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| 1 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 2 | Degradation of chlorophenols by means of advanced oxidation processes: a general review 显示文摘 | Marc P T Veronica G M Miguel A B | 2004 | Applied Catalysis B: Environmental2004，47，： | 1 |
| 3 | IL-6,RANKL,TNF-alpha/IL-1:interrelations in bone resorption pathophysiology显示文摘 | Steeve KT Marc P Sandrine T | | 0，，： | 1 |
| 4 | Degradation of chlorophenols by means of advanced oxidation processes: a general review 显示文摘 | Marc P T Veronica G M Miguel A B | 2004 | Applied Catalysis B : Environmental2004，47，4： | 1 |
| 5 | Comparison of beta,johnson'ssb,weibull and truncated weibull functions for modeling the diame-ter distribution of forest stands in catalonia(North-East of Spain)显示文摘 | MARC P PUKKALA T BLASCO E | 2007 | European Journal of Forest Research2007，126，4： | 1 |
| 6 | Diagnostic perfor- mance of copeptin in patients with acute nontraumatic chest pain: BWH-TIMI ED chest pain study显示文摘 | Devraj Sukul Marc P Bonaca Christian T Ruff | 2014 | Clinical cardiology2014，37，4： | 1 |
| 7 | Insect herbivores drive real-time ecological and evolu- tionary change in plant populations 显示文摘 | Anurag A Agrawal Amy P Hastings Marc T J Johnson | 2012 | Science2012，338，6103： | 1 |
| 8 | Verónica G M,Miguel A B,Degradation of chlorophenols by means of advanced oxidation processes:a general review显示文摘 | Marc P T | 2004 | Applied Catalysis B:Environmental2004，47，4： | 1 |
| 9 | Morphological changes of the nucleolus during oogenesis in oviparous teleost Wsh, Barbus barbus 显示文摘 | Marc T Pascal P | 2005 | J Struct Biol2005，152，： | 1 |
| 10 | A study on human activity recognition using accelerometer data from smartphones显示文摘 | AKRAM B MARC P DUC A T | 2014 | Procedia Computer Science2014，34，： | 1 |
| 11 | Appli Cat B: Environ显示文摘 | Marc P T Veronica G M Miguel A B | 2004 | 47(4):219-2562004，47，4： | 1 |
| 12 | Melanin is an essential component for the integrity of the cell wall of Aspergillus fumigates conidia显示文摘 | Marc P Patrick V Guy T | 2009 | BMC Microbiology2009，9，1： | 1 |
| 13 | Sotagliflozin, a Dual SGLT1 and SGLT2 Inhibitor, as Adjunct Therapy to Insulin in Type 1 Diabetes显示文摘 | Sands Arthur T Zambrowicz Brian P Rosenstock Julio Lapuerta Pablo Bode Bruce W Garg Satish K Buse John B Banks Phillip Heptulla Rubina Rendell Marc Cefalu William T Strumph Paul | 2015 | Diabetes Care2015，，7： | 1 |
| 14 | Assessment of chitosan gels for the controlled release of agrochemicals 显示文摘 | Marc A T William J P Edward J D | 1990 | Ind Eng Chem Res1990，29，： | 1 |
| 15 | IL-6, RANKL, TNF-al- pha/IL-1: interrelations in bone resorption pathophysiology显示文摘 | Steeve K T Marc P Sandrine T | 2004 | Cytokine Growth Factor Rev2004，15，01： | 1 |
| 16 | A novel method for determining the nature of time series显示文摘 | Gautama T Mandic D P Marc M | 2004 | IEEE Transaction on Biomedical Engineering2004，51，5： | 1 |
| 17 | Temperature- dependent mechanical and long crack behavior of zirconium diboride silicon carbide composite 显示文摘 | Marc W B Robert P A Alfred F T | 2012 | Journal of the European Ceramic Society2012，32，12： | 1 |
| 18 | Two human host defense ribonucleases against mycobacteria,the eosinophil cationic protein(RNase 3)and rNase 7显示文摘 | DAVID P MARC T | 2013 | Antimicrobial Agents Chemother2013，57，： | 1 |
| 19 | Modeling the Channel Time-Variance for Fixed Wireless Communication显示文摘 | Steven T Liesbet V D P Marc E | 2002 | IEEE Communication Letters2002，6，8： | 1 |
| 20 | Porous inorganic membranes for CO2capture:present and prospects显示文摘 | Marc P T | 2014 | Chemical Reviews2014，114，2： | 1 |
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