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| 1 | Rapid report of the 8 January 2022 M_(S)6.9 Menyuan earthquake,Qinghai,China显示文摘The M_(S)6.9 Menyuan earthquake in Qinghai Province,west China is the largest earthquake by far in 2022.The earthquake occurs in a tectonically active region,with a background b-value of 0.87 within 100 km of the epicenter that we derived from the unified catalog produced by China Earthquake Networks Center since late 2008.Field surveys have revealed surface ruptures extending 22 km along strike,with a maximum ground displacement of 2.1 m.We construct a finite fault model with constraints from In SAR observations,which showed multiple fault segments during the Menyuan earthquake.The major slip asperity is confined within 10 km at depth,with the maximum slip of 3.5 m.Near real-time back-projection results of coseismic radiation indicate a northwest propagating rupture that lasted for~10 s.Intensity estimates from the back-projection results show up to a Mercalli scale of IX near the ruptured area,consistent with instrumental measurements and the observations from the field surveys.Aftershock locations(up to January 21,2022)exhibit two segments,extending to~20 km in depth.The largest one reaches M_(S)5.3,locating near the eastern end of the aftershock zone.Although the location and the approximate magnitude of the mainshock had been indicated by previous studies based on paleoearthquake records and seismic gap,as well as estimated stressing rate on faults,significant surfacebreaching rupture leads to severe damage of the high-speed railway system,which poses a challenge in accurately assessing earthquake hazards and risks,and thus demands further investigations of the rupture behaviors for crustal earthquakes. | Hongfeng Yang Dun Wang Rumeng Guo Mengyu Xie Yang Zang Yue Wang Qiang Yao Chuang Cheng Yanru An Yingying Zhang | 2022 | Earthquake Research Advances2022，2，1： | 14 |
| 2 | All-small-molecule dynamic covalent gels with antibacterial activity by boronate-tannic acid gelation显示文摘Reversible boronate-catechol linkage was widely used to construct two-dimensional coatings and threedimensional nanostructures or hydrogels.The construction of these functional materials usually requires the pre-synthesis of macro molecular building blocks,and direct gelation between natural polyphenols and small molecule boranic acids is yet to be investigated.In this study,we fabricated a family of allsmall-molecule dynamic covalent gels consisting of tannic acid and boronic acids.Transparent and thixotropic gels were formed by boronate affinity towards catechol groups abundant on natural polyphenols.The gels showed multi-responsiveness,such as acid-,base-,reduction-and oxidantsensitive depending on the used boronic acid building blocks.The chemistry for gel formation and stimuli-responsiveness was characterized by11B NMR spectroscopy.The multi-stimuli responsiveness,green processing and facile modular design make the boronic acid-tannic acid gels promising candidates for the development of smart soft materials. | Xuejing Cheng Mengyu Li Hui Wang Yiyun Cheng | 2020 | Chinese Chemical Letters2020，31，3： | 6 |
| 3 | Mitochondrial localization of ORF346 causes pollen abortion in alloplasmic male sterility显示文摘The Nsa cytoplasmic male sterility(CMS) system confers stable male sterility and offers great potential for production of hybrid seeds in oilseed rape. However, genes responsible for male sterility in Nsa CMS have not been identified. By mitochondrial genome sequencing of Nsa CMS and its maintainer line,we identified in an Nsa CMS line several chimeric genes encoding hypothetical proteins harboring transmembrane domains. One novel chimeric gene orf346 showed high identity with cox1 at the 50 terminal region and was co-transcribed with nad3 and rps12 genes. Transgenic plants of orf346 fused with or without mitochondrial targeting peptide conferred complete male sterility in Arabidopsis. ORF346 was mitochondrion-localized. Expression of orf346 in Escherichia coli inhibited bacterial growth, with excessive accumulation of reactive oxygen species and decreased ATP content. These results reveal a link between the newly identified mitochondrial gene orf346 and the abortion of Nsa CMS. Inadequate energy supply and excessive accumulation of reactive oxygen species may account for pollen abortion in Nsa CMS plants. | Shifei Sang Hongtao Cheng Mengyu Hao Bingli Ding Desheng Mei Hui Wang Wenxiang Wang Jia Liu Li Fu Kede Liu Qiong Hu | 2021 | The Crop Journal2021，9，6： | 5 |
