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| 1 | Grazing alters environmental control mechanisms of evapotranspiration in an alpine meadow of the tibetan Plateau显示文摘Aims Evapotranspiration(Et)is an important component of the terrestrial water cycle and is easily affected by external disturbances,such as climate change and grazing.Identifying Et responses to grazing is instructive for determining grazing activity and informative for understanding the water cycle.Methods this study utilized 2 years(2014 and 2017)of eddy covariance data to test how grazing regulated Et for an alpine meadow ecosystem on the tibetan Plateau(tP)by path analysis.Important Findings Radiation dominated Et with a decision coefficient of 64-74%.the soil water content(SWc)worked as the limiting factor in the fenced site.However,in the grazing site,the limiting factor was the vapor pressure deficit(VPD).Grazing had large effects on Et because it greatly affected the water conditions.the SWc and VPD were enhanced by 14.63%and 4.36%in the grazing site,respectively.therefore,sufficient water was supplied to Et,especially during drought,and strengthened the transpiration pull.As a result,a favorable micrometeorological environment was created for Et.Grazing shifted the limiting factor of Et from the SWc to VPD,which weakened the limiting effect of the water conditions on Et and advanced the Et peak time.In addition,grazing altered the compositions of Et by changing the community structure,which directly resulted in an increased Et.In summary,grazing enhanced Et through altering the community structure and micrometeorological environments.the findings of this study further improve our understanding of the driving mechanisms of grazing on Et and will improve our predictions for the global water cycle. | Tingting An Mingjie Xu Tao Zhang Chengqun Yu Yingge Li Ning Chen Jiaxing Zu Junxiang Li Juntao Zhu Yi Sun Tingting Zhao Guirui Yu | 2019 | Journal of Plant Ecology2019，12，5： | 3 |
| 2 | Protection of Immuno-Compromised Mice from Lethal Infection of Klebsiella pneumonia by rAAV2-BPI23-Fcγ1 Gene Transfer显示文摘In previous research, chimerical BPI23-Fcγ1 gene which consisted of human bactericidal/permeability increasing protein (BPI) gene of encoding the functional N terminus (amino acid residues 1 to 199) of human BPI and Fcγ1 gene of encoding the Fc segment of human immunoglobulin G1 was successfully reconstructed within a recombinant adeno-associated virus serotype 2 (rAAV2) vector as rAAV2-BPI23-Fcγ1. Here, to evaluate the potentiality of applying gene therapy to gram negative bacterial (GNB) infection in high-risk patients, we investigated protection of immuno-compromised mice and immunocompetent mice from challenge with minimal lethal dose (MLD) Klebsiella pneumonia infection after rAAV2-BPI23-Fcγ1 gene transferred. The results showed that the survival rate of rAAV2-BPI23-Fcγ1 transferred immunocompetent mice as well as immuno-compromised mice (40.0% and 44.4%, respectively) were significantly higher than that of corresponding control mice (6.7% and 4.4%, respectively); the bacteria counting, level of endotoxin and proinflammatory cytokines in the rAAV2-BPI23- Fcγ1 transferred immuno-compromised mice were markedly lower than that of rAAV2-EGFP and rAAV2-Null transferred immuno-compromised mice. Our data suggest that rAAV2-BPI23-Fcγ1 gene transferring offered immuno-compromised mice with resistance against GNB infection, so it is quite potential in preventing GNB infection of clinical high-risk patients. | Jing Li Qingli Kong Zhe Lv Yuanzhi Guan Yong Qiu Chen Li Mingjie Sun Zhenlong Liu Yunqing An | 2008 | Cellular & Molecular Immunology2008，5，6： | 2 |
