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| 1 | Folfirinox in elderly patients with pancreatic or colorectal cancer-tolerance and efficacy显示文摘AIM To study the tolerance and the efficiency of FOLFIRINOX in elderly patients diagnosed with colorectal or pancreatic cancer.METHODS This retrospective study included elderly patients aged over 70 years of age treated at Georges-Francois Leclerc Center by FOLFIRINOX for histological proved colorectal or pancreatic cancer between January 2009 and January 2015. Chemotheapy regimen consisted of oxaliplatin(85 mg/m2 in over 120 min) followed by leucovorin(400 mg/m2 in over 120 min), with the addition, after 30 min of irinotecan(180 mg/m2 in over 90 min) then 5 fluorouracil(5FU)(400 mg/m2 administred intravenous bolus), followed by 5FU(2400 mg/m2 intraveinous infusion over 46 h) repeated every 2 wk. Geriatric parameters were recorded at the beginning. Toxicities were evaluated with the Common Terminology Criteria for Adverse Events 4.03. Tumor response was evaluated by CT scan. Treatment continued until disease progression, unacceptable toxicities or patient refusal.RESULTS Fifty-two patients aged from 70 to 87 years were treated by FOLFIRINOX, 34 had colorectal cancer and 18 had pancreatic cancer. Most of them were in good general condition, 82.7% had a 0-1 performance status and 61.5% had a Charlson Comorbidity Index < 10. The most frequent severe toxicities were neutropenia(17 patients, n = 32.7%) and diarrhea(35 patients n = 67.3%); 10 of the case of neutropenia and 5 of diarrhea registered a grade 4 toxicity. Thirty-nine patients(75%) initially received an adapted dose of chemotherapy. The dosage was adjusted for 26% of patients during the course of treatment. Tumor response evaluated by RECIST criteria showed a controlled disease for 25 patients(48.1%), a stable disease for 13 and a partial response for 12 patients. Time under treatment was higher for colorectal cancer with a median time of 2.44 mo(95%CI: 1.61-3.25). Overall survival was 43.88 mo for colorectal cancer and 12.51 mo for pancreatic cancer. In univariate or multivariate analysis, none of geriatric parameters were linked to overall survival. Only the type of tumor(pancreatic/colorectal) was linked in both analysis.CONCLUSION For people over 70 years old, FOLFIRINOX regimen seems to induce manageable toxicities but similar, even higher, median survival rates compared to younger people. | Jean-Florian Guion-Dusserre Aurélie Bertaut Fran?ois Ghiringhelli Julie Vincent Valérie Quipourt Sophie Marilier Zoé Tharin Leila Bengrine-Lefevre | 2016 | World Journal of Gastroenterology2016，22，42： | 2 |
| 2 | A Functional Polymorphism of Toll-Like Receptor 4 Gene Increases Risk of Gastric Carcinoma and Its Precursors显示文摘 | Georgina L. Hold Charles S. Rabkin Wong–Ho Chow Malcolm G. Smith Marilie D. Gammon Harvey A. Risch Thomas L. Vaughan Kenneth E.L. McColl Jolanta Lissowska Witold Zatonski Janet B. Schoenberg William J. Blot N. Ashley G. Mowat Joseph F. Fraumeni Emad M. El | 2007 | Gastroenterology2007，，3： | 2 |
| 3 | Overexpression of cyclin D1 occurs in both squamous carcinomas and adenocarcinomas of the esophagus and in adenocarcinomas of the stomach 显示文摘 | Nadir A Marilie DG Hanma H | 1999 | Hum Pathol1999，30，9： | 1 |
| 4 | Octreotide,a somatostatin analogue,mediates its antiproliferative action in pituitary tumor cells by altering phosphatidylinositol 3-kinase signaling and inducing Zac1 expression显示文摘 | Marily T Zhang J Laupheimer S | 2006 | Cancer Res2006，66，： | 1 |
| 5 | Environmental tobacco smoke and breast cancer incidence 显示文摘 | Marilie D Gammon Sybil M Eng | 2004 | Environment d Research2004，96，： | 1 |
