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28篇 您的检索式:作者名="Mengli Li"
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1Elevated plasma levels of selective cytokines in COVID-19 patients reflect viral load and lung injury显示文摘A recent outbreak of pneumonia in Wuhan,China was found to be caused by a 2019 novel coronavirus(2019-nCoV or SARS-CoV-2 or HCoV-19).We previously reported the clinical features of 12 patients with2019-n Co V infections in Shenzhen,China.To further understand the pathogenesis of COVID-19 and find better ways to monitor and treat the disease caused by 2019-n Co V,we measured the levels of 48 cytokines in the blood plasma of those 12 COVID-19 patients.Thirty-eight out of the 48 measured cytokines in the plasma of 2019-n Co V-infected patients were significantly elevated compared to healthy individuals.Seventeen cytokines were linked to 2019-nCoV loads.Fifteen cytokines,namely M-CSF,IL-10,IFN-α2,IL-17,IL-4,IP-10,IL-7,IL-1 ra,G-CSF,IL-12,IFN-γ,IL-1α,IL-2,HGF and PDGF-BB,were strongly associated with the lung-injury Murray score and could be used to predict the disease severity of2019-n Co V infections by calculating the area under the curve of the receiver-operating characteristics.Our results suggest that 2019-nCoV infections trigger extensive changes in a wide array of cytokines,some of which could be potential biomarkers of disease severity of 2019-n Co V infections.These findings will likely improve our understanding of the immunopathologic mechanisms of this emerging disease.Our results also suggest that modulators of cytokine responses may play a therapeutic role in combating the disease once the functions of these elevated cytokines have been characterized.Yingxia Liu Cong Zhang Fengming Huang Yang Yang Fuxiang Wang Jing Yuan Zheng Zhang Yuhao Qin Xiaoyun Li Dandan Zhao Shunwang Li Shuguang Tan Zhaoqin Wang Jinxiu Li Chenguang Shen Jianming Li Ling Peng Weibo Wu Mengli Cao Li Xing Zhixiang Xu Li Chen Congzhao Zhou William J Liu Lei Liu Chengyu Jiang 2020National Science Review2020,7,6:6
2Distribution and removal of antibiotic resistance genes during anaerobic sludge digestion with alkaline, thermal hydrolysis and ultrasonic pretreatments显示文摘Sewage sludge in the wastewater treatment plants contains considerable amount of antibiotic resistance genes (ARGs). A few studies have reported that anaerobic digestion (AD) could successfully remove some ARGs from sewage sludge, but information on the fate of ARGs in sludge pretreatment-AD process is still very limited. In this study, three sludge pretreatment methods, including alkaline, thermal hydrolysis and ultrasonic pretreatments, were compared to investigate the distribution and removal of ARGs in the sludge pretreatment-AD process. Results showed that the ARGs removal efficiency of AD itself was approximately 50.77%, and if these three sludge pretreatments were applied, the total ARGs removal efficiency of the whole pretreatment-AD process could be improved up to 52.50%-75.07%. The ultrasonic pretreatment was more efficient than alkaline and thermal hydrolysis pretreatments. Although thermal hydrolysis reduced ARGs obviously, the total ARGs rebounded considerably after inoculation and were only removed slightly in the subsequent AD process. Furthermore, it was found that the total ARGs concentration significantly correlated with the amount of 16S rRNA gene during the pretreatment and AD processes, and the bacteria carrying ARGs could be mainly affiliated with Proteobacteria.Mengli Wang Ruying Li Qing Zhao 2019Frontiers of Environmental Science & Engineering2019,13,3:5
