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| 1 | Combination drug regimens for metastatic clear cell renal cell carcinoma显示文摘Renal cell carcinomas(RCC)make up about 90%of kidney cancers,of which 80%are of the clear cell subtype.About 20%of patients are already metastatic at the time of diagnosis.Initial treatment is often cytoreductive nephrectomy,but systemic therapy is required for advanced RCC.Single agent targeted therapies are moderately toxic and only somewhat effective,leading to development of immunotherapies and combination therapies.This review identifies limitations of monotherapies for metastatic renal cell carcinoma,discusses recent advances in combination therapies,and highlights therapeutic options under development.The goal behind combining various modalities of systemic therapy is to potentiate a synergistic antitumor effect.However,combining targeted therapies may cause increased toxicity.The initial attempts to create therapeutic combinations based on inhibition of the vascular endothelial growth factor or mammalian target of rapamycin pathways were largely unsuccessful in achieving a profile of increased synergy without increased toxicity.To date,five combination therapies have been approved by the U.S.Food and Drug Administration,with the most recently approved therapies being a combination of checkpoint inhibition plus targeted therapy.Several other combination therapies are under development,including some in the phase 3 stage.The new wave of combination therapies for metastatic RCC has the potential to increase response rates and improve survival outcomes while maintaining tolerable side effect profiles. | Viraj V Khetani Daniella E Portal Mansi R Shah Tina Mayer Eric A Singer | 2020 | World Journal of Clinical Oncology2020，11，8： | 2 |
| 2 | Efficient screening of process variables 显示文摘 | STOWE R A MAYER R P | 1966 | Industrial and Engineering Chemistry1966，58，2： | 1 |
| 3 | Fluorouracil and highdose leuco -vorin in previously untreated patients with advanced adenocarcinoma of the pancreas : re - suits of a phase * trial显示文摘 | DECAPRIO J A MAYER R J GONIN R | 1991 | J Clin Oncol1991，9，12： | 1 |
| 4 | Assessment of intake from the diet显示文摘 | R Kroes D Müller J Lambe M.R.H L?wik J van Klaveren J Kleiner R Massey S Mayer I Urieta P Verger A Visconti | 2002 | Food and Chemical Toxicology2002，，2： | 1 |
| 5 | An- alytical Method for the Dentermination of Cyromazine and Melamine Residues in Soilusing LC-UV and GC- MS显示文摘 | YOKLEY R A Mayer L C Rezaiyan R etal | 2000 | J Agric Food Chem2000，48，： | 1 |
| 6 | Palladium-catalyzed dehydrogenative cross-couplings of benzazoles with azoles显示文摘 | Han W Mayer P Ofial A R | 2011 | Angew Chem Int Ed2011，50，9： | 1 |
| 7 | New insights to the MLL recombinome of acute leukemias显示文摘 | Meyer C Kowarz E Hofmann J Renneville A Zuna J Trka J Ben Abdelali R Macintyre E De Braekeleer E De Braekeleer M Delabesse E de Oliveira MP Cavé H Clappier E van Dongen JJ Balgobind BV van den Heuvel-Eibrink MM Beverloo HB Panzer-Grümayer R Teigler-Schleg | | 0，，08： | 1 |
| 8 | The Journal of Organic Chemistry显示文摘 | Mayer S F Steinreiber A Orru R V A Faber K | 2003 | 67(26):91152003，67，26： | 1 |
| 9 | Analytical method for the determination of metolachlor, acetochlor, alachlor, dimethenamid and their corresponding ethanesulfonic and oxanillic acid degradates in water using SPE and LC/ESI-MS/MS显示文摘 | Yokley R A Mayer L C Huang S B | 2002 | Analytical Chemistry2002，74，： | 1 |
| 10 | Fluorouracil and high does leucovorin in previously untreated patients with advanced adenocareinoma of the pancreas: results of a phasetrial显示文摘 | DeCaprio J A Mayer R J Gonin R | 1991 | J Clin Oncol1991，，12： | 1 |
| 11 | The ubiquitin protein catabolic disorders显示文摘 | Layfield R Alban A Mayer R J | 2001 | Neuropathol Appl Neurobiol2001，27，3： | 1 |
| 12 | Linkage analy sis in teraploid potato and association of makers with quanti rive resistance to late blight (Phytophthora infestans) 显示文摘 | Mayer R C Milbourne D Hackett C A | 1998 | Molecular Genetics and Genomics1998，59，2： | 1 |
| 13 | A prospective diffusion tensor imaging study in mild traumatic brain injury显示文摘 | Mayer A R Ling J Mannell M V et aI | 2010 | Neurology2010，74，8： | 1 |
| 14 | Mercury porosimetry-breakthrough pressure for penetration between packed spheres显示文摘 | MAYER R P STOWE R A | 1965 | Journal of Colloid Science1965，20，8： | 1 |
| 15 | Laeease: new functions for an old enzyme 显示文摘 | MAYER A M STAPLES R C | 2002 | Phytochemistry2002，60，6： | 1 |
| 16 | 显示文摘 | Grebner W Wannemacher R | 2000 | J Phys Chem B2000，104，31： | 1 |
| 17 | Hybrid organic -inorganic polyoxometalate compounds: from structural diversity to applications 显示文摘 | DOLBECQ A DUMAS E MAYER C R | 2010 | Chem Rev2010，110，： | 1 |
| 18 | The evolution of brain activation during temporal processing 显示文摘 | Rao S M Mayer A R Harrington D L | 2001 | Nature N euroscience2001，4，3： | 1 |
| 19 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
| 20 | Applications of Topology Optimization Techniques to Structural Crashworthiness显示文摘 | Mayer R R Kikuehi N Scott R A | 1996 | International Journal of Nu- merical Methods in Engineering1996，39，13： | 1 |
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