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| 1 | Adaptation of HIV-1to human leukocyte antigen class I显示文摘 | Kawashima Y Pfafferott K Frater J Matthews P Payne R Addo M Gatanaga H Fujiwara M Hachiya A Koizumi H Kuse N Oka S Duda A Prendergast A Crawford H Leslie A Brumme Z Brumme C Allen T Brander C Kaslow R Tang J Hunter E Allen S Mulenga J Branch S Roach T John M Mallal S Ogwu A Shapiro R Prado J G Fidler S Weber J Pybus O G Klenerman P Ndung'u T Phillips R Heckerman D Harrigan P R Walker B D Takiguchi M Goulder P | 2009 | Nature2009，458，7238： | 1 |
| 2 | Community factors affecting rising caesarean section rates in developing countries: an analysis of six countries显示文摘 | Leone T Padmadas SS Matthews Z | 2008 | Soc SciMed2008，67，12： | 1 |
| 3 | Going to scale with professional skilled care 显示文摘 | Koblinsky M Matthews Z Hussein J | 2006 | Lancet2006，368，9544： | 1 |
| 4 | Obesity and diabetes accelerate hepatocarcinogenesis via hepatocyte proliferation independent of NF-κB or Akt/mTORC1显示文摘Background:There are strong links between obesity,diabetes and hepatocellular carcinoma(HCC),but molecular mechanisms remain unclear.Aim:We tested the proposed involvement of NF-κB,IL-6/STAT3 and Akt/mTORC1 before onset(at 3 months)and at onset(6 months)of accelerated hepatocarcinogenesis in DEN-injected obese and diabetic foz/foz compared to lean wildtype(Wt)mice,and also studied the hepatocyte proliferative response to DNA damage between the obese and lean lines.Methods:Male foz/foz and Wt littermates fed normal chow were DEN-injected(10mg/kg i.p.)at age 12-15 days.To test the effect of mTOR inhibitor on growth of dysplastic hepatocytes,a separate cohort of DEN-injected foz/foz mice was administered rapamycin(4 mg/kg body weight/day).Results:foz/foz mice developed obesity,hyperinsulinemia,diabetes,adipokine dysregulation and fatty liver,without increased serum or liver TNF-αor serum IL-6.All DEN-injected foz/foz mice developed HCC by 6 mths vs.0/10 lean Wt.At 3 mths,there were more dysplastic hepatocytes in DEN-injected foz/foz than Wt,with increased liver injury(serum ALT),hepatocyte apoptosis(M30-positive cells)and proliferation(cyclin D1,cyclin E,PCNA),but neither NF-κB nor STAT3 activation.foz/foz livers exhibited upregulation of DNA damage sensors ATM and ATR,with inadequate cell cycle checkpoint controls(CHK1,CHK2,p53,p21).Akt and mTORC1 were highly activated in livers from foz/foz vs.Wt mice.Despite such activation,rapamycin failed to reduce growth of dysplastic hepatocytes.Conclusions:Accelerated DEN-induced HCC in obese/diabetic mice is linked to enhanced growth of dysplastic hepatocytes that cannot be attributed to NF-κB or IL-6/STAT3 activation,nor to sustained mTORC1 activation.The critical mechanism for obesity-enhanced hepatocarcinogenesis lies in the disconnection between hepatocellular injury with DNA damage,and an unrestrained proliferative response.Relevance for patients:This study supports the epidemiological data linking obesity,diabetes and fatty liver disease with increased risk for developing HCC.The findings also suggest that mTORC1 inhibition may not be beneficial in the prevention of obesity-related hepatocarcinogenesis. | Evi Arfianti Claire Z Larter Seungsoo Lee Vanessa Barn Geoffrey Haigh Matthew M.Yeh George NIoannou Narci C.Teoh Geoffrey C.Farrell | 2016 | Journal of Clinical & Translational Research2016，2，1： | 1 |
| 5 | Host cytokine genotype is related to adverse prognosis and systemic inflammation in gastro-esophageal cancer显示文摘 | Chris D Matthew R Z Stephen W | 2006 | Ann Surg Oncol2006，10，14： | 1 |
| 6 | Linezolid versus glycopeptide or β - lactam for treatment of Gram - positive bacterial infections : meta - analysis of randomised controlled trials显示文摘 | Matthew E Falagas Ilias I Siempos Konstantinos Z Vardakas | 2008 | The Lancet Infect Dis2008，8，1： | 1 |
| 7 | Going to scale with professional skilled care显示文摘 | Koblinsky M Matthews Z Hussein J | 2006 | Lancet2006，368，9544： | 1 |
| 8 | Carbon dioxide emulsion assisted loading of polymer mierospheres toward sustained release materials 显示文摘 | GARY A B MARY L C MATTHEW Z Y | 2005 | Langmuir2005，21，9： | 1 |
| 9 | Expression of apical membrane L-glutamate transporters in neonatal porcine epithelial cells along the small intestinal crypt-villus axis显示文摘 | FAN M Z MATTHEWS J C ETIENNE N M P | 2004 | American Journal of Physiology Gastrointestinal and Liver Physiology2004，287，2： | 1 |
| 10 | Organic chemicals in sewage sludges显示文摘 | Ellen Z H Summer R O Matthew H | 2006 | Science of the Total Environment2006，367，23： | 1 |
| 11 | Accumulation of a thermostable endo-1,4-β-D-glucanase in the apoplast of Arabidopsis thaliana leaves显示文摘 | MATTHEW T Z STEVEN R T KATHLEEN J D | 2000 | Molecular Breeding2000，6，1： | 1 |
| 12 | Population relationships o{ perennial ryegrass and white clover mixtures under dif{ering grazing intensities 显示文摘 | Yu Y W Nan Z B Matthew C | 2008 | Agriculture Ecosys tems and Environment2008，124，： | 1 |
| 13 | Development of a process-based model for dynamic interaction in spatiotempral gis 显示文摘 | MATTHEW Y PANG C SHI W Z | 2002 | GeoInformatic2002，6，3： | 1 |
| 14 | Use of microarrays with different probe sizes for monitoring gene expression显示文摘 | He Z L Wu L Y Matthew W F | 2005 | A Environ Microbiol2005，71，9： | 1 |
| 15 | Defect cluster formation in M2O3-doped cubic ZrO2 显示文摘 | Matthew O Z Licia M | 2000 | Soild State Ionics2000，128，： | 1 |
| 16 | A framework of ERP systems implementation success in China:An empirical study显示文摘 | ZHANG Z MATTHEW K O L PEI H | 2005 | International Journal of Production Economics2005，，98： | 1 |
| 17 | Application of Motion Analysis System in Pre-Impact Fall Detection显示文摘 | Nyan M N Francis E H Matthew Z E | 2008 | Journal of Biome- chanies2008，41，： | 1 |
| 18 | Moisture determination in hygroscopic drug substances by near infrared spectroscopy 显示文摘 | XIANGJ Z PATRICAI H MATTHEW W B | 1998 | J Pharm Biom Anal1998，17，2： | 1 |
| 19 | Perceptual learning on orientation and direction discrimination显示文摘 | Matthews N Liu Z Geesaman B J | 1999 | Vision Res1999，39，： | 1 |
| 20 | Going to scale with professional skilled care 显示文摘 | Koblinsky M Matthews Z Hussein J | 2006 | Lancet2006，368，9544： | 1 |
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