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| 1 | Fast increasing of surface ozone concentrations in Pearl River Delta characterized by a regional air quality monitoring network during 2006–2011显示文摘Based on the observation by a Regional Air Quality Monitoring Network including 16 monitoring stations, temporal and spatial variations of ozone(O3), NO2and total oxidant(Ox) were analyzed by both linear regression and cluster analysis. A fast increase of regional O3concentrations of 0.86 ppbV/yr was found for the annual averaged values from 2006 to 2011 in Guangdong, China. Such fast O3increase is accompanied by a correspondingly fast NOx reduction as indicated by a fast NO2 reduction rate of 0.61 ppbV/yr. Based on a cluster analysis, the monitoring stations were classified into two major categories – rural stations(non-urban) and suburban/urban stations. The O3concentrations at rural stations were relatively conserved while those at suburban/urban stations showed a fast increase rate of 2.0 ppbV/yr accompanied by a NO2 reduction rate of 1.2 ppbV/yr. Moreover, a rapid increase of the averaged O3 concentrations in springtime(13%/yr referred to 2006 level) was observed, which may result from the increase of solar duration, reduction of precipitation in Guangdong and transport from Eastern Central China. Application of smog production algorithm showed that the photochemical O3production is mainly volatile organic compounds(VOC)-controlled. However, the photochemical O3production is sensitive to both NOx and VOC for O3pollution episode. Accordingly, it is expected that a combined NOx and VOC reduction will be helpful for the reduction of the O3 pollution episodes in Pearl River Delta while stringent VOC emission control is in general required for the regional O3 pollution control. | Jinfeng Li Keding Lu Wei Lv Jun Li Liuju Zhong Yubo Ou Duohong Chen Xin Huang Yuanhang Zhang | 2014 | Journal of Environmental Sciences2014，26，1： | 51 |
| 2 | Significance of dredging on sediment denitrification in Meiliang Bay,China:A year long simulation study显示文摘An experiment for studying the effects of sediment dredging on denitrification in sediments was carried out through a one-year incubation of undredged (control) and dredged cores in laboratory. Dredging the upper 30 cm of sediment can significantly affect physico-chemical characteristics of sediments. Less degradation of organic matter in the dredged sediments was found during the experiment. Denitrification rates in the sediments were estimated by the acetylene blockage technique, and ranged from 21.6 to 102.7 nmol N2/(g dry weight (dw)·hr) for the undredged sediment and from 6.9 to 26.9 nmol N2/(g dw·hr) for dredged sediments. The denitrification rates in the undredged sediments were markedly higher (p<0.05) than those in the dredged sediments throughout the incubation, with the exception of February 2006. The importance of various environmental factors on denitrification was assessed, which indicated that denitrification was regulated by temperature. Nitrate was probably the key factor limiting denitrification in both undredged and dredged sediments. Organic carbon played some role in determining the denitrification rates in the dredged sediments, but not in the undredged sediments. Sediment dredging influenced the mineralization of organic matter and denitrification in the sediment; and therefore changed the pattern of inherent cycling of nitrogen. | Jicheng Zhong Chengxin Fan Lu Zhang Edward Hall Shiming Ding Bao Li Guofeng Liu | 2010 | Journal of Environmental Sciences2010，22，1： | 40 |
