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| 1 | Foxtail millet:nutritional and eating quality,and prospects for genetic improvement显示文摘Foxtail millet is a minor yet important crop in some areas of the world,particularly northern China.It has strong adaptability to abiotic stresses,especially drought,and poor soil.It also has high nutritional value.Foxtail millet is rich in essential amino acids,fatty acids and minerals,and is considered to be one of the most digestible and non-allergenic grains available and has significant importance for human health.Given foxtail millet’s ability to adapt to abiotic stresses associated with climate change,it is more important than ever to develop breeding strategies that facilitate the increasing demand for high quality grain that better satisfies consumers.Here we review research on foxtail millet quality evaluation,appearance,cooking and eating quality at the phenotypic level.We review analysis of the main nutrients in foxtail millet,their relationships and the biochemical and genetic factors affecting their accumulation.In addition,we review past progress in breeding this regionally important crop,outline current status of breeding of foxtail millet,and make suggestions to improve grain quality. | Lu HE Bin ZHANG Xingchun WANG Hongying LI Yuanhuai HAN | 2015 | Frontiers of Agricultural Science and Engineering2015，2，2： | 8 |
| 2 | Comparison of the short-term and long-term outcomes of laparoscopic hysterectomies and of abdominal hysterectomies: a case study of 4,895 patients in the Guangxi Zhuang Autonomous Region, China显示文摘Background: To evaluate the short-term and long-term outcomes after laparoscopic hysterectomy(LH) compared with abdominal hysterectomy(AH) in case of benign gynecological disease. Methods: A multi-center cohort retrospective comparative study of population among 4,895 hysterectomies(3,539 LH vs.1,356 AH) between 2007 and 2013 was involved. Operative time(OT), estimated blood loss(EBL), intra-operative and post-operative complications, passing flatus; days with indwelling catheter, questionnaires covering pelvic floor functions and sexual functions were assessed.Results: The EBL(174.1±157.4 vs. 263.1±183.2 cc, LH and AH groups, respectively), passing flatus(38.7±14.1 vs. 48.1±13.2 hours), days with indwelling catheter(1.5±0.6 vs. 2.2±0.8 days), use of analgesics(6.5% vs. 73.1%), intra-operative complication rate(2.4% vs. 4.1%), post-operative complication rate(2.3% vs. 5.7%), post-operative constipation(12.1% vs. 24.6%), mild and serious stress urinary incontinence(SUI) post-operative(P<0.001; P=0.014), and proportion of Female Sexual Functioning Index(FSFI) total score <26.55 post-operative(P<0.001) of the LH group were significantly less than those of AH group. There wereno significant differences in OT(106.5±34.5 vs. 106.2±40.3 min) between the two groups.Conclusions: LH is a safe and efficient operation for improving patients' long-term quality of life(Qo L), and LH is a cost-effectiveness procedure for treating benign gynecological disease. LH is superior to AH due to reduced EBL, reduced post-operative pain and earlier passing flatus. | Hongying He Zhijun Yang Dingyuan Zeng Jiangtao Fan Xiaoxia Hu Yuan Ye Hua Bai YanmingJiang Zhong Lin Zhiying Lei Xinlin Li Lian Li Jinghua Gan Ying Lan Xiongzhi Tang Danxia Wang Junsong Jiang Xiaoyan Wu Meiying Li Xiaoqing Ren Xiaomin Yang Mei Liu Qinmei Wang Fuyan jiang Li Li | 2016 | Chinese Journal of Cancer Research2016，28，2： | 6 |
| 3 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 4 | PROTACs: great opportunities for academia and industry显示文摘Although many kinds of therapies are applied in the clinic,drug-resistance is a major and unavoidable problem.Another disturbing statistic is the limited number of drug targets,which are presently only 20–25%of all protein targets that are currently being studied.Moreover,the focus of current explorations of targets are their enzymatic functions,which ignores the functions from their scaffold moiety.As a promising and appealing technology,PROteolysis TArgeting Chimeras(PROTACs)have attracted great attention both from academia and industry