| 3 | Multiple periodic oscillations in the radio light curves of NRAO 530显示文摘In this paper,the time series analysis method CLEANest is employed to search for characteristic periodicities in the radio light curves of the blazar NRAO 530 at 4.8,8.0 and 14.5 GHz over a time baseline of three decades.Two prominent periodicities on time scales of ~6.3 and ~9.5 a are identified at all three frequencies,in agreement with previous results derived from different numerical techniques,confirming the multiplicity of the periodicities in NRAO 530.In addition to these two significant periods,there is also evidence of shorter-timescale periodicities of ~5.0,~4.2,~3.4 and ~2.8 a showing lower amplitude in the periodograms.The physical mechanisms responsible for the radio quasi-periodic oscillations and the multiplicity of the periods are discussed. | XIE MingJie WANG JunYi AN Tao ZHENG Lin HAN Xu | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，9： | 2 |
| 4 | Shape/size controlling syntheses, properties and applications of two-dimensional noble metal nanocrystals显示文摘二维(2D ) 高贵金属的 nanocrystals (例如, Au, Ag,磅) 经常有在电子学,光学,传感器和 biomedicines 为应用使他们有用的唯一的结构、环境的性质。在最近的年里,发现管理这些 2D 金属 nanocrystals 的多样的几何学的合成的基本机制上有一个焦点(例如,形状,厚度,和侧面的尺寸) 。这导致了能更好为特定的应用程序控制这些 2D 结构的性质。在这评论,内在的各向异性的性质的简短历史的调查和 2D 的量尺寸效果,高贵金属 nanocrystals 被给然后合成途径的一篇摘要被介绍控制他们的形状和尺寸。唯一的性质和这些 nanocrystals 的迷人的应用也被讨论。 | Baozhen An Mingjie Li Jialin Wang Chaoxu Li | 2016 | Frontiers of Chemical Science and Engineering2016，10，3： | 1 |
| 5 | Synergy of in-situ heterogeneous interphases tailored lithium deposition显示文摘The implementation of a robust artificial solid electrolyte interphase(ASEI)to replace the unstable natural SEI can regulate lithium deposition behaviors and avoid the safety hazards caused by dendrites permeation in lithium metal batteries.Despite of devoted efforts in tailoring components of ASEI,the intrinsic mechanism of interfacial synergy within the heterogeneous interphases has not been well elucidated yet.Herein,we show that the lithium plating/striping behaviors can be substantially enhanced(over 900 h with an overpotential of less than 20 mV at 1 mA·cm^(−2)in Li|Li symmetric cells and 146 cycles in anode-free cells)by regulating the heterogeneous interphases.This favorable ASEI composed of LiF and Li_(3)N components can be in-situ generated during cycling by large-scale fabricated fluorinated boron nitride coatings.Further,the synergy of each heterogeneous component within ASEI was explored theoretically and experimentally.Li_(3)N has high adsorption energy and low ion diffusion barrier,which facilitates the transport of lithium ions and avoids its local accumulation to evolve into dendrites.Both the substrate and LiF are interfacially stable with high electron tunneling barriers,preventing the electrolyte decomposition and parasitic reactions.Finally,the high stiffness of the boron nitride also ensures lithium dendrites are suppressed once they grow,providing a stable environment for long-term cycling of lithium metal batteries. | Yinuo Li Anjun Hu Xingdong Gan Miao He Jun Zhu Wei Chen Yin Hu Tianyu Lei Fei Li Yaoyao Li Yuxin Fan Fan Wang Mingjie Zhou An Wen Baihai Li | 2023 | Nano Research2023，16，6： | 0 |
| 6 | Inhaled heparin polysaccharide nanodecoy against SARS-CoV-2 and variants显示文摘To the Editor:As of January 27,2022,there were 363,062,293 cases and 5,645,884deaths from the COVID-19 pandemic1.The prevalent mutated strains have aggravated the global pandemic2.SARS-Co V-2 is highly mutable,and the mutations on the spike(S)protein resulted in a high transmission of COVID-19 and vaccine breakthrough infection3.For example,there is a notable decrease in neutralizing ability of BNT162b2 vaccination-elicited antibodies against the Delta and other variants4,5,and attenuation of peak viral burden and vaccine effectiveness are reduced with Delta variant6. | Bin Tu Huiyuan Wang Xinran An Jingkun Qu Qianqian Li Yanrong Gao Mingjie Shi Hong Qiu Yongzhuo Huang | 2022 | Acta Pharmaceutica Sinica B2022，12，7： | 0 |
