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| 1 | Inflammation in irritable bowel syndrome:Myth or newtreatment target?显示文摘Low-grade intestinal inflammation plays a key role in the pathophysiology of irritable bowel syndrome(IBS), and this role is likely to be multifactorial. The aim of this review was to summarize the evidence on the spectrum of mucosal inflammation in IBS, highlighting the relationship of this inflammation to the pathophysiology of IBS and its connection to clinical practice. We carried out a bibliographic search in Medline and the Cochrane Library for the period of January 1966 to December 2014, focusing on publications describing an interaction between inflammation and IBS. Several evidences demonstrate microscopic and molecular abnormalities in IBS patients. Understanding the mechanisms underlying low-grade inflammation in IBS may help to design clinical trials to test the efficacy and safety of drugs that target this pathophysiologic mechanism. | Emanuele Sinagra Giancarlo Pompei Giovanni Tomasello Francesco Cappello Gaetano Cristian Morreale Georgios Amvrosiadis Francesca Rossi Attilio Ignazio Lo Monte Aroldo Gabriele Rizzo Dario Raimondo | 2016 | World Journal of Gastroenterology2016，22，7： | 16 |
| 2 | New therapeutic perspectives in irritable bowel syndrome: Targeting low-grade inflammation, immuno-neuroendocrine axis, motility, secretion and beyond显示文摘Irritable bowel syndrome(IBS)is a chronic,recurring,and remitting functional disorder of the gastrointestinal tract characterized by abdominal pain,distention,and changes in bowel habits.Although there are several drugs for IBS,effective and approved treatments for one or more of the symptoms for various IBS subtypes are needed.Improved understanding of pathophysiological mechanisms such as the role of impaired bile acid metabolism,neurohormonal regulation,immune dysfunction,the epithelial barrier and the secretory properties of the gut has led to advancements in the treatment of IBS.With regards to therapies for restoring intestinal permeability,multiple studies with prebiotics and probiotics are ongoing,even if to date their efficacy has been limited.In parallel,much progress has been made in targeting low-grade inflammation,especially through the introduction of drugs such as mesalazine and rifaximin,even if a better knowledge of the mechanisms underlying the low-grade inflammation in IBS may allow the design of clinical trials that test the efficacy and safety of such drugs.This literature review aims to summarize the findings related to new and investigational therapeutic agents for IBS,most recently developed in preclinical as well as Phase 1 and Phase 2clinical studies. | Emanuele Sinagra Gaetano Cristian Morreale Ghazaleh Mohammadian Giorgio Fusco Valentina Guarnotta Giovanni Tomasello Francesco Cappello Francesca Rossi Georgios Amvrosiadis Dario Raimondo | 2017 | World Journal of Gastroenterology2017，23，36： | 14 |
| 3 | Microbiota-gut-brain axis and its affect inflammatory bowel disease:Pathophysiological concepts and insights for clinicians显示文摘Despite the bi-directional interaction between gut microbiota and the brain not being fully understood,there is increasing evidence arising from animal and human studies that show how this intricate relationship may facilitate inflammatory bowel disease(IBD)pathogenesis,with consequent important implications on the possibility to improve the clinical outcomes of the diseases themselves,by acting on the different components of this system,mainly by modifying the microbiota.With the emergence of precision medicine,strategies in which patients with IBD might be categorized other than for standard gut symptom complexes could offer the opportunity to tailor therapies to individual patients.The aim of this narrative review is to elaborate on the concept of the gutbrain-microbiota axis and its clinical significance regarding IBD on the basis of recent scientific literature,and finally to focus on pharmacological therapies that could allow us to favorably modify the function of this complex system. | Emanuele Sinagra Erika Utzeri Gaetano Cristian Morreale Carlo Fabbri Fabio Pace Andrea Anderloni | 2020 | World Journal of Clinical Cases2020，8，6： | 7 |