| 3 | 基于小基线DInSAR技术监测太原市2003-2009年地表形变场显示文摘基于高相干点目标反演缓慢地表形变已成为当前DInSAR技术的研究热点.本文通过融合PS方法和相干目标法优点,采用小基线DInSAR技术提取城市地表形变场,并重点分析了地表线性形变的反演.在此基础上,以太原市为研究区,利用23景ENVISAT ASAR影像,提取了该市2003~2009年的地表形变场.研究结果表明:(1)在该阶段太原市存在有4个明显的沉降中心,即下元、吴家堡、小店、孙家寨,其中最大沉降中心孙家寨的平均沉降速率为-77.28 mm/a;(2)老沉降中心万柏林沉降趋于缓和,北部地区沉降停止,甚至出现反弹;(3)沉降中心的变化说明太原市采取的'关井压采'控沉措施取得初步成效;(4)水准数据验证了监测结果,精度达到2.90 mm,表明小基线DInSAR技术可满足城市地表形变监测需求. | 吴宏安 张永红 陈晓勇 Lu Zhong 都洁 孙中惠 孙广通 | 2011 | 地球物理学报2011，54，3： | 35 |
| 4 | New vacuum solar telescope and observations with high resolution显示文摘The New Vacuum Solar Telescope(NVST) is a one meter vacuum solar telescope that aims to observe fine structures on the Sun. The main goals of NVST are high resolution imaging and spectral observations, including measurements of the solar magnetic field. NVST is the primary ground-based facility used by the Chinese solar research community in this solar cycle. It is located by Fuxian Lake in southwest China, where the seeing is good enough to perform high resolution observations. We first introduce the general conditions at the Fuxian Solar Observatory and the primary science cases of NVST. Then, the basic structures of this telescope and instruments are described in detail. Finally, some typical high resolution data of the solar photosphere and chromosphere are also shown. | Zhong Liu Jun Xu Bo-Zhong Gu Sen Wang Jian-Qi You Long-Xiang Shen Ru-Wei Lu Zhen-Yu Jin Lin-Fei Chen Ke Lou Zhi Li Guang-Qian Liu Zhi Xu Chang-Hui Rao Qi-Qian Hu Ru-Feng Li Hao-Wen Fu Feng Wang Men-Xian Bao Ming-Chan Wu Bo-Rong Zhang | 2014 | Research in Astronomy and Astrophysics2014，14，6： | 37 |
| 5 | Does Helicobacter pylori infection play a role in iron deficiency anemia? A meta-analysis显示文摘AIM:To perform a meta-analysis of observational studies and randomized controlled trials(RCTs)on the association between Helicobacter pylori(H.pylori)and iron deficiency anemia(IDA).METHODS:A defined search strategy was used to search Medline,Embase,the Cochrane Library,Clinical Trials,Cochrane Central Register of Controlled Trials,Premedline and Healthstar.Odds ratio(OR)was used to evaluate observational epidemiology studies,and weighted mean difference(WMD)was used to demonstrate the difference between control and intervention groups.RESULTS:Fifteen observational studies and 5 RCTs were identified and used for calculation.The pooled OR for observational studies was 2.22(95%CI:1.52-3.24,P<0.0001).The WMD for hemoglobin(HB) was 4.06 g/L(95%CI:-2.57-10.69,P=0.01),and the WMD for serum ferritin(SF)was 9.47μg/L(95%CI:-0.50-19.43,P<0.0001).Results were heterogeneous for all comparisons.CONCLUSION:This meta-analysis on observational studies suggests an association between H.pylori and IDA.In RCTs,eradication of H.pylori can improve HB and SF levels but not significantly. | Qu, Xin-Hua Huang, Xiao-Lu Xiong, Ping Zhu, Cui-Ying Huang, You-Liang Lu, Lun-Gen Sun, Xu Rong, Lan Zhong, Liang Sun, Da-Yu Lin, Hai Cai, Ming-Ci Chen, Zhi-Wei Hu, Bing Wu, Lian-Ming Jiang, Yi-Bin Yan, Wei-Li | 2010 | World Journal of Gastroenterology2010，16，7： | 34 |