| 4 | Traditional Chinese Medicine guidelines for coronavirus disease 2019显示文摘OBJECTIVE:To summarize the evidence from Traditional Chinese Medicine(TCM)practice in the treatment of coronavirus disease 2019(COVID-19)and provide timely clinical practice guidance.METHODS:The guidelines were developed in accordance with the World Health Organization rapid guideline process.The evidence on TCM for COVID-19 from published guidelines,direct and indirect published clinical evidence,first hand clinical data,and expert experience and consensus were collected.The grading of recommendations assessment,development and evaluation(GRADE)method was used to grade the evidence and make the recommendations.RESULTS:Based on the available evidence,the guidelines recommended 17 Chinese medicines for COVID-19:2 Chinese herbal granules,7 Chinese patent medicines,and 8 Chinese herbal injections.CONCLUSION:As the literature search was conducted on March,any subsequent versions of these guidelines require an up-to-date literature review.We hope that the evidence summary in these guidelines will be helpful in global efforts to address COVID-19. | Liang Ning Ma Yanfang Wang Jingya Li Huizhen Wang Xiaohui Jiao Liwen Liu Bin Ma Yan Zhao Chen Luo Xufei Zhao Siya Lu Meng Cao Jin Hu Wenpin Zhang Hairong Liu Guoxiu Lu Cheng Liu Mengyu Li Li Han Xuejie Liu Yuqi Wang Liying Zhao Xueyao Wei Dongfeng Bai Jing Sun Mingyu Yang Yong Wu Xiaodan Chen Yaolong Shi Nannan Wang Yanping Wang Yongyan | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 2 |
| 5 | Mg(OH)_(2)nanosheets on Ti with immunomodulatory function for orthopedic applications显示文摘Macrophages play a vital role for guiding the fate of osteogenesisrelated cells.It is well known that nano-topography and bioactive ions can directly enhance osteogenic behavior.However,the effects of nano-structure combined with bioactive ions release on macrophage polarization and the following osteogenesis and angiogenesis are rarely reported.Herein,Mg(OH)_(2)films with nano-sheet structures were constructed on the surface of Ti using hydrothermal treatment.The film presented nanosheet topography and sustained release of Mg ions.The results of in vitro culture of bone marrow-derived macrophages(BMDMs),including PCR,western blot and flow cytometry suggested that the nano-Mg(OH)_(2)films were more favorable for macrophages polarizing to tissue healing M2 phenotype.Moreover,air-pouch model confirmed that the nano-Mg(OH)_(2)film coated Ti would induce milder inflammation and thinner fibrous layer in vivo,compared with untreated Ti.Furthermore,macrophages-conditioned culture mediums were collected from nano-Mg(OH)_(2)coated Ti group was superior for the osteogenic behaviors of mice bone marrow stem cells and the angiogenic behaviors of human umbilical vein endothelial cells.With harmonious early inflammatory response and subsequently improved osteogenesis and angiogenesis,the nano-Mg(OH)_(2)coated Ti is promising for orthopedic applications. | Yue He Mengyu Yao Jielong Zhou Juning Xie Changxiang Liang Dong Yin Shuaihao Huang Yu Zhang Feng Peng Shi Cheng | 2022 | Regenerative Biomaterials2022，9，1： | 1 |
| 6 | A lignified-layer bridge controlled by a single recessive gene is associated with high pod-shatter resistance in Brassica napus L.显示文摘Pod shattering causes severe yield loss in rapeseed(Brassica napus L.)under modern agricultural practice.Identification of highly shatter-resistant germplasm is desirable for the development of rapeseed cultivars for mechanical harvesting.In the present study,an elite line OR88 with strong shatter resistance and a lignified-layer bridge(LLB)structure was identified.The LLB structure was unique to OR88 and co-segregated with high pod-shatter resistance.The LLB structure is differentiated at stage 12 of gynoecium development without any gynoecium defects.Genetic analysis showed that LLB is controlled by a single recessive gene.By BSA-Seq and map-based cloning,the resistance gene location was delimited to a0.688 Mb region on chromosome C09.Transcriptome analysis suggested Bn TCP8.C09 as the gene responsible for LLB.The expression of Bn TCP.C09 was strongly downregulated in OR88,suppressing cell proliferation in the pod valve margin.KASP markers linked to the candidate gene were developed.This pod shatter-resistant line could be used in rapeseed breeding programs by direct transfer of the gene with the assistance of the DNA markers. | Wen Chu Jia Liu Hongtao Cheng Chao Li Li Fu Wenxiang Wang Hui Wang Mengyu Hao Desheng Mei Kede Liu Qiong Hu | 2022 | The Crop Journal2022，10，3： | 1 |
