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| 1 | Cytokines in adipose-derived mesenchymal stem cells promote the healing of liver disease显示文摘Adipose-derived mesenchymal stem cells(ADSCs) are a treatment cell source for patients with chronic liver injury. ADSCs are characterized by being harvested from the patient's own subcutaneous adipose tissue, a high cell yield(i.e., reduced immune rejection response), accumulation at a disease nidus, suppression of excessive immune response, production of various growth factors and cytokines, angiogenic effects, antiapoptotic effects, and control of immune cells via cellcell interaction. We previously showed that conditioned medium of ADSCs promoted hepatocyte proliferation and improved the liver function in a mouse model of acute liver failure. Furthermore, as found by many other groups, the administration of ADSCs improved liver tissue fibrosis in a mouse model of liver cirrhosis. A comprehensive protein expression analysis by liquid chromatography with tandem mass spectrometry showed that the various cytokines and chemokines produced by ADSCs promote the healing of liver disease. In this review, we examine the ability of expressed protein components of ADSCs to promote healing in cell therapy for liver disease. Previous studies demonstrated that ADSCs are a treatment cell source for patients with chronic liver injury. This review describes the various cytokines and chemokines produced by ADSCs that promote the healing of liver disease. | Saifun Nahar Yoshiki Nakashima Chika Miyagi-Shiohira Takao Kinjo Zensei Toyoda Naoya Kobayashi Issei Saitoh Masami Watanabe Hirofumi Noguchi Jiro Fujita | 2018 | World Journal of Stem Cells2018，10，11： | 11 |
| 2 | Effects of adacolumn selective leukocytapheresis on plasma cytokines during active disease in patients with active ulcerative colitis显示文摘瞄准:调查在临床的活动索引的 ulcerative (UC )( 蔡) 和 IL-1ra, IL-10, IL-6 和 IL-18 的传播层次之间的关系。方法:IL-1ra, IL-10, IL-6 和 IL-18 的血层次与活跃 UC 在 31 个病人被测量,吝啬的蔡是 11.1,从 5-25 ;并且是的 12 个健康个人控制。病人们与 Adacolumn 被给粒细胞和单核白血球 adsorptive 词首字母的脱落(GMA ) 。忍受 FcgammaR 并且补充受体的白细胞被吸附到列 leucocytapheresis 搬运人。每个病人能在 8 wk 上收到多达 11 个 GMA 会议。结果:我们发现了在蔡和 IL-10 之间的强壮的关联(r = 0.827, P <
0.001 ) , IL-6 (r = 0.785, P <
0.001 ) 并且 IL-18 (r = 0.791, P <
0.001 ) 。IL-1ra 没与蔡一起被相关。后面的 GMA 治疗, 31 个病人中的 24 个完成了宽恕,所有 4 cytokines 的层次掉在健康控制里到层次。进一步, IL-1ra 和 IL-10 的血层次在从遵守了搬运人的白细胞建议版本的 60 min 在列流出和流入增加了。 | Hiroyuki Hanai Takayuki Iida Masami Yamada Yoshihiko Sato Ken Takeuchi Tatsuo Tanaka Kenji Kondo Masataka Kikuyama Yasuhiko Maruyama Yasushi Iwaoka Akiko Nakamura Kazuhisa Hirayama Abby R Saniabadi Fumitoshi Watanabe | 2006 | World Journal of Gastroenterology2006，12，21： | 8 |
| 3 | Curcumin Maintenance Therapy for Ulcerative Colitis: Randomized, Multicenter, Double-Blind, Placebo-Controlled Trial显示文摘 | Hiroyuki Hanai Takayuki Iida Ken Takeuchi Fumitoshi Watanabe Yasuhiko Maruyama Akira Andoh Tomoyuki Tsujikawa Yosihihide Fujiyama Keiichi Mitsuyama Michio Sata Masami Yamada Yasushi Iwaoka Kazunari Kanke Hideyuki Hiraishi Kazuhisa Hirayama Hajime Arai Shi | 2006 | Clinical Gastroenterology and Hepatology2006，，12： | 2 |
| 4 | Potential of adenovirus‐mediated REIC / Dkk ‐3 gene therapy for use in the treatment of pancreatic cancer显示文摘 | Daisuke Uchida Hidenori Shiraha Hironari Kato Teruya Nagahara Masaya Iwamuro Junro Kataoka Shigeru Horiguchi Masami Watanabe Akinobu Takaki Kazuhiro Nouso Yasutomo Nasu Takahito Yagi Hiromi Kumon Kazuhide Yamamoto | 2014 | J Gastroenterol Hepatol2014，，5： | 1 |