| 6 | The role of autophagy in cardiac hypertrophy显示文摘Autophagy 从更低的优核质在自然被保存到哺乳动物并且是一重要自我吃, degradative processthat 贡献过剩材料的消除。心脏的肥大被过量 proteinsynthesis,增加的 cardiomyocyte 尺寸,和变厚的室的墙首先描绘并且是支持 arrhythmiaand 心失败的一个主要风险因素。在最近的年里, cardiomyocyte autophagy 被认为在控制 hypertrophicresponse 起一个作用。然而,在心脏的肥大的 cardiomyocyte autophagy 的有益或加重的角色仍然是在心脏的肥大的 cardiomyocyte autophagy 的准确机制进一步要求的 controversial.The 学习。在这评论,我们在心脏的肥大与 autophagy 联系的 summarizethe 争吵并且在心脏的肥大的 thedevelopment 提供卓见进 autophagy 的角色。我们断定未来研究应该强调在 autophagy andthe 之间的关系心脏的肥大的不同阶段,以及 autophagic 流动和选择 autophagy。Autophagy 将是为心脏的肥大的一个 potentialtherapeutic 目标。 | Lanfang Li Jin Xu Lu He Lijun Peng Qiaoqing Zhong Linxi Chen Zhisheng Jiang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，6： | 30 |
| 7 | Influence of Sediment Dredging on Chemical Forms and Release of Phosphorus显示文摘A laboratory experiment was carried out through a six-month incubation of undredged (control) and dredged cores to study the effect of sediment dredging on phosphorus (P) release from the sediment in the Taihu Lake.During the experiment,dredging the upper 30 cm layer could efficiently reduce the interstitial PO_4^(3-)-P concentration and different P forms in the sediment.The P fluxes of the undredged and dredged cores ranged from-5.1 to 3047.6 and-60.7 to 14.4μg m^(-2) d^(-1),respectively.The fluxes of the dredged cores were generally lower than those of the control.Differences in the fluxes between the dredged and undredged cores were statistically significant (P<0.05) from March to June 2006. The sediment P in the dredged cores had a lower release potential than that in the control.Dredging can be considered as a useful measure for rehabilitating the aquatic ecosystem after the external P loading in the Taihu Lake catchment was efficiently reduced. | ZHONG Ji-Cheng YOU Ben-Sheng FAN Cheng-Xin LI Bao ZHANG Lu DING Shi-Ming | 2008 | Pedosphere2008，18，1： | 27 |
| 8 | Postoperative adjuvant antiviral therapy for hepatitis B/C virus-related hepatocellular carcinoma:A meta-analysis显示文摘AIM:To investigate the impact of postoperative antiviral treatment on tumor recurrence and survival of patients with chronic hepatitis B virus(HBV) or hepatitis C virus(HCV) infection-related primary hepatocellular carcinoma(HCC) after curative therapy.METHODS:We performed a meta-analysis of randomized and non-randomized control trials from electronic search and manual search.The fixed effect model of Mantel-Haenszel method and the random effect model of Der Simonian and Laird method were used for homogeneous and heterogeneous studies,respectively.Seven HCV-related studies,three HBV-related studies and three studies on HBV or HCV-related HCC were identified.RESULTS:A total of 1224 patients were included in this analysis.The estimated odds ratios(OR) for the 1-,2-,3-and 5-year recurrence were 0.54 [15.4% vs 24.1%,95% confidence interval(CI):0.32-0.89,P=0.02],0.42(36.9% vs 58.0%,95% CI:0.19-0.90,P=0.03),0.37(47.9% vs 63.8%,95% CI:0.19-0.71,P=0.003),and 0.32(66.7% vs 74.3%,95% CI:0.15-0.66,P=0.002),respectively;and the OR for the 1-,2-,3-,5-and 7-year mortality were 0.23(1.2% vs 9.1%,95% CI:0.07-0.71,P=0.01),0.31(6.4% vs 22.1%,95% CI:0.12-0.79,P=0.01),0.43(12.7% vs 20.8%,95% CI:0.21-0.89,P=0.02),0.42(25.1% vs 42.0%,95% CI:0.27-0.66,P=0.0002) and 0.28(31.9% vs 52.2%,95% CI:0.13-0.59,P=0.0008).CONCLUSION:This meta-analysis indicates the postoperative antiviral therapy,interferon in particular,may serve as a favorable alternative to reduce recurrence and mortality in patients with HBV/HCV related HCCs. | Miao, Ruo-Yu Zhao, Hai-Tao Yang, Hua-Yu Mao, Yi-Lei Lu, Xin Zhao, Yi Liu, Chang-Ning Zhong, Shou-Xian Sang, Xin-Ting Huang, Jie-Fu | 2010 | World Journal of Gastroenterology2010，16，23： | 26 |
