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| 1 | Effectiveness of probiotic therapy for the prevention of relapse in patients with inactive ulcerative colitis显示文摘AIM: to evaluate the effectiveness of probiotic therapy for suppressing relapse in patients with inactive ulcerative colitis(UC).METHODS: Bio-Three tablets, each containing 2 mg of lactomin(Streptococcus faecalis T-110), 10 mg of Clostridium butyricum TO-A, and 10 mg of Bacillus mesentericus TO-A, were used as probiotic therapy.Sixty outpatients with UC in remission were randomly assigned to receive 9 Bio-Three tablets/day(BioThree group) or 9 placebo tablets/day(placebo group)for 12 mo in addition to their ongoing medications.Clinical symptoms were evaluated monthly or on the exacerbation of symptoms or need for additional medication. Fecal samples were collected to analyze bacterial DNA at baseline and 3-mo intervals. Terminal restriction fragment length polymorphism and cluster analyses were done to examine bacterial components of the fecal microflora.RESULTS: Forty-six patients, 23 in each group,completed the study, and 14 were excluded. The relapse rates in the Bio-Three and placebo groups were respectively 0.0% vs 17.4% at 3 mo(P = 0.036), 8.7%vs 26.1% at 6 mo(P = 0.119), and 21.7% vs 34.8%(P = 0.326) at 9 mo. At 12 mo, the remission rate was 69.5% in the Bio-Three group and 56.6% in the placebo group(P = 0.248). On cluster analysis of fecal flora, 7 patients belonged to cluster Ⅰ, 32 to cluster Ⅱ,and 7 to cluster Ⅲ.CONCLUSION: Probiotics may be effective formaintaining clinical remission in patients with quiescent UC, especially those who belong to cluster Ⅰ on fecal bacterial analysis. | Yasushi Yoshimatsu Akihiro Yamada Ryuichi Furukawa Koji Sono Aisaku Osamura Kentaro Nakamura Hiroshi Aoki Yukiko Tsuda Nobuo Hosoe Nobuo Takada Yasuo Suzuki | 2015 | World Journal of Gastroenterology2015，21，19： | 21 |
| 2 | S-1 in the treatment of pancreatic cancer显示文摘S-1 is an oral 5-fluorouracil(5-FU) prodrug,which is designed to improve the antitumor activity of 5-FU by inhibiting dihydropyrimidine dehydrogenase,the key enzyme of 5-FU catabolism.Recently,two important studies on the clinical use of S-1 for pancreatic cancer have been reported from Japan.In the first study(GEST study),S-1 demonstrated non-inferiority to gemcitabine(GEM) in overall survival(OS) for metastatic or locally advanced pancreatic cancer,but combination chemotherapy with GEM and S-1 did not show superiority to GEM in OS.In the second study(JASPAC-01 study),S-1 showed superiority to adjuvant chemotherapy with GEM in OS in patients with resected pancreatic cancer.In addition to GEM,S-1 is now regarded as the key drug in the management of pancreatic cancer in Japan.To date,many studies have investigated the effectiveness of S-1 in various settings,such as first-line chemotherapy for metastatic or locally advanced pancreatic cancer,second-line chemotherapy after GEM failure,and chemoradiotherapy for locally advanced disease.In this review,we focus on recent clinical trials of S-1-based chemotherapy for advanced pancreatic cancer. | Kentaro Sudo Kazuyoshi Nakamura Taketo Yamaguchi | 2014 | World Journal of Gastroenterology2014，20，41： | 9 |
| 3 | Distributed polymer optical fiber sensors:a review and outlook显示文摘Aging degradation and seismic damage of civil infrastructures have become a serious issue for society,and one promising technology for monitoring their conditions is optical fiber sensing.Glass optical fibers have been predominantly used for the past several decades to develop fiber sensors,but currently polymer or plastic optical fibers(POFs)have also been used extensively to develop advanced fiber sensors because of their unique features,such as high flexibility,large breakage strain,and impact resistance.This review focuses on recently developed distributed and quasi-distributed POF-based sensing techniques based on Rayleigh scattering,Brillouin scattering,and fiber Bragg gratings. | YOSUKE MIZUNO ANTREAS THEODOSIOU KYRIACOS KALLI SASCHA LIEHR HEEYOUNG LEE KENTARO NAKAMURA | 2021 | Photonics Research2021，9，9： | 4 |
| 4 | A high power ultrasonic linear motor using a longitudinal and bending hybrid bolt-clamped langevin type transducer显示文摘 | YUN C H ISHII Takaaki NAKAMURA Kentaro | 2001 | Jpn J Appl Phys2001，40，： | 2 |
| 5 | Phase II Study of Oral S-1 and Concurrent Radiotherapy in Patients With Unresectable Locally Advanced Pancreatic Cancer显示文摘 | Kentaro Sudo Taketo Yamaguchi Takeshi Ishihara Kazuyoshi Nakamura Taro Hara Tadamichi Denda Katsunobu Tawada Toshiyuki Imagumbai Hitoshi Araki Mitsuhiro Sakai Kazuo Hatano Hiroyuki Kawakami Takashi Uno Hisao Ito Osamu Yokosuka | 2011 | International Journal of Radiation Oncology Biology Physics2011，，1： | 2 |
