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| 1 | Gastric low-grade mucosal-associated lymphoid tissue-lymphoma: Helicobacter pylori and beyond显示文摘The stomach is the most frequently involved site for extranodal lymphomas,accounting for nearly two-thirds of all gastrointestinal cases.It is widely accepted that gastric B-cell,low-grade mucosal-associated lymphoid tissue(MALT)-lymphoma is caused by Helicobacter pylori(H.pylori)infection.MALT-lymphomas may engender different clinical and endoscopic patterns.Often,diagnosis is confirmed in patients with only vague dyspeptic symptoms and without macroscopic lesions on gastric mucosa.H.pylori eradication leads to lymphoma remission in a large number of patients when treatment occurs at an early stage(Ⅰ-Ⅱ1).Neoplasia confined to the submucosa,localized in the antral region of the stomach,and without API2-MALT1 translocation,shows a high probability of remission following H.pylori eradication.When both bacterial infection and lymphoma recur,further eradication therapy is generally effective.Radiotherapy,chemotherapy and,in selected cases,surgery are the available therapeutic options with a high success rate for those patients who fail to achieve remission,while data on immunotherapy with monoclonal antibodies (rituximab)are still scarce.The 5-year survival rate is higher than 90%,but careful,long-term follow-up is required in these patients since lymphoma recurrence has been reported in some cases. | Angelo Zullo Cesare Hassan Francesca Cristofari Francesco Perri Sergio Morini | 2010 | World Journal of Gastrointestinal Oncology2010，2，4： | 21 |
| 2 | Relationship between adipose tissue dysfunction, vitamin D deficiency and the pathogenesis of non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease worldwide.Its pathogenesis is complex and not yet fully understood.Over the years many studies have proposed various pathophysiological hypotheses,among which the currently most widely accepted is the'multiple parallel hits'theory.According to this model,lipid accumulation in the hepatocytes and insulin resistance increase the vulnerability of the liver to many factors that act in a coordinated and cooperative manner to promote hepatic injury,inflammation and fibrosis.Among these factors,adipose tissue dysfunction and subsequent chronic low grade inflammation play a crucial role.Recent studies have shown that vitamin D exerts an immune-regulating action on adipose tissue,and the growing wealth of epidemiological data is demonstrating that hypovitaminosis D is associated with both obesity and NAFLD.Furthermore,given the strong association between these conditions,current findings suggest that vitamin D may be involved in the relationship between adipose tissue dysfunction and NAFLD.The purpose of this review is to provide an overview of recent advances in the pathogenesis of NAFLD in relation to adipose tissue dysfunction,and in the pathophysiology linking vitamin D deficiency with NAFLD and adiposity,together with an overview of the evidence available on the clinical utility of vitamin D supplementation in cases of NAFLD. | Flavia A Cimini Ilaria Barchetta Simone Carotti Laura Bertoccini Marco G Baroni Umberto Vespasiani-Gentilucci Maria-Gisella Cavallo Sergio Morini | 2017 | World Journal of Gastroenterology2017，23，19： | 9 |
| 3 | Starring role of toll-like receptor-4 activation in the gutliver axis显示文摘Since the introduction of the term 'gut-liver axis', many studies have focused on the functional links of intestinal microbiota, barrier function and immune responses to liver physiology. Intestinal and extra-intestinal diseases alter microbiota composition and lead to dysbiosis, which aggravates impaired intestinal barrier function via increased lipopolysaccharide translocation. The subsequent increased passage of gut-derived product from the intestinal lumen to the organ wall and bloodstream affects gut motility and liver biology. The activation of the toll-like receptor 4(TLR-4) likely plays a key role in both cases. This review