| 9 | pORF5 plasmid protein of Chlamydia trachomatis induces MAPK-mediated pro-inflammatory cytokines via TLR2 activation in THP-1 cells显示文摘Infection with Chlamydia trachomatis induces inflammatory pathologies in the urogenital tract that can lead to infertility and ectopic pregnancy.Pathogenesis of infection has been mostly attributed to excessive cytokine production.However,precise mechanisms on how C.trachomatis triggers this production,and which protein(s) stimulate inflammatory cytokines remains unknown.In the present study,the C.trachomatis pORF5 protein induced tumor necrosis factor alpha(TNF-α),interleukin-1 beta(IL-1β) and interleukin-8(IL-8) in dose-and time-dependent manners in the THP-1 human monocyte cell line.We found that intracellular p38/mitogen-activated protein kinase(MAPK) and extracellular signal-regulated kinase(ERK)/MAPK signaling pathways were required for the induction of TNF-α,IL-1β and IL-8.Blockade of toll-like receptor 2(TLR2) signaling reduced induction levels of TNF-α,IL-8 and IL-1β.We concluded that the C.trachomatis pORF5 protein might contribute to the inflammatory processes associated with chlamydial infections. | ZHOU Hui HUANG QiuLin LI ZhongYu WU YiMou XIE XiaoBing MA KangKang CAO WenJuan ZHOU Zhou LU ChunXue ZHONG GuangMing | 2013 | Science China(Life Sciences)2013，56，5： | 26 |
| 10 | Relative Contributions of Boundary-Layer Meteorological Factors to the Explosive Growth of PM2.5 during the Red-Alert Heavy Pollution Episodes in Beijing in December 2016显示文摘Based on observations of urban mass concentration of fine particulate matter smaller than 2.5 μm in diameter(PM_(2.5)), ground meteorological data, vertical measurements of winds, temperature, and relative humidity(RH), and ECMWF reanalysis data, the major changes in the vertical structures of meteorological factors in the boundary layer(BL) during the heavy aerosol pollution episodes(HPEs) that occurred in winter 2016 in the urban Beijing area were analyzed. The HPEs are divided into two stages: the transport of pollutants under prevailing southerly winds, known as the transport stage(TS), and the PM_(2.5) explosive growth and pollution accumulation period characterized by a temperature inversion with low winds and high RH in the lower BL, known as the cumulative stage(CS). During the TS, a surface high lies south of Beijing, and pollutants are transported northwards. During the CS, a stable BL forms and is characterized by weak winds, temperature inversion, and moisture accumulation. Stable atmospheric stratification featured with light/calm winds and accumulated moisture(RH > 80%) below 250 m at the beginning of the CS is closely associated with the inversion, which is strengthened by the considerable decrease in near-surface air temperature due to the interaction between aerosols and radiation after the aerosol pollution occurs. A significant increase in the PLAM(Parameter Linking Aerosol Pollution and Meteorological Elements) index is found, which is linearly related to PM mass change. During the first 10 h of the CS, the more stable BL contributes approximately 84% of the explosive growth