| 7 | Improved osteointegration and angiogenesis of strontium-incorporated 3D-printed tantalum scaffold via bioinspired polydopamine coating显示文摘Tantalum(Ta)is used in orthopedic implants because it has excellent biocompatibility.However,high elastic modulus,bio-inertness,and unsatisfactory osteointegration limits its wider use in clinical applications.Herein,a 3 D porous Ta scaffold with low elastic modulus was fabricated using selective laser melting(SLM).Strontium(Sr)was incorporated on the surface of the scaffold with the aid of polydopamine(PDA)to further improve its osteointegration ability.The prepared scaffolds exhibited a stable Sr ion release in 14 d.Rat bone marrow stem cells(BMSCs)showed improved early adhesion and spreading after Sr was incorporated on the porous Ta surface.The osteogenic behavior,including extracellular matrix mineralization(ECM),alkaline phosphatase activity(ALP),and expression of bone-related RNA,were all enhanced.Furthermore,the Sr-incorporated porous Ta scaffolds exhibited better angiogenic behavior,such as promoting migration,tube formation,and angiogenesis-related RNA expression abilities of human vascular endothelial cells(HUVECs).Additionally,histological images(H&E,Masson and CD31 immunofluorescent staining)suggested that Sr-incorporated porous Ta scaffolds displayed enhanced osteointegration and angiogenesis after implantation in rat femur for 12 weeks.These findings prove that the PDA-based Sr-incorporated porous Ta scaffolds show promising use in orthopedic implants. | Shi Cheng Jin Ke Mengyu Yao Hongwei Shao Jielong Zhou Ming Wang Xiongfa Ji Guoqing Zhong Feng Peng Limin Ma Yu Zhang | 2021 | Journal of Materials Science & Technology2021，，10： | 1 |
| 8 | Molecular Motions in Polymer Matrix for Microenvironment Sensing显示文摘Polymer science entails the structural study at multi-levels from nano-to micro-and mesoscale,which is highly important to transfer or even amplify the molecular information to macroscopic materials.Multiple polymer structural transitions from lower-order to higher-order superstructures are normally involved to achieve selective,efficient and sophisticated functions.Therefore,in-situ visualization of these processes is highly important,not only for fundamental understanding the structural evolution,but also for the optimization of the process flow during the materials processing.Fluorescence imaging based on aggregation-induced emission(AIE)provides an ideal tool that offers a simple,accurate,and easy-readable method to fulfill the above requirements.Owing to the twisted propeller-like structure of AIE luminogens(AIEgens),they show high fluorescence sensitivity to the surrounding microenvironment(e.g.,viscosity,rigidity,and polarity)through intramolecular motions.In this short review,we summarize the recent applications of AIEgens to serve as“built-in”sensors to analyze the process of polymerization,microphase separation,glass/vitrification transition,polymer solvation,crystallization,etc.The perspective on the future application of AIE technology in polymer engineering,especially fiber materials,is also discussed. | GAO Mengyue CHENG Yanhua ZHANG Junyan XU Chengjian YU Xiaoxiao ZHU Meifang | 2021 | Chemical Research in Chinese Universities2021，37，1： | 0 |
