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| 1 | Evolving concepts in bone infection: redefining “biofilm”,“acute vs. chronic osteomyelitis”, “the immune proteome” and “local antibiotic therapy”显示文摘Osteomyelitis is a devastating disease caused by microbial infection of bone. While the frequency of infection following elective orthopedic surgery is low, rates of reinfection are disturbingly high. Staphylococcus aureus is responsible for the majority of chronic osteomyelitis cases and is often considered to be incurable due to bacterial persistence deep within bone. Unfortunately, there is no consensus on clinical classifications of osteomyelitis and the ensuing treatment algorithm. Given the high patient morbidity,mortality, and economic burden caused by osteomyelitis, it is important to elucidate mechanisms of bone infection to inform novel strategies for prevention and curative treatment. Recent discoveries in this field have identified three distinct reservoirs of bacterial biofilm including: Staphylococcal abscess communities in the local soft tissue and bone marrow, glycocalyx formation on implant hardware and necrotic tissue, and colonization of the osteocyte-lacuno canalicular network(OLCN) of cortical bone. In contrast, S.aureus intracellular persistence in bone cells has not been substantiated in vivo, which challenges this mode of chronic osteomyelitis. There have also been major advances in our understanding of the immune proteome against S. aureus, from clinical studies of serum antibodies and media enriched for newly synthesized antibodies(MENSA), which may provide new opportunities for osteomyelitis diagnosis, prognosis, and vaccine development. Finally, novel therapies such as antimicrobial implant coatings and antibiotic impregnated 3D-printed scaffolds represent promising strategies for preventing and managing this devastating disease. Here, we review these recent advances and highlight translational opportunities towards a cure. | Elysia A. Masters Ryan P. Trombetta Karen L. de Mesy Bentley Brendan F Boyce Ann Lindley Gill Steven R. Gill Kohei Nishitani Masahiro Ishikawa Yugo Morita Hiromu Ito Sheila N. Bello-Irizarry Mark Ninomiya James D. Brodell Jr. Charles C. Lee Stephanie P. Hao Irvin Oh Chao Xie Hani A. Awad John L. Daiss John R. Owen Stephen L. Kates Edward M. Schwarz Gowrishankar Muthukrishnan | 2019 | Bone Research2019，7，3： | 19 |
| 2 | Impact of formal training in endoscopic submucosal dissection for early gastrointestinal cancer: A systematic review and a meta-analysis显示文摘AIM: To summarize the clinical impact of a formal training for the effectiveness and safety of endoscopic submucosal dissection for gastrointestinal cancer.METHODS: We searched databases including PubM ed, EMBASE and the Cochrane Library and Science citation Index updated to August 2014 to include eligible articles. In the Meta-analysis, the main outcome measurements were en bloc resection rate, local recurrence rate(R0) and the incidence of procedure-related complications(perforation, bleeding). RESULTS: En bloc resection was high for both, dissecting stomach tumors with an overall percentage of 93.2%(95%CI: 90.5-95.8) and dissecting colorectal tumors with an overall percentage of 89.4%(95%CI: 85.1-93.7). Although the number of studies reporting R0 resection(the dissected specimen was revealed free of tumor in both vertical and lateral margins) was small, the overall estimates for R0 resection were 81.4%(95%CI: 72-90.8) for stomach and 85.9%(95%CI: 77.5-95.5) for colorectal tumors, respectively. The analysis showed that the percentage of immediate perforation and bleeding were very low; 4.96(95%CI: 3.6-6.3) and 1.4%(95%CI: 0.8-1.9) for colorectal tumors and 3.1%(95%CI: 