3Comparison of nonhuman primates identified the suitable model for COVID-19显示文摘Identification of a suitable nonhuman primate(NHP)model of COVID-19 remains challenging.Here,we characterized severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in three NHP species:Old World monkeys Macaca mulatta(M.mulatta)and Macaca fascicularis(M.fascicularis)and New World monkey Callithrix jacchus(C.jacchus).Infected M.mulatta and M.fascicularis showed abnormal chest radiographs,an increased body temperature and a decreased body weight.Viral genomes were detected in swab and blood samples from all animals.Viral load was detected in the pulmonary tissues of M.mulatta and M.fascicularis but not C.jacchus.Furthermore,among the three animal species,M.mulatta showed the strongest response to SARS-CoV-2,including increased inflammatory cytokine expression and pathological changes in the pulmonary tissues.Collectively,these data revealed the different susceptibilities of Old World and New World monkeys to SARS-CoV-2 and identified M.mulatta as the most suitable for modeling COVID-19.Shuaiyao Lu Yuan Zhao Wenhai Yu Yun Yang Jiahong Gao Junbin Wang Dexuan Kuang Mengli Yang Jing Yang Chunxia Ma Jingwen Xu Xingli Qian Haiyan Li Siwen Zhao Jingmei Li Haixuan Wang Haiting Long Jingxian Zhou Fangyu Luo Kaiyun Ding Daoju Wu Yong Zhang Yinliang Dong Yuqin Liu Yinqiu Zheng Xiaochen Lin Li Jiao Huanying Zheng Qing Dai Qiangming Sun Yunzhang Hu Changwen Ke Hongqi Liu Xiaozhong Peng 2020Signal Transduction and Targeted Therapy2020,5,1:5
4Promotion of Mn Doped Co/CNTs Catalysts for CO Hydrogenation to Light Olefins显示文摘与各种各样的内容, Mn 被介绍进支持的碳 nanotubes ( CNT )钴催化剂和获得的 Mn-Co/CNTs 催化剂被调查让公司加氢点亮链烯并且由 N2 吸附描绘了,X光检查衍射( XRD ),X光检查光电子系列( XPS ), H2 温度规划了减小( TPR ),公司温度规划了解吸附作用( TPD )和传播电子显微镜( TEM )。结果显示到支持 CNTs 的公司催化剂的 Mn (0.3 wt%) 的小数量的增加显著地增加了 C2C4 石蜡的选择并且减少 CH4 的选择。与到钴催化剂的 Mn 的进一步的增加,然而, CH4 选择与 C5+ 选择的增加一起显然减少了。与 unpromoted 催化剂相比,支持 Mn 的钴催化剂增加了 C2C4/C20C40 臼齿的比率。Liping Tang Chengli Song Xiaolong Yang Mengli Li Bin Hu 2013Chinese Journal of Chemistry2013,31,6:4
5Study of K/Mn-MgO Supported Fe Catalysts with Fe(CO)5 and Fe(NO3)3 as Precursors for CO Hydrogenation to Light Alkenes显示文摘二 K/Mn-MgO 支持了催化剂被 Fe (公司) 准备 5 并且 Fe (NO3 ) 3 是先锋分别地。获得的 Fe-K/Mn-MgO 催化剂被测试让公司加氢点亮链烯并且由 X 光检查描绘了粉末衍射(XRD ) , X 光检查光电子系列(XPS ) , H2 规划温度的减小(H2-TPR ) , H2,公司和 CO2 规划温度的解吸附作用(H2, CO/CO2-TPD ) 并且传播电子显微镜(TEM ) 。结果显示有装载的 10 wt% Fe 的催化剂由 Fe (公司) 准备了 5 当先锋显示了在 syngas 的更好的性能比从 Fe (NO3 ) 获得的点亮链烯 3 作为先锋,在 CO 变换是 62.50% ,选择在 350 摀畲獧是 55.95% 的地方吗?Liping Tang Chengli Song Mengli Li Xiaolong Yang Bin Hu 2013Chinese Journal of Chemistry2013,31,10:3
6In vitro comparison of the hemocompatibility of diamond-like carbon and carbon nitride coatings with different atomic percentages of N显示文摘Carbon nitride (CNx) and diamond-like carbon (DLC) coatings were prepared by dc magnetron sputtering at room temperature. Different partial pressures of N2 were used to synthesize CNx to evaluate the relationship between the atomic percentage of nitrogen and hemocompatibility. Auger electron spectroscopy and atomic force microscopy indicated atomic percentages of N of 0.12 and 0.22 and that the CNx coatings were smooth. An in vitro study of the hemocompatibility of the coatings revealed that both CNx coatings had better anticoagulant properties and lower platelet adhesion than DLC. Compared with CN0.12, the CN0.22 coating showed longer dynamic clotting time (about 42 min), static clotting time (23.6 min) and recalcification time (45.6 s), as well as lower platelet adhesion (102 cells μm 2), aggregation, and activation. The presence of nitrogen in the CNx coatings induced their enhanced hemocompatibility compared with DLC.ZHAO MengLi LI DeJun ZHANG YiTeng GUO MeiXian DENG XiangYun GU HanQing WAN RongXin 2012Science China(Life Sciences)2012,55,4:3
7Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells显示文摘Neutrophil extracellular traps(NETs)can capture and kill viruses,such as influenza viruses,human immunodeficiency virus(HIV),and respiratory syncytial virus(RSV),thus contributing to host defense.Contrary to our expectation,we show here that the histones released by NETosis enhance the infectivity of SARS-CoV-2,as found by using live SARS-CoV-2 and two pseudovirus systems as well as a mouse model.The histone H3 or H4 selectively binds to subunit 2 of the spike(S)protein,as shown by a biochemical binding assay,surface plasmon resonance and binding energy calculation as well as the construction of a mutant S protein by replacing four acidic amino acids.Sialic acid on the host cell surface is the key molecule to which histones bridge subunit 2 of the S protein.Moreover,histones enhance cell-cell fusion.Finally,treatment with an inhibitor of NETosis,histone H3 or H4,or sialic acid notably affected the levels of sgRNA copies and the number of apoptotic cells in a mouse model.These findings suggest that SARS-CoV-2 could hijack histones from neutrophil NETosis to promote its host cell attachment and entry process and may be important in exploring pathogenesis and possible strategies to develop new effective therapies for COVID-19.Weiqi Hong Jingyun Yang Jun Zou Zhenfei Bi Cai He Hong Lei Xuemei He Xue Li Aqu Alu Wenyan Ren Zeng Wang Xiaohua Jiang Kunhong Zhong Guowen Jia Yun Yang Wenhai Yu Qing Huang Mengli Yang Yanan Zhou Yuan Zhao Dexuan Kuang Junbin Wang Haixuan Wang Siyuan Chen Min Luo Ziqi Zhang Tiangi Lu Li Chen Haiying Que Zhiyao He Qiu Sun Wei Wang Guobo Shen Guangwen Lu Zhiwei Zhao Li Yang Jinliang Yang Zhenling Wang Jiong Li Xiangrong Song Lunzhi Dai Chong Chen Jia Geng Maling Gou Lu Chen Haohao Dong Yong Peng Canhua Huang Zhiyong Qian Wei Cheng Changfa Fan Yuquan Wei Zhaoming Su Aiping Tong Shuaiyao Lu Xiaozhong Peng Xiawei Wei 2022Cellular & Molecular Immunology2022,19,5:2
8MiR146a-loaded engineered exosomes released from silk fibroin patch promote diabetic wound healing by targeting IRAK1显示文摘Unhealable diabetic wounds need to be addressed with the help of newer,more efficacious strategies.Exosomes combined with biomaterials for sustained delivery of therapeutic agents are expected to bring new hope for chronic wound treatment.Here,the engineered exosomes modified for efficiently loading miR146a and attaching to silk fibroin patch(SFP)were demonstrated to promote diabetic wound healing.Silk fibroin binding peptide(SFBP)was screened through phage display,and SFBP-Gluc-MS2(SGM)and pac-miR146a-pac fusion protein were constructed.The designed exosomes(SGM-Exos,miR146a-Exos,and SGM-miR146a-Exos)were isolated from the engineered placental mesenchymal stem cells(PMSCs)transduced with SGM or/and pac-miR146a-pac protein.Gluc signals indicated SGM-Exo@SFP markedly increased the binding rate and the stability of SGM-Exo.Moreover,the loading efficiency of miR146a in SGM-miR146a-Exos was ten-fold higher than that in miR146a-Exos.Superior to untreated,SGM-miR146a-Exo-only treated,and SFP-only treated groups,SGM-miR146a-Exo@SFP drived wound healing associated with less inflammation,collagen deposition,and neovascularization.The transcriptomics analysis suggested anti-inflammatory and regenerative effects with SGM-miR146a-Exo@SFP treatment.Here,we show efficient exosome@biomaterial-based miRNA delivery systems for regenerative medicine and tissue engineering.Qiankun Li Wenzhi Hu Qilin Huang Jie Yang Bingmin Li Kui Ma Qian Wei Yaxi Wang Jianlong Su Mengli Sun Shengnan Cui Rungong Yang Haihong Li Xiaobing Fu Cuiping Zhang 2023Signal Transduction and Targeted Therapy2023,8,3:2
9Robust temperature control for microwave heating of ceramics显示文摘Beale Guy O LI Mengli 1997IEEE Transactions on IndustrialElectronics1997,44,1:1
10A chromosome-scale genome assembly of Dasypyrum villosum provides insights into its application as a broad-spectrum disease resistance resource for wheat improvement显示文摘Dasypyrum villosum is one of the most valuable gene resources in wheat improvement,especially for disease resistance.The mining of favorable genes from D.villosum is frustrated by the lack of a whole genome sequence.In this study,we generated a doubled-haploid line,91C43^(DH),using microspore culture and obtained a 4.05-GB high-quality,chromosome-scale genome assembly for D.villosum.The assembly contains39727 high-confidence genes,and 85.31% of the sequences are repetitive.Two reciprocal translocation events were detected,and 7VS-4VL is a unique translocation in D.villosum.The prolamin seed storage protein-coding genes were found to be duplicated;in particular,the genes encoding low-molecular-weight glutenin at the Glu-V3 locus were significantly expanded.RNA sequencing(RNA-seq)analysis indicated that,after Blumeria graminearum f.sp tritici(Bgt)inoculation,there were more upregulated genes involved in the pattern-triggered immunity and effector-triggered immunity defense pathways in D.villosum than in Triticum urartu.MNase hypersensitive sequencing(MH-seq)identified two Bgt-inducible MH sites(MHSs),one in the promoter and one in the 3'terminal region of the powdery mildew resistance(Pm)gene NLR1-V.Each site had two subpeaks and they were termed MHS1(MHS1.1/1.2)and MHS2(MHS2.1/2.2).Bgt-inducible MHS2.2 was uniquely present in D.villosum,and MHS1.1 was more inducible in D.villosum than in wheat,suggesting that MHSs may be critical for regulation of NLR1-V expression and plant defense.In summary,this study provides a valuable genome resource for functional genomics studies and wheat-D.villosum introgression breeding.The identified regulatory mechanisms may also be exploited to develop new strategies for enhancing Pm resistance by optimizing gene expression in wheat.Xu Zhang Haiyan Wang Haojie Sun Yingbo Li Yilong Feng Chengzhi Jiao Mengli Li Xinying Song Tong Wang Zongkuan Wang Chunxia Yuan Li Sun Ruju Lu Wenli Zhang Jin Xiao Xiue Wang 2023Molecular Plant2023,16,2:1
11Localization in Supermarket Based on RFID Technology显示文摘Song Wei LI Mengli 2012Procedia Engineering2012,29,:1
12Realizing a“solid to solid”process via in situ cathode electrolyte interface(CEI)by solvent-in-salt electrolyte for Li-S batteries显示文摘Lithium-sulfur batteries(LSBs)are regarded as the most promising next-generation energy system due to their high theoretical energy density.However,LSBs suffer the“shuttle effect”if undergoing the solid-liquid-solid sulfur conversion process during cycling.Herein,we design a solvent-in-salt(SIS)electrolyte with co-solvent vinylene carbonate(VC)to synthesize an in situ dense cathode electrolyte interface(CEI)and successfully change sulfur conversion into a solid-solid way to avoid shuttle effect by separating the contact of sulfur and ether solvent.Dense CEI is formed at the beginning of first discharge by the combined action of SIS electrolyte and filmogen VC.Experiments and simulations show that SIS electrolyte controls the initial formed lithium polysulfides(LiPSs)to stay very closely on the cathode surface,and then converts them into a dense CEI film.As a result,Coulombic efficiency(above 99%)and cycling performance of LSBs are improved.Furthermore,the in situ dense CEI can nearly stop the self-discharge of LSBs,and enable the LSBs to work under a pretty lean electrolyte condition.Jiajun Huang Mengli Tao Weifeng Zhang Guangli Zheng Li Du Zhiming Cui Xiujun Wang Zhenxing Liang Shijun Liao Huiyu Song 2023Nano Research2023,16,4:1