| 9 | Confinement fluorescence effect of an aggregation-induced emission luminogen in crystalline polymer显示文摘Despite the impressive progress of stimuli-responsive fluorescent materials,little is known about the influence of confinement created by crystalline polymer over the fluorescence properties of fluorescent molecules.The effects of confinement on the fluorescence of an aggregation-induced emission luminogen(AIEgen)are investigated using computational simulations,which reveal that the confined space induces the AIEgens to take a more planar conformation,resulting in a red-shifted emission spectrum.With this property,the study is extended to explore the confinement generated by various polymer crystalline forms,and it is shown that different fluorescence colors are activated.This confinement fluorescence effect is attributed to the different spatial dimensions of the polymer amorphous layer between lamellar crystals where the AIEgens are located.These results indicate the immediate association between crystalline structure and fluorescence signals,activating unprecedented photophysical properties of luminescent materials,and also providing the possibility for crystalline structure visualization,it is important for the many polymer crystallization processes occurring in the materials processing. | Lan Zhou Linlin Zheng Xiaoxiao Yu Mengyue Gao Chengjian Xu Yifan Ge Tianxiang Bai Jin Wen Yanhua Cheng Meifang Zhu | 2023 | Aggregate2023，4，5： | 0 |
| 10 | Fibrous Aerogels with Tunable Superwettability for High-Performance Solar-Driven Interfacial Evaporation显示文摘Solar-driven interfacial evaporation is an emerging technology for water desalination.Generally,double-layered structure with separate surface wettability properties is usually employed for evaporator construction.However,creating materials with tunable properties is a great challenge because the wettability of existing materials is usually monotonous.Herein,we report vinyltrimethoxysilane as a single molecular unit to hybrid with bacterial cellulose(BC)fibrous network,which can be built into robust aerogel with entirely distinct wettability through controlling assembly pathways.Siloxane groups or carbon atoms are exposed on the surface of BC nanofibers,resulting in either superhydrophilic or superhydrophobic aerogels.With this special property,single component-modified aerogels could be integrated into a double-layered evaporator for water desalination.Under 1 sun,our evaporator achieves high water evaporation rates of 1.91 and 4.20 kg m^(-2)h^(-1)under laboratory and outdoor solar conditions,respectively.Moreover,this aerogel evaporator shows unprecedented lightweight,structural robustness,long-term stability under extreme conditions,and excellent salt-resistance,highlighting the advantages in synthesis of aerogel materials from the single molecular unit. | Chengjian Xu Mengyue Gao Xiaoxiao Yu Junyan Zhang Yanhua Cheng Meifang Zhu | 2023 | Nano-Micro Letters2023，15，5： | 0 |
| 11 | Establishment of new convenient two-line system for hybrid production by targeting mutation of OPR3 in allopolyploid Brassica napus显示文摘The two-line pollination control system,which usually depends on the utilization of thermosensitive or photoperiod genic male-sterile lines,has been widely used in various crops.However,this system is susceptible to instability issues caused by uncontrollable weather fluctuations.A stable and handy two-line pollination control system is highly desirable in many crop species for heterosis exploitation.Oxophytodienoic acid reductase 3(OPR3)was proven to be involved in jasmonate biosynthesis.In the present study,CRISPR/Cas9(Clustered Regularly Interspaced Short Palindromic Repeat)was utilized to mutate two OPR3 homologs in Brassica napus.After two OPR3 homologs were simultaneously mutated,mutants exhibited complete male sterility,and fertility could be easily restored by exogenous MeJA treatment.Hybrids produced from crosses between the opr3 sterile lines and normal varieties exhibited heterosis.This new two-line system based on OPR3 mutation provides higher stability and convenience than traditional systems.By using exogenous MeJA treatment to restore fertility,the system enables more precise control of male fertility transition,which has great potential to significantly contribute to the maneuverable production of hybrid seeds in rapeseed as well as other Brassica species crops. | Hongtao Cheng Mengyu Hao Shifei Sang Yunfei Wen Yating Cai Hui Wang Wenxiang Wang Desheng Mei Qiong Hu | 2023 | Horticulture Research2023，10，12： | 0 |