of PM_(2.5) mass. Additional accumulated near-surface moisture caused by the ground temperature decrease, weak turbulent diffusion, low BL height, and inhibited vertical mixing of water vapor is conducive to the secondary aerosol formation through chemical reactions, including liquid phase and heterogeneous reactions, which further increases the PM_(2.5) concentration levels. The contribution of these reaction mechanisms to the explosive growth of PM_(2.5) mass during the early CS and subsequent pollution accumulation requires further investigation. | junting zhong xiaoye zhang yaqiang wang junying sun yangmei zhang jizhi wang kaiyan tan xiaojing shen haochi che lu zhang zhouxiang zhang xuefei qi huarong zhao sanxue ren yang li | 2017 | Journal of Meteorological Research2017，31，5： | 25 |
| 11 | Protective effects of polydatin against CCl_4-induced injury to primarily cultured rat hepatocytes显示文摘NTRODUCTIONPolygonumcuspidatumSieb.etZucc.(Polygonaceae)isatraditionalChineseherbaldrug,withbitertasteandcoldnature.Itmainly... | HUANG Zhao Sheng, WANG Zong Wei, LIU Ming Ping, ZHONG Shi Qing, LI Qiao Mei and RONG Xiang Lu | 1999 | World Journal of Gastroenterology1999，5，1： | 24 |
| 12 | Effects of hydrodynamics processes on phosphorus fluxes from sediment in large,shallow Taihu Lake显示文摘在湖沉积,超营养作用的一个主要原因和水质的随后的恶化的磷(P) 的周转,需要深理解。在这研究, P 版本上的暂停的效果与 Y 形状仪器在圆柱的缩影被学习。结果显示在越过沉积水接口(Fss ) 和风速度的推迟的物质的流动之间有一道正相关,并且增加的 FSS 在各个期间弯屈由一个稳定的状态跟随的过程。在轻、中等、大的风条件下面的最大的 FSS 是 299.9 ± 4 1.1, 573.4 ± 6 1.7,和 2093.8 ± 2 15.7 g/m2 分别地。然而,越过沉积水接口(FP ) 的 P 的流动没作为反应弯屈紧张的 Fss 跟随一个类似的模式,它增加了并且到达最大值在起始为光的 120 min 弯屈,然后逐渐地减少了,与 9.4 ± 1 .9 mg/m2 的最大的流动。在开始的 30 min 的 FP 的快速的增加在中等的风下面被观察,与 11.2 ± 0 .6 mg/m2 的最大的流动。令人惊讶地,大风与 3.5 ± 0 .9 mg/m2 的最大的流动比在轻、中等的风条件下面引起了更少的 FP。在水列的 Fss 在风以后在沉积过程期间显然衰退了,但是 FP 与风政体变化了。没有明显的差别在 8 h 沉积过程以后在 FP 上被检测,与起始的值相比,它意味着小冗余的 P 在风以后在水列离开了。 | YOU Ben-sheng ZHONG Ji-cheng FAN Cheng-xin WANG Tong-cheng ZHANG Lu DING Shi-ming | 2007 | Journal of Environmental Sciences2007，19，9： | 23 |
| 13 | Assessment of selenium pollution in agricultural soils in the Xuzhou District,Northwest Jiangsu, China显示文摘Xuzhou City is an important base for coal production and coal-fired power. To evaluate selenium contamination in this area, we sampled agricultural soil, soil profile, irrigation water, bedrock, coal, fly ash, paddy rice, and vegetables from the north of Xuzhou City, and determined their selenium contents. The background level of selenium in the soil profile was 0.08 mg/kg. The selenium concentrations in agricultural soils and irrigation water were in the range of 0.21-4.08 mg/kg and 0.002-0.29 mg/L, respectively. Soils with high selenium content were located closely to coalmines and power plants. The average selenium concentrations in coal and coal fly ash were 5.46 and 2.81 mg/kg, respectively. In contrast, the concentrations of selenium in bedrock and in the soil profile were very low. These results imply that the high selenium level in agricultural soils is mainly caused by anthropogenic activities, rather than by parent material. The arithmetic mean of selenium concentration in paddy rice was 0.116 mg/kg, and in cabbage was 0.05 mg/kg. The selenium concentration in rice was positively correlated with total selenium concentration in soil, suggesting that selenium in soil is readily transferred into the crops. Furthermore, the estimated dietary intake (88.8 μg) of selenium from paddy rice and cabbage exceeds the recommended dietary allowance (55 μg). Therefore, there is a potential health risk from consumption of local staple food in the study area. | HUANG Shunsheng HUA Ming FENG Jinshun ZHONG Xinyong JIN Yang ZHU Baiwan LU Hua | 2009 | Journal of Environmental Sciences2009，21，4： | 22 |