analyzed the most recent literature on the gut-liver axis, with a particular focus on the role of TLR-4 activation. Findings that linked liver disease with dysbiosis are evaluated, and links between dysbiosis and alterations of intestinal permeability and motility are discussed. We also examine the mechanisms of translocated gut bacteria and/or the bacterial product activation of liver inflammation and fibrogenesis via activity on different hepatic cell types. | Simone Carotti Michele Pier Luca Guarino Umberto Vespasiani-Gentilucci Sergio Morini | 2015 | World Journal of Gastrointestinal Pathophysiology2015，6，4： | 8 |
| 4 | Endoscopic findings in patients with upper gastrointestinal bleeding clinically classified into three risk groups prior to endoscopy显示文摘AIM: To investigate in a prospective study whether a simplifi ed clinical score prior to endoscopy in upper gastrointestinal bleeding (UGIB) patients was able to predict endoscopic findings at urgent endoscopy. METHODS: All consecutive UGIB patients referred to a single endoscopic center during a 16 mo period were enrolled. Before endoscopy patients were strati- fied according to a simple clinical score (T-score), including T1 (high-risk), T2 (intermediate-risk) and T3 (low-risk). Endoscopy was performed in all cases within 2 h, and high-risk stigmata were considered for further analysis. RESULTS: Out of the 436 patients included into the study, 126 (29%) resulted to be T1, 135 (31%) T2, and 175 (40%) T3. Overall, stigmata of recent haem-orrhage (SRH) were detected in 118 cases (27%). SRH occurred more frequently in T1 patients than in T2/T3 cases (85% vs 3.2%; χ2 = 304.5309, P < 0.001). Older age (t=3.311; P < 0.01) and presence of comor-bidities (χ2 = 14.7458; P < 0.01) were more frequently detected in T1 than in T2/T3 patients. CONCLUSION: Our simplifi ed clinical score appeared to be associated with the detection of endoscopic findings which may deserve urgent endoscopy. A further,randomised study is needed to assess its accuracy in safely scheduling endoscopy in UGIB patients. | Leonardo Tammaro Maria Carla Di Paolo Angelo Zullo Cesare Hassan Sergio Morini SebastianoCaliendo Lorella Pallotta | 2008 | World Journal of Gastroenterology2008，14，32： | 6 |
| 5 | Overview of studies of the vitamin D/vitamin D receptor system in the development of non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease in the world.NAFLD is known to be associated with obesity,type 2 diabetes,metabolic syndrome and increased cardiovascular events:for these reasons,it is becoming a global public health problem and represents an important challenge in terms of prevention and treatment.The mechanisms behind the pathogenesis of NAFLD are multiple and have not yet been completely unraveled;consequently,at moment there are not effective treatments.In the past few years a large body of evidence has been assembled that attributes an important role in hepatic aberrant fat accumulation,inflammation and fibrosis,to the vitamin D/vitamin D receptor(VD/VDR)axis,showing a strong association between hypovitaminosis D and the diagnosis of NAFLD.However,the data currently available,including clinical trials with VD supplementation,still provides a contrasting picture.The purpose of this editorial is to provide an overview of recent advances in the pathogenesis of NAFLD in relation to VD/VDR.Based on recent data from literature,we focused in particular on the hypothesis that VDR itself,independently from its traditional ligand VD,may have a crucial function in promoting hepatic fat accumulation.This might also offer new possibilities for future innovative therapeutic approaches in the management of NAFLD. | Flavia Agata Cimini Ilaria Barchetta Simone Carotti Sergio Morini Maria Gisella Cavallo | 2019 | World Journal of Gastrointestinal Pathophysiology2019，10，2： | 4 |
| 6 | Effects of Helicobacter pylori Eradication on Early Stage Gastric Mucosa–Associated Lymphoid Tissue Lymphoma显示文摘 | Angelo Zullo Cesare Hassan Francesca Cristofari Alessandro Andriani Vincenzo De Francesco Enzo Ierardi Silverio Tomao Manfred Stolte Sergio Morini Dino Vaira | 2010 | Clinical Gastroenterology and Hepatology2010，，2： | 3 |