| 6 | Common parameters of acupuncture for the treatment of hypertension used in animal models显示文摘Hypertension is associated with at least 7.6 million annual deaths worldwide.While pharmacotherapy may provide good control for blood pressure,it sometimes induces adverse effects.Meanwhile,acupuncture has been used for the treatment of cardiovascular diseases,such as hypertension,coronary artery disease,and stroke,but its mechanisms of actions remain poorly understood.The efficacy of acupuncture depends on multiple constituent elements including acupoints,manipulation skills,and implementation programs,which are termed as acupuncture prescription.This review summarized the previous information of experimental use of acupuncture on animals including species,hypertension models,acupoints selection,acupoint location,stimulation protocols,and evaluation of effectiveness to provide useful guidance for researchers when performing acupuncture in animal experiments. | Lu Shengfeng Cao Xin Hiroshi Ohara Yuji Nakamura Hiroko Izumi-Nakaseko Kentaro Ando Liu Wanxin Atsushi Sugiyama Zhu Bingmei | 2015 | Journal of Traditional Chinese Medicine2015，35，3： | 2 |
| 7 | Randomized controlled study of gemcitabine plus S-1 combination chemotherapy versus gemcitabine for unresectable pancreatic cancer显示文摘 | Kentaro Sudo Takeshi Ishihara Nobuto Hirata Fumiaki Ozawa Tadashi Ohshima Ryosaku Azemoto Kenji Shimura Takeshi Nihei Takayoshi Nishino Akihiko Nakagawa Kazuyoshi Nakamura Taro Hara Motohisa Tada Rintaro Mikata Katsunobu Tawada Osamu Yokosuka So Nakaji Ta | 2014 | Cancer Chemotherapy and Pharmacology2014，，2： | 2 |
| 8 | An estimation of load characteristics of an ultrasonic motor by measuring transient responses 显示文摘 | Kentaro Nakamura Minoru Kurosawa Hisayuki Kurebayashi | 1991 | IEEE Transactions on UFFC1991，38，5： | 1 |
| 9 | A non-contact linear bearing and actuator via ultrasonic levitation显示文摘 | Takeshi Idl James Friend Kentaro Nakamura | 2007 | Sensors and Actuators A2007，，135： | 1 |
| 10 | Preoperative Histological Subtype Classification of Intraductal Papillary Mucinous Neoplasms (IPMN) by Pancreatic Juice Cytology With MUC Stain显示文摘 | Taro Hara Dai Ikebe Akiko Odaka Kentaro Sudo Kazuyoshi Nakamura Hiroshi Yamamoto Makiko Itami Tetsushi Hirata Junya Kashimura Taketo Yamaguchi | 2013 | Annals of Surgery2013，，6： | 1 |
| 11 | Analysis of the prognostic factors and evaluation of surgical treatment for synchronous liver metastases from gastric cancer显示文摘 | Kentaro Ueda Makoto Iwahashi Mikihito Nakamori Masaki Nakamura Teiji Naka Koichiro Ishida Toshiyasu Ojima Hiroki Yamaue | 2009 | Langenbeck’s Archives of Surgery2009，，4： | 1 |
| 12 | Cytotoxic human peripheral blood-derived γδT cells kill glioblastoma cell lines: implications for cell-based immunotherapy for patients with glioblastoma显示文摘 | Tsutomu Nakazawa Mitsutoshi Nakamura Young Soo Park Yasushi Motoyama Yasuo Hironaka Fumihiko Nishimura Ichiro Nakagawa Shuichi Yamada Ryosuke Matsuda Kentaro Tamura Tadashi Sugimoto Yasuhiro Takeshima Akiko Marutani Takahiro Tsujimura Noriko Ouji Yukiteru | 2014 | Journal of Neuro-Oncology2014，，1： | 1 |
| 13 | Development of a hand-held sensor probe for detection of sound components radiated from a specific device using surface intensity measurements显示文摘 | Yoshihiro Hirao Kohei Yamamoto a Kentaro Nakamura | 2004 | Applied Acoustics2004，65，7： | 1 |
| 14 | Compact, high- speed variable-focus liquid lens using acoustic radiation force显示文摘 | Daisuke Koyama Ryoiehi Isago Kentaro Nakamura | 2010 | Optics Express2010，18，25： | 1 |
| 15 | Stabilization of milk protein dispersion by soybean soluble polysaccharide under acidic pH conditions显示文摘 | Tatsunori Nobuhara Kentaro Matsumiya Yuko Nambu Akihiro Nakamura Nanae Fujii Yasuki Matsumura | 2013 | Food Hydrocolloids2013，，： | 1 |
| 16 | Deep-sea mud in the pacific ocean as a potential resource for rareearth elements显示文摘 | Yasuhiro Kato Koichiro Fujinaga Kentaro Nakamura | | 0，，： | 1 |
| 17 | Myelosuppression induced by concurrent chemoradiotherapy as a prognosticfactor for patients with locally advanced non-small cell lung cancer显示文摘 | Yukiko Kishida Takashi Hirose Takao Shirai Tomohide Sugiyama Soujiro Kusumoto Toshimitsu Yamaoka Kentaro Okuda Mitsuru Adachi Akihiro Nakamura | 2011 | Oncology Letters2011，，5： | 1 |
| 18 | Spinal Kyphosis Causes Demyelination and Neuronal Loss in the Spinal Cord:A New Model of Kyphotic Deformity Using Juvenile Japanese Small Game Fowls显示文摘 | Shimizu Kentaro Nakamura | 2005 | Spine2005，30，21： | 1 |
| 19 | A Piezoelectric Micromotor Using In-Plane Sheafing of PZT Elements 显示文摘 | James Friend Kentaro Nakamura Sadayuki Ueha | 2004 | IEEE Transactions on Mechatronies2004，9，3： | 1 |
| 20 | Expression profiling of starch metabolism-related plastidic translocator genes in rice显示文摘 | Kentaro Toyota Masahiro Tamura Takashi Ohdan Yasunori Nakamura | 2006 | Planta2006，，2： | 1 |
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