| 12 | A novel TNKS/USP25 inhibitor blocks the Wnt pathway to overcome multi-drug resistance in TNKS-overexpressing colorectal cancer显示文摘Modulating Tankyrases(TNKS),interactions with USP25 to promote TNKS degradation,rather than inhibiting their enzymatic activities,is emerging as an alternative/specific approach to inhibit the Wnt/β-catenin pathway.Here,we identified UAT-B,a novel neoantimycin analog isolated from Streptomyces conglobatus,as a small-molecule inhibitor of TNKS-USP25 protein-protein interaction(PPI)to overcome multi-drug resistance in colorectal cancer(CRC).The disruption of TNKS-USP25 complex formation by UAT-B led to a significant decrease in TNKS levels,triggering cell apoptosis through modulation of the Wnt/β-catenin pathway.Importantly,UAT-B successfully inhibited the CRC cells growth that harbored high TNKS levels,as demonstrated in various in vitro and in vivo studies utilizing cell line-based and patient-derived xenografts,as well as APC^(min/+)spontaneous CRC models.Collectively,these findings suggest that targeting the TNKS-USP25 PPI using a small-molecule inhibitor represents a compelling therapeutic strategy for CRC treatment,and UAT-B emerges as a promising candidate for further preclinical and clinical investigations. | Hongrui Zhu Yamin Gao Liyun Liu Mengyu Tao Xiao Lin Yijia Cheng Yaoyao Shen Haitao Xue Li Guan Huimin Zhao Li Liu Shuping Wang Fan Yang Yongjun Zhou Hongze Liao Fan Sun Houwen Lin | 2024 | Acta Pharmaceutica Sinica B2024，14，1： | 0 |
| 13 | A large-scale proteogenomic atlas of pear显示文摘Pear is an important fruit tree that is widely distributed around the world.The first pear genome map was reported from our laboratory approximately 10 years ago.To further study global protein expression patterns in pear,we generated pear proteome data based on 24 major tissues.The tissue-resolved profiles provided evidence of the expression of 17953 proteins.We identified 4294 new coding events and improved the pear genome annotation via the proteogenomic strategy based on 18090 peptide spectra with peptide spectrum matches>1.Among the eight randomly selected new short coding open reading frames that were expressed in the style,four promoted and one inhibited the growth of pear pollen tubes.Based on gene coexpression module analysis,we explored the key genes associated with important agronomic traits,such as stone cell formation in fruits.The network regulating the synthesis of lignin,a major component of stone cells,was reconstructed,and receptor-like kinases were implicated as core factors in this regulatory network.Moreover,we constructed the online database PearEXP(http://gffzz20aea264798e4804h6ncv5fq5x9pk6kkn.ffgz.tsg.suse.edu.cn)to enable access to the pear proteogenomic resources.This study provides a paradigm for in-depth proteogenomic studies of woody plants. | Peng Wang Xiao Wu Zebin Shi Shutian Tao Zhe Liu Kaijie Qi Zhihua Xie Xin Qiao Chao Gu Hao Yin Mengyu Cheng Xiaoyu Gu Xueying Liu Chao Tang Peng Cao Shaohang Xu Baojin Zhou Tingting Gui Yangyang Bian Juyou Wu Shaoling Zhang | 2023 | Molecular Plant2023，16，3： | 0 |
| 14 | A pH-response chemotherapy synergistic photothermal therapy for tumor suppression and bone regeneration by mussel-inspired Mg implant显示文摘Primary malignant bone tumors can be life-threatening.Surgical resection of tumor plus chemotherapy is the standard clinical treatment.However,postoperative recovery is hindered due to tumor recurrence caused by residual tumor cells and bone defect caused by resection of tumor tissue.Herein,a multifunctional mussel-inspired film was fabricated on Mg alloy,that is,an inner hydrothermal-treated layer,a middle layer of polydopamine,and an outer layer of doxorubicin.The modified Mg alloy showed excellent photothermal effect and thermal/pH-controlled release of doxorubicin.The synergistic effect of chemotherapy and photothermal therapy enabled the modified Mg alloy to kill bone tumor in vitro and inhibit tumor growth in nude mice.Moreover,because of the controlled release of Mg ions and biocompatibility of polydopamine,the modified Mg alloy supported extracellular matrix mineralization,alkaline phosphatase activity,and bone-related gene expression in C3H10T1/2.Bone implantation model in rats verified that the modified Mg showed excellent osteointegration.These findings prove that the use of mussel-inspired multifunction film on Mg alloy offers a promising strategy for the therapy of primary malignant bone tumor. | Hongwei Shao Shi Cheng Mengyu Yao Xiongfa Ji Hua Zhong DonghuiWang Xiujuan Fan Qian Li Jielong Zhou Yu Zhang Feng Peng | 2021 | Regenerative Biomaterials2021，8，6： | 0 |