for finding available approaches to solve the above problems.PROTACs regulate protein function by degrading target proteins instead of inhibiting them,providing more sensitivity to drug-resistant targets and a greater chance to affect the nonenzymatic functions.PROTACs have been proven to show better selectivity compared to classic inhibitors.PROTACs can be described as a chemical knockdown approach with rapidity and reversibility,which presents new and different biology compared to other gene editing tools by avoiding misinterpretations that arise from potential genetic compensation and/or spontaneous mutations.PRTOACs have been widely explored throughout the world and have outperformed not only in cancer diseases,but also in immune disorders,viral infections and neurodegenerative diseases.Although PROTACs present a very promising and powerful approach for crossing the hurdles of present drug discovery and tool development in biology,more efforts are needed to gain to get deeper insight into the efficacy and safety of PROTACs in the clinic.More target binders and more E3 ligases applicable for developing PROTACs are waiting for exploration. | Xiuyun Sun Hongying Gao Yiqing Yang Ming He Yue Wu Yugang Song Yan Tong Yu Rao | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 3 |
| 5 | Removal of fluorescence and ultraviolet absorbance of dissolved organic matter in reclaimed water by solar light显示文摘Storing reclaimed water in lakes is a widely used method of accommodating changes in the consumption of reclaimed water during wastewater reclamation and reuse. Solar light serves as an important function in degrading pollutants during storage, and its effect on dissolved organic matter(DOM) was investigated in this study. Solar light significantly decreased the UV_(254) absorbance and fluorescence(FLU) intensity of reclaimed water.However, its effect on the dissolved organic carbon(DOC) value of reclaimed water was very limited. The decrease in the UV_(254) absorbance intensity and FLU excitation–emission matrix regional integration volume(FLU volume) of reclaimed water during solar light irradiation was fit with pseudo-first order reaction kinetics. The decrease of UV_(254) absorbance was much slower than that of the FLU volume. Ultraviolet light in solar light had a key role in decreasing the UV_(254) absorbance and FLU intensity during solar light irradiation. The light fluence-based removal kinetic constants of the UV_(254) and FLU intensity were independent of light intensity. The peaks of the UV_(254) absorbance and FLU intensity with an apparent molecular weight(AMW) of 100 Da to 2000 Da decreased after solar irradiation, whereas the DOC value of the major peaks did not significantly change. | Qianyuan Wu Chao Li Wenlong Wang Tao He Hongying Hu Ye Du Ting Wang | 2016 | Journal of Environmental Sciences2016，28，5： | 2 |
| 6 | Sensing cytochrome P4501A1 activity by a resorufin-based isoform-specific fluorescent probe显示文摘Cytochrome P4501 A1(CYP1A1),a heme-containing monooxygenase,is of particular importance for human health because of its vital roles in the metabolic activation of pro-carcinogenic compounds to the carcinogens.Deciphering the relevance of CYP1A1 to human diseases and screening of CYP1A1 modulators require reliable tool(s)for probing this key enzyme in complex biological matrices.Herein,a practical and ultrasensitive fluorescence-based assay for real-time sensing CYP1A1 activities in biological systems has been developed,via designing an isoform-specific fluorogenic sensor for CYP1A1(CHPO).The newly developed fluorogenic substrate for CYP1A1 has been carefully investigated in terms of specificity,sensitivity,precision,quantitative linear range and the anti-interference ability.The excellent selectivity,strong anti-interference ability and fast response kinetics,making the practicability of CHPObased CYP1A1 activity assay is better than that of most reported CYP1A1 activity assays.Furthermore,CHPO has been successfully used for imaging CYP1A1 activities in living cells and human tissues,as well as for high-throughput screening of CYP1A1 inhibitors using tissue preparations as enzyme sources.Collectively,this study provided a practical fluorogenic sensor for real-time sensing CYP1A1 in complex biological systems,which would strongly facilitate the investigations on the relevance of CYP1A1 to human diseases and promote high-throughput screening of CYP1A1 modulators for biomedical applications. | Qiang Jin Hongying Ma Lei Feng Ping Wang Rongjing He Jing Ning Ling Yang Guangbo Ge | 2020 | Chinese Chemical Letters2020，31，11： | 2 |