| 14 | Paleoproterozoic reworking of ancient crust in the Cathaysia Block,South China:Evidence from zircon trace elements,U-Pb and Lu-Hf isotopes显示文摘A combined study of zircon LA-ICP-MS U-Pb dating, trace elements and Hf isotope was carried out for gneissic granite from the Sanzhishu area in Jingning, SW Zhejiang Province. Nearly all the zircons separated from the granite exhibited oscillatory zoning and high Th/U ratios (>0.1). The REE profile showed a pronounced positive Ce anomaly, negative Eu anomaly and an enrichment of HREE, which are typical characteristics of magmatic zircon. Thirteen concordant or nearly concordant analytical data yielded a weighted mean 207Pb/206Pb age of 1860±13 Ma (MSWD=0.084), representing the formation age of the granite. The magmatic zircons had negative εHf(t) values of -15.6 to -10.0 and two-stage Hf model ages of 3.1 to 3.4 Ga, indicating that the granites were formed by reworking of ancient crust. The major- and trace-element data indicate that the gneissic granites are metaluminous high-K calc-alkaline rocks and exhibit the same geochemical characteristics as aluminous A-type granites, implying the emplacement of the granite in a post-orogenic extensional tectonic setting. We conclude that the Pa-leoproterozoic crustal reworking event in the Cathaysia Block of South China marked the transition from assembly to break-up of the Columbia supercontinent. | LIU Rui ZHOU Han Wen ZHANG Li ZHONG ZengQiu ZENG Wen XIANG Hua JIN Song LU Xin Qian LI ChunZhong | 2009 | Chinese Science Bulletin2009，54，9： | 22 |
| 15 | Relationship between serum HBV DNA level and HBV-specific, nonspecific cytotoxic T lymphocytes and natural killer cells in patients with chronic hepatitis B显示文摘有到对肝炎 B 病毒(HBV ) 的抗病毒的治疗的长期的肝炎 B (CHB ) 的病人的反应与 HBV DNA 的基础线水平有关的背景,而是机制不是清楚的。现在的学习试图理解在 HBV DNA 的水平之间的可能的关系并且HBV特定, nonspecific 细胞毒素的 T 淋巴细胞( CTL )和生来的杀手( NK ) CHB 病人和机制的房间 HBV DNA 水平怎么完全影响抗病毒的治疗学的 effect.Methods 为 HBV DNA 积极的有 CHB 的 100 个成年病人, HBeAg 并且( HLA ) -A2 被注册进这研究。HBV DNA 被实时荧光测试量的聚合酶链反应(PCR ) 。特定的 HBV 和 nonspecific CTL 和 NK 房间被 flowcytometry 测试。浆液丙氨酸 aminotransferase (中高音) 和全部的 bilirubin (Tbil ) 用平淡的生物化学的测试为每个病人被决定。100 个盒子基于他们的 HBV DNA 水平被分到二个组:组 A 有 48 个盒子,他们的 HBV DNA 水平是 104-105 copies/ml,组 B 有 52 个盒子,他们的 HBV DNA 水平是 106-107 copies/ml。 HBV 特定的 CTL , nonspecific CTL , NK 房间,二个组的中高音和 Tbil 是组 A 的 compared.Results HBV DNA 水平, B 是( 4.81 ???????????????????????????????倠???‵??吗????????湯汣獵潩獮?? | GU Xi-bing YANG Xiao-juan WANG Dong HUA Zhong XU Yue-qin LU Zhong-hua | 2009 | Chinese Medical Journal2009，，18： | 23 |
| 16 | Somatosensory neuron types identified by high-coverage single-cell RNA-sequencing and functional heterogeneity显示文摘感觉神经原被不同发信号的网络和接受特征区分。因此,感觉神经原类型能被连接基于 transcriptome 的神经原与感觉显型打字定义。这里,我们分类老鼠的 somatosensory 神经原由高范围的单个房间的定序 RNA 的背面的根中心(DRG )(10 950 ±1 218 基因每神经原) 并且神经原基于尺寸的层次聚类。而且,对皮肤的刺激作出回应的单个 DRG 神经原被记录用一在里面 vivo 整个房间的补丁夹钳技术并且由神经原类型分类基因标记。小直径 DRG 神经原被分类进低阀值的 mechanoreceptor 的一种类型和 mechanoheat nociceptors (MHN ) 的五种类型。每 MHN 类型进一步被分成二种子类型。大 DRG 神经原被分成四种类型,包括表示联系 BAI1 的蛋白质 2-like 的 neurexophilin 1 快车 MHN 和机械 nociceptors (MN ) 1 (Baiap2l1 ) 。表示 trafficking 蛋白质粒子建筑群 3-like 和 Baiap2l1 显著的 MN 的 Mechanoreceptors 各被细分进二种子类型。这些结果为编目 somatosensory 神经原和他们的 transcriptome 数据库提供一个新系统。 | Chang-Lin Li Kai-Cheng Li Dan Wu Yan Chen Hao Luo Jing-Rong Zhao Sa-Shuang Wang Ming-Ming Sun Ying-Jin Lu Yan-Qing Zhong Xu-Ye Hu Rui Hou Bei-Bei Zhou Lan Bao Hua-Sheng Xiao Xu Zhang | 2016 | Cell Research2016，26，1： | 21 |