| 15 | Enhanced osteogenesis of titanium with nano-Mg(OH)_(2) film and a mechanism study via whole genome expression analysis显示文摘Titanium(Ti)has been the most widely used orthopedic implant in the past decades.However,their inert surface often leads to insufficient osteointegration of Ti implant.To solve this issue,two bioactive Mg(OH)_(2) films were developed on Ti surfaces using hydrothermal treatment(Ti-M1#and Ti-M2#).The Mg(OH)_(2) films showed nano-flake structures:sheets on Ti-M1#with a thickness of 14.7±0.7 nm and a length of 131.5±2.9 nm,and on Ti-M2#with a thickness of 13.4±2.2 nm and a length of 56.9±5.6 nm.Both films worked as Mg ions releasing platforms.With the gradual degradation of Mg(OH)_(2) films,weakly alkaline microenvironments will be established surrounding the modified implants.Benefiting from the sustained release of Mg ions,nanostructures,and weakly alkaline microenvironments,the as-prepared nano-Mg(OH)_(2) coated Ti showed better in vitro and in vivo osteogenesis.Notably,Ti-M2#showed better osteogenesis than Ti-M1#,which can be ascribed to its smaller nanostructure.Moreover,whole genome expression analysis was applied to study the osteogenic mechanism of nano-Mg(OH)_(2) films.For both coated samples,most of the genes related to ECM-receptor interaction,focal adhesion,and TGF-β pathways were upregulated,indicating that these signaling pathways were activated,leading to better osteogenesis.Furthermore,cells cultured on Ti-M2#showed markedly upregulated BMP-4 gene expression,suggesting that the nanostructure with Mg ion release ability can better activate BMP-4 related signaling pathways,resulting in better osteogenesis.Nano-Mg(OH)_(2) films demonstrated a superior osteogenesis and are promising surface modification strategy for orthopedic applications. | Mengyu Yao Shi Cheng Guoqing Zhong Jielong Zhou Hongwei Shao Limin Ma Chang Du Feng Peng Yu Zhang | 2021 | Bioactive Materials2021，6，9： | 0 |
| 16 | Investigation and Aesthetic Assessment of Plant Landscapes in Southwest University of Science and Technology显示文摘Through field investigation and comprehensive analysis, this paper classified green space system on campus of Southwest University of Science & Technology into points, lines and surfaces, and used basic theories of ecology, botany, garden aesthetics, and plant landscape assessment to analyze ornamental characteristics, seasonal changes, spatial layers and cultural connotations of its typical plant landscapes, so as to assess campus plant landscape comprehensively in the near future. | JIANG Tingting YUAN Li CHENG Dandan WANG Mengyu | 2016 | Journal of Landscape Research2016，8，1： | 0 |
| 17 | Control of crystal growth to obtain needle-shaped violet phosphorus with excellent photocatalytic degradation performance显示文摘The control of crystal growth is important but challenging for multi-disciplinary research.Violet phosphorus,the most stable phosphorus allotrope,has recently been produced as a unique semiconducting layered structure.The crystal orientation and morphology bring extra performance due to its unique structure and anisotropy.Herein,the layered violet phosphorus has been controlled to grow along the c-axis to give tunable length up to centimeters with the assistance of tin,while the reported flat bulk ones with thickness are limited to micrometers.The as-produced needle-shaped violet phosphorus has also been demonstrated to significantly enhance the photocatalytic degradation of methyl orange pollutants due to its special crystallographic orientation.About 98.6%of methyl orange pollutants with a concentration of 50 ppm were degraded within 80 min under visible light conditions by needle-shaped violet phosphorus,which is much more effective than that of amorphous red phosphorus with only 14.1%degradation. | Mengting Jin Yanhao Wang Mengyue Gu Xuewen Zhao Rongzheng Zhao Yuhao Zhang Yonghong Cheng Jinying Zhang | 2023 | Nano Research2023，16，2： | 0 |
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