| 7 | SUMOylation-triggered ALIX activation modulates extracellular vesicles circTLCD4-RWDD3 to promote lymphatic metastasis of non-small cell lung cancer显示文摘Lymph node(LN)metastasis is one of the predominant metastatic routes of non-small cell lung cancer(NSCLC)and is considered as a leading cause for the unsatisfactory prognosis of patients.Although lymphangiogenesis is well-recognized as a crucial process in mediating LN metastasis,the regulatory mechanism involving lymphangiogenesis and LN metastasis in NSCLC remains unclear.In this study,we employed high-throughput sequencing to identify a novel circular RNA(circRNA),circTLCD4-RWDD3,which was significantly upregulated in extracellular vesicles(EVs)from LN metastatic NSCLC and was positively associated with deteriorated OS and DFS of patients with NSCLC from multicenter clinical cohort.Downregulating the expression of EV-packaged circTLCD4-RWDD3 inhibited lymphangiogenesis and LN metastasis of NSCLC both in vitro and in vivo.Mechanically,circTLCD4-RWDD3 physically interacted with hnRNPA2B1 and mediated the SUMO2 modification at K108 residue of hnRNPA2B1 by upregulating UBC9.Subsequently,circTLCD4-RWDD3-induced SUMOylated hnRNPA2B1 was recognized by the SUMO interaction motif(SIM)of ALIX and activated ALIX to recruit ESCRT-III,thereby facilitating the sorting of circTLCD4-RWDD3 into NSCLC cell-derived EVs.Moreover,EV-packaged circTLCD4-RWDD3 was internalized by lymphatic endothelial cells to activate the transcription of PROX1,resulting in the lymphangiogenesis and LN metastasis of NSCLC.Importantly,blocking EV-mediated transmission of circTLCD4-RWDD3 via mutating SIM in ALIX or K108 residue of hnRNPA2B1 inhibited the lymphangiogenesis and LN metastasis of NSCLC in vivo.Our findings reveal a precise mechanism underlying SUMOylated hnRNPA2B1-induced EV packaging of circTLCD4-RWDD3 in facilitating LN metastasis of NSCLC,suggesting that EV-packaged circTLCD4-RWDD3 could be a potential therapeutic target against LN metastatic NSCLC. | Xiayao Diao Chao Guo Hanhao Zheng Ke Zhao Yuming Luo Mingjie An Yan Lin Jiancheng Chen Yuanlong Li Yuting Li Xuehan Gao Jiaqi Zhang Mengxin Zhou Wenliang Bai Lei Liu Guige Wang Lanjun Zhang Xiaotian He Rusi Zhang Zhihua Li Changhao Chen Shanqing Li | 2023 | Signal Transduction and Targeted Therapy2023，8，12： | 0 |
| 8 | An HGF-dependent positive feedback loop between bladder cancer cells and fibroblasts mediates lymphangiogenesis and lymphatic metastasis显示文摘Background Cancer-associated fibroblasts (CAFs) play a vital role in facilitating tumor progression through extensive reciprocal interplay with cancer cells. Tumor-derived extracellular vesicles (EVs) are the critical mediators involved in the crosstalk between cancer cells and stromal cells, contributing to the metastasis of cancers. Yet, the biological mechanisms of tumor-derived EVs in triggering CAFs phenotype to stimulate the lymph node (LN) metastasis of bladder cancer (BCa) are largely unknown. Here, we aimed to explore the effects and molecular mechanisms of tumor-derived EV-mediated CAFs phenotype in regulating BCa LN metastasis. Methods The high-throughput sequencing was utilized to identify the crucial long non-coding RNA (lncRNA) associated with CAF enrichment in BCa. The functional role of the transition of fibroblasts to CAFs induced by LINC00665-mediated EVs was investigated through the in vitro and in vivo assays. Chromatin isolation by RNA purification assays, fluorescence resonance energy transfer assays, cytokine profiling and patient-derived xenograft (PDX) model were performed to explore the underlying mechanism of LINC00665 in the LN metastasis of BCa. Results We found that CAFs are widely enriched in the tumor microenvironment of BCa, which correlated with BCa lymphangiogenesis and LN metastasis. We then identified a CAF-associated long non-coding RNA, LINC00665, which acted as a crucial mediator of CAF infiltration in BCa. Clinically, LINC00665 was associated with LN metastasis and poor prognosis in patients with BCa. Mechanistically, LINC00665 transcriptionally upregulated RAB27B expression and induced H3K4me3 modification on the promoter of RAB27B through the recruitment of hnRNPL. Moreover, RAB27B-induced EVs secretion endowed fibroblasts with the CAF phenotype, which reciprocally induced LINC00665 overexpression to form a RAB27B-HGF-c-Myc positive feedback loop, enhancing the lymphangiogenesis and LN metastasis of BCa. Importantly, we demonstrated that blocking EV-transmitted LINC00665 or HGF broke this loop and impaired BCa lymphangiogenesis in a PDX model. Conclusion Our study uncovers a precise mechanism that LINC00665 sustains BCa LN metastasis by inducing a RAB27B-HGF-c-Myc positive feedback loop between BCa cells and fibroblasts, suggesting that LINC00665 could be a promising therapeutic target for patients with LN metastatic BCa. | Yuting Li Hanhao Zheng Yuming Luo Yan Lin Mingjie An Yao Kong Yue Zhao Yina Yin Le Ai Jian Huang Changhao Chen | 2023 | Cancer Communications2023，43，12： | 0 |