| 5 | Cytopathic effects and local immune responses in repeated neoadjuvant HSV-tk+ ganciclovir gene therapy for prostate cancer显示文摘Objective:Cytopathic effects and local immune response were analyzed histologically in prostatic cancer(PCa)with in situ herpes simplex virus-thymidine kinase(HSV-tk)/ganciclovir(GCV)gene therapy(GT).Methods:Four high-risk PCa patients who received HSV-tk/GCV GT were investigated.After two cycles of intraprostatic injection of HSV-tk and administration of GCV,radical prostatectomy was performed.Formalin-fixed,paraffin-embedded sections were evaluated using immunohistochemistry.PCa with hormone therapy(HT,n=3)or without neoadjuvant therapy(NT,n=4)that were equivalent in terms of risk were also examined as reference.Immunoreactively-positive cells were counted in at least three areas in cancer tissue.Labeling indices(LI)were calculated as percentage values.Results:ssDNA LI in GT increased,indicating apoptosis,as well as tumor-infiltrating lymphocytes and CD68-positive macrophages,compared with their biopsies.GT cases showed significantly higher numbers of single-stranded DNA(ssDNA)LI,CD4/CD8-positive T cells and CD68-positive macrophages including M1/M2 macrophages than HT or NT cases.However,there was no significant difference in CD20-positive B cells among the types of case.There were strong correlations between CD8+T cells and CD68+macrophages(ρ=0.656,p<0.0001)as well as CD4+T cells and CD20+B cells(ρ=0.644,p<0.0001)in PCa with GT.Conclusions:Enhanced cytopathic effect and local immune response might be indicated in PCa patients with HSV-tk/GCV gene therapy. | Nobuyuki Yanagisawa Takefumi Satoh Ken-ichi Tabata Hideyasu Tsumura Yasutomo Nasu Masami Watanabe Timothy C.Thompson Isao Okayasu Yoshiki Murakumo Shiro Baba Masatsugu Iwamura | 2021 | Asian Journal of Urology2021，8，3： | 1 |
| 6 | Elastic and damping properties from room temperature to 673 K in an AZ31 magnesium alloy 显示文摘 | Hiroyuki Watanabe Toshiji Mukai Masami Sugioka | 2004 | Scr Mater2004，51，： | 1 |
| 7 | Characteristic properties of water-soluble cutting fluid additives derived from ricinoleic acid oligomers and dimmer acid显示文摘 | Watanabe Shoji Fujita Tsutomu Sakamoto Masami | 1997 | Kogakubu Kenkyu Hokoku1997，49，1： | 1 |
| 8 | A Randomized Prospective Trial Comparing Unsedated Endoscopy via Transnasal and Transoral Routes Using 5.5-mm Video Endoscopy显示文摘 | Hidetaka Watanabe Naomi Watanabe Rieko Ogura Noriyuki Nishino Yasuyuki Saifuku Genyo Hitomi Yutaka Okamoto Keiichi Tominaga Naoto Yoshitake Michiko Yamagata Masami Orui Hideyuki Hiraishi | 2009 | Digestive Diseases and Sciences2009，，10： | 1 |
| 9 | Cells deficient in PARP-1 show an accelerated accumulation of DNA single strand breaks, but not AP sites, over the PARP-1-proficient cells exposed to MMS显示文摘 | Brian F. Pachkowski Keizo Tano Valeriy Afonin Rhoderick H. Elder Shunichi Takeda Masami Watanabe James A. Swenberg Jun Nakamura | 2009 | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis2009，，1： | 1 |
| 10 | Nucleolin as cell surface receptor for tumor necrosis factor-α inducing protein: a carcinogenic factor of Helicobacter pylori显示文摘 | Tatsuro Watanabe Hideaki Tsuge Takahito Imagawa Daisuke Kise Kazuya Hirano Masatoshi Beppu Atsushi Takahashi Kensei Yamaguchi Hirota Fujiki Masami Suganuma | 2010 | Journal of Cancer Research and Clinical Oncology2010，，6： | 1 |
