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| 1 | Concordance of non-invasive mechanical and serum tests for liver fibrosis evaluation in chronic hepatitis C显示文摘AIM To determine the sensitivity and specificity of liver stiffness measurement(LSM) and serum markers(SM) for liver fibrosis evaluation in chronic hepatitis C.METHODS Between 2012 and 2014,81 consecutive hepatitis C virus(HCV) patients had METAVIR score from liver biopsy compared with concurrent results from LSM [transient elastography(TE) [FibroS can~/ARFI technology(Virtual Touch~)] and SM [FIB-4/aspartate aminotransferase-toplatelet ratio index(APRI)].The diagnostic performance of these tests was assessed using receiver operating characteristic curves.The optimal cut-off levels of each test were chosen to define fibrosis stages F ≥ 2,F ≥ 3 and F = 4.The Kappa index set the concordance analysis.RESULTS Fifty point six percent were female and the median age was 51 years(30-78).Fifty-six patients(70%) weretreatment-na?ve.The optimal cut-off values for predicting F ≥ 2 stage fibrosis assessed by TE were 6.6 kP a,for acoustic radiation force impulse(ARFI) 1.22 m/s,for APRI 0.75 and for FIB-4 1.47.For F ≥ 3 TE was 8.9 kP a,ARFI was 1.48 m/s,APRI was 0.75,and FIB-4 was 2.For F = 4,TE was 12.2 kP a,ARFI was 1.77 m/s,APRI was 1.46,and FIB-4 was 3.91.The APRI could not distinguish between F2 and F3,P = 0.92.The negative predictive value for F = 4 for TE and ARFI was 100%.Kappa index values for F ≥ 3 METAVIR score for TE,ARFI and FIB-4 were 0.687,0.606 and 0.654,respectively.This demonstrates strong concordance between all three screening methods,and moderate to strong concordance between them and APRI(Kappa index = 0.507).CONCLUSION Given the costs and accessibility of LSM methods,and the similarity with the outcomes of SM,we suggest that FIB-4 as well as TE and ARFI may be useful indicators of the degree of liver fibrosis.This is of particular importance to developing countries. | Denise C Paranaguá-Vezozzo Adriana Andrade Daniel F C Mazo Vinicius Nunes Ana L Guedes Taisa G Ragazzo Renata Moutinho Lucas S Nacif Suzane K Ono Venancio A F Alves Flair J Carrilho | 2017 | World Journal of Hepatology2017，9，8： | 7 |
| 2 | Calibration of Line-Scan Cameras 显示文摘 | Luna C A Mazo M Lazaro J L | 2010 | IEEE Transactions on Instrumentation and Measurement(S0018-9456)2010，59，8： | 1 |
| 3 | Distributed architecture for control and path planning of autonomous vehicles显示文摘 | Lazaro J L Garcla J C Mazo M | 2001 | Microprocessors and Microsystems2001，25，3： | 1 |
| 4 | Percutaneous distal metatarsal osteotomy for the correction of hallux valgus显示文摘 | VALLES-FIGUEROA J F RODR(I)GUEZ-RES(E)NDIZ F CALETI-Del MAZO E | 2010 | Acta Ortop Mex2010，24，6： | 1 |
| 5 | Diversity coding for transparent self-healing and fault-tolerant communication networks 显示文摘 | AYANOGLU E GITLIN R C I MAZO J | 1993 | IEEE Yrans on Communications1993，41，11： | 1 |
| 6 | Calibration of line- scan cameras 显示文摘 | Luna C A Mazo M Lzaro J L | 2010 | Instrumentation and Measurement IEEE Transactions on2010，59，8： | 1 |
| 7 | On the minimum distance problem for fas-ter-than-Nyquist signaling 显示文摘 | Mazo J E Landau H | 1988 | IEEE Trans on In formation Theory1988，34，6： | 1 |
| 8 | Pro- and anti-inflammatory cytokines in steatosis and steatohepatitis 显示文摘 | Rabelo F Oliveira CP Faintuch J Mazo DF Lima VM Stefano JT Barbeiro HV Soriano FG Alves VA Carrilho FJ | 2010 | Obes Surg2010，20，7： | 1 |
| 9 | Faster-than-Nyquist signaling显示文摘 | Mazo J E | 1975 | Bell System Technical Journal1975，54，8： | 1 |
| 10 | Faster-Than-Nyquist Signaling显示文摘 | Mazo J E | 1975 | Bell Sys- tem Technical Journal1975，54，8： | 1 |
| 11 | Anisotro py effects in atomic scale friction显示文摘 | Gnecco E Fajardo O Y Pina C M Mazo J J | 2012 | Tribology Let- ters2012，48，1： | 1 |
| 12 | Surface defects and tempera ture on atomic friction显示文摘 | Fajardo O Y Mazo J J | 2011 | Journal of Physics: Con- densed Matter2011，23，35： | 1 |
| 13 | Reduction of blind zone in ultrasonic transmitter/receiver transducers显示文摘 | Hemhndez A Urea J Mazo M | 2007 | Sensors and Actuators2007，133，1： | 1 |
| 14 | Design and signal processing of a magnetic sensor array for train wheel detection 显示文摘 | DONATO P G URE A J MAZO M | 2006 | Sensors and Actuators A: Physical2006，132，2： | 1 |
| 15 | High reliability outdoor sonar prototype based on efficient signal coding显示文摘 | Alvarez F Urefia J Mazo M | 2006 | IEEE Transactions on Ultrasonics Ferroelectfics and Frequency Control2006，53，10： | 1 |
| 16 | Fasler-than-nyquisl signaling显示文摘 | Mazo J E | 1975 | The bell sys- tem tec''h nic al jnurnal1975，54，8： | 1 |
| 17 | Postoperative pulmonary complications 显示文摘 | Canet J Mazo V | 2010 | Minerva Anestesiol2010，76，2： | 1 |
| 18 | Modeling a radiant floor system with phase change material (PCM) integrated into a building simulation tool: Analysis of a case study of a floor heating system coupled to a heat pump显示文摘 | Mazo J Delgado M Zalba B | 2012 | Energy Buil- dings2012，47，： | 1 |
| 19 | Faster-than-Nyquist Signaling显示文摘 | Mazo J E | 1975 | The Bell System Technical Journal1975，54，08： | 1 |
| 20 | Opioid growth factor modulates angiogenesisl显示文摘 | Blebea J Mazo J E Kihara T K | 2000 | Journal Of Vascular Surgery2000，32，2： | 1 |
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