| 7 | Characteristics of Metachronous Gastric Tumors after Endoscopic Submucosal Dissection for Gastric Intraepithelial Neoplasms显示文摘 | Tomoyuki Boda Masanori Ito Shiro Oka Yoko Kitamura Norifumi Numata Yoji Sanomura Taiji Matsuo Shinji Tanaka Masaharu Yoshihara Koji Arihiro Kazuaki Chayama Sergio Morini | 2014 | Gastroenterology Research and Practice2014，，： | 2 |
| 8 | Effects of human immunodeficiency virus on the erythrocyte and megakaryocyte lineages显示文摘Anaemia and thrombocytopenia are haematological disorders that can be detected in many human immunodeficiency virus(HIV)-positive patients during the development of HIV infection. The progressive decline of erythrocytes and platelets plays an important role both in HIV disease progression and in the clinical and therapeutic management of HIV-positive patients. HIV-dependent impairment of the megakaryocyte and erythrocyte lineages is multifactorial and particularly affects survival, proliferation and differentiation of bone marrow(BM) CD34+ haematopoietic progenitor cells, the activity of BM stromal cells and the regulation of cytokine networks. In this review, we analyse the ma-jor HIV-related mechanisms that are involved in the genesis and development of the anaemia and thrombocytopenia observed in HIV positive patients. | Davide Gibellini Alberto Clò Silvia Morini Anna Miserocchi Cristina Ponti Maria Carla Re | 2013 | World Journal of Virology2013，2，2： | 2 |
| 9 | Electromagnetic Optimization of EMS-MAGLEV Systems显示文摘 | M Andriollo G Martinelli A Morini A Tortella | 1998 | IEEE Transactions on Magnetics1998，34，4： | 1 |
| 10 | Morphological changes of isolated rat pancreatic islets:a structural,ultrastructural and morphometric study显示文摘 | Morini S Braun M Onori P | 2006 | J Anat2006，209，3： | 1 |
| 11 | An afiqne scaling trust - region approach to bound - constrained nonlinear systems 显示文摘 | BELLAVIA S MACCONI M MORINI B | 2003 | Applied Numerical Mathematics2003，44，： | 1 |
| 12 | Hepatic Encephalopathy and Helicobacter pylori 显示文摘 | Angelo Zullo Cesare Hassan Sergio Morini | 2003 | Clin Gastroenterol2003，37，2： | 1 |
| 13 | Influence of the thermal energy storage on the profitability of micro-CHP systems for residential building applications显示文摘 | Barbieri E S Melino F Morini M | 2012 | Appl Energy2012，，97： | 1 |
| 14 | Alphali- poic acid is e{fective in prevention and treatment of experimental autoimmune encephalomyelitis显示文摘 | Morini M Roccatagliata L Dell Eva R | 2004 | Journal of Euroirnmunology2004，148，12： | 1 |
| 15 | Optimization of the on-board Linear Generator in EMS-MAGLEV Trains显示文摘 | M Andriollo G Martinelli A Morini A Tortella | 1997 | IEEE Transactions on Magnetics1997，33，5： | 1 |
| 16 | The alpha 3 beta 1 integrin is associated with mammary carcinoma cell metastasis, invasion, and gelatinase B ( MMP-9 ) activity 显示文摘 | MORINI M MOTTOLESE M FERRARI N | 2000 | Int J Cancer2000，87，3： | 1 |
| 17 | Effects of Helicobacter pylori Eradication on Early Stage Gastric Mucosa–Associated Lymphoid Tissue Lymphoma显示文摘 | Angelo Zullo Cesare Hassan Francesca Cristofari Alessandro Andriani Vincenzo De Francesco Enzo Ierardi Silverio Tomao Manfred Stolte Sergio Morini Dino Vaira | 2010 | Clinical Gastroenterology and Hepatology2010，，2： | 1 |
| 18 | Performance evaluation of non-uniformly fouled axial compressor stages by means of computational fluid dynamics analyses显示文摘 | ALDI N MORINI M | 2013 | Journal of Turbomachinery2013，136，2： | 1 |
| 19 | The alpha 3 beta 1 integrin is associated with mammary carcinoma cell metastasis,invasion,and gelatinase B (MMP-9) activity显示文摘 | Morini M Mottolese M Ferrari N | 2000 | Int J Cancer2000，87，3： | 1 |
| 20 | Low molecular weight hyaluronic acid prevents oxygen free radical damage to granulation tissue during wound healing显示文摘 | TRABUCCtII E PALLOTTA S MORINI M | 2002 | Int J Tissue React2002，24，2： | 1 |
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