| 17 | Caledonian reworking of Paleoproterozoic basement in the Cathaysia Block: Constraints from zircon U-Pb dating, Hf isotopes and trace elements显示文摘A combined study of zircon U-Pb dating, Hf isotopes and trace elements has been carried out for granodioritic neosomes of migmatites from the Tianjingping area in northwestern Fujian Province. Zircons are characterized by zoning, higher Th/U ratios (mostly ≥0.1), HREE enrichment, and positive Ce and negative Eu anomalies, and show features similar to magmatic or anatectic zircons. Apparent 206Pb/238U ages for the zircons are 447±2 Ma (95% conf., MSWD = 0.88), corresponding to a Caledonian event. εHf(t) values are ?13.3 to ?9.7, indicating a crustal source. Two-stage Hf model ages are 1.7 to 1.9 Ga, suggesting that protolith of the migmates was probably formed in the Paleoproterozoic. The granodioritic neosomes have the characteristics of peraluminous calc-alkaline granite, and their REE patterns and trace elements spidergrams show features of middle to upper crustal rocks. Together with previous studies, we conclude that the protolith of the Cathaysia basement in the Tianjingping area was likely formed in the middle-late Paleoproterozoic and experienced partial melting during the Caledonian period. The recognition of Caledonian reworking of the Paleoproterozoic basement in the Cathaysia Block provides a new insight into the tectonic evolution of the Cathaysia Block in the Caledonian pe- riod and the interaction between the Cathaysia Block and the Yangtze Block. | ZENG Wen ZHANG Li ZHOU HanWen ZHONG ZengQiu XIANG Hua LIU Rui JIN Song LU XinQian LI ChunZhong | 2008 | Chinese Science Bulletin2008，53，6： | 21 |
| 18 | Increased expression of Toll-like receptor 4 on peripheral-blood mononuclear cells in patients with coronary arteriosclerosis disease显示文摘 | Geng HL Lu HQ Zhang LZ Zhang H Zhou L Wang H Zhong RQ | 2006 | 第二军医大学学报2006，27，5： | 20 |
| 19 | Magnesium isoglycyrrhizinate inhibits inflammatory response through STAT3 pathway to protect remnant liver function显示文摘AIM: To investigate the protective effect of magnesium isoglycyrrhizinate(Mg IG) on excessive hepatectomy animal model and its possible mechanism.METHODS: We used the standard 90% hepatectomy model in Sprague-Dawley rats developed using the modified Emond's method,in which the left,middle,right upper,and right lower lobes of the liver were removed. Rats with 90% liver resection were divided into three groups,and were injected intraperitoneally with 3 m L saline(control group),30 mg/kg(low-dose group) and 60 mg/kg(high-dose group) of Mg IG,respectively. Animals were sacrificed at various time points and blood was drawn from the vena cava. Biochemical tests were performed with an automatic biochemical analyzer for the following items: serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),glutamyl endopeptidase,total bilirubin(TBil),direct bilirubin(DBil),total protein,albumin,blood glucose(Glu),hyper-sensitivity