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| 1 | NEAT1-TFE3和KAT6A-TFE3肾细胞癌:MiT家族易位性肾细胞癌中的新成员显示文摘小眼畸型相关转录因子(MiT)家族易位性肾细胞癌涉及TFE3或TFEB基因在内不同的基因融合。 据报道,TFE3的5′端可有多种融合基因伴侣,包括ASPSCR1、CLTC、DVL2、LUC7L3、KHSRP、PRCC、PARP14、NONO、SFPQ1、MED15以及RBM10。 通过免疫组化染色可以检测到这些融合基因激活TFE3转录。作者采用靶向RNA测序技术,鉴定了5例TFE3免疫组化染色阳性肾细胞癌的TFE3融合基因伴侣。3例为已知的基因融合,分别为ASPSCR1-TFE3、MED15-TFE3和RBM10-TFE3。2例为尚未报道的NEAT1-TFE3和KAT6A-TFE3基因融合。 | Pei J Cooper H Flieder D B 魏建国(摘译) 袁晓露(审校) | 2019 | 临床与实验病理学杂志2019，35，8： | 10 |
| 2 | Association of overexpression of TIF1γ with colorectal carcinogenesis and advanced colorectal adenocarcinoma显示文摘AIM:To determine the expression and clinical significance of transcriptional intermediary factor 1 gamma (TIF1γ),Smad4 and transforming growth factor-beta (TGFβR) across a spectrum representing colorectal cancer (CRC) development.METHODS:Tissue microarrays were prepared from archival paraffin embedded tissue,including 51 colorectal carcinomas,25 tubular adenomas (TA) and 26 HPs,each with matched normal colonic epithelium.Immunohistochemistry was performed using antibodies against TIF1γ,Smad4 and TGFβ RⅡ.The levels of expression were scored semi-quantitatively (score 0-3 or loss and retention for Smad4).RESULTS:Overexpression of TIF1γ was detected in 5/26 (19%) HP;however,it was seen in a significantly higher proportion of neoplasms,15/25 (60%) TAs and 24/51 (47%) CRCs (P<0.05).Normal colonic mucosa,HP,and TAs showed strong Smad4 expression,while its expression was absent in 22/51 (43%) CRCs.Over-expression of TGFβ RⅡ was more commonly seen in neoplasms,13/25 (52%) TAs and 29/51 (57%) CRCs compared to 9/26 (35%) HP (P<0.05).Furthermore,there was a correlation between TIF1γ overexpression and Smad4 loss in CRC (Kendall tau rank correlation value=0.35,P<0.05).The levels of TIF1γ overexpression were significantly higher in stage Ⅲ than in stage Ⅰ and Ⅱ CRC (P<0.05).CONCLUSION:The findings suggest that over-expression of TIF1γ occurs in early stages of colorectal carcinogenesis,is inversely related with Smad4 loss,and may be a prognostic indicator for poor outcome. | Shilpa Jain Shashideep Singhal Franto Francis Cristina Hajdu Jin-Hua Wang Arief Suriawinata Yin-Quan wang Miao Zhang Elizabeth H Weinshel Fritz Francois Zhi-Heng Pei Peng Lee Ru-Liang Xu | 2011 | World Journal of Gastroenterology2011，17，35： | 3 |
| 3 | The reduction of RE3+ in SrB6O2 prepared in air and the luminescence of∶RE2+(RE=Eu,Sm,Tm) 显示文摘 | Zheng Q H Pei Z W WANG S B | 1999 | Spectroscopy Letters1999，32，6： | 2 |
| 4 | Effect of river landscape on the sediment concentrations of antibiotics and corresponding antibiotic resistance genes(ARG)显示文摘 | PEI R KIM S C CARLSON K H PRUDEN A | 2006 | Water Res2006，40，12： | 1 |
| 5 | Haploinsufficiency of p18INK4c sensitizes mice to carcinogen-induced tumorigenesis显示文摘 | BAI F PEI X H VIRGINIA L G | 2003 | Molecular and Cellular2003，23，4： | 1 |
| 6 | Conjugate heat and mass transfer in membrane-formed channels in all entry regions显示文摘 | Zhang L Z Liang C H Pei L X | 2010 | International Journal of Heat and Mass Transfer2010，53，56： | 1 |
| 7 | 查看详情显示文摘 | Li J Xie W X Pei J H | | 0，，5： | 1 |
| 8 | Study on magnetite nanoparticles synthesized by chemical method显示文摘 | W Pei H Kumada T Natusme H Saito S Ishio | 2007 | Journal of Magnetism and Magnetic Materials2007，310，： | 1 |
| 9 | Preparation of silicon carbide nanotubes by hydrothermal method显示文摘 | Pei L Z Tang Y H Chen Y W | 2006 | J Appl Phys2006，99，11： | 1 |
| 10 | In vivo delivery of a Bcl-xL fusion protein containing the TAT protein transduction domain protects against ischemic brain injury and neuronal apoptosis显示文摘 | Cao G Pei W Ge H | 2002 | J Neurosci2002，22，13： | 1 |
| 11 | 显示文摘 | Chuu D S Won W L Pei J H | 1994 | Phys Rev B1994，49，14： | 1 |
| 12 | Low Temperature Growth and Characterizations of Single Crystalline CuGeO3 Nanowires 显示文摘 | Pei L Z Zhao H S Tan W | 2009 | Cost Eng Comm2009，11，7： | 1 |
| 13 | ELID grinding of silicon wa- fers: A literature review 显示文摘 | Liu J H Pei Z J Fisher G R | 2007 | Int J Mach Tools Manuf2007，47，34： | 1 |
| 14 | Suport for linkage of familial combined hyperlipidemia to chromosome1q21-q23 in Chinese and German families显示文摘 | Pei W Baron H MμLler-Myhsok B etal | 2000 | Clin Genet2000，57，1： | 1 |
| 15 | The clinical observation of different dose sufentanil combined bupivacaine on spinal anesthesia in elderly patients显示文摘 | Pei H Zeng LM | 2012 | Chin J Postgraduates Med2012，35，： | 1 |
| 16 | Application of ENVISAT ASAR data in mapping rice crop growth in Southern China显示文摘 | Chen C Lin H Pei Z | 2007 | IEEE Geoscience and Remote Sensing Letters2007，4，： | 1 |
| 17 | Kinetic study of methoxycarbonylation of methylene dianiline with dimethyl carbonate using lead acetate catalyst显示文摘 | Pei Y Li H Liu H | 2011 | Industrial&Engineering Chemistry Research2011，50，4： | 1 |
| 18 | Main factors affecting the lifetime of proton exchange membrane fuel cells in vehicle applications: A review显示文摘 | Pei P C Chen H C | 2014 | Applied Energy2014，125，： | 1 |
| 19 | Antibiotic re sistance genes as emerging contaminants: studies in northern Colorado显示文摘 | PRUDEN A PEI R STORTEBOOM H | 2006 | Environ Sci Technol2006，40，23： | 1 |
| 20 | A novel thermotropic liquid crystalline-benzoylated bacterial cellulos 显示文摘 | Wang Y Luo Q P Pei C H | 2008 | Carbohydr Polym2008，74，： | 1 |
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