| 11 | Prognostic analysis and a new risk model for Hodgkin lymphoma in Japan显示文摘 | Kuniaki Itoh Tomohiro Kinoshita Takashi Watanabe Kenichi Yoshimura Rumiko Okamoto Takaaki Chou Michinori Ogura Masami Hirano Hideki Asaoku Mitsutoshi Kurosawa Yoshiharu Maeda Ken Omachi Yukiyoshi Moriuchi Masaharu Kasai Kazunori Ohnishi Nobuyuki Takayama | 2010 | International Journal of Hematology2010，，3： | 1 |
| 12 | Is It Possible to Estimate the Depth of Submucosal Invasion of Early Gastric Cancer By Chromoendoscopy?显示文摘 | Yasuaki Nagami Hirohisa Machida Masami Nakatani Natsuhiko Kameda Hirotoshi Okazaki Hirokazu Yamagami Tetsuya Tanigawa Kenji Watanabe Toshio Watanabe Kazunari Tominaga Yasuhiro Fujiwara Nobuhide Oshitani Tetsuo Arakawa | 2009 | Gastrointestinal Endoscopy2009，，5： | 1 |
| 13 | Initiation of some energetic materials by microwave heating显示文摘 | Hasue Kazuo Tanabe Masami Watanabe Nobutune | 1990 | Propellants Explos Pyrotech1990，15，5： | 1 |
| 14 | Curcumin Maintenance Therapy for Ulcerative Colitis: Randomized, Multicenter, Double-Blind, Placebo-Controlled Trial显示文摘 | Hiroyuki Hanai Takayuki Iida Ken Takeuchi Fumitoshi Watanabe Yasuhiko Maruyama Akira Andoh Tomoyuki Tsujikawa Yosihihide Fujiyama Keiichi Mitsuyama Michio Sata Masami Yamada Yasushi Iwaoka Kazunari Kanke Hideyuki Hiraishi Kazuhisa Hirayama Hajime Arai Shi | 2006 | Clinical Gastroenterology and Hepatology2006，，12： | 1 |
| 15 | Elastic and damping properties from room temperature to 673 K in an AZ31 magnesium alloy 显示文摘 | Hiroyuki Watanabe Toshiji Mukai Masami Sugioka | 2004 | Scripta Materialia2004，51，： | 1 |
| 16 | Nucleolin as cell surface receptor for tumor necrosis factor-α inducing protein: a carcinogenic factor of Helicobacter pylori显示文摘 | Tatsuro Watanabe Hideaki Tsuge Takahito Imagawa Daisuke Kise Kazuya Hirano Masatoshi Beppu Atsushi Takahashi Kensei Yamaguchi Hirota Fujiki Masami Suganuma | 2010 | Journal of Cancer Research and Clinical Oncology2010，，6： | 1 |
| 17 | CASE REPORT: Acute Pancreatitis Induced by Diffuse Pancreatic Invasion of Adult T-cell Leukemia/Lymphoma Cells显示文摘 | Akinori Mori Yasuharu Kikuchi Shigeatsu Motoori Jun’ichiro Watanabe Masami Shinozaki Masanobu Eguchi | 2003 | Digestive Diseases and Sciences2003，，10： | 1 |
| 18 | LGR5‐Positive Colon Cancer Stem Cells Interconvert with Drug‐Resistant LGR5‐Negative cells and are Capable of Tumor Reconstitution显示文摘 | Shinta Kobayashi Hisafumi Yamada‐Okabe Masami Suzuki Osamu Natori Atsuhiko Kato Koichi Matsubara Yu Jau Chen Masaki Yamazaki Shinichi Funahashi Kenji Yoshida Eri Hashimoto Yoshinori Watanabe Hironori Mutoh Motooki Ashihara Chie Kato Takeshi Watanabe Takas | 2012 | STEM CELLS2012，，12： | 1 |
| 19 | Excitons in organic-inorganic hybrid cornpound(Cn H2n+1 NH3)2PbBr4(n= 4,5,7 and 12) 显示文摘 | NOBUAKI K MASAMI A WATANABE Y | 2010 | Thin Solid Films2010，518，： | 1 |
| 20 | Water‐soluble argatroban for antithrombogenic surface coating of tissue‐engineered cardiovascular tissues显示文摘 | Yasuhide Nakayama Saori Yamaoka Masashi Yamanami Megumi Fujiwara Masami Uechi Keiichi Takamizawa Hatsue Ishibashi‐Ueda Marie Nakamichi Kingo Uchida Taiji Watanabe Keiichi Kanda Hitoshi Yaku | 2011 | J Biomed Mater Res2011，，2： | 1 |
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