| 1 | A novel long-term intravenous combined with local treatment with human amnion-derived mesenchymal stem cells for a multidisciplinary rescued uremic calciphylaxis patient and the underlying mechanism显示文摘Calciphylaxis is a rare disease characterized histologically by microvessel calcification and microthrombosis,with high mortality and no proven therapy.Here,we reported a severe uremic calciphylaxis patient with progressive skin ischemia,large areas of painful malodorous ulcers,and mummified legs.Because of the worsening symptoms and signs refractory to conventional therapies,treatment with human amnion-derived mesenchymal stem cells(hAMSCs)was approved.Preclinical release inspections of hAMSCs,efficacy,and safety assessment,including cytokine secretory ability,immunocompetence,tumorigenicity,and genetics analysis in vitro,were introduced.We further performed acute and long-term hAMSC toxicity evaluations in C57BL/6 mice and rats,abnormal immune response tests in C57BL/6 mice,and tumorigenicity tests in neonatal Balbc-nu nude mice.After the preclinical research,the patient was treated with hAMSCs by intravenous and local intramuscular injection and external supernatant application to the ulcers.When followed up to 15 months,the blood-based markers of bone and mineral metabolism improved,with skin soft tissue regeneration and a more favorable profile of peripheral blood mononuclear cells.Skin biopsy after 1-month treatment showed vascular regeneration with mature noncalcified vessels within the dermis,and 20 months later,the re-epithelialization restored the integrity of the damaged site.No infusion or local treatment-related adverse events occurred.Thus,this novel long-term intravenous combined with local treatment with hAMSCs warrants further investigation as a potential regenerative treatment for uremic calciphylaxis due to effects of inhibiting vascular calcification,stimulating angiogenesis and myogenesis,anti-inflammatory and immune modulation,multidifferentiation,re-epithelialization,and restoration of integrity. | Lianju Qin Jing Zhang Yujie Xiao Kang Liu Yugui Cui Fangyan Xu Wenkai Ren Yanggang Yuan Chunyan Jiang Song Ning Xiaoxue Ye Ming Zeng Hanyang Qian Anning Bian Fan Li Guang Yang Shaowen Tang Zhihong Zhang Juncheng Dai Jing Guo Qiang Wang Bin Sun Yifei Ge Chun Ouyang Xueqiang Xu Jing Wang Yaoyu Huang Hongqing Cui Jing Zhou Meilian Wang Zhonglan Su Yan Lu Di Wu Jingping Shi Wei Liu Li Dong Yinbing Pan Baiqiao Zhao Ying Cui Xueyan Gao Zhanhui Gao Xiang Ma Aiqin Chen Jie Wang Meng Cao Qian Cui Li Chen Feng Chen Youjia Yu Qiang Ji Zhiwei Zhang Mufeng Gu Xiaojun Zhuang Xiaolin Lv Hui Wang Yanyan Pan Ling Wang Xianrong Xu Jing Zhao Xiuqin Wang Cuiping Liu Ningxia Liang Changying Xing Jiayin Liu Ningning Wang | 2022 | Journal of Molecular Cell Biology2022，14，2： | 1 |
| 2 | An Electromagnetic Perspective of Artificial Intelligence Neuromorphic Chips显示文摘The emergence of artificial intelligence has represented great potential in solving a wide range of complex problems.However,traditional general-purpose chips based on von Neumann architectures face the“memory wall”problem when applied in artificial intelligence applications.Based on the efficiency of the human brain,many intelligent neuromorphic chips have been proposed to emulate its working mechanism and neuron-synapse structure.With the emergence of spiking-based neuromorphic chips,the computation and energy efficiency of such devices could be enhanced by integrating a variety of features inspired by the biological brain.Aligning with the rapid development of neuromorphic chips,it is of great importance to quickly initiate the investigation of the electromagnetic interference and signal integrity issues related to neuromorphic chips for both CMOS-based and memristor-based artificial intelligence integrated circuits.Here,this paper provides a review of neuromorphic circuit design and algorithms in terms of electromagnetic issues and opportunities with a focus on signal integrity issues,modeling,and optimization.Moreover,the heterogeneous structures of neuromorphic circuits and other circuits,such as memory arrays and sensors using different integration technologies,are also reviewed,and locations where signal integrity might be compromised are discussed.Finally,we provide future trends in electromagnetic interference and signal integrity and outline prospects for upcoming neuromorphic devices. | Er-Ping Li Hanzhi Ma Manareldeen Ahmed Tuomin Tao Zheming Gu Mufeng Chen Quankun Chen Da Li Wenchao Chen | 2023 | Electromagnetic Science2023，1，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员