C-reactive protein,prothrombin time(PT),and thrombin time(TT). Postoperative survival time was observed hourly until death. Hepatocyte regeneration was analyzed by immunohistochemistry. Serum inflammatory cytokines(IL-1,IL-6,IL-10,and i NOS) was analyzed by ELISA. STAT3 protein and m RNA were analyzed by Western blot and quantitative reversetranscription PCR,respectively.RESULTS: The high-dose group demonstrated a significantly prolonged survival time,compared with both the control and the low-dose groups(22.0 ± 4.7 h vs 8.9 ± 2.0 vs 10.3 ± 3.3 h,P = 0.018). There were significant differences among the groups in ALT,Glu and PT levels starting from 6 h after surgery. The ALT levels were significantly lower in the Mg IG treated groups than in the control group. Both Glu and PT levels were significantly higher in the Mg IG treated groups than in the control group. At 12 h,ALT,AST,TBil,DBil and TT levels showed significant differences between the Mg IG treated groups and the control group. No significant differences in hepatocyte regeneration were found. Compared to the control group,the high-dose group showed a significantly increase in serum inflammatory cytokines IL-1 and IL-10,and a decrease in IL-6. Both STAT3 protein and m RNA levels were significantly lower in the Mg IG treated groups than in the control group at 6 h,12 h,and 18 h after surgery.CONCLUSION: High-dose Mg IG can extend survival time in rats after excessive hepatectomy. This hepatoprotective effect is mediated by inhibiting the inflam-matory response through inhibition of the STAT3 pathway. | Guang-Hua Tang Hua-Yu Yang Jin-Chun Zhang Jin-Jun Ren Xin-Ting Sang Xin Lu Shou-Xian Zhong Yi-Lei Mao | 2015 | World Journal of Gastroenterology2015，21，43： | 20 |
| 20 | Preliminary results of environmental monitoring of the natural gas hydrate production test in the South China Sea显示文摘Natural gas hydrate (NGH)is considered as one of the new clean energy sources of the 21st century with the highest potential.The environmental issues of NGH production have attracted the close attention of scientists in various countries.From May 10 to July 9,2017,the first offshore NGH production test in the South China Sea (SCS)was conducted by the China Geological Survey.In addition,environmental security has also been effectively guaranteed via a comprehensive environmental monitoring system built during the NGH production test.The monitoring system considered sea-surface atmosphere methane and carbon dioxide concentrations,dissolved methane in the sea water column,and the seafloor physical oceanography and marine chemistry environment.The whole process was monitored via multiple means, in multiple layers,in all domains,and in real time.After the production test,an environmental investigation was promptly conducted to evaluate the environmental impact of the NGH production test. The monitoring results showed that the dissolved methane concentration in seawater and the near-seabed environment characteristics after the test were consistent with the background values,indicating that the NGH production test did not cause environmental problems such as methane leakage. | Jian-liang Ye Xu-wen Qin Hai-jun Qiu Qian-yong Liang Yi-fei Dong Jian-gong Wei Hai-long Lu Jing-an Lu Yao-hong Shi Chao Zhong Zhen Xia | 2018 | China Geology2018，1，2： | 19 |
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