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| 1 | Should antibiotics be administered before arthroscopic knee surgery? A systematic review of the literature显示文摘AIM To explore the current evidence surrounding the administration of prophylactic antibiotics for arthroscopic knee surgery. METHODS Databases were searched from inception through May of 2018 for studies examining prophylactic antibiotic use and efficacy in knee arthroscopy. Studies with patient data were further assessed for types of arthroscopic procedures performed,number of patients in the study,use of antibiotics,and outcomes with the intention of performing a pooled analysis. Data pertaining to 'deep tissue infection' or 'septic arthritis' were included in our analysis. Reported data on superficial infection were not included in our data analysis. For the pooled analysis,a relative risk ratio was calculated and χ~2 tests were used to assess for statistical significance between rates of infection amongst the various patient groups. Post hoc power analyses were performed to compute the statistical power obtained from our sample sizes. Number needed to treat analyses were performed for statistically significant differences by dividing 1 by the difference between the infection rates of the antibiotic and no antibiotic groups. An alpha value of 0.05 was used for our analysis. Study heterogeneity was assessed by Cochrane's Q test as well as calculation of the I^2 value.RESULTS A total of 49682 patients who underwent knee ar-throscopy for a diverse set of procedures across 19 studies met inclusion critera for pooled analysis. For those not undergoing graft procedures,there were 27 cases of post-operative septic arthritis in 34487 patients(0.08%) who received prophylactic antibiotics and 16 cases in 10911(0.15%) who received none [risk ratio(RR) = 0.53,95% confidence interval(CI): 0.29-0.99,P = 0.05]. A sub-group analysis in which bony procedures were excluded was performed which found no significant difference in infection rates between patients that received prophylactic antibiotics and patients that did not(P > 0.05). All anterior cruciate ligament reconstruction studies used prophylactic antibiotics,but two studies investigating the effect of soaking the graft in vancomycin in addition to standard intravenous(IV) prophylaxis were combined for analysis. There were 19 cases in 1095 patients(1.74%) who received IV antibioitics alone and no infections in 2034 patients who received IV antibiotics and had a vancomycin soaked graft(RR = 0.01,95%CI: 0.001-0.229,P < 0.01).CONCLUSION Prophylactic antibiotics are effective in preventing septic arthritis following simple knee arthroscopy. In procedures involving graft implantation,graft soaking reduces the rate of infection. | John Carney Nathanael Heckmann Erik N Mayer Ram K Alluri Carleton Thomas Vangsness George F Hatch Ⅲ Alexander E Weber | 2018 | World Journal of Orthopedics2018，9，11： | 2 |
| 2 | The Journal of Organic Chemistry显示文摘 | Mayer S F Steinreiber A Orru R V A Faber K | 2003 | 67(26):91152003，67，26： | 1 |
| 3 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
| 4 | An expression system matures: a highly efficient and cost-effective process for phytase production by recombinant strains of Hansenula polymorpha 显示文摘 | MAYER A F HELLMUTH K SCHLIEKER H | 1999 | Biotechnol Bioeng APGM1999，63，： | 1 |
| 5 | The WUSCHEL gene is required for shoot and floral meristem integrity in Arabidopsis 显示文摘 | Laux T Mayer K F Berger J | 1996 | Develop- ment1996，122，： | 1 |
| 6 | FTY720 prolongs clear corneal allograft survival with a differential effect on different lymphocyte populations显示文摘 | Mayer K Birnbaum F Reinhard T Reis A Braunstein S Claas F | 2004 | Br J Ophthamol2004，88，7： | 1 |
| 7 | A physical, genetic and functional sequence assembly of the barley genome 显示文摘 | Mayer K F Waugh R Brown J W et a/ | 2012 | Nature2012，491，7426： | 1 |
| 8 | MIPS:analysis and annotation of proteins from whole gcnomes in 2005 显示文摘 | Mewes H W Frishman D Mayer K F X | 2006 | Nueleie Acids Research2006，34，： | 1 |
| 9 | Parenteral nutrition with n-3 lipids in sepsis显示文摘 | Mayer K Grimm H Grimminger F | 2002 | Br J Nutr2002，87，1： | 1 |
| 10 | Obstructive sleep apnea and atherosclerosis 显示文摘 | Sehulz R Reichenberger F Mayer K | 2009 | Prog Cardiovasc Dis2009，51，5： | 1 |
| 11 | Dysregulation of interleukin-7 receptor may generate loss of cytotoxic T cell response in human immunodeficiency virus type 1 infection显示文摘 | Carini C McLane M F Mayer K H | 1994 | Eur J Immunol1994，24，12： | 1 |
| 12 | The pyrolysis of nopinone显示文摘 | Mayer C F Crandall J K | 1970 | J Org Chem1970，35，8： | 1 |
| 13 | Thymectomy for myasthenia gravis:14-years experience显示文摘 | HANKINS J R MAYER R F SATERFIELD J K | 1985 | Ann Surg1985，，： | 1 |
| 14 | Role of WUSCHEL in regulating stem cell fate in the Arabidopsis shoot meristem 显示文摘 | Mayer K F X School H Haecker A | 1998 | Cell1998，95，6： | 1 |
| 15 | Role of WUSCHEL in regulating stem cell fate in the Arabidopsis shoot meristem显示文摘 | MAYER K F SCHOOF H HAECKER A LENHARD M JURGENS G LAUX T | 1998 | Cell1998，95，： | 1 |
| 16 | Die ASF-Karossericdes Audi AS显示文摘 | Mayer H Venier F Koglin K | 2002 | ATZ MTZ extra(Sonderausgahe yon ATZ and MTZ)2002，104，8： | 1 |
| 17 | MIPS: analysis and annotation of proteins from whole genomes in 2005显示文摘 | Mewes H W Frishman D Mayer K F X | 2006 | Nucleic Acids Research2006，34，： | 1 |
| 18 | Enzyme - initiated domino(cascade) reaction显示文摘 | Sandra F Mayer Wolfgang K Kurt F | 2001 | Chem Soc Rew2001，30，： | 1 |
| 19 | Preexposure chemoprophylaxis for HIV prevention in men who have sex with men 显示文摘 | Grant RM Lama JR Anderson PL McMahan V Liu AY Vargas L Goicochea P Casapa M Guanira-Carranza JV Ramirez-Cardich ME Montoya-Herrera O Ferndndez T Veloso VG Buchbinder SP Chariyalertsak S Schechter M Bekker LG Mayer KH Kallds EG Amico KR Mulli- gan K Bushman LR Hance RJ Ganoza C Defechereux P Postle B Wang F McConnell JJ Zheng JH Lee J Rooney JF Jaffe HS Martinez AI Burns DN Glidden DV iPrEx Study Team | 2010 | N Engl J Med2010，363，27： | 1 |
| 20 | The WUSCHEL gene is required for shoot and floral meristem integrity in Arabidopsis显示文摘 | Laux T Mayer K F Berger J Jurgens G | | 0，，： | 1 |
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