| 7 | Separation of two constituents from purple sweet potato by combination of silica gel column and high-speed counter-current chromatography显示文摘 | Kai He Xiaoli Ye Xuegang Li Hongying Chen Lujiang Yuan Yafei Deng Xin Chen Xiaoduo Li | 2011 | Journal of Chromatography B2011，，： | 1 |
| 8 | The genetic control of glabrous glume during African rice domestication显示文摘African cultivated rice,Oryza glaberrima,is characterized by its glabrous glumes.During domestication,the pubescent glumes of its wild ancestor,Oryza barthii,lost their trichomes,and in this study,we show that glabrous glume 5(GLAG5),a WUSCHEL-like homeobox transcription factor gene on chromosome 5,is required for trichome development.DNA methylation associated with an hATtransposable element inserted in the promoter region of GLAG5 is found to reduce its expression,leading to the formation of glabrous glumes and leaves in African cultivated rice.Among 82 African cultivated rice varieties investigated in this study,59(approximately 71%)lines exhibit glabrous glumes and harbor the hAT transposon;however,the other 23 varieties(approximately 29%),which exhibit pubescent glumes,lack the hAT transposon,indicating that glag5 had undergone strong artificial selection.Theπ;/π;ratios also show the hAT transposon insertions influence the genetic diversity of an approximately 150-kb interval encompassing the GLAG5 locus.The identification of the GLAG5 gene provides new insights into the domestication of cultivated rice in Africa.We speculate that the selection of varieties with mutations in their promoter regions is an important aspect of crop domestication. | Leqin Chang Min Hu Jing Ning Wei He Jiayu Gao Marie-Noelle Ndjiondjop Yongcai Fu Fengxia Liu Hongying Sun Ping Gu Chuanqing Sun Zuofeng Zhu | 2022 | Journal of Genetics and Genomics2022，49，5： | 1 |
| 9 | Effects of Litter Removal and Addition on Soil Nitrogen Mineralization of Eucalyptus Plantation显示文摘[Objectives]This study was conducted to understand the process of soil nitrogen mineralization in Eucalyptus plantations,and to identify the characteristics of soil nitrogen mineralization with different litter inputs.[Methods]With the soil of the Eucalyptus plantation in Fusui County,Guangxi as the research object,the soil nitrogen mineralization of the Eucalyptus plantation under different litter treatments(removing litter,adding litter and retaining litter)was studied by PVC tube closed-top in-situ incubation.[Results]①After 1 year of litter treatment,the inorganic nitrogen(NH_(4)^(+)-N+NO_(3)^(-)-N)in the soil of different treatments ranked as adding litter(20.15 mg/kg)>retaining litter(16.02 mg/kg)>removing litter(11.60) mg/kg),and the differences reached a significant level(P<0.05).②After 30 d of in-situ incubation,there were significant differences in soil nitrate nitrogen content before and after incubation in the three treatments(removing litter,adding litter,and retaining litter)before and after incubation(P<0.05),but no significant differences were observed in soil ammonium nitrogen content(P>0.05).Soil nitrate nitrogen contents increased from 1.47,2.01 and 1.72 mg/kg before incubation to 3.66,6.73 and 5.02 mg/kg,respectively,and soil ammonium nitrogen content increased from 11.60,20.15 and 16.02 mg/kg before incubation to 13.65,21.54 and 17.18 mg/kg,respectively.The net nitrogen mineralization quantities of the three treatments were 4.24,6.11 and 4.46 mg/kg,respectively,and the net nitrogen mineralization rates from large to small were adding litter[0.180 mg/(kg·d)]>retaining litter[0.141 mg/(kg·d)]>removing litter[0.125 mg/(kg·d)].Therefore,both removal and addition of litter affected the soil nitrogen input and nitrogen mineralization rate of the Eucalyptus plantation,thereby affecting soil nitrogen availability and the ability of soil to maintain plant-available nitrogen.[Conclusions]This study provides a theoretical basis for nutrient management in Eucalyptus plantations,especially nitrogen nutrient management. | Wanpeng LU Hongying LIU Chunning LI Bin HE | 2022 | Agricultural Biotechnology2022，11，3： | 1 |