2.0-4.1) and 4.8%(95%CI: 2.8-6.7) for stomach tumors, respectively. CONCLUSION: In order to obtain the same rate of success of the analyzed studies it is a necessity to create training centers in the western countries during the 'several years' of gastroenterology residence first only to teach EGC diagnose and second only to train endoscopic submucosal dissection. | Miguel A Tanimoto M Lourdes Guerrero Yoshinori Morita Jonathan Aguirre-Valadez Elisa Gomez Carlos Moctezuma-Velazquez Jose A Estradas-Trujillo Miguel A Valdovinos Luis F Uscanga Rikiya Fujita | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，4： | 2 |
| 3 | Deposition of suberin in roots of soybean induced by excess boron显示文摘 | Ghanati F Morita A Yokota H | 2005 | Plant Sci2005，168，2： | 1 |
| 4 | Pulsed Electrodeposition of Dy-Fe显示文摘 | Matsada T F Yoshimoto N Morita M | 1993 | Journal of Alloys and Compounds1993，，193： | 1 |
| 5 | Intestinal bifidobacterium species induce varying cytokine production 显示文摘 | He F Morita H Hashimoto H | 2002 | J Allergy Clin Immunol2002，109，： | 1 |
| 6 | Induction of suberin and increase oflignin content by excess boron in tobacco cells 显示文摘 | Ghanati F Morita A Yokota H | 2002 | Soil Science and Plant Nutrition2002，48，3： | 1 |
| 7 | Adhesion of lactic acid bacteria to Caco-2 cells and their effect on eytokine secretion 显示文摘 | Morita H He F Fuse T | 2002 | Microbiol Immunol2002，46，： | 1 |
| 8 | Interleukin - 6 prevents ischemia - induced learning disability and neuronal and synaptic loss in gerbils 显示文摘 | Matsuda S Wen TC Morita F | 1996 | Neurosci Lett1996，204，： | 1 |
| 9 | Feasibility study of wood biomass gasification/molten carbonate fuel cell power system-comparative characterization of fuel cell and gas turbine systems显示文摘 | Morita H Yoshiba F Woudstra N | 2004 | Journal of Power Sources2004，138，： | 1 |
| 10 | Fragmented QRS as a marker of conduction abnormality and a predictor of prognosis of Brugada syndrome 显示文摘 | Morita H Kusano K F Miura D | 2008 | Circulation2008，21，17： | 1 |
| 11 | Ecotoxicological effect of polycyclic musks on Caenorhabditis elegans 显示文摘 | Mori T Morita F Inokuchi A | 2006 | Journal of Health Science2006，52，3： | 1 |
| 12 | Dialysis-related amyloidosis of the heart in long-term hemodialysis patients显示文摘 | Takayama F Miyazaki S Morita T | 2001 | Kidney Int Suppl2001，78，： | 1 |
| 13 | Effect of Lipo-PGE1 and PGE1- CD in diabetics with ASO complication显示文摘 | Shimiyo T Morita C Nakaya F | 1996 | Angiology1996，36，： | 1 |
| 14 | Safety assess- ment of dietary diacylglyeerol oil: a two - generation repro- ductive toxicity study in rats 显示文摘 | MORITA O KNAPP J F TAMAKI Y | 2008 | Food Chem Toxicol2008，46，9： | 1 |
| 15 | Sevoflurane anaesthesia causes a transient decrease in aquaporin-2 and impairment of urine concentration 显示文摘 | Morita K Otsuka F Ogura T | 1999 | Br J Anaesth1999，83，： | 1 |
| 16 | Robust force control of a flexible arm with a nonsymmetric rigid tip body 显示文摘 | Morita Y Matsuno F | 2001 | Journal of Robotic Systems2001，18，5： | 1 |
| 17 | Mechansim study on the formation of liquid calcium auminate inclusion from MgAl2O4 spinel显示文摘 | Y Kang F Li K Morita | 2006 | Steel Research International2006，77，11： | 1 |
| 18 | Inhibitory effects of antioxidants on N F-KB activation in bovine carotid artery endothelial cells 显示文摘 | Zhao F Murota SI Morita I Yao XS | 2000 | Acta Biochim Biophy Sin2000，32，： | 1 |
| 19 | Analysis of dielectric properties of soy sauce显示文摘 | TANAKA F MORITA K MALIKARJUNANB P | 2005 | Journal of Food Engineering2005，71，： | 1 |
| 20 | Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phoshate therapy显示文摘 | Morita L Perez G I Paris F | 2000 | Nature Med2000，，6： | 1 |
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