| 9 | Polarizable Additive with Intermediate Chelation Strength for Stable Aqueous Zinc‑Ion Batteries显示文摘Aqueous zinc-ion batteries are promising due to inherent safety,low cost,low toxicity,and high volumetric capacity.However,issues of dendrites and side reactions between zinc metal anode and the electrolyte need to be solved for extended storage and cycle life.Here,we proposed that an electrolyte additive with an intermediate chelation strength of zinc ion—strong enough to exclude water molecules from the zinc metal-electrolyte interface and not too strong to cause a significant energy barrier for zinc ion dissociation—can benefit the electrochemical stability by suppressing hydrogen evolution reaction,overpotential growth,and den-drite formation.Penta-sodium diethylene-triaminepentaacetic acid salt was selected for such a purpose.It has a suitable chelating ability in aqueous solutions to adjust solvation sheath and can be readily polarized under electrical loading conditions to further improve the passivation.Zn||Zn symmetric cells can be stably operated over 3500 h at 1 mA cm^(-2).Zn||NH4V4O10 full cells with the additive show great cycling stability with 84.6%capacity retention after 500 cycles at 1 A g^(-1).Since the additive not only reduces H2 evolution and corrosion but also modifies Zn2+diffusion and deposition,highlyreversible Zn electrodes can be achieved as verified by the experimental results.Our work offers a practical approach to the logical design of reliable electrolytes for high-performance aqueous batteries. | Yuting Xia Rongao Tong Jingxi Zhang Mingjie Xu Gang Shao Hailong Wang Yanhao Dong Chang‑An Wang | 2024 | Nano-Micro Letters2024，16，5： | 0 |
| 10 | 干旱条件下蒸散变异由气象因子主控转变为生物因子主控显示文摘青藏高原被称为中国水塔,其蒸散(evapotranspiration,ET)影响着青藏高原的水分平衡及高寒草甸生态系统的稳定性。然而,全球变化进程对青藏高原蒸散的变异及其控制机制的影响尚不明晰。因此,本研究旨在明晰不同水分条件下,青藏高原高寒草甸生态系统蒸散变异受气象因子主控亦或是受生物因子主控。基于6年(2013-2018)的碳通量与气象因子和生物因子数据,采用线性扰动分析法量化了各气象因子和生物因子对蒸散变异的贡献。研究结果表明,在湿润年的生长旺季(7-8月),气象因子主控蒸散的变异。能量供应的不足限制了蒸散,因此净辐射和温度主控了蒸散的变异。在干旱年的生长旺季,蒸散变异由气象因子主控转变为生物因子主控,蒸散变异主要受到冠层导度和叶面积指数的控制。此时,生态系统受水分限制。本研究为深入研究不同水分条件下气象和生物因子如何控制蒸散变异提供了经验:有助于深刻理解水循环过程,可为未来气候变化条件下有效管理高寒草甸生态系统水资源提供理论基础。 | Mingjie Xu Tingting An Zhoutao Zheng Tao Zhang Yangjian Zhang Guirui Yu | 2022 | Journal of Plant Ecology2022，15，5： | 0 |
| 11 | Extracellular vesicle-mediated heterogeneous communication between cancer and the lymphatic system facilitates lymphatic metastasis显示文摘Introduction The dissemination of cancer cells to organs initiates the formation of an aggressive cancer phenotype and is a predominant cause of cancer-associated death.For most epithelial cancers,lymphatic system metastasis has been characterized as the most common and earliest metastatic pathway,and the detection of metastasis in lymph nodes(LNs)often predicts poor survival among patients'.Although increasing attention is being paid to the clinical importance of LN metastasis,the underlying mechanisms have remained unclear in the past decade.Accumulating evidence suggests that the occurrence of LN metastasis is not stochastic but is a programming biological event regulated by the bidirectional crosstalk between metastasis-initiating cancer cells and the tumor microenvironment(TME)2.However,the regulators and patterns of cancer-TME communication in LN metastasis remain to be furtherexplored. | Changhao Chen Yuming Luo Hanhao Zheng Dingwen Zhang Yao Kong Jiabin Yang Mingjie An Yan Lin Daowei Lin Rufu Chen | 2023 | Cancer Biology & Medicine2023，20，3： | 0 |
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