| 10 | Ore-bearing Formations and Mineral Resource Prospects of the Peripheral Areas of the Tarim Block显示文摘The tectonic development of the Tarim block has experienced four stages, i. e. Earth’s core accretion and block formation in the Precambrian, margin splitting, opening-closing and piecing up in the Early Palaeozoic, rift formation and plate unification in the Late Palaeozoic, and basin-mountain coupling and landform shaping in the Meso-Cenozoic, forming six ore-bearing formations and ore deposits of various genetic types in the Tianshan Mountains, Kunlun Mountains and Altun Mountains. In the peripheral areas of Tarim there are four giant intercontinental metallogenic belts passing through, the Central Tianshan and southwestern Tianshan belts in the former USSR and the Qinling-Qilian-Kunlun and Palaeo-Tethys belts in China. According to the macro-analysis on the nearly one thousand known deposits (occurrences) and geophysical-geochemical anomalies, and the information from reconnaissance in some areas, the region has very good prospects for mineral resources. Some of the metallogenic belts may well | HE Jurui RUI Xinjian GUO Kunyi WU Quanhuai LIU Hongying WANG Futong SUN Chuanmin | 2000 | Acta Geologica Sinica(English Edition)2000，74，3： | 1 |
| 11 | The distribution and economic losses of alien species invasion to China显示文摘 | Haigen Xu Hui Ding Mingyan Li Sheng Qiang Jianying Guo Zhengmin Han Zongguo Huang Hongying Sun Shunping He Hairong Wu Fanghao Wan | 2006 | Biological Invasions2006，，7： | 1 |
| 12 | Utility function of TCP Reno under precise end-to-end drop probability显示文摘TCP Reno can be regarded as a distributed algorithm over the Internet to maximize aggregate utility subject to capacity.The equilibrium reached by the interaction of many competing TCPs,each implemented only on the source and destination computers,is effectively maximizing an objective function for the entire network.In this paper,a new utility function is derived for TCP Reno under the precise end-to-end drop probability.The results show theoretically that the TCP Reno model proposed by Kelly [1] is reasonable.And simulation results are provided. | LIU Ying LI He LIU HongYing | 2013 | Science China(Information Sciences)2013，56，1： | 0 |
| 13 | Effects of temperature and particle size on the thermophysical properties of six plant-origin protein supplements显示文摘Reasonable design of the parameters of thermal processing such as conditioning and cooling according to formula changes of pelleted feeds has always been a serious challenge for Chinese feed mills and feed equipment manufacturers. Studying the thermophysical properties of different protein feeds under different temperatures and particle sizes will facilitate the equipment design, parameter optimization, and simulation for the thermal processing of pelleted feeds. In this study, the specific heat (Cp), thermal conductivity (kb), and thermal diffusivity (α) of six plant protein supplements with three particle sizes were determined over a temperature range of 25℃-100℃. The differences in Cp, kb, and α among different feedstuffs and particle sizes were analyzed and the influences of temperature and particle size on these properties were evaluated. Results showed that the Cp, kb, and α of all the feedstuffs increased with increasing temperature and varied from 1.622 to 2.417 kJ/(kg∙℃), 0.080 to 0.362 W/(m∙℃), 6.379×10^(-8) to 21.984×10^(-8) m^(2)/s, respectively. To rise to the same temperature, the distiller’s dried grain with solubles (DDGS) needed to absorb 3% more heat than that required for soybean meal (SBM), while the rest four feedstuffs just needed to absorb 93%-98% heat for SBM. Particle size had no significant effect on Cp for all the feedstuffs (p>0.05). However, descending trends in kb and α were observed with increasing particle size for a certain feedstuff at the same bulk density. In addition, regression equations with only statistically significant terms were developed to describe Cp, kb, and α as a function of temperature and particle size for six feedstuffs. The results can provide basic theory and data for the optimization of thermal processing parameters required for the plant-protein ingredient change in compound feed formulations. | Dandan Kong Jiyuan Chen Hongying Wang Yong He | 2023 | International Journal of Agricultural and Biological Engineering2023，16，6： | 0 |
