized polyps were excised and sent for pathological examination. Advanced adenoma was defined as a lesion >10 mm in diameter, with high-grade dysplasia or villous histology. The results were compared with those of an age- and gender-matched random sample of healthy adults undergoing routine screening at the ICPC.RESULTS: There were 270 pilots(mean age 55.2 ± 7.4 years) and 1150 controls(mean age 55.7 ± 7.8 years). The prevalence of colorectal neoplasms was 15.9% among the pilots and 20.6% among the controls(P = 0.097, χ2 test). There were significantly more hyperplastic polyps among pilots(15.5% vs 9.4%, P = 0.004) and a trend towards fewer adenomas(14.8% vs 20.3% P = 0.06). The prevalence of advanced lesions among pilots and control groups was 5.9% and 4.7%, respectively(P = 0.49), and the prevalence of cancer was 0.7% and 0.69%, respectively(P = 0.93).CONCLUSION: There tends to be a lower colorectal adenoma, advanced adenoma and cancer prevalence but a higher hyperplastic polyp prevalence among pilots than the general population. | Menachem Moshkowitz Ohad Toledano Lior Galazan Aharon Hallak Nadir Arber Erwin Santo | 2014 | World Journal of Gastroenterology2014，20，27： | 0 |
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