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| 1 | Microbiota analysis revealed vertical transmission and microbial adjusting function of symbiotic fungus in the attelabid weevil fungiculture显示文摘Dear Editor,Microbial symbionts are crucial participants in the life history of fungus-farming insects (Mueller et al., 2005;Youngsteadt, 2008). The attelabid weevil (Euops chinensis)feeding on Fallopia japonica in southern China, has evolved a special proto-farming bipartite symbiosis with the fungus(Penicillium herquei), which produces antibiotic (+)-scleroderolide in the leaf-rolls ('cradle' for offspring development) to protect the offspring from potential microbial parasites and pathogens (Sakurai, 1985;Wang et al., 2015). | Bin Lin Lin Wang Muzammi Hussain Xiaoling Zhang Jianqing Tian Sha Qi Xingzhong Liu Meichun Xiang | 2019 | Science China(Life Sciences)2019，62，12： | 3 |
| 2 | T1 locus in cotton is the candidate gene affecting lint percentage, fiber quality and spiny bollworm (Earias spp.) resistance显示文摘 | Qun Wan Zhengsheng Zhang Meichun Hu Li Chen Dajun Liu Xiao Chen Wei Wang Jing Zheng | 2007 | Euphytica (-)2007，，1： | 1 |
| 3 | Applying latent tree analysis to classify Traditional Chinese Medicine syndromes(Zheng)in patients with psoriasis vulgaris显示文摘OBJECTIVE:To treat patients with psoriasis vulgaris using Traditional Chinese Medicine(TCM),one must stratify patients into subtypes(known as TCM syndromes or Zheng)and apply appropriate TCM treatments to different subtypes.However,no unified symptom-based classification scheme of subtypes(Zheng)exists for psoriasis vulgaris.The present paper aims to classify patients with psoriasis vulgaris into different subtypes via the analysis of clinical TCM symptom and sign data.METHODS:A cross-sectional survey was carried out in Beijing from 2005-2008,collecting clinical TCM symptom and sign data from 2764 patients with psoriasis vulgaris.Roughly 108 symptoms and signs were initially analyzed using latent tree analysis,with a selection of the resulting latent variables then used as features to cluster patients into subtypes.RESULTS:The initial latent tree analysis yielded a model with 43 latent variables.The second phase of the analysis divided patients into three subtype groups with clear TCM Zheng connotations:'blood deficiency and wind dryness';'blood heat';and'blood stasis'.CONCLUSIONS:Via two-phase analysis of clinic symptom and sign data,three different Zheng subtypes were identified for psoriasis vulgaris.Statistical characteristics of the three subtypes are presented.This constitutes an evidence-based solution to the syndromedifferentiation problem that exists with psoriasis vulgaris. | XU Wenjie ZHANG Nevin L. LI Ping WANG Tianfang CHEN Weiwen LIU April H. MOHLER-KUO Meichun | 2022 | Journal of Traditional Chinese Medicine2022，42，1： | 1 |
| 4 | Mechanical properties and crystallization of Poly(L-lactide) films with several percents of ACR nanoparticles显示文摘 | Ningjing Wu Meichun Ding Jianming Zhang Runxiong Lin | 2012 | Materials Letters2012，，： | 1 |
| 5 | Common genetic heterogeneity of human interleukin-37 leads to functional variance显示文摘Interleukin-37(IL-37)is an inhibitory member of the IL-1 family of cytokines.We previously found that balanced selection maintains common variations of the human IL37 gene.However,the functional consequences of this selection have yet to be validated.Here,using cells expressing exogenous IL-37 variants,including IL-37 Ref and IL-37 Var1 and Var2,we found that the three variants of IL-37 exhibited different immunoregulatory potencies in response to immune stimulation.The protein level of IL-37 Var2 was found to be significantly less than that of IL-37 Ref or Var1,despite the comparable mRNA levels of all three variants.Further study showed that IL-37 Var2 was rapidly degraded by a proteasome-dependent mechanism