| 14 | Phase separation of Nur77 mediates XS561-induced apoptosis by promoting the formation of Nur77/Bcl-2 condensates显示文摘The orphan nuclear receptor Nur77 is a critical regulator of the survival and death of tumor cells.The pro-death effect of Nur77 can be regulated by its interaction with Bcl-2,resulting in conversion of Bcl-2 from a survival to killer.As Bcl-2 is overexpressed in various cancers preventing them from apoptosis and promoting their resistance to chemotherapy,targeting the apoptotic pathway of Nur77/Bcl-2 may lead to new cancer therapeutics.Here,we report our identification of XS561 as a novel Nur77 ligand that induces apoptosis of tumor cells by activating the Nur77/Bcl-2 pathway.In vitro and animal studies revealed an apoptotic effect of XS561 in a range of tumor cell lines including MDA-MB-231 triple-negative breast cancer(TNBC)and MCF-7/LCC2 tamoxifen-resistant breast cancer(TAMR)in a Nur77-dependent manner.Mechanistic studies showed XS561 potently induced the translocation of Nur77 from the nucleus to mitochondria,resulting in mitochondria-related apoptosis.Interestingly,XS561-induced accumulation of Nur77 at mitochondria was associated with XS561 induction of Nur77 phase separation and the formation of Nur77/Bcl-2 condensates.Together,our studies identify XS561 as a new activator of the Nur77/Bcl-2 apoptotic pathway and reveal a role of phase separation in mediating the apoptotic effect of Nur77 at mitochondria. | Xiaohui Chen Meichun Gao Yongzhen Xia Xin Wang Jingbo Qin Hongying He Weirong Liu Xiaowei Zhang Shuangzhou Peng Zhiping Zeng Ying Su Xiaokun Zhang | 2024 | Acta Pharmaceutica Sinica B2024，14，3： | 0 |
| 15 | Synthesis of Quaternary Carbon-Centered Benzoindolizidinones via Novel Photoredox-Catalyzed Alkene Aminoarylation: Facile Access to Tylophorine and Analogues显示文摘Photoredox-catalyzed aminoarylation and thioami-nation of unactivated alkenes have been developed,providing novel synthetic routes to access synthe-tically challenging quaternary carbon-centered benzoindolizidinones and trifluoromethylthiolated piperidines using readily available starting materials.Notably,these transformations were enabled by merging amidyl radical generation from N-alkyl benzamides with oxidant incorporation.Density functional theory calculations were performed to understand the reaction mechanism and to rationa-lize the regioselectivities.Moreover,the newly deve-loped catalytic aminoarylation provided a convenient synthetic route for natural product tylophorine and its gem-dimethyl analogues with greatly improved drug-like properties such as enhanced solubility and stability. | Chao Zhang Yi Wang Yugang Song Hongying Gao Yonghui Sun Xiuyun Sun Yiqing Yang Ming He Zimo Yang Lingpeng Zhan Zhi-Xiang Yu Yu Rao | 2019 | CCS Chemistry2019，1，4： | 0 |
| 16 | Anthropogenic ^(129)I in seawaters along the north-central part of the English Channel:Levels and tracer applications显示文摘The English Channel(the Channel)represents a major sink and transport pathway of anthropogenic radioactive ^(129)I.Despite this important role,data concerning the distribution of ^(129)I in seawater of the Channel are scarce,and most of existing data are restricted to the eastern part of the Channel.The advection and dispersion of ^(129)I from the French coast toward the central and further the English coast,especially in the Channel west of Cap de La Hague,are not fully investigated.We present results of iodine isotopes( ^(127)I and ^(129)I)analyses of surface water samples collected along the central