| 6 | Likelihood of spontaneous conversion of atrial fibrillation to sinus rhythm显示文摘 | Peter GD Todd AC Marily JW | 1998 | JACC1998，31，5： | 1 |
| 7 | Transcriptome analysis of MENX-associated rat pituitary adenomas identifies novel molecular mechanisms involved in the pathogenesis of human pituitary gonadotroph adenomas显示文摘 | Misu Lee Ilaria Marinoni Martin Irmler Tsambika Psaras Jürgen B. Honegger Rudi Beschorner Natasa Anastasov Johannes Beckers Marily Theodoropoulou Federico Roncaroli Natalia S. Pellegata | 2013 | Acta Neuropathologica2013，，1： | 1 |
| 8 | Overexpression of cyclin D1 oceures in both squamous carcinomas and adeno careiomas of the esophagus and in adenoearlnomasof the stomach 显示文摘 | Arber N Marilie Cammon | 1999 | Human Pathology1999，60，9： | 1 |
| 9 | Procedure for determining maximum sustainable power generated by microbial fuel cells 显示文摘 | Menicucci J Beyenal H Marili E | 2006 | Environmental Science Technology2006，40，3： | 1 |
| 10 | IGFl CA repeat polymorphisms,lifestyle factors and breast cancer risk in the Long Island Breast Cancer Study Project显示文摘 | Rebecca J Clevelandl Marilie D Gammonl Sharon N Edmiston | 2006 | Carcinogenesis2006，27，4： | 1 |
| 11 | Polymorphisms in Nucleotide Excision Repair Genes, Polycyelie Aromatic Hydrocarbon- DNA Adduets, and Breast Cancer Risk 显示文摘 | Katherine D Crew Marilie D | 2007 | Cancer Epidemiol Biomarkers Prey2007，16，10： | 1 |
| 12 | Likelihood of Spontaneous Conversion of Atrial Fibrillation to Sinus Rhythm 显示文摘 | Peter GD Todd AC Marily JW | 1998 | JACC1998，31，： | 1 |
| 13 | Principal Component Analysis of Dietary and Lifestyle Patterns in Relation to Risk of Subtypes of Esophageal and Gastric Cancer显示文摘 | Stephanie A. Navarro Silvera Susan T. Mayne Harvey A. Risch Marilie D. Gammon Thomas Vaughan Wong-Ho Chow Joel A. Dubin Robert Dubrow Janet Schoenberg Janet L. Stanford A. Brian West Heidrun Rotterdam William J. Blot | 2011 | Annals of Epidemiology2011，，7： | 1 |
| 14 | Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms显示文摘 | Emad M El-Omar Charles S Rabkin Marilie D Gammon Thomas L Vaughan Harvey A Risch Janet B Schoenberg Janet L Stanford Susan T Mayne James Goedert William J Blot Joseph F Fraumeni Wong-ho Chow | 2003 | Gastroenterology2003，，5： | 1 |
| 15 | Likelihood of spontaneous conversion of atrial fibrillation to sinus rhythm显示文摘 | Peter GD Todd AC Marily JW | 1998 | JACC1998，31，： | 1 |
| 16 | Phylogenetic and functional diversity of metagenomic libraries of phenol degrading sludge from petroleum refinery wastewater treatment system显示文摘 | Cynthia Silva Helen Hayden Tim Sawbridge Pauline Mele Ricardo Kruger Marili Rodrigues Gustavo Costa Ramon Vidal Maíra Sousa Ana Torres Vania Santiago Valéria Oliveira | 2012 | AMB Express2012，，1： | 1 |
| 17 | Bone Morphogenetic Protein-4 Inhibits Corticotroph Tumor Cells:Involvement in the Retinoic Acid Inhibitory Action显示文摘 | Damiana Giacomini Marcelo Paez-Pereda Marily Theodoropoulou | 2006 | Endocrinology2006，147，1： | 1 |
| 18 | 查看详情显示文摘 | Yong Marily A Schorr P | | 0，，： | 1 |
| 19 | Overexpression of cyclin D1 occurs in both squamous carcinomas and adenocarcinomas of the esophagus and in adenocarcinomas of the stomach显示文摘 | Nadir Arber Marilie D Gammon Hanina Hibshoosh Julie A Britton Yen Zhang Janet B Schonberg Heidrun Roterdam Ina Fabian Peter R Holt I.Bernard Weinstein | 1999 | Human Pathology1999，，： | 1 |
| 20 | overexpression of cyclinD1 occurs in both squamous carcinomas and adenocarcinomas of the esophagus and in adenocarcinomas of the stomach显示文摘 | Arber N Marilie Gammon | 1999 | Humanpathology1999，30，9： | 1 |
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