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| 1 | 氧化磷酸化与糖酵解:精子以何种途径获取能量?显示文摘精子为高度特异性的细胞,提供精子重要功能的主要能源一一三磷酸腺苷(ATP)主要通过两种代谢途径形成,即糖酵解和氧化磷酸化(OXPHOS)。ATP除了在精子的头部和鞭毛的主段通过糖酵解的方式产生外,在线粒体主要通过OXPHOS的方式产生。然而,在精子成功受精的过程中主要以何种方式产生ATP具有很大的差异性。与糖酵解相比,线粒体呼吸被认为是一种更有效的ATP合成代谢过程。然而,研究表明ATP从线粒体到精子鞭毛末端的扩散电位不足以支持精子的运动,这表明糖酵解是精子尾部区域主要的获能方式。多项研究表明虽然糖酵解是鞭毛产生ATP的主要方式,但是,精子运动所需要的能量主要还是来自于线粒体的呼吸。有些研究表明当糖酵解受到抑制的时候,精子仍能维持其正常的运动和功能,虽然目前尚未明确这种运动是否能持续足够长的时间,是否能够达到有效受精。本文主要目的是对哺乳动物精子能量的代谢进行综述,分析人类精子在受精的过程中以何种ATP代谢途径作为主要的能量供应方式。 | Stefan S du Plessis Ashok Agarwal Gayatri Mohanty Michelle van der Linde | 2015 | Asian Journal of Andrology2015，17，2： | 19 |
| 2 | Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity显示文摘 | Corbin Amie S Agarwal Anupriya Loriaux Marc Cortes Jorge Deininger Michael W Druker Brian J | 2011 | Journal of Clinical Investigation2011，，1： | 3 |
| 3 | Choledochal cyst with large stone cast and portal hypertension显示文摘BACKGROUND:Choledochal cysts in adults are more commonly associated with complications such as cystolithiasis,recurrent cholangitis,portal hypertension and malignancy,than in the pediatric age group.METHOD:We report a case of adult choledochal cyst with long-term complication of large stone cast and portal hypertension due to secondary biliary cirrhosis.RESULTS:A 50-year-old patient presented with obstructive jaundice and hepatosplenomegaly.On investigation,she was diagnosed as having a choledochal cyst with large stone cast and portal hypertension.Single stage resection of the choledochal cyst with Roux-en-Y hepaticojejunostomy was done by meticulous dissection and ligation of collaterals.CONCLUSION:Single stage resection of a choledochal cyst is possible in spite of associated portal hypertension,if the portal vein is patent. | Shivendra Singh Laxman Singh Kheria Sunil Puri Amrinder S Puri Anil K Agarwal | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，6： | 2 |
| 4 | 1800V NPN Bipolar Junction Transistors in 4H-SiC显示文摘 | Ryu S H Agarwal A K Singh R | 2001 | IEEE Electron Device Letter2001，22，2： | 2 |
| 5 | 有胰 divisum 的 Choledochocele : 在磁性的回声 cholangiopancreatography 上诊断的稀罕同现显示文摘 We report a case of a 42-year-old male with symptomatic choledochocele and incidental pancreas divisum diagnosed with magnetic resonance cholangiopancreatography (MRCP). Small choledochocele is rare congenital malformation associated with non-specific symptoms and a delay in diagnosis. The coexistence of choledochocele and pancreas divisum is extremely rare with only two case reports published in literature. In both cases MRCP failed to diagnose any biliary or pancreatic abnormality. This case suggests that the patients with recurrent abdominal pain and pancreas divisum should not be presumed to be suffering from pancreatitis. Careful evaluated for additional anomalies in the biliary tree should be sought for refractory symptoms. MRCP is a useful one-stop-shop for diagnosing pancreatic and biliary ductal anomalies. | Yashwant Patidar Nitesh Agarwal Shailesh Gupta Ankur Arora Amar Mukund S Rajesh | 2013 | World Journal of Radiology2013，5，7： | 2 |
| 6 | Mechanism of lovastatin-induced apotosis in intesnalepithelial cells显示文摘 | Banke Agarwal Balazs Halmos Aleksander S | 2002 | Carcinogenesis2002，23，3： | 2 |
| 7 | Ultrasonographic evaluation of gallbladder volume in diabetics显示文摘 | Agarwal AK Miglani S Singla S | 2004 | J Aseoc Physicians India2004，52，： | 1 |
| 8 | Generalization of a retarded Gronwall-like inequality and its applications 显示文摘 | Agarwal R P Deng S Zhang W | 2005 | Appl Math Comput2005，165，： | 1 |
| 9 | Restructuring seaside tourism-the resort lifecycle显示文摘 | | 2002 | Annals of Tourism Research2002，29，： | 1 |
| 10 | An improved model for protective-system reliability显示文摘 | Anderson P Agarwal S | 1992 | IEEE Transactions on Reliability1992，41，3： | 1 |
| 11 | Predictors of long-term survival in patients with gallbladder cancer 显示文摘 | Balachandran P Agarwal S Krishnani N | 2006 | J Gastrointest Surg2006，10，6： | 1 |
| 12 | Prevalence of coronary risk factors in type 2 diabetics without manifestations of overt coronary heart disease 显示文摘 | Agarwal A K Singla S Singla S | 2009 | J Assoc Physicians India2009，57，： | 1 |
| 13 | A fast and elitist multiobjective genetic algorithm: NSGA-II显示文摘 | Deb K Pratap A Agarwal S | 2002 | IEEE Transactions on Evolutionary Computation2002，6，2： | 1 |
| 14 | Atomic Schrodinger Cat States显示文摘 | AGARWAL G S PURI R R SINGH R P | 1997 | Phys Rev A1997，56，： | 1 |
| 15 | Tomato lycopene and low density lipoprotein oxidation: a human dietary intervention study显示文摘 | Agarwal S Rao AV | 1998 | Lipids1998，33，10： | 1 |
| 16 | Eigenvalues and the one-dimensional p-Laplacian显示文摘 | AGARWAL R P LU H S O'REGAN D | 2002 | J Math Anal Appl2002，266，： | 1 |
| 17 | Nonclassical properties of states generated by the excitations on a coherent state显示文摘 | Agarwal G S Tara K | 1991 | Phys Rev1991，43，1： | 1 |
| 18 | A fast and elitist multi objecttive genetic algorithm:NSGA-Ⅱ显示文摘 | DEB K PRATAP A AGARWAL S | 2002 | IEEE Transactions on Evolutionary Computation2002，6，2： | 1 |
| 19 | A fast and elitist multi objective genetic algorithm : NSGA- Ⅱ显示文摘 | DEB K PRATAP A AGARWAL S | 2002 | IEEE Trans on Evolutionary Computation2002，6，2： | 1 |
| 20 | Fallen lung sign (onchest radiograph )显示文摘 | Magu S Agarwal K Lohchab S S | 2011 | J Trauma2011，70，4： | 1 |
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