English Channel in October,2010.The data show high ^(129)I concentrations between Dover Strait and La Hague,followed by a dramatic drop towards the Celtic Sea and reveal the dispersal of ^(129)I towards central and northern part of the Channel.Our observation also implies that the entire British coast is contaminated by ^(129)I. ^(129)I levels in the westernmost English Channel,close to the English coast,may reflect combined influences from La Hague and Sellafield.Evolution of ^(129)I between 2005 and 2010 suggests a strong link to temporal marine discharges from La Hague plant.The discharges from the nuclear reprocessing facility have continued since 2010 and thus an ecological evaluation of ^(129)I radioactive hazards in the environment of the Channel may be needed. | Peng He Zheng Yang Hongying Pang Ala Aldahan Xiaolin Hou Goran Possnert Xiangjun Pei Yi Huang | 2022 | Acta Oceanologica Sinica2022，41，11： | 0 |
| 17 | Fine-tuning the structure-tolerance-antitumor efficacy axis of prodrug nanoassemblies via branched aliphatic functionalization显示文摘Small-molecule prodrug nanoassemblies have emerged as efficient antitumor drug delivery systems.However,in the case of camptothecins-based prodrug nanoassemblies,linear aliphatic side chain modification often results in rod-shaped or irregularly shaped nanoassemblies,which are highly unfavorable for sterilization through filtration,and may cause capillary blockage upon intravenous injection.The rational design of camptothecins-based prodrug nanoassemblies remains a challenge.Herein,we propose that branched aliphatic alcohol(BAA)functionalization could fine-tune the structure-tolerance-antitumor efficacy axis of prodrug nanoassemblies.Correspondingly,four SN38-BAA prodrugs were synthesized by conjugating 7-ethyl-10-hydroxycamptothecin(SN38)with BAAs of varying lengths via a tumor redox-responsive disulfide bond,which self-assemble into uniform spherical nanoparticles.The length of BAA was found to significant impact the multiple drug delivery process,including colloidal stability,drug release profiles and pharmacokinetics.Overall,SN38-C21 NPs(SN38-11-heneicosanol nanoparticles),featuring the longest BAA,showcased multiple therapeutic advantages,ultimately culminating the optimal antitumor efficacy and tolerance.The findings underscore the potential of BAA functionalization in strengthening the therapeutic outcomes of prodrug nanoassemblies,and provide valuable insights for developing translational camptothecins-based nanomedicines. | Guanting Li Fengli Xia Hongying Xiao Shunzhe Zheng Shuwen Fu Han Qiao Qianhui Jin Xuanbo Zhang Dun Zhou Chutong Tian Jin Sun Zhonggui He Bingjun Sun | 2024 | Nano Research2024，17，4： | 0 |
| 18 | Performance of CMIP6 models in simulating the dynamic sea level:Mean and interannual variance显示文摘本研究采用卫星测高数据与第六次国际耦合模式比较计划(CMIP6)海平面动力进行对比,重点针对40S-40N地区的动力海平面(DSL),评估了模式对其平均态与年际变率的综合模拟能力,结果表明,对于DSL平均态的模拟,模式与观测结果非常吻合,模式之间的差异较小.其中,副热带北大西洋是模拟偏差和模式间差异较为显著的区域,对于DSL年际变率的模拟,模式之间保持较高的一致性,但是,模式与观测结果存在明显差异,模式普遍低估了DSL的年际方差;其中,误差大值区域出现在副热带西边界流附近,模式分辨率会影响CMIP6对中小尺度海洋过程的重现能力,这可能是导致CMIP6历史模拟出现误差的原因之一. | Hongying Chen Zhuoqi He Qiang Xie Wei Zhuang | 2023 | Atmospheric and Oceanic Science Letters2023，16，1： | 0 |
| 19 | Isolation and characterization of spike S2-specific monoclonal antibodies with reactivity to pan-coronaviruses显示文摘Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),theseventh coronavirus known to jump from intermediate hosts to humans,has resulted in a worldwide pandemic and caused immense economicdamage(Tan et al.,2020;Zhu et al.,2020).It is believed that coronavirus spillover may occur again in the future.Human exposure to a bat coro-navirus has been serologically confimed in a rural area of China,indi-cating that the coronavirus spillover occurred,although the origin andfrequency of spillovers are unclear(Wang et al.,2018). | Yabin Hu Jun Chen Jing Yang Zhanpeng Liu Xiaoyue Zhang Qian Wu Lulu Liu Shishan Teng Rongzhang He Bo Liu Xingyu Zheng Rui Lu Dong Pan You Wang Liting Peng Hongying chen Yi-Ping Li Wenpei Liu Xiaowang Qu | 2024 | Virologica Sinica2024，39，1： | 0 |
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