| 4 | Effectiveness of very low-volume preparation for colonoscopy:A prospective, multicenter observational study显示文摘BACKGROUND The effectiveness of colonoscopy strictly depends on adequate bowel cleansing.Recently,a 1 L polyethylene glycol plus ascorbate(PEG-ASC)solution(Plenvu;Norgine,Harefield,United Kingdom)has been introduced on the evidence of three phase-3 randomized controlled trials,but it had never been tested in the real-life.AIM To assess the effectiveness and tolerability of the 1 L preparation compared to 4 L and 2 L-PEG solutions in a real-life setting.METHODS All patients undergoing a screening or diagnostic colonoscopy after a 4,2 or 1 L PEG preparation,were consecutively enrolled in 5 Italian centers from September 2018 to February 2019.The primary endpoints of the study were the assessment of bowel cleansing success and high-quality cleansing of the right colon.The secondary endpoints were the evaluation of tolerability,adherence and safety of the different bowel preparations.Bowel cleansing was assessed through the Boston Bowel Preparation Scale.Adherence was defined as consumption of at least 75%of each dose,while tolerability was evaluated through a semiquantitative scale.Safety was systematically monitored through adverse events reporting.RESULTS Overall,1289 met the inclusion criteria and were enrolled in the study.Of these,490 patients performed a 4 L-PEG preparation(Selgesse^■),566 a 2 L-PEG cleansing(Moviprep^■or Clensia^■)and 233 a 1 L-PEG preparation(Plenvu^■).Bowel cleansing by Boston Bowel Preparation Scale was 6.5±1.5 overall and 6.3±1.5,6.2±1.5,7.3±1.5(P<0.001)in the subgroups of 4 L,2 L and 1 L-PEG preparation,respectively.Cleansing success was achieved in 72.4%,74.1%and 90.1%(P<0.001),while a high-quality cleansing of the right colon in 15.9%,12.0%and 41.4%(P<0.001)for 4 L,2 L and 1 L-PEG preparation groups,respectively.The 1 L preparation was the most tolerated compared to the 2 and 4 L-PEG solutions in the absence of serious adverse events within any of the three groups.Multiple regression models confirmed 1 L PEG-ASC preparation as an independent predictor of overall cleansing success,high-quality cleansing of the right colon and of tolerability.CONCLUSION This study supports the effectiveness and tolerability of 1 L PEG-ASC,also showing it is an independent predictor of overall cleansing success,high-quality cleansing of the right colon and of tolerability. | Marcello Maida Emanuele Sinagra Gaetano Cristian Morreale Sandro Sferrazza Giuseppe Scalisi Dario Schillaci Marco Ventimiglia Fabio Salvatore Macaluso Giovanni Vettori Giuseppe Conoscenti Concetta Di Bartolo Serena Garufi Domenico Catarella Michele Manganaro Clara Maria Virgilio Salvatore Camilleri | 2020 | World Journal of Gastroenterology2020，26，16： | 2 |
| 5 | A Brain Tumor Model Utilizing Stereotact Implantation of A Permanent Cannula显示文摘 | Vottorio M Morreale V M Herman B H | 1993 | Neurosurg1993，78，： | 1 |
| 6 | Surgical treatment of spontancous spinalcerebrospinal fluid leaks显示文摘 | Schievink WI Morreale VM Atkinson JL | 1998 | J Neurosurg1998，88，： | 1 |
| 7 | Neurodevelopment of preterm infants born at 28 to 36 weeks of gestational age: the role of hypothyroxinemia and long-term outcome at 4 years显示文摘 | Susana Ares José Quero Jesus Diez Gabriella Morreale de Escobar | 2011 | Journal of Pediatric Endocrinology and Metabolism . 2011 (11-1)2011，，11： | 1 |
| 8 | A brain-tumor model utilizing stereotactic implantion of a permanent cannulas显示文摘 | Morreale VM Herman BH | 1993 | J Neusurg1993，78，6： | 1 |
| 9 | Wld S protein re- quires Nmnat activity and a short N-terminal sequence to protect axons in mice 显示文摘 | Conforti L Wilbrey A Morreale G | 2009 | J Cell Biol2009，184，4： | 1 |
| 10 | Advances in CO 2 capture technology: A patent review显示文摘 | Bingyun Li Yuhua Duan David Luebke Bryan Morreale | 2013 | Applied Energy2013，，： | 1 |
| 11 | Deepsclerectomyversuspunchtrabeculectomywithorwithoutphacoemulsification:arandomizedclinicaltrial显示文摘 | CillinoS DiPaceF CasuccioA CalvarusoL MorrealeD VadalM etal | 2004 | JGlaucoma2004，13，50： | 1 |
| 12 | Role of thyroid hormone during early brain develop- ment显示文摘 | Morreale de Escobar G Obregon MJ Escobar del Rey F | 2004 | Eur J Endocrinol2004，151，3： | 1 |
| 13 | High dose therapy and autologous hematopoietic stem cell transplantation in poor risk solid tumors of childhood显示文摘 | Dallorso S Manzitti C Morreale G | 2000 | Haematologica2000，85，11： | 1 |
| 14 | Only the combined treatment with thyroxine and triiodothyronine ensures euthy- roidism in all tissues of the thyroidectomized rat显示文摘 | Escobar - Morreale HF del Rey FE Obreg6n MJ | 1996 | Endocrinology1996，137，6： | 1 |
| 15 | Fluoroquinolone - induced liver injury:three new cases and a review of the literature显示文摘 | Licata A Randazzo C Morreale I | 2012 | Euro- pean Journal of Clinical Pharmacology2012，68，5： | 1 |
| 16 | Product distributions from isothermal co-pyrolysis of coal and biomass显示文摘 | WEILAND N T MEANS N C MORREALE B D | 2012 | Fuel2012，94，： | 1 |
| 17 | A brain-tumor model utilizing stereotactic implantation of a permanent cannula 显示文摘 | Morreale VM Herman BH Der-Minassian V | 1993 | J Neurosurg1993，78，6： | 1 |
| 18 | Probable interaction of warfarin and acarbose显示文摘 | Morreale AP Janetzky K | 1997 | Am J Health Syst Pharm1997，54，13： | 1 |
| 19 | A brain-tumor model utilizing implantation of a permanent cannula显示文摘 | Herman BH Der-Minassian | 1993 | J Neurosurg1993，78，： | 1 |
| 20 | Effects of periliyi alcohol on melanoma in the TPras mouse model 显示文摘 | Lluria-Prevatt M Morreale J Gregus J | 2002 | Cancer Epiderniol Biorn Prey2002，11，： | 1 |
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