mediated by enhanced polyubiquitination,leading to a transient upregulation of IL-37 Var2 after immune stimulation.Finally,when ectopically expressed in cells,human IL-37 Var2 exerted less inhibition on proinflammatory cytokine production than did other IL-37 variants.Conversely,purified extracellular IL-37 variant proteins demonstrated comparable inhibitory abilities in vitro.In conclusion,our study reveals that common genetic variants of IL37 lead to different immune-inhibitory potencies,primarily as a result of differences in IL-37 protein stability,suggesting the possible involvement of these variants in various human diseases. | Jingjing Yan Yuling Zhang Shimeng Cheng Bin Kang Jinbiao Peng Xiaodan Zhang Meichun Yuan Wenqi Chu Wen Zhang Jiayin Shen Shuye Zhang | 2017 | Cellular & Molecular Immunology2017，14，9： | 1 |
| 6 | Phase separation of Nur77 mediates XS561-induced apoptosis by promoting the formation of Nur77/Bcl-2 condensates显示文摘The orphan nuclear receptor Nur77 is a critical regulator of the survival and death of tumor cells.The pro-death effect of Nur77 can be regulated by its interaction with Bcl-2,resulting in conversion of Bcl-2 from a survival to killer.As Bcl-2 is overexpressed in various cancers preventing them from apoptosis and promoting their resistance to chemotherapy,targeting the apoptotic pathway of Nur77/Bcl-2 may lead to new cancer therapeutics.Here,we report our identification of XS561 as a novel Nur77 ligand that induces apoptosis of tumor cells by activating the Nur77/Bcl-2 pathway.In vitro and animal studies revealed an apoptotic effect of XS561 in a range of tumor cell lines including MDA-MB-231 triple-negative breast cancer(TNBC)and MCF-7/LCC2 tamoxifen-resistant breast cancer(TAMR)in a Nur77-dependent manner.Mechanistic studies showed XS561 potently induced the translocation of Nur77 from the nucleus to mitochondria,resulting in mitochondria-related apoptosis.Interestingly,XS561-induced accumulation of Nur77 at mitochondria was associated with XS561 induction of Nur77 phase separation and the formation of Nur77/Bcl-2 condensates.Together,our studies identify XS561 as a new activator of the Nur77/Bcl-2 apoptotic pathway and reveal a role of phase separation in mediating the apoptotic effect of Nur77 at mitochondria. | Xiaohui Chen Meichun Gao Yongzhen Xia Xin Wang Jingbo Qin Hongying He Weirong Liu Xiaowei Zhang Shuangzhou Peng Zhiping Zeng Ying Su Xiaokun Zhang | 2024 | Acta Pharmaceutica Sinica B2024，14，3： | 0 |
| 7 | 沃尔巴克氏菌(Wolbachia)结合放射线的应用现场清除白纹伊蚊种群显示文摘《自然》杂志近期发表论文介绍中国、美国、国际原子能机构和澳大利亚科学家通过合作于2014—2017年在中国广东省广州市南沙区和番禺区2个江中沙洲岛屿,开展清除白纹伊蚊即登革病毒主要传播蚊虫的现场研究。该研究结合昆虫绝育技术(sterile insect technique,SIT),通过释放携带沃尔巴克氏菌(Wolbachia)的白纹伊蚊雄蚊,而达到靶向消灭现场野生白纹伊蚊的目的。研究结果显示,此项技术可年平均消灭现场白纹伊蚊83%~94%雌性成蚊和94%蚊卵,在部分区域实现了野生白纹伊蚊种群的灭绝。 | Xiaoying Zheng Dongjing Zhang Yongjun Li Cui Yang Yu Wu Xiao Liang Yongkang Liang Xiaoling Pan Linchao Hu Qiang Sun Xiaohua Wang Yingyang Wei Jian Zhu Wei Qian Ziqiang Yan Andrew GParker jeremie r.l.Gilles Kostas Bourtzis Jeremy Bouyer Moxun tang Bo Zheng Jianshe Yu Julian Liu Jiajia Zhuang Zhigang Hu Meichun Zhang Juntao Gong Xiaoyue Hong Zhoubing Zhang Lifeng Lin Qiyong Liu Zhiyong Hu Zhongdao Wu Luke Anthony Baton Ary AHoffmann Zhiyong Xi 毛伟(编译) 曾琴(编译) 潘晓玲(编译) 梁国栋(审校) | 2019 | 中华实验和临床病毒学杂志2019，33，5： | 0 |
| 8 | Effect of the Two Distinct Bi on the Electronic Structure of BaBiO_(3)显示文摘The band-structure of BaBiO_(3) has been calculated by using LMTO-ASA method to a supercell,in which the breathing-mode displacements of oxygen atoms and two oxidation states of Bi were considered.The results indicate that BaBiO_(3) is a semiconductor with a gap of 1.5eV,which,unlike previous calculations,is essentially consistent with experiments. | ZHANG Zhipeng SHEN Yaowen HUANG Meichun | 1993 | Chinese Physics Letters1993，10，6： | 0 |
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