13An implantable antibacterial drug-carrier:Mesoporous silica coatings with size-tunable vertical mesochannels显示文摘Implant-associated bacterial infection remains one of the most common and serious complications.Therefore,a surface boasting long-term antibacterial ability for implants is highly desirable.Herein,mesoporous silica coatings(MSCs)with vertical and size-tunable mesochannels are fabricated on a variety of metal substrates via a nano-interfacial oriented assembly approach.Such facile and versatile approach relies on the vertically oriented fusion of composite micelles on the nanoscale flatness surface of substrates.Such orientation assembly process endows the MSCs with vertical mesochannels,tunable mesopore size(ca.5.5-13.5 nm),and switchable substrates even with complex and diversified surfaces.Importantly,the MSCs on titanium substrates(Ti@MSCs)exhibit excellent performances for drug adsorption and sustained release.The saturation adsorption capacity can reach 0.544 μg·cm^(-2) towards minocycline hydrochloride(MC-HCl)antibiotic molecules,which is 6.5 times as the bare titanium(Ti)substrate.In addition,the drug release time can be controlled from 84 to 216 h by simply adjusting the mesopore size.As a proof of concept,the Ti@MSCs can realize a higher antibacterial rate(95.9%),compared with the bare Ti(70.3%).The results highlight the high potential of MSCs as implant coating for long-term preventing and eliminating peri-implantitis.Mengli Liu Fang Huang Chin-Te Hung Liwei Wang Wei Bi Yupu Liu Wei Li 2022Nano Research2022,15,5:1
14Application ofthe Al2O3-PVDF nanocomposite tubular ultrafiltration(UF)membrane for oily wastewater treatment and itsantifouling research显示文摘Lu Yan Sun Hong Li Mengli 2009Sep Purif Technol2009,66,:1
15Characterization of a Tn MAVS protein from Tetraodon nigroviridis显示文摘Zhiming Xiang Lin Qi Weijian Chen Chuanfu Dong Zhaoyu Liu Dong Liu Mengli Huang Wei Li Gan Yang Shaoping Weng Jianguo He 2011Developmental and Comparative Immunology2011,,11:1
16Characterization of microbial diversity and community in water flooding oil reservoirs in China显示文摘Lingxia Zhao Ting Ma Mengli Gao Peike Gao Meina Cao Xudong Zhu Guoqiang Li 2012World Journal of Microbiology and Biotechnology2012,,10:1
17Effect of pH on biologic degradation of Microcystis aeruginosa by alga-lysing bacteria in sequencing batch biofilm reactors显示文摘In this paper, the effect of pH on biological degradation of Microcystis aeruginosa by alga-lysing bacteria in laboratory-scale sequencing batch biofilm reactors (SBBRs) was investigated. After 10 d filming with waste activated sludge, the biological film could be formed, and the bioreactors in which laid polyolefin resin filler were used to treat algal culture. By comparing the removal efficiency of chlorophyll a at different aerobic time, the optimum time was determined as 5 h. Under pH 6.5, 7.5, and 8.5 conditions, the removal rates of Microcystis aeruginosa were respectively 75.9%, 83.6%, and 78.3% (in term of chlorophyll a), and that of Chemical Oxygen Demand (CODMn) were 30.6%, 35.8%, and 33.5%. While the removal efficiencies of ammonia nitrogen (NH+ -N) were all 100%. It was observed that the sequence of the removal efficiencies of algae, NH+ -N and organic matter were pH 7.5 〉 pH 8.5 〉 pH 6.5. The results showed that the dominant alga-lysing bacteria in the SBBRs was strain HM-01, which was identified as Bacillus sp. by Polymerase Chain Reaction (PCR) amplification of the 16S rRNA gene, Basic Local Alignment Search Tool (BLAST) analysis, and compar- ison with sequences in the GenBank nucleotide database. The algicidal activated substance which HM-01 strain excreted could withstand high temperature and pressure, also had better hydrophily and stronger polarity.Hongjing LI Mengli HAO Jingxian LIU Chen CHEN Zhengqiu FAN Xiangrong WANG 2012Frontiers of Environmental Science & Engineering2012,6,2:1
18Soft-to-hard templating 到经由一个壶碳 / 硅石来源 copolymerization 的分散得好的做 N 的 mesoporous 碳 nanospheres显示文摘这里,我们报导一条新途径为很好驱散的做 N 的 mesoporous 碳 nanospheres (MCN ) 的合成经由碳来源(多巴胺) 和硅石来源(tetraethyl orthosilicate ) 的 copolymerization 作为 soft-to-hard templating 策略参考了,它为电气化学的 supercapacitor 展出高效。这个方法分别地克服不受管束的 dispersity 和软模板或难模板的方法的复杂过程的缺点。而且,综合 MCN 特征在一个壶合成期间由高贵金属的 nanoparticles 充实 heteroatom 做 N 和容易的 functionalization。所有上述字符在许多应用程序使同样准备的 MCN 成为一个有希望的平台。表明综合做氮的 MCN 的适用性,这材料为高效的电气化学的 supercapacitor 作为一个电极被采用了,它显示出 223 和 140 的一个电容 ? 在 0.5 和 10 的当前的密度的 F/g ? 在 1 的 A/g ? mol/L KOH 电解质分别地。Qinglu Kong Lingxia Zhang Min Wang Mengli Li Heliang Yao Jianlin Shi 2016Science Bulletin2016,61,15:1
19Highly stable hybrid single-micelle:A universal nanocarrier for hydrophobic bioimaging agents显示文摘As the first-line technology,micelles play a pivotal role in in vivo delivery of theranostic agents because of their high biocompatibility and universality.However,in complex physiological environments(extreme dilution,pH,and oxidation or reduction,etc.),they generally suffer from structural instability and insufficient protection for encapsulated cargos.It is urgent to reinforce the structural stability of the micelles at the single-micelle level.By using the FDA-approved Pluronic F127 surfactants and indocyanine green(ICG)bioimaging agents as model,herein,we propose the silane-crosslinking assisted strategy to reinforce the structural stability of the single-micelle.Different from the traditional silane hydrolysis under the harsh experimental conditions(acidic,alkaline,and high temperature hydrothermal,etc.),the ICG loaded F127@SiO_(2) hybrid single-micelles(ICG@H-micelles)with controllable sizes(15-35 nm)are synthesized at neutral pH and room temperature,which is crucial for the maintenance of the physicochemical properties of the encapsulated cargos.With the ultra-thin SiO_(2)(<5 nm)at hydrophilic layer of the single-micelle,the structural and fluorescence stability of ICG@H-micelles are much higher than the conventional micelle(ICG@micelles)in the simulated physiological environments of dilution,oxidation or reduction,and low pH.Because of the high structural and fluorescence stability,the ICG@H-micelles also exhibit longer duration time in the tumor and gastrointestinal tract bioimaging.Qiaoyu Zhou Tiancong Zhao Mengli Liu Dongrui Yin Minchao Liu Ahmed AElzatahry Fan Zhang Dongyuan Zhao Xiaomin Li 2022Nano Research2022,15,5:1
20Clinical characteristics and vaccine effectiveness against SARS-CoV-2 Omicron subvariant BA.2 in the children显示文摘Dear Editor,The Omicron variant of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has rapidly replaced the Delta variant as a dominating SARS-CoV-2 variant because of natural selection,which favors the variant with higher infectivity and stronger vaccine breakthrough ability.1 Among three lineages BA.1(B.1.1.529.1),BA.2(B.1.1.529.2),and BA.3(B.1.1.529.3)of Omicron,BA.2 is rising rapidly worldwide since January 2022 and become a new dominating“variant of concern”in China.2 With the current surge in Omicron in China,both the absolute number of children hospitalized with COVID-19 and the percentage of total COVID-19 hospitalizations have been boosting recently.Understanding the clinical characteristics of SARS-CoV-2 Omicron subvariant BA.2 in children and the protective effect of vaccines is of great help for epidemic prevention strategies.However,so far no sufficient experimental data have been reported about infectivity,disease severity,vaccine breakthrough capability,and antibody resistance from pediatric BA.2.Xiaohe Li Liwen Wu Youzhi Qu Mengli Cao Jiaqi Feng Hua Huang Yi Liu Hongzhou Lu Quanying Liu Yingxia Liu 2022Signal Transduction